Yost, H. Joseph, PhD

Vice-Chair, Basic Science Research, Department of Pediatrics


Lab Website


  • English

Academic Information

  • Departments: Neurobiology & Anatomy - Professor, Pediatrics - Adjunct Professor
  • Divisions: Pediatric Hematology/Oncology

Academic Office Information

  • George and Dolores Eccles Institute of Human Genetics
    15 N 2030 E, Room: 3160
    Salt Lake City, UT 84112

Email: joseph.yost@utah.edu

Academic Bio

Joseph Yost, PhD, is a professor of Neurobiology and Anatomy, an adjunct professor of Pediatrics at the University of Utah, and a member of the Cell Response and Regulation group.

He studies genetics, particularly the difference between genes that develop normally and genes that can lead to cancer. Yost researches an important cellular process in which small molecules (proteoglycans) are added to proteins and allow for these proteins to be in the right place to transmit their signals. These signals are important when cells communicate with each other and are often not working correctly during cancer metastasis (when cancer spreads to other parts of the body).

Yost received his undergraduate degree from Creighton University, Omaha, and a PhD from the University of Chicago.

Education History

Type School Degree
Other Training University of Utah School of Business
Business Administration
Postdoctoral Fellowship University of California, Berkeley
Molecular and Cell Biology
Postdoctoral Fellow
Postdoctoral Fellowship University of California, Berkeley
Molecular and Cell Biology
Postdoctoral Fellow
Postdoctoral Fellowship University of Chicago
Molecular Genetics and Cell Biology
Postdoctoral Fellow
Doctoral Training University of Chicago
Undergraduate Creighton University
Honors Program and Biology

