Andrew S. Weyrich, PhD

Languages

  • English

Academic Information

  • Departments: Internal Medicine - Professor, Pathology - Adjunct Professor
  • Divisions: Microbiology and Immunology, Pulmonary

Academic Office Information

  • 801-581-7236
  • John R. Park Building
    201 Presidents Cir, Room: 210
    Salt Lake City, UT 84112

Email: andy.weyrich@utah.edu

Academic Bio

Dr. Andrew S. Weyrich’s research examines how blood clots in health and disease. His group made the seminal discovery in 2005 that anucleate human platelets splice precursor messenger RNA into products that regulate inflammation. This paradigm shifting observation revolutionized the field of hematology, and has led to thousands of studies that use mRNA profiling to understand how platelets regulate thrombosis and inflammation - which is now referred to as "thromboinflammation". Dr. Weyrich has delivered more than 100 national and international talks and keynote addresses, and he has received numerous investigator research awards from the Arteriosclerosis, Thrombosis and Vascular Biology (ATVB), the International Society of Thrombosis and Haemostasis (ISTH), and the prestigious William Dameshek prize from the American Society of Hematology (ASH). The University of Utah has also recognized him with an H.A. and Edna Benning Presidential Endowed Chair and he recently received the John R. Hoidal Senior Investigator Award. Dr. Weyrich has published more than 150 peer-reviewed articles and has been funded by the National Institute of Health (NIH) for over 25 years, including during his tenure as the Vice President for Research (VPR). Dr. Weyrich is also a member of the esteemed NIH National Heart, Lung, and Blood (NHLBI) advisory council.

U Research Leadership

In addition to Dr. Weyrich’s prolific research work, he also serves as the University of Utah’s Vice President for Research and President of the University’s Research Foundation and Innovation District since July 2016. Previous to these appointments, he was the Associate Dean of Research at the Health Sciences. As a leader of the U’s research community, Dr. Weyrich has implemented strategic initiatives and programs that continues to drive diverse and inclusive research excellence at the U and also contributes more than $500 million annually to the Utah economy. During his service, the U’s research portfolio has been on an upward trajectory with an average annual increase of 27% in extramural awards that totaled over $3.5 billion dollars. The U received national research recognitions including membership in the Association of American Universities and the Association of Public and Land-grant Universities (APLU) Innovation and Economic Prosperity designation. He has also launched numerous research programs, including critical topics in: Women in Violence; COVID-19; Opioid Crisis; and Equity, Diversity, and Inclusion in Research. Since assuming responsibility in 2019, Dr. Weyrich spearheaded important safety initiatives in research laboratories and work spaces to strengthen campus-wide safety that included restructuring of Environmental Health and Safety (EHS) and the development of stronger working relationships between EHS and research-intensive units. He also worked with UU Health Operations and the Research Cores to stand-up surveillance testing for the entire UU community. Dr. Weyrich’s support for future generations in research is built upon his passion for mentorship and student engagement. Dr. Weyrich has taught and mentored undergraduate, graduate, and medical students since his career began, and he currently directs training grant programs that support research for medical students and postdoctoral fellows. He also works closely with Undergraduate Research Programs at the U to help provide impactful resources to enhance the U student research experience and career mobility.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah, Nora Eccles Harrison CVRTI
 Postdoctoral Fellow
Postdoctoral Fellowship Thomas Jefferson University, Jefferson Medical College
 Postdoctoral Fellow
Doctoral Training Bowman Gray School of Medicine
Physiology/Pharmacology		 Ph.D.
Graduate Training Wake Forest University
Exercise Physiology		 M.A.
Undergraduate Baldwin-Wallace College, Ohio
Biology		 B.S.

