Baehr, Wolfgang , PhD

Languages

  • English
  • German

Academic Information

  • Departments: Neurobiology & Anatomy - Adjunct Professor, Ophthalmology/Visual Sciences - Professor

Academic Office Information

  • John A. Moran Eye Center
    65 N Mario Capecchi, Room: S6881B
    Salt Lake City, UT 84132

Email: u0028583@utah.edu

Education History

Type School Degree
Postdoctoral Fellowship Department of Molecular Biology, Max-Planck-Institut für Biophysikalische Chemie
Molecular Biology
Postdoctoral Fellow
Doctoral Training University of Heidelberg
Organic Chemistry
Ph.D.
Diploma University of Heidelberg
Organic Chemistry
Diploma

Global Impact

Education History

Type School Degree Country
Postdoctoral Fellowship Department of Molecular Biology, Max-Planck-Institut für Biophysikalische Chemie
Molecular Biology
Postdoctoral Fellow Germany
Doctoral Training University of Heidelberg
Organic Chemistry
Ph.D. Germany
Diploma University of Heidelberg
Organic Chemistry
Diploma Germany

Selected Publications

Journal Article

  1. Ruether K, Feigenspan A, Pirngruber J, Leitges M, Baehr W, Strauss O (2010 Nov). PKC{alpha} is essential for the proper activation and termination of rod bipolar cell response. Invest Ophthalmol Vis Sci, 51(11), 6051-8.
  2. Bereta G, Wang B, Kiser PD, Baehr W, Jang GF, Palczewski K (2010 Jan 15). A functional kinase homology domain is essential for the activity of photoreceptor guanylate cyclase 1. J Biol Chem, 285(3), 1899-908.
  3. Kirschman LT, Kolandaivelu S, Frederick JM, Dang L, Goldberg AF, Baehr W, Ramamurthy V (2010 Mar 15). The Leber congenital amaurosis protein, AIPL1, is needed for the viability and functioning of cone photoreceptor cells. Hum Mol Genet, 19(6), 1076-87.
  4. Baehr W, Palczewski K (2009 Jun 15). Focus on molecules: guanylate cyclase-activating proteins (GCAPs). Exp Eye Res, 89(1), 2-3.
  5. Avasthi P, Watt CB, Williams DS, Le YZ, Li S, Chen CK, Marc RE, Frederick JM, Baehr W (2009 Nov 11). Trafficking of membrane proteins to cone but not rod outer segments is dependent on heterotrimeric kinesin-II. J Neurosci, 29(45), 14287-98.
  6. Fan J, Rohrer B, Frederick JM, Baehr W, Crouch RK (2008 Jun). Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis. Invest Ophthalmol Vis Sci, 49(6), 2384-9.
  7. Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W (2008 Apr 9). Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal. J Neurosci, 28(15), 4008-14.
  8. Yang Z, Chen Y, Lillo C, Chien J, Yu Z, Michaelides M, Klein M, Howes KA, Li Y, Kaminoh Y, Chen H, Zhao C, Chen Y, Al-Sheikh YT, Karan G, Corbeil D, Escher P, Kamaya S, Li C, Johnson S, Frederick JM, Zhao Y, Wang C, Cameron DJ, Huttner WB, Schorderet DF, Munier FL, Moore AT, Birch DG, Baehr W, Hunt DM, Williams DS, Zhang K (2008 Aug). Mutant prominin 1 found in patients with macular degeneration disrupts photoreceptor disk morphogenesis in mice. J Clin Invest, 118(8), 2908-16.
  9. Jiang L, Wheaton D, Bereta G, Zhang K, Palczewski K, Birch DG, Baehr W (2008 Oct). A novel GCAP1(N104K) mutation in EF-hand 3 (EF3) linked to autosomal dominant cone dystrophy. Vision Res, 48(23-24), 2425-32.
  10. Baehr W, Karan S, Maeda T, Luo DG, Li S, Bronson JD, Watt CB, Yau KW, Frederick JM, Palczewski K (2007 Mar 23). The function of guanylate cyclase 1 and guanylate cyclase 2 in rod and cone photoreceptors. J Biol Chem, 282(12), 8837-47.
  11. Zhang H, Li S, Doan T, Rieke F, Detwiler PB, Frederick JM, Baehr W (2007 May 22). Deletion of PrBP/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments. Proc Natl Acad Sci U S A, 104(21), 8857-62.
  12. Maeda A, Maeda T, Sun W, Zhang H, Baehr W, Palczewski K (2007 Dec 4). Redundant and unique roles of retinol dehydrogenases in the mouse retina. Proc Natl Acad Sci U S A, 104(49), 19565-70.
  13. Maeda A, Maeda T, Imanishi Y, Sun W, Jastrzebska B, Hatala DA, Winkens HJ, Hofmann KP, Janssen JJ, Baehr W, Driessen CA, Palczewski K (2006 Dec 8). Retinol dehydrogenase (RDH12) protects photoreceptors from light-induced degeneration in mice. J Biol Chem, 281(49), 37697-704.
  14. Paillart C, Zhang K, Rebrik TI, Baehr W, Korenbrot JI (2006 Jan-Feb). Cloning and molecular characterization of cGMP-gated ion channels from rod and cone photoreceptors of striped bass ( M. saxatilis ) retina. Vis Neurosci, 23(1), 99-113.
  15. Moise AR, Kuksa V, Blaner WS, Baehr W, Palczewski K (2005 Jul 29). Metabolism and transactivation activity of 13,14-dihydroretinoic acid. J Biol Chem, 280(30), 27815-25.
  16. OByrne SM, Wongsiriroj N, Libien J, Vogel S, Goldberg IJ, Baehr W, Palczewski K, Blaner WS (2005 Oct 21). Retinoid absorption and storage is impaired in mice lacking lecithin:retinol acyltransferase (LRAT). J Biol Chem, 280(42), 35647-57.
  17. Batten ML, Imanishi Y, Tu DC, Doan T, Zhu L, Pang J, Glushakova L, Moise AR, Baehr W, Van Gelder RN, Hauswirth WW, Rieke F, Palczewski K (2005 Nov). Pharmacological and rAAV gene therapy rescue of visual functions in a blind mouse model of Leber congenital amaurosis. PLoS Med, 2(11), e333.