Selected Publications

Journal Article

  1. Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM (2007 Mar 1). Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer, 120(5), 1005-12.
  2. Cadwallader AB, Yost HJ (2007 Feb). Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: III. 2-O-sulfotransferase and C5-epimerases. Dev Dyn, 236(2), 581-6.
  3. Takeuchi JK, Lickert H, Bisgrove BW, Sun X, Yamamoto M, Chawengsaksophak K, Hamada H, Yost HJ, Rossant J, Bruneau BG (2007 Jan 16). Baf60c is a nuclear Notch signaling component required for the establishment of left-right asymmetry. Proc Natl Acad Sci U S A, 104(3), 846-51.
  4. Luo W, Peterson A, Garcia BA, Coombs G, Kofahl B, Heinrich R, Shabanowitz J, Hunt DF, Yost HJ, Virshup DM (2007 Mar 21). Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex. EMBO J, 26(6), 1511-21.
  5. Tsai IC, Amack JD, Gao ZH, Band V, Yost HJ, Virshup DM (2007 Mar). A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein. Dev Cell, 12(3), 335-47.
  6. Sato M, Tsai HJ, Yost HJ (2006 Oct 1). Semaphorin3D regulates invasion of cardiac neural crest cells into the primary heart field. Dev Biol, 298(1), 12-21.
  7. Nadauld LD, Chidester S, Shelton DN, Rai K, Broadbent T, Sandoval IT, Peterson PW, Manos EJ, Ireland CM, Yost HJ, Jones DA (2006 Sep 5). Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development. Proc Natl Acad Sci U S A, 103(36), 13409-14.
  8. Cadwallader AB, Yost HJ (2006 Dec). Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: I. The 3-O-sulfotransferase family. Dev Dyn, 235(12), 3423-31.
  9. Cadwallader AB, Yost HJ (2006 Dec). Combinatorial expression patterns of heparan sulfate sulfotransferases in zebrafish: II. The 6-O-sulfotransferase family. Dev Dyn, 235(12), 3432-7.
  10. Yoshigi M, Hoffman LM, Jensen CC, Yost HJ, Beckerle MC (2005 Oct 24). Mechanical force mobilizes zyxin from focal adhesions to actin filaments and regulates cytoskeletal reinforcement. J Cell Biol, 171(2), 209-15.
  11. Essner JJ, Amack JD, Nyholm MK, Harris EB, Yost HJ (2005 Mar). Kupffer's vesicle is a ciliated organ of asymmetry in the zebrafish embryo that initiates left-right development of the brain, heart and gut. Development, 132(6), 1247-60.
  12. Nadauld LD, Shelton DN, Chidester S, Yost HJ, Jones DA (2005 Aug 26). The zebrafish retinol dehydrogenase, rdh1l, is essential for intestinal development and is regulated by the tumor suppressor adenomatous polyposis coli. J Biol Chem, 280(34), 30490-5.
  13. Bisgrove BW, Snarr BS, Emrazian A, Yost HJ (2005 Nov 15). Polaris and Polycystin-2 in dorsal forerunner cells and Kupffer's vesicle are required for specification of the zebrafish left-right axis. Dev Biol, 287(2), 274-88.
  14. Liang P, Jones CA, Bisgrove BW, Song L, Glenn ST, Yost HJ, Gross KW (2004 Feb 13). Genomic characterization and expression analysis of the first nonmammalian renin genes from zebrafish and pufferfish. Physiol Genomics, 16(3), 314-22.
  15. Swiatek W, Tsai IC, Klimowski L, Pepler A, Barnette J, Yost HJ, Virshup DM (2004 Mar 26). Regulation of casein kinase I epsilon activity by Wnt signaling. J Biol Chem, 279(13), 13011-7.
  16. Chen Y, Mironova E, Whitaker LL, Edwards L, Yost HJ, Ramsdell AF (2004 Apr 15). ALK4 functions as a receptor for multiple TGF beta-related ligands to regulate left-right axis determination and mesoderm induction in Xenopus. Dev Biol, 268(2), 280-94.
  17. Amack JD, Yost HJ (2004 Apr 20). The T box transcription factor no tail in ciliated cells controls zebrafish left-right asymmetry. Curr Biol, 14(8), 685-90.
  18. Nadauld LD, Sandoval IT, Chidester S, Yost HJ, Jones DA (2004 Dec 3). Adenomatous polyposis coli control of retinoic acid biosynthesis is critical for zebrafish intestinal development and differentiation. J Biol Chem, 279(49), 51581-9.
  19. Yoshigi M, Clark EB, Yost HJ (2003 Oct). Quantification of stretch-induced cytoskeletal remodeling in vascular endothelial cells by image processing. Cytometry, 55A(2), 109-18.
  20. Sato M, Yost HJ (2003 May 1). Cardiac neural crest contributes to cardiomyogenesis in zebrafish. Dev Biol, 257(1), 127-39.
  21. Bisgrove BW, Morelli SH, Yost HJ (2003). Genetics of human laterality disorders: insights from vertebrate model systems. Annu Rev Genomics Hum Genet, 4, 1-32.
  22. Kramer KL, Yost HJ (2002 Jan). Ectodermal syndecan-2 mediates left-right axis formation in migrating mesoderm as a cell-nonautonomous Vg1 cofactor. Dev Cell, 2(1), 115-24.
  23. Morgan D, Goodship J, Essner JJ, Vogan KJ, Turnpenny L, Yost HJ, Tabin CJ, Strachan T (2002 Apr). The left-right determinant inversin has highly conserved ankyrin repeat and IQ domains and interacts with calmodulin. Hum Genet, 110(4), 377-84.
  24. Essner JJ, Vogan KJ, Wagner MK, Tabin CJ, Yost HJ, Brueckner M (2002 Jul 4). Conserved function for embryonic nodal cilia. Nature, 418(6893), 37-8.
  25. Branford WW, Yost HJ (2002 Dec 23). Lefty-dependent inhibition of nodal- and wnt-responsive organizer gene expression is essential for normal gastrulation. Curr Biol, 12(24), 2136-41.