Selected Publications

Journal Article

  1. Basak I, Bhatlekar S, Manne BK, Stoller M, Hugo S, Kong X, Ma L, Rondina MT, Weyrich AS, Edelstein LC, Bray PF (2019). miR-15a-5p regulates expression of multiple proteins in the megakaryocyte GPVI signaling pathway. J Thromb Haemost, 17(3), 511-524.
  2. Denis HL, Lamontagne-Proulx J, St-Amour I, Mason SL, Rowley JW, Cloutier N, Tremblay ME, Vincent AT, Gould PV, Chouinard S, Weyrich AS, Rondina MT, Barker RA, Boilard E, Cicchetti F (2019). Platelet abnormalities in Huntington's disease. J Neurol Neurosurg Psychiatry, 90(3), 272-283.
  3. Mesquita EC, Hottz ED, Amancio RT, Carneiro AB, Palhinha L, Coelho LE, Grinsztejn B, Zimmerman GA, Rondina MT, Weyrich AS, Bozza PT, Bozza FA (2018). Persistent platelet activation and apoptosis in virologically suppressed HIV-infected individuals. Sci Rep, 8(1), 14999.
  4. Manne BK, Munzer P, Badolia R, Walker-Allgaier B, Campbell RA, Middleton E, Weyrich AS, Kunapuli SP, Borst O, Rondina MT (2018 Jun). PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost, 16(6), 1211-1225.
  5. Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina MT (2018). Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids. Arterioscler Thromb Vasc Biol, 38(4), 801-815.
  6. Campbell RA, Franks Z, Bhatnagar A, Rowley JW, Manne BK, Supiano MA, Schwertz H, Weyrich AS, Rondina MT (2018). Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. J Immunol, 200(1), 295-304.
  7. Schwertz H, Rowley JW, Zimmerman GA, Weyrich AS, Rondina MT (2017). Retinoic acid receptor-alpha regulates synthetic events in human platelets. J Thromb Haemost, 15(12), 2408-2418.
  8. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 21(6), 1705.
  9. Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich AS (2017). Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis. Arterioscler Thromb Vasc Biol, 37(10), 1819-1827.
  10. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED (2017). Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol, 37(9), 1628-1639.
  11. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W (2017). Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv, 1(18), 1398-1408.
  12. Michael JV, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, Hoffman NE, Rajan S, Tomar D, Madesh M, Nieman MT, Yu J, Edelstein LC, Rowley JW, Weyrich AS, Goldfinger LE (2017). Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood, 130(5), 567-580.
  13. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 20(4), 881-894.
  14. Kapur R, Kim M, Aslam R, McVey MJ, Tabuchi A, Luo A, Liu J, Li Y, Shanmugabhavananthan S, Speck ER, Zufferey A, Yousef G, Zhang H, Rondina MT, Weyrich AS, Porcelijn L, Kuebler WM, Slutsky AS, Semple JW (2017). T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10. Blood, 129(18), 2557-2569.
  15. Rowley JW, Weyrich AS (2017). Ribosomes in platelets protect the messenger. Blood, 129(17), 2343-2345.
  16. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT (2016). Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. J Thromb Haemost, 14(11), 2230-2240.
  17. Rondina MT, Freitag M, Pluthero FG, Kahr WH, Rowley JW, Kraiss LW, Franks Z, Zimmerman GA, Weyrich AS, Schwertz H (2016). Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets. J Thromb Haemost, 14(5), 1082-94.
  18. Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-51.
  19. Rondina MT, Weyrich AS (2016). Arf6 arbitrates fibrinogen endocytosis. Blood, 127(11), 1383-4.
  20. Rondina MT, Weyrich AS (2015 Jul 16). Dengue virus pirates human platelets. Blood, 126(3), 286-7.
  21. Rondina MT, Carlisle M, Fraughton T, Brown SM, Miller RR 3rd, Harris ES, Weyrich AS, Zimmerman GA, Supiano MA, Grissom CK (2015). Platelet-monocyte aggregate formation and mortality risk in older patients with severe sepsis and septic shock. J Gerontol A Biol Sci Med Sci, 70(2), 225-31.
  22. Madden JL, Drakos SG, Stehlik J, McKellar SH, Rondina MT, Weyrich AS, Selzman CH (2014). Baseline red blood cell osmotic fragility does not predict the degree of post-LVAD hemolysis. ASAIO J, 60(5), 524-8.
  23. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS (2014). Proteasome function is required for platelet production. J Clin Invest, 124(9), 3757-66.
  24. Hottz ED, Medeiros-de-Moraes IM, Vieira-de-Abreu A, de Assis EF, Vals-de-Souza R, Castro-Faria-Neto HC, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT (2014). Platelet activation and apoptosis modulate monocyte inflammatory responses in dengue. J Immunol, 193(4), 1864-72.
  25. Schubert S, Weyrich AS, Rowley JW (2014). A tour through the transcriptional landscape of platelets. Blood, 124(4), 493-502.