  18. Zhang H, Hosier S, Terew JM, Zhang K, Cote RH, Baehr W (2005). Assay and functional properties of PrBP(PDEdelta), a prenyl-binding protein interacting with multiple partners. Methods Enzymol, 403, 42-56.
  19. Norton AW, Hosier S, Terew JM, Li N, Dhingra A, Vardi N, Baehr W, Cote RH (2005 Jan 14). Role of the 17 kda prenyl binding protein as a regulatory protein for phototransduction in retinal photoreceptors. J Biol Chem, 280(2), 1248-56.
  20. Yang Z, Alvarez BV, Chakarova C, Jiang L, Karan G, Frederick JM, Zhao Y, Sauve Y, Li X, Zrenner E, Wissinger B, Hollander AI, Katz B, Baehr W, Cremers FP, Casey JR, Bhattacharya SS, Zhang K (2005 Jan 15). Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum Mol Genet, 14(2), 255-65.
  21. Jiang L, Katz BJ, Yang Z, Zhao Y, Faulkner N, Hu J, Baird J, Baehr W, Creel DJ, Zhang K (2005 Feb 20). Autosomal dominant cone dystrophy caused by a novel mutation in the GCAP1 gene (GUCA1A). Mol Vis, 11, 143-51.
  22. Maeda A, Maeda T, Imanishi Y, Kuksa V, Alekseev A, Bronson JD, Zhang H, Zhu L, Sun W, Saperstein DA, Rieke F, Baehr W, Palczewski K (2005 May 13). Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. J Biol Chem, 280(19), 18822-32.
  23. Sokal I, Dupps WJ, Grassi MA, Brown J Jr, Affatigato LM, Roychowdhury N, Yang L, Filipek S, Palczewski K, Stone EM, Baehr W (2005 Apr). A novel GCAP1 missense mutation (L151F) in a large family with autosomal dominant cone-rod dystrophy (adCORD). Invest Ophthalmol Vis Sci, 46(4), 1124-32.
  24. Wu SM, Baehr W, Crair M (2004). The mouse visual system: from photoreceptors to cortex. Vision Res, 44, 3233-4.
  25. Yang Z, Alvarez BV, Chakarova C, Jiang L, Karan G, Frederick JM, Zhao Y, Sauve Y, Li X, Zrenner E, Wissinger B, Den Hollander AI, Katz B, Baehr W, Cremers FP, Casey JR, Bhattacharya SS, Zhang K (2004). Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration. Hum Mol Genet, 14, 255-65.
  26. Zhang H, Liu XH, Zhang K, Chen CK, Frederick JM, Prestwich GD, Baehr W (2004 Jan 2). Photoreceptor cGMP phosphodiesterase delta subunit (PDEdelta) functions as a prenyl-binding protein. J Biol Chem, 279(1), 407-13.
  27. Batten ML, Imanishi Y, Maeda T, Tu DC, Moise AR, Bronson D, Possin D, Van Gelder RN, Baehr W, Palczewski K (2004 Mar 12). Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver. J Biol Chem, 279(11), 10422-32.
  28. Imanishi Y, Batten ML, Piston DW, Baehr W, Palczewski K (2004 Feb 2). Noninvasive two-photon imaging reveals retinyl ester storage structures in the eye. J Cell Biol, 164(3), 373-83.
  29. Palczewski K, Sokal I, Baehr W (2004 Oct 1). Photoreceptor guanylate cyclase-activating proteins: structure, function, and diversity. Biochem Biophys Res Commun, 322(4), 1123-30.
  30. Howes KA, Liu Y, Dunaief JL, Milam A, Frederick JM, Marks A, Baehr W (2004 Oct). Receptors for advanced glycation end products as progressive factors in age-related macular degeneration. Invest Ophthalmol Vis Sci, 45(10), 3713-20.
  31. Imanishi Y, Yang L, Sokal I, Filipek S, Palczewski K, Baehr W (2004 Aug). Diversity of guanylate cyclase-activating proteins (GCAPs) in teleost fish: characterization of three novel GCAPs (GCAP4, GCAP5, GCAP7) from zebrafish (Danio rerio) and prediction of eight GCAPs (GCAP1-8) in pufferfish (Fugu rubripes). J Mol Evol, 59(2), 204-17.
  32. Nishiguchi KM, Sokal I, Yang L, Roychowdhury N, Palczewski K, Berson EL, Dryja TP, Baehr W (2004 Nov). A novel mutation (I143NT) in guanylate cyclase-activating protein 1 (GCAP1) associated with autosomal dominant cone degeneration. Invest Ophthalmol Vis Sci, 45(11), 3863-70.
  33. Pennesi ME, Howes KA, Baehr W, Wu SM (2003 May 27). GCAP1 rescues cone photoreceptor responses in GCAP1/GCAP2 knockout mice. Proc Natl Acad Sci U S A, 100(11), 6783-8.
  34. Zhang H, Huang W, Zhang H, Zhu X, Craft CM, Baehr W, Chen CK (2003 Jun 9). Light-dependent redistribution of visual arrestins and transducin subunits in mice with defective phototransduction. Mol Vis, 9, 231-7.
  35. Zhang H, Cuenca N, Ivanova T, Church-Kopish J, Frederick JM, MacLeish PR, Baehr W (2003 Jul). Identification and Light-dependent Translocation of a Cone-specific Antigen, (Cone Arrestin) Recognized by Monoclonal Antibody 7G6. Invest Ophthalmol Vis Sci, 44(7), 2858-67.
  36. Zhang XM, Yang Z, Karan G, Hashimoto T, Baehr W, Yang XJ, Zhang K (2003 Jul 3). Elovl4 mRNA distribution in the developing mouse retina and phylogenetic conservation of Elovl4 genes. Mol Vis, 9, 301-7.
  37. Jones BW, Watt CB, Frederick JM, Baehr W, Chen CK, Levine EM, Milam AH, Lavail MM, Marc RE (2003 Sep 8). Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol, 464(1), 1-16.
  38. Yu J, Farjo R, MacNee SP, Baehr W, Stambolian DE, Swaroop A (2003). Annotation and analysis of 10,000 Expressed Sequence Tags from 3 mouse eye cDNA libraries. Genome Biol, 4(10), R65.
  39. Baehr W, Wu SM, Bird AC, Palczewski K (2003 Dec). The retinoid cycle and retina disease. Vision Res, 43(28), 2957-8.