  26. Kramer KL, Barnette JE, Yost HJ (2002 Dec 27). PKCgamma regulates syndecan-2 inside-out signaling during xenopus left-right development. Cell, 111(7), 981-90.
  27. Liu J, Stevens J, Rote CA, Yost HJ, Hu Y, Neufeld KL, White RL, Matsunami N (2001 May). Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell, 7(5), 927-36.
  28. Bisgrove BW, Yost HJ (2001 Jul 15). Classification of left-right patterning defects in zebrafish, mice, and humans. Am J Med Genet, 101(4), 315-23.
  29. Li X, Yost HJ, Virshup DM, Seeling JM (2001 Aug 1). Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus. EMBO J, 20(15), 4122-31.
  30. Hu N, Yost HJ, Clark EB (2001 Sep 1). Cardiac morphology and blood pressure in the adult zebrafish. Anat Rec, 264(1), 1-12.
  31. Hu N, Sedmera D, Yost HJ, Clark EB (2000 Oct 1). Structure and function of the developing zebrafish heart. Anat Rec, 260(2), 148-57.
  32. Essner JJ, Branford WW, Zhang J, Yost HJ (2000 Mar). Mesendoderm and left-right brain, heart and gut development are differentially regulated by pitx2 isoforms. Development, 127(5), 1081-93.
  33. Branford WW, Essner JJ, Yost HJ (2000 Jul 15). Regulation of gut and heart left-right asymmetry by context-dependent interactions between xenopus lefty and BMP4 signaling. Dev Biol, 223(2), 291-306.
  34. Bisgrove BW, Essner JJ, Yost HJ (2000 Aug). Multiple pathways in the midline regulate concordant brain, heart and gut left-right asymmetry. Development, 127(16), 3567-79.
  35. Angelo S, Lohr J, Lee KH, Ticho BS, Breitbart RE, Hill S, Yost HJ, Srivastava D (2000 Jul). Conservation of sequence and expression of Xenopus and zebrafish dHAND during cardiac, branchial arch and lateral mesoderm development. Mech Dev, 95(1-2), 231-7.
  36. Schroeder KE, Condic ML, Eisenberg LM, Yost HJ (1999 Oct 15). Spatially regulated translation in embryos: asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in Xenopus. Dev Biol, 214(2), 288-97.
  37. Bisgrove BW, Essner JJ, Yost HJ (1999 Jun). Regulation of midline development by antagonism of lefty and nodal signaling. Development, 126(14), 3253-62.
  38. Ramsdell AF, Yost HJ (1999 Dec). Cardiac looping and the vertebrate left-right axis: antagonism of left-sided Vg1 activity by a right-sided ALK2-dependent BMP pathway. Development, 126(23), 5195-205.
  39. Hyatt BA, Yost HJ (1998 Apr 3). The left-right coordinator: the role of Vg1 in organizing left-right axis formation. Cell, 93(1), 37-46.
  40. Lohr JL, Danos MC, Groth TW, Yost HJ (1998). Maintenance of asymmetric nodal expression in Xenopus laevis. Dev Genet, 23(3), 194-202.
  41. Lohr JL, Danos MC, Yost HJ (1997 Apr). Left-right asymmetry of a nodal-related gene is regulated by dorsoanterior midline structures during Xenopus development. Development, 124(8), 1465-72.
  42. Schroeder KE, Yost HJ (1996). Xenopus poly (A) binding protein maternal RNA is localized during oogenesis and associated with large complexes in blastula. Dev Genet, 19(3), 268-76.
  43. Danos MC, Yost HJ (1996 Jul 10). Role of notochord in specification of cardiac left-right orientation in zebrafish and Xenopus. Dev Biol, 177(1), 96-103.
  44. Teel AL, Yost HJ (1996 Oct). Embryonic expression patterns of Xenopus syndecans. Mech Dev, 59(2), 115-27.
  45. Hyatt BA, Lohr JL, Yost HJ (1996 Nov 7). Initiation of vertebrate left-right axis formation by maternal Vg1. Nature, 384(6604), 62-5.
  46. Galeazza MT, Garry MG, Yost HJ, Strait KA, Hargreaves KM, Seybold VS (1995 May). Plasticity in the synthesis and storage of substance P and calcitonin gene-related peptide in primary afferent neurons during peripheral inflammation. Neuroscience, 66(2), 443-58.
  47. Danos MC, Yost HJ (1995 May). Linkage of cardiac left-right asymmetry and dorsal-anterior development in Xenopus. Development, 121(5), 1467-74.
  48. Yost HJ, Phillips CR, Boore JL, Bertman J, Whalon B, Danilchik MV (1995 Jul). Relocation of mitochondria to the prospective dorsal marginal zone during Xenopus embryogenesis. Dev Biol, 170(1), 83-90.
  49. Yost HJ (1992 May 14). Regulation of vertebrate left-right asymmetries by extracellular matrix. Nature, 357(6374), 158-61.
  50. Yost HJ (1991). Development of the left-right axis in amphibians. Ciba Found Symp, 162, 165-76; discussion 176-81.
  51. Yost HJ, Lindquist S (1991 Feb). Heat shock proteins affect RNA processing during the heat shock response of Saccharomyces cerevisiae. Mol Cell Biol, 11(2), 1062-8.
  52. Yost HJ (1990 Nov). Inhibition of proteoglycan synthesis eliminates left-right asymmetry in Xenopus laevis cardiac looping. Development, 110(3), 865-74.
  53. Yost HJ, Lindquist S (1988 Dec 16). Translation of unspliced transcripts after heat shock. Science, 242(4885), 1544-8.
  54. Yost HJ, Lindquist S (1986 Apr 25). RNA splicing is interrupted by heat shock and is rescued by heat shock protein synthesis. Cell, 45(2), 185-93.
  55. Martinez-Arias A, Yost HJ, Casadaban MJ (1984 Feb 23-29). Role of an upstream regulatory element in leucine repression of the Saccharomyces cerevisiae leu2 gene. Nature, 307(5953), 740-2.