  26. Major HD, Campbell RA, Silver RM, Branch DW, Weyrich AS (2014). Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia. Am J Obstet Gynecol, 210(6), 547.e1-7.
  27. Hottz ED, Lopes JF, Freitas C, Valls-de-Souza R, Oliveira MF, Bozza MT, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza FA, Bozza PT (2013). Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation. Blood, 122(20), 3405-14.
  28. Kahr WH, Lo RW, Li L, Pluthero FG, Christensen H, Ni R, Vaezzadeh N, Hawkins CE, Weyrich AS, Di Paola J, Landolt-Marticorena C, Gross PL (2013). Abnormal megakaryocyte development and platelet function in Nbeal2(-/-) mice. Blood, 122(19), 3349-58.
  29. Chen K, Coonrod EM, Kumanovics A, Franks ZF, Durtschi JD, Margraf RL, Wu W, Heikal NM, Augustine NH, Ridge PG, Hill HR, Jorde LB, Weyrich AS, Zimmerman GA, Gundlapalli AV, Bohnsack JF, Voelkerding KV (2013). Germline mutations in NFKB2 implicate the noncanonical NF-kappaB pathway in the pathogenesis of common variable immunodeficiency. Am J Hum Genet, 93(5), 812-24.
  30. Kraemer BF, Weyrich AS, Lindemann S (2013). Protein degradation systems in platelets. Thromb Haemost, 110(5), 920-4.
  31. Holly SP, Chang JW, Li W, Niessen S, Phillips RM, Piatt R, Black JL, Smith MC, Boulaftali Y, Weyrich AS, Bergmeier W, Cravatt BF, Parise LV (2013). Chemoproteomic discovery of AADACL1 as a regulator of human platelet activation. Chem Biol, 20(9), 1125-34.
  32. Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss LW (2013). Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells. J Cell Biochem, 114(7), 1519-28.
  33. Rowley JW, Weyrich AS (2013). Coordinate expression of transcripts and proteins in platelets. Blood, 121(26), 5255-6.
  34. Hottz ED, Oliveira MF, Nunes PC, Nogueira RM, Valls-de-Souza R, Da Poian AT, Weyrich AS, Zimmerman GA, Bozza PT, Bozza FA (2013). Dengue induces platelet activation, mitochondrial dysfunction and cell death through mechanisms that involve DC-SIGN and caspases. J Thromb Haemost, 11(5), 951-62.
  35. Franks Z, Campbell RA, Vieira de Abreu A, Holloway JT, Marvin JE, Kraemer BF, Zimmerman GA, Weyrich AS, Rondina MT (2013). Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thromb Haemost, 109(4), 684-95.
  36. Kraemer BF, Weyrich AS (2013). Polyubiquinated protein depots in platelets and megakaryocytes from patients with ANKRD26-RT. Thromb Haemost, 109(2), 180.
  37. Chen K, Rondina MT, Weyrich AS (2013). A sticky story for signal transducer and activator of transcription 3 in platelets. Circulation, 127(4), 421-3.
  38. Weyrich AS, Zimmerman GA (2013). Platelets in lung biology. Annu Rev Physiol, 75, 569-91.
  39. Harris ES, Weyrich AS, Zimmerman GA (2013). Lessons from rare maladies: leukocyte adhesion deficiency syndromes. Curr Opin Hematol, 20(1), 16-25.
  40. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-20.
  41. Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW (2012). Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano, 6(11), 9900-10.
  42. Rowley JW, Schwertz H, Weyrich AS (2012). Platelet mRNA: the meaning behind the message. Curr Opin Hematol, 19(5), 385-91.
  43. Thon JN, Peters CG, Machlus KR, Aslam R, Rowley J, Macleod H, Devine MT, Fuchs TA, Weyrich AS, Semple JW, Flaumenhaft R, Italiano JE Jr (2012). T granules in human platelets function in TLR9 organization and signaling. J Cell Biol, 198(4), 561-74.
  44. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm, 9(6), 1599-611.
  45. Rondina MT, Brewster B, Grissom CK, Zimmerman GA, Kastendieck DH, Harris ES, Weyrich AS (2012). In vivo platelet activation in critically ill patients with primary 2009 influenza A(H1N1). Chest, 141(6), 1490-5.
  46. Rondina MT, Grissom CK, Men S, Harris ES, Schwertz H, Zimmerman GA, Weyrich AS (2012). Whole blood flow cytometry measurements of in vivo platelet activation in critically-Ill patients are influenced by variability in blood sampling techniques. Thromb Res, 129(6), 729-35.
  47. Jiang H, Schwertz H, Schmid DI, Jones BB, Kriesel J, Martinez ML, Weyrich AS, Zimmerman GA, Kraiss LW (2012). Different mechanisms preserve translation of programmed cell death 8 and JunB in virus-infected endothelial cells. Arterioscler Thromb Vasc Biol, 32(4), 997-1004.
  48. Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA (2012). Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. Progress in Inflammatory Bowel Disease, 34(1), 5-30.
  49. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich AS (2012). Assessing protein synthesis by platelets. Methods Mol Biol, 788, 141-53.
  50. Rondina MT, Weyrich AS (2012). Targeting phosphodiesterases in anti-platelet therapy. Handb Exp Pharmacol