  40. Howes KA, Frederick JM, Marks A, Baehr W (2003). Progressive pathways in age-related macular degeneration. Adv Exp Med Biol, 533, 91-6.
  41. Yamazaki M, Li N, Bondarenko VA, Yamazaki RK, Baehr W, Yamazaki A (2002). Cloning of frog rod photoreceptor cGMP phosphodiesterase subunits (P-alpha, P-beta, P-gamma) and identification of P-gamma) sites involved in the stimulation of cGMP binding to P-alpha and P-beta non-catalytic sites. J Biol Chem, 277, 40675-86.
  42. Sokal I, Alekseev A, Baehr W, Haeseleer F, Palczewski K (2002 Jan 8). Soluble fusion proteins between single transmembrane photoreceptor guanylyl cyclases and their activators. Biochemistry, 41(1), 251-7.
  43. Farjo R, Yu J, Othman MI, Yoshida S, Sheth S, Glaser T, Baehr W, Swaroop A (2002 Feb). Mouse I-Gene microarrays for investigating ocular development and disease. Vision Res, 42(4), 463-70.
  44. Imanishi Y, Li N, Sokal I, Sowa ME, Lichtarge O, Wensel TG, Saperstein DA, Baehr W, Palczewski K (2002 Jan). Characterization of retinal guanylate cyclase-activating protein 3 (GCAP3) from zebrafish to man. Eur J Neurosci, 15(1), 63-78.
  45. Howes KA, Pennesi ME, Sokal I, Church-Kopish J, Schmidt B, Margolis D, Frederick JM, Rieke F, Palczewski K, Wu SM, Detwiler PB, Baehr W (2002 Apr 2). GCAP1 rescues rod photoreceptor response in GCAP1/GCAP2 knockout mice. EMBO J, 21(7), 1545-54.
  46. Mendez A, Burns M, Sokal I, Palczewski K, Baehr W, Baylor DA, Chen J (2001 Aug 14). Calcium regulation of guanylate cyclase activity determines the flash sensitivity of mouse rod photoreceptor cells. Proc Natl Acad Sci U S A, 98(17), 9948-53.
  47. Sokal I, Li N, Klug CS, Filipek S, Hubbell WL, Baehr W, Palczewski K (2001 Nov 16). Calcium-sensitive regions of GCAP1 as observed by chemical modifications, fluorescence, and EPR spectroscopies. J Biol Chem, 276(46), 43361-73.
  48. Li N, Sokal I, Bronson JD, Palczewski K, Baehr W (2001 Aug). Identification of functional regions of guanylate cyclase-activating protein 1 (GCAP1) using GCAP1/GCIP chimeras. Biol Chem, 382(8), 1179-88.
  49. Baehr W, Chen CK (2001 Nov). RP11 and RP13: unexpected gene loci. Trends Mol Med, 7(11), 484-6.
  50. Chen CK, Zhang K, Church-Kopish J, Huang W, Zhang H, Chen YJ, Frederick JM, Baehr W (2001 Dec 21). Characterization of human GRK7 as a potential cone opsin kinase. Mol Vis, 7, 305-13.
  51. Frederick JM, Krasnoperova NV, Hoffmann K, Church-Kopish J, Ruther K, Howes K, Lem J, Baehr W (2001 Mar). Mutant rhodopsin transgene expression on a null background. Invest Ophthalmol Vis Sci, 42(3), 826-33.
  52. McBee JK, Palczewski K, Baehr W, Pepperberg DR (2001 Jul). Confronting complexity: the interlink of phototransduction and retinoid metabolism in the vertebrate retina. Prog Retin Eye Res, 20(4), 469-529.
  53. Sokal I, Li N, Verlinde CL, Haeseleer F, Baehr W, Palczewski K (2000 Dec 20). Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1). Biochim Biophys Acta, 1498(2-3), 233-51.
  54. Frederick J, Bronson JD, Baehr W (1999). Animal models for inherited retinal diseases. In "Vertebrate Phototransduction and the Visual Cycle". Methods Enzymol, 316, 515-526.
  55. Zhang K, Howes KA, He W, Bronson JD, Pettenati MJ, Chen C, Palczewski K, Wensel TG, Baehr W (1999 Nov 15). Structure, alternative splicing, and expression of the human RGS9 gene. Gene, 240(1), 23-34.
  56. Haeseleer F, Sokal I, Li N, Pettenati M, Rao N, Bronson D, Wechter R, Baehr W, Palczewski K (1999 Mar 5). Molecular characterization of a third member of the guanylyl cyclase-activating protein subfamily. J Biol Chem, 274(10), 6526-35.
  57. Wolbring G, Baehr W, Palczewski K, Schnetkamp PP (1999 Mar 2). Light inhibition of bovine retinal rod guanylyl cyclase mediated by beta gamma-transducin. Biochemistry, 38(9), 2611-6.
  58. Surguchov A, Surgucheva I, Solessio E, Baehr W (1999 Feb). Synoretin--A new protein belonging to the synuclein family. Mol Cell Neurosci, 13(2), 95-103.
  59. Larkin P, Baehr W, Semple-Rowland SL (1999 Jul 5). Circadian regulation of iodopsin and clock is altered in the retinal degeneration chicken retina. Brain Res Mol Brain Res, 70(2), 253-63.
  60. Semple-Rowland SL, Larkin P, Bronson JD, Nykamp K, Streit WJ, Baehr W (1999 Jul 28). Characterization of the chicken GCAP gene array and analyses of GCAP1, GCAP2, and GC1 gene expression in normal and rd chicken pineal. Mol Vis, 5, 14.
  61. Thulin CD, Howes K, Driscoll CD, Savage JR, Rand TA, Baehr W, Willardson BM (1999 Dec 29). The immunolocalization and divergent roles of phosducin and phosducin-like protein in the retina. Mol Vis, 5, 40.
  62. Howes K, Bronson JD, Dang YL, Li N, Zhang K, Ruiz C, Helekar B, Lee M, Subbaraya I, Kolb H, Chen J, Baehr W (1998 May). Gene array and expression of mouse retina guanylate cyclase activating proteins 1 and 2. Invest Ophthalmol Vis Sci, 39(6), 867-75.
  63. Rudnicka-Nawrot M, Surgucheva I, Hulmes JD, Haeseleer F, Sokal I, Crabb JW, Baehr W, Palczewski K (1998 Jan 6). Changes in biological activity and folding of guanylate cyclase-activating protein 1 as a function of calcium. Biochemistry, 37(1), 248-57.