  1. Bisgrove BW, Yost HJ (2006 Nov). The roles of cilia in developmental disorders and disease. [Review]. Development, 133(21), 4131-43.
  2. Yost HJ (2004). Brain Asymmetry. [Review]. Neuron.
  3. Branford WW, Yost HJ (2004 May 4). Nodal signaling: Cryptic Lefty mechanism of antagonism decoded. [Review]. Curr Biol, 14(9), R341-3.
  4. Yost HJ (2003 Oct 14). Left-right asymmetry: nodal cilia make and catch a wave. [Review]. Curr Biol, 13(20), R808-9.
  5. Kramer KL, Yost HJ (2003). Heparan sulfate core proteins in cell-cell signaling. [Review]. Annu Rev Genet, 37, 461-84.
  6. Prescott SM, Yost HJ (2002 Jul 9). The COXes of Danio: from mechanistic model to experimental therapeutics. [Review]. Proc Natl Acad Sci U S A, 99(14), 9084-6.
  7. Yost HJ (2001). Establishment of left-right asymmetry. [Review]. Int Rev Cytol, 203, 357-81.
  8. Wagner MK, Yost HJ (2000 Feb 24). Left-right development: the roles of nodal cilia. [Review]. Curr Biol, 10(4), R149-51.
  9. Yost HJ (2000). Specification of cardiac mesenchyme and heart morphogenesis in vitro. [Review]. Methods Mol Biol, 136, 39-43.
  10. Lohr JL, Yost HJ (2000 Winter). Vertebrate model systems in the study of early heart development: Xenopus and zebrafish. [Review]. Am J Med Genet, 97(4), 248-57.
  11. Yost HJ (1999 Aug). Diverse initiation in a conserved left-right pathway? [Review]. Curr Opin Genet Dev, 9(4), 422-6.
  12. Yost HJ (1998 Feb). Left-right development in Xenopus and zebrafish. [Review]. Semin Cell Dev Biol, 9(1), 61-6.
  13. Yost HJ (1998 May). The genetics of midline and cardiac laterality defects. [Review]. Curr Opin Cardiol, 13(3), 185-9.
  14. Ramsdell AF, Yost HJ (1998 Nov). Molecular mechanisms of vertebrate left-right development. [Review]. Trends Genet, 14(11), 459-65.
  15. Yost HJ (1998). Left-right development from embryos to brains. [Review]. Dev Genet, 23(3), 159-63.
  16. Bowers PN, Brueckner M, Yost HJ (1996). Laterality Disturbances in "The Genetics of Congenital Cardiovascular Disease". [Review]. Prog Ped Cardiol, 6, 53-62.
  17. Bowers PN, Brueckner M, Yost HJ (1996 Dec). The genetics of left-right development and heterotaxia. [Review]. Semin Perinatol, 20(6), 577-88.
  18. Yost HJ (1995 Sep 8). Vertebrate left-right development. [Review]. Cell, 82(5), 689-92.
  19. Yost HJ (1992). Xenopus: Getting Reorganized. (Review of "The Early Development of Xenopus laevis: An Atlas of the Histology". [Review]. Trends Genet, 8, 186.
  20. Yost HJ, Petersen RB, Lindquist S (1990 Jul). RNA metabolism: strategies for regulation in the heat shock response. [Review]. Trends Genet, 6(7), 223-7.