  64. Semple-Rowland SL, Lee NR, Van Hooser JP, Palczewski K, Baehr W (1998 Feb 3). A re-arrangement in the photoreceptor guanylate cyclase (retGC) gene causes retinal degeneration in the rd chicken retina. Proc Natl Acad Sci U S A, 95(3), 1271-6.
  65. Li N, Fariss RN, Zhang K, Otto-Bruc A, Haeseleer F, Bronson D, Qin N, Yamazaki A, Subbaraya I, Milam AH, Palczewski K, Baehr W (1998 Mar 15). Guanylate-cyclase-inhibitory protein is a frog retinal Ca2+-binding protein related to mammalian guanylate-cyclase-activating proteins. Eur J Biochem, 252(3), 591-9.
  66. Li N, Florio SK, Pettenati MJ, Rao PN, Beavo JA, Baehr W (1998 Apr 1). Characterization of human and mouse rod cGMP phosphodiesterase delta subunit (PDE6D) and chromosomal localization of the human gene. Genomics, 49(1), 76-82.
  67. Moon C, Jaberi P, Otto-Bruc A, Baehr W, Palczewski K, Ronnett GV (1998 May 1). Calcium-sensitive particulate guanylyl cyclase as a modulator of cAMP in olfactory receptor neurons. J Neurosci, 18(9), 3195-205.
  68. Sokal I, Li N, Surgucheva I, Warren MJ, Payne AM, Bhattacharya SS, Baehr W, Palczewski K (1998 Jul). GCAP1 (Y99C) mutant is constitutively active in autosomal dominant cone dystrophy. Mol Cell, 2(1), 129-33.
  69. Li N, Baehr W (1998 Dec 4). Expression and characterization of human PDEdelta and its Caenorhabditis elegans ortholog CEdelta. FEBS Lett, 440(3), 454-7.
  70. Surguchov A, Bronson JD, Banerjee P, Knowles JA, Ruiz C, Subbaraya I, Palczewski K, Baehr W (1997 Feb 1). The human GCAP1 and GCAP2 genes are arranged in a tail-to-tail array on the short arm of chromosome 6 (p21.1). Genomics, 39(3), 312-22.
  71. Zhao X, Haeseleer F, Fariss RN, Huang J, Baehr W, Milam AH, Palczewski K (1997 Mar-Apr). Molecular cloning and localization of rhodopsin kinase in the mammalian pineal. Vis Neurosci, 14(2), 225-32.
  72. Otto-Bruc A, Buczylko J, Surgucheva I, Subbaraya I, Rudnicka-Nawrot M, Crabb JW, Arendt A, Hargrave PA, Baehr W, Palczewski K (1997 Apr 8). Functional reconstitution of photoreceptor guanylate cyclase with native and mutant forms of guanylate cyclase-activating protein 1. Biochemistry, 36(14), 4295-302.
  73. Otto-Bruc A, Fariss RN, Haeseleer F, Huang J, Buczylko J, Surgucheva I, Baehr W, Milam AH, Palczewski K (1997 Apr 29). Localization of guanylate cyclase-activating protein 2 in mammalian retinas. Proc Natl Acad Sci U S A, 94(9), 4727-32.
  74. Duda T, Goraczniak R, Surgucheva I, Rudnicka-Nawrot M, Gorczyca WA, Palczewski K, Sitaramayya A, Baehr W, Sharma RK (1996 Jul 2). Calcium modulation of bovine photoreceptor guanylate cyclase. Biochemistry, 35(26), 8478-82.
  75. Marcus DM, Lasudry JG, Carpenter JL, Windle J, Howes KA, al-Ubaidi MR, Baehr W, Overbeek PA, Font RL, Albert DM (1996 Feb). Trilateral tumors in four different lines of transgenic mice expressing SV40 T-antigen. Invest Ophthalmol Vis Sci, 37(2), 392-6.
  76. Semple-Rowland SL, Gorczyca WA, Buczylko J, Helekar BS, Ruiz CC, Subbaraya I, Palczewski K, Baehr W (1996 Apr 29). Expression of photoreceptor guanylyl cyclase activating proteins in normal and rd/rd chicken retina. FEBS Lett, 385(1-2), 47-52.
  77. Feng L, Subbaraya I, Yamamoto N, Baehr W, Kraus-Friedmann N (1996 Oct 14). Expression of photoreceptor cation channel alpha subunit (CNGCalpha) in the liver and skeletal muscle. FEBS Lett, 395(1), 77-81.
  78. Polans A, Baehr W, Palczewski K (1996 Dec). Turned on by Ca2+! The physiology and pathology of Ca(2+)-binding proteins in the retina. Trends Neurosci, 19(12), 547-54.
  79. Alvarez RA, Ghalayini AJ, Xu P, Hardcastle A, Bhattacharya S, Rao PN, Pettenati MJ, Anderson RE, Baehr W (1995 Sep 1). cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4). Genomics, 29(1), 53-61.
  80. Gorczyca WA, Polans AS, Surgucheva IG, Subbaraya I, Baehr W, Palczewski K (1995 Sep 15). Guanylyl cyclase activating protein. A calcium-sensitive regulator of phototransduction. J Biol Chem, 270(37), 22029-36.
  81. Palczewski K, Subarayya I, Gorczyca WA, Helekar BS, Ruiz CC, Ohguro H, Huang J, Zhao X, Crabb JW, Johnson RS, Walsh KA, Gray-Keller MP, Detwiler PB, Baehr W (1994). Molecular cloning and characterization of retinal photoreceptor guanylyl cyclase activating protein (GCAP). Neuron, 13, 395-404.
  82. Qin N, Baehr W (1994 Feb 4). Expression and mutagenesis of mouse rod photoreceptor cGMP phosphodiesterase. J Biol Chem, 269(5), 3265-71.
  83. Gal A, Orth U, Baehr W, Schwinger E, Rosenberg T (1994 May). Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness. Nat Genet, 7(1), 64-8.
  84. Gal A, Orth U, Baehr W, Schwinger E, Rosenberg T (1994 Aug). Heterozygous missense mutation in the rod cGMP phosphodiesterase beta-subunit gene in autosomal dominant stationary night blindness. Nat Genet, 7(4), 551.