Book Chapter

  1. Tran A, Sato M, Yost HJ (2003). Morphological Analysis of Cardiac Defects in Neural Crest Deficient Zebrafish Embryos. In Proceedings NCUR. Asheville, NC: Univ. of North Carolina.
  2. Ramsdell AF, Yost HJ (2001). Cardiac looping and the left-right axis: integrating morphological, molecular and genetic analyses of vertebrate left-right development. In Tomanek RJ, Runyon R (Eds.), Development of the Cardiovascular System (1). Greenwich, CT: JAI Press.
  3. Yost HJ (2000). Axes, situs and the vertebrate body plan. In Clark EB, Nakazawa M, Takao A (Eds.), Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology (pp. 3-10). Futura N.Y.
  4. Opitz JM, Yost HJ, Clark EB (2000). Syndromes, developmental fields and human congenital cardiovascular malformations. In Clark EB, Nakazawa M, Takao A (Eds.), Etiology & Morphogenesis of Congenital Heart Disease: Twenty Years of Progress in Genetics and Developmental Biology (pp. 311-320). Futura N.Y.
  5. Yost HJ (1998). Establishing cardiac left-right asymmetry. In Harvey RP, Rosenthal N (Eds.), Heart Development (pp. 373-389). San Diego: Academic Press.
  6. Yost HJ (1995). Breaking Symmetry: Left-Right Cardiac Development in Xenopus laevis. In Markwald MM,Clark EB, Takao A (Eds.), Fourth International Symposium on Etiology & Morphogenesis of Congenital Heart Disease - Developmental Mechanisms (pp. 505-511). Futura N.Y.
  7. Yost HJ, Petersen RB, Lindquist S (1990). Posttranscriptional regulation of heat shock protein synthesis in Drosophila. In Morimoto RI, Tissieres A, Georgopoulos C (Eds.), Stress Proteins in Biology and Medicine (pp. 379-409). Cold Spring Laboratory Press.


  1. Kramer, KL, Prewitt, EM, McGrail M, Beckerle MC, Yost HJ (2005). Syndecan-2:Pinch:B1- Integrin complex drives fibronectin fibrillogenesis and directs cell migration. in preparation ((0), p. 0).
  2. Yost HJ (2003). Halpern Explores Asymmetry Using Zebrafish as Model Organism. American Association of Anatomists (12(2), pp. 12-13).
  3. Kramer KL, Yost HJ (2003). Cardiac Left-Right Development: Are the early steps conserved? Cold Spring Harbor Symposium on Quantitative Biology (149, pp. 37-43).