  85. Subbaraya I, Ruiz CC, Helekar BS, Zhao X, Gorczyca WA, Pettenati MJ, Rao PN, Palczewski K, Baehr W (1994 Dec 9). Molecular characterization of human and mouse photoreceptor guanylate cyclase-activating protein (GCAP) and chromosomal localization of the human gene. J Biol Chem, 269(49), 31080-9.
  86. Naash MI, Hollyfield JG, Al-Ubaidi MR, Baehr W (1993). An animal model for human autosomal dominant retinitis pigmentosa (ADRP). Proc Natl Acad Sci U S A, 90, 5499-5503.
  87. Suber ML, Pittler SJ, Qin N, Wright GC, Holcombe V, Lee RH, Craft CM, Lolley RN, Baehr W, Hurwitz RL (1993 May 1). Irish setter dogs affected with rod/cone dysplasia contain a nonsense mutation in the rod cGMP phosphodiesterase beta-subunit gene. Proc Natl Acad Sci U S A, 90(9), 3968-72.
  88. Qin N, Baehr W (1993 Apr 19). Expression of mouse rod photoreceptor cGMP phosphodiesterase gamma subunit in bacteria. FEBS Lett, 321(1), 6-10.
  89. Naash MI, Hollyfield JG, al-Ubaidi MR, Baehr W (1993 Jun 15). Simulation of human autosomal dominant retinitis pigmentosa in transgenic mice expressing a mutated murine opsin gene. Proc Natl Acad Sci U S A, 90(12), 5499-503.
  90. Pittler SJ, Keeler CE, Sidman RL, Baehr W (1993 Oct 15). PCR analysis of DNA from 70-year-old sections of rodless retina demonstrates identity with the mouse rd defect. Proc Natl Acad Sci U S A, 90(20), 9616-9.
  91. al-Ubaidi MR, Hollyfield JG, Overbeek PA, Baehr W (1992 Feb 15). Photoreceptor degeneration induced by the expression of simian virus 40 large tumor antigen in the retina of transgenic mice. Proc Natl Acad Sci U S A, 89(4), 1194-8.
  92. Pittler SJ, Lee AK, Altherr MR, Howard TA, Seldin MF, Hurwitz RL, Wasmuth JJ, Baehr W (1992 Mar 25). Primary structure and chromosomal localization of human and mouse rod photoreceptor cGMP-gated cation channel. J Biol Chem, 267(9), 6257-62.
  93. Altherr MR, Wasmuth JJ, Seldin MF, Nadeau JH, Baehr W, Pittler SJ (1992 Apr). Chromosome mapping of the rod photoreceptor cGMP phosphodiesterase beta-subunit gene in mouse and human: tight linkage to the Huntington disease region (4p16.3). Genomics, 12(4), 750-4.
  94. Qin N, Pittler SJ, Baehr W (1992 Apr 25). In vitro isoprenylation and membrane association of mouse rod photoreceptor cGMP phosphodiesterase alpha and beta subunits expressed in bacteria. J Biol Chem, 267(12), 8458-63.
  95. McGinnis JF, Stepanik PL, Baehr W, Subbaraya I, Lerious V (1992 May 11). Cloning and sequencing of the 23 kDa mouse photoreceptor cell-specific protein. FEBS Lett, 302(2), 172-6.
  96. Gallagher DS Jr, Womack JE, Baehr W, Pittler SJ (1992 Nov). Syntenic assignments of visual transduction genes in cattle. Genomics, 14(3), 699-706.
  97. Pittler SJ, Fliesler SJ, Baehr W (1992 Nov 23). Primary structure of frog rhodopsin. FEBS Lett, 313(2), 103-8.
  98. al-Ubaidi MR, Font RL, Quiambao AB, Keener MJ, Liou GI, Overbeek PA, Baehr W (1992 Dec). Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J Cell Biol, 119(6), 1681-7.
  99. Holbach LM, Font RL, Baehr W, Pittler SJ (1991). HSV antigens and HSV DNA in avascular and vascularized lesions of human herpes simplex keratitis. Curr Eye Res, 10 Suppl, 63-8.
  100. Pittler SJ, Baehr W (1991). The molecular genetics of retinal photoreceptor proteins involved in cGMP metabolism. Prog Clin Biol Res, 362, 33-66.
  101. Liou GI, Geng L, Baehr W (1991). Interphotoreceptor retinoid-binding protein: biochemistry and molecular biology. Prog Clin Biol Res, 362, 115-37.
  102. Baehr W, Champagne MS, Lee AK, Pittler SJ (1991 Jan 14). Complete cDNA sequences of mouse rod photoreceptor cGMP phosphodiesterase alpha- and beta-subunits, and identification of beta'-, a putative beta-subunit isozyme produced by alternative splicing of the beta-subunit gene. FEBS Lett, 278(1), 107-14.
  103. Hackstadt T, Baehr W, Ying Y (1991 May 1). Chlamydia trachomatis developmentally regulated protein is homologous to eukaryotic histone H1. Proc Natl Acad Sci U S A, 88(9), 3937-41.
  104. Pittler SJ, Baehr W (1991 Oct 1). Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase beta-subunit gene of the rd mouse. Proc Natl Acad Sci U S A, 88(19), 8322-6.
  105. Pittler SJ, Baehr W, Wasmuth JJ, McConnell DG, Champagne MS, vanTuinen P, Ledbetter D, Davis RL (1990 Feb). Molecular characterization of human and bovine rod photoreceptor cGMP phosphodiesterase alpha-subunit and chromosomal localization of the human gene. Genomics, 6(2), 272-83.
  106. Liou GI, Geng L, al-Ubaidi MR, Matragoon S, Hanten G, Baehr W, Overbeek PA (1990 May 25). Tissue-specific expression in transgenic mice directed by the 5'-flanking sequences of the human gene encoding interphotoreceptor retinoid-binding protein. J Biol Chem, 265(15), 8373-6.
  107. al-Ubaidi MR, Pittler SJ, Champagne MS, Triantafyllos JT, McGinnis JF, Baehr W (1990 Nov 25). Mouse opsin. Gene structure and molecular basis of multiple transcripts. J Biol Chem, 265(33), 20563-9.
  108. Baehr W, Gotschlich EC, Hitchcock PJ (1989 Jan). The virulence-associated gonococcal H.8 gene encodes 14 tandemly repeated pentapeptides. Mol Microbiol, 3(1), 49-55.
  109. Zhang YX, Morrison SG, Caldwell HD, Baehr W (1989 May). Cloning and sequence analysis of the major outer membrane protein genes of two Chlamydia psittaci strains. Infect Immun, 57(5), 1621-5.
  110. Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (1989 May 15). Human interstitial retinoid-binding protein. Gene structure and primary structure. J Biol Chem, 264(14), 8200-6.
  111. Baehr W, Zhang YX, Joseph T, Su H, Nano FE, Everett KD, Caldwell HD (1988 Jun). Mapping antigenic domains expressed by Chlamydia trachomatis major outer membrane protein genes. Proc Natl Acad Sci U S A, 85(11), 4000-4.
  112. Baehr W, Falk JD, Bugra K, Triantafyllos JT, McGinnis JF (1988 Oct 10). Isolation and analysis of the mouse opsin gene. FEBS Lett, 238(2), 253-6.
  113. Baehr W, Applebury ML (1986). Exploring visual transduction with recombinant DNA techniques. Trends Neurosci, 9, 198-203.
  114. Martin RL, Wood C, Baehr W, Applebury ML (1986 Jun 6). Visual pigment homologies revealed by DNA hybridization. Science, 232(4755), 1266-9.
  115. Mangini NJ, Pepperberg DR, Baehr W (1986 Nov). Light-dependent changes in G-protein binding to ROS membranes in intact Bufo retinas. J Gen Physiol, 88(5), 675-94.
  116. OTousa JE, Baehr W, Martin RL, Hirsh J, Pak WL, Applebury ML (1985 Apr). The Drosophila ninaE gene encodes an opsin. Cell, 40(4), 839-50.
  117. Baehr W, Morita EA, Swanson RJ, Applebury ML (1982 Jun 10). Characterization of bovine rod outer segment G-protein. J Biol Chem, 257(11), 6452-60.
  118. Baehr W, Devlin MJ, Applebury ML (1979 Nov 25). Isolation and characterization of cGMP phosphodiesterase from bovine rod outer segments. J Biol Chem, 254(22), 11699-77.
  119. Damjanovich S, Bahr W, Jovin TM (1977 Feb). The functional and fluorescence properties of Escherichia coli RNA polymerase reacted with fluorescamine. Eur J Biochem, 72(3), 559-69.
  120. Arndt-Jovin DJ, Jovin TM, Bahr W, Frischauf AM, Marquardt M (1975 Jun). Covalent attachment of DNA to agarose. Improved synthesis and use in affinity chromatography. Eur J Biochem, 54(2), 411-8.
  121. Schnfeld B, Baehr W, Buss B, Glemser O (1975). Ein Makroheteropolyanion mit antiviralem Effekt: Wolframantimonate (Sb8W20O80)16-. Zeitschrift fuer Naturforschung. Section A: Physics, Physical Chemistry, Cosmic Physics, 30B, 831-833.
  122. Kownatzki E, Bahr W (1974 May). The molecular weight of J chains of human IgM. Hoppe Seylers Z Physiol Chem, 355(5), 600-2.
  123. Peters R, Peters J, Tews KH, Bahr W (1974 Nov 15). A microfluorimetric study of translational diffusion in erythrocyte membranes. Biochim Biophys Acta, 367(3), 282-94.
  124. Baehr W (1974). 1874-1974: 100 Jahre Stereochemie. Chemie fuer Labor und Betrieb, 25, 385-391.
  125. Bahr W, Faerber P, Scheit KH (1973 Mar 15). The effects of thioketo substitution upon uracil-adenine interactions in polyribonucleotides. Synthesis and properties of poly (2-thiouridylic acid) and poly(2,4-dithiouridylic acid). Eur J Biochem, 33(3), 535-44.
  126. Baehr W, Sommer H, Scheit KH (1973). Synthesis and Properties of Oligo-deoxy-4-thiothymidylic acid. Biochim Biophys Acta, 287, 427-437.
  127. Pohl FM, Jovin TM, Baehr W, Holbrook JJ (1972 Dec). Ethidium bromide as a cooperative effector of a DNA structure. Proc Natl Acad Sci U S A, 69(12), 3805-9.
  128. Weinges K, Bahr W, Ebert W, Kloss P (1972 Feb). [Norlobelanidine, the main alkaloid from Lobelia polyphylla Hook and Arn]. Justs Liebigs Ann Chem, 756, 177-80.
  129. Weinges K, Bahr W (1972 May). [Natural products from medicinal plants. XVI. A comparison of the NMR- and mass spectra of bilobalide C 15 H 18 O 8 and of the ginkgolides C 20 H 24 O 9 -11]. Justs Liebigs Ann Chem, 759, 158-72.
  130. Weinges K, Baehr W, Rao NP (1971). Naturstoffsynthesen, I Synthese von Hexahydro-5H-dicyclopenta(B, C)furan-5A(6H)-ol. Liebigs Ann Chem, 753, 100-105.
  131. Nakanishi K, Habaguchi K, Nakadaira Y, Woods MC, Maruyama M, Major RT, Alauddin M, Patel AR, Weinges K, Baehr W (1971). Structure of Bilobalide, a Rare tertiary-Butyl Containing Sesquiterpenoid related to the C20-Ginkgolides. J Am Chem Soc, 93, 3544-3546.
  132. Weinges K, Bahr W, Theobald H, Wiesenhutter A, Wild R, Kloss P (1969 Mar). [On the appearance of proanthocyanidines in plant extracts]. Arzneimittelforschung, 19(3), 328-30.
  133. Weinges K, Baehr W, Ebert W, Goeritz K, Marx HD (1969). Konstitution, Bildung und Bedeutung der Flavonoidgerbstoffe. Fortschr Chem Org Naturst, XXVII, 158-260.
  134. Weinges K, Baehr W (1969). Kondensierte Ringsysteme, II Bilobalid A, ein neues Sesquiterpen mit tertiaerer Butylgruppe aus den Blättern von Ginkgo biloba L. Liebigs Ann Chem, 724, 214-216.
  135. Weinges K, Bahr W, Kloss P (1968 May). [Survey of the components from the leaves of the Ginkge-tree (Ginkge bileba L)]. Arzneimittelforschung, 18(5), 537-9.
  136. Weinges K, Bahr W, Kloss P (1968 May). [Phenolic components from the leaves of the Ginkgo tree (Ginkgo biloba L)]. Arzneimittelforschung, 18(5), 539-43.

Review

  1. Karan S, Frederick JM, Baehr W (2010 Jan). Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. [Review]. Mol Cell Biochem, 334(1-2), 141-55.
  2. Baehr W, Frederick JM (2009 Nov). Naturally occurring animal models with outer retina phenotypes. [Review]. Vision Res, 49(22), 2636-52.
  3. Karan S, Zhang H, Li S, Frederick JM, Baehr W (2008 Feb). A model for transport of membrane-associated phototransduction polypeptides in rod and cone photoreceptor inner segments. [Review]. Vision Res, 48(3), 442-52.
  4. Karan S, Frederick JM, Baehr W (2008). Involvement of guanylate cyclases in transport of photoreceptor peripheral membrane proteins. [Review]. Adv Exp Med Biol, 613, 351-9.
  5. Baehr W, Palczewski K (2007). Guanylate cyclase-activating proteins and retina disease. [Review]. Subcell Biocehm, 45, 71-91.
  6. Zhang H, Frederick JM, Baehr W (2006). Functional study of photoreceptor PDEdelta. [Review]. Adv Exp Med Biol, 572, 485-90.
  7. Palczewski K, Polans AS, Baehr W, Ames JB (2000 Apr). Ca(2+)-binding proteins in the retina: structure, function, and the etiology of human visual diseases. [Review]. BioEssays, 22(4), 337-50.

Book

  1. Baehr W, Theobald H (1974). Organische Stereochemie: Begriffe und Definitionen (Organic Stereochemistry: Conceptions and Definitions). Springer Verlag Berlin Heidelberg New York.

Edited Book

  1. Baehr W, Palczewski K (Eds.) (2002). Photoreceptors and Calcium. Landes Bioscience and Kluwer Academics/Plenum Publishers.

Book Chapter

  1. Thompson DA, Gal A, Baehr W (2002). Retinal Proteins. In Creighton TE (Ed.), Utah Special Educator (5, pp. 2769-2772). New York, NY: John Wiley & Sons, Inc.
  2. Frederick J, Krasnoperova N, Hoffmann K, Baehr W, Lem J, Ruether K (1999). Retinal degeneration is accelerated when a mutant rhodopsin transgene is expressed on haploid or null rhodopsin background. In Hollyfield JG; Anderson RE; LaVail MM (Ed.), Retinal Degenerative Diseases and Experimental Therapy. New York: Plenum Publishing Corp.
  3. Hurwitz RL, Pittler SJ, Suber ML, Qin N, Lee RH, Craft CM, Lolley RN, Baehr W (1993). Nonsense mutations in the subunit genes of the rod cGMP phosphodiesterase that are associated with inherited retinal degenerative disease. In Hollyfield JG, Anderson RE, LaVail M (Eds.), Retinal Degenerations. New York: Plenum Press.
  4. Anderson RE, Alvarez RA, Guo XX, Nordquist RE, Baehr W, Ghalayini AJ (1995). Genes encoding enzymes of the phosphoinositide metabolism are candidate genes for inherited retinal degenerations in humans. In Anderson RE; Hollyfield JG; LaVail M (Ed.), Degenerative Diseases of the Retina (pp. 339-347). New York: Plenum Press.
  5. Veske A, Orth U, Ruether K, Zrenner E, Rosenberg T, Baehr W, Gal A (1995). Mutations in the gene for the ²-subunit of photoreceptor-specific cGMP phosphodiesterase (PDE²) in patients with retinal dystrophies and dysfunctions. In Anderson, Hollyfield, LaVail (Eds.), Degenerative Diseases of the Retina (pp. 313-322). New York: Plenum Press.
  6. Baehr W, Subbaraya I, Gorczyca W, Palczewski K (1995). Guanylate cyclase activating protein (GCAP): A novel Ca binding protein in vertebrate photoreceptors. In Anderson, Hollyfield, LaVail (Eds.), Degenerative Diseases of the Retina (pp. 339-347). New York: Plenum Press.
  7. Hurwitz RL, Pittler SJ, Suber ML, Qin N, Lee RH, Craft CM, Lolley RN, Baehr W (1993). Nonsense mutations in the beta subunit genes of the rod cGMP phosphodiesterase that are associated with inherited retinal degenerative disease. In Hollyfield JG, Anderson RE, LaVail MM (Eds.), Retinal Degenerations. New York, NY: Plenum Press.
  8. Al-Ubaidi MR, Hollyfield JG, Baehr W (1993). Photoreceptor cell death induced by the expression of a viral oncogene in the retina of transgenic mice. In Hollyfield JG, Anderson RE, LaVail M (Eds.), Retinal Degenerations (pp. 243-250). New York: Plenum Press.
  9. Al-Ubaidi MR, Hollyfield JG, Font RL, Baehr W (1993). Retinal development under the influence of SV40 T-antigen in transgenic mice. In Hollyfield JG, Anderson RE, LaVail M (Eds.), Retinal Degenerations (pp. 243-250). New York: Plenum Press.
  10. Naash MI, Al-Ubaidi MR, Hollyfield JG, Baehr W (1993). Simulation of human autosomal dominant retinitis pigmentosa (ADRP) in transgenic mice. In Hollyfield JG, Anderson RE, LaVail M (Eds.), Retinal Degenerations (pp. 201-210). New York: Plenum Press.
  11. Baehr W, Pittler SJ (1992). The Molecular Biology of the Rod Photoreceptor cGMP PDE alpha and beta subunits. In Hargrave PA; Hofmann KP; Kaupp UB (Ed.), Signal Transduction in Photoreceptor Cells, Proceedings of an International Workshop Held at the Research Center Jülich, Germany (pp. 132-147). Springer Verlag Berlin .
  12. Pittler SJ, Baehr W (1991). Identification of the Precise Molecular Defect Responsible for Blindness in the Mouse Retinal Degeneration Mutant, rd. In Anderson RE; Hollyfield JG; LaVail M (Ed.), Retinal Degenerations (pp. 455-465). Boca Raton: CRC Press.
  13. Baehr W, Al-Ubaidi MR (1991). The Molecular Biology of Retinal Degenerations: Perspectives and New Directions. In Anderson RE; Hollyfield JG; LaVail M (Ed.), Retinal Degenerations (pp. 437-443). Boca Raton: CRC Press.
  14. Baehr W, Stender W, Scheit KH, Jovin TM (1976). Binding of rifampicin to Escherichia coli RNA polymerase: Thermodynamic and kinetic studies. In Losick H; Chamberlain M (Ed.), RNA Polymerase (pp. 369-396). Cold Spring Harbor Laboratory.

Conference Proceedings

  1. Baehr W, Palczewski K (1995). Two distinct guanylate cyclase-binding proteins in the mammalian retina. Great Basin Symposium, Moran Eye Center, Salt Lake City, UT.

Editorial

  1. Baehr W, Hageman G, Wensel T, Wu S, Zack D (2010 Mar 31). Mechanisms of macular degeneration. Vision Res, 50(7), 637.
  2. Palczewski K, Hofmann KP, Baehr W (2006 Dec). Rhodopsin--advances and perspectives. Vision Res, 46(27), 4425-6.
  3. Pugh EN Jr, Baehr W, Zrenner E (2005 Dec). Neuroimaging the retina. Vision Res, 45(28), 3431.
  4. Baehr W, Spekreijse H, Zrenner E (1999 Jul). Retinal development, degeneration and functional restitution. Vision Res, 39(15), 2439-40.

Video/Film/CD/Web/Podcast

  1. Palczewski K, Baehr W (In Press). The retinoid cycle and retinal diseases [Web]. Encyclopedia of Life Sciences MacMillan Reference Ltd. Available: http://mrw.interscience.wiley.com/emrw/9780470015902/search/firstpage.
  2. Baehr W, Frederick JM (2000). Inherited retina diseases: Vertebrate animal models [Web]. MacMillan Reference Ltd. Available: http://retina.hmbg.utah.edu.
  3. Baehr W, Liebman P (2000). The Visual Cascade [Web]. MacMillan Reference Ltd., article A225. Available: http://retina.hmbg.utah.edu.

News

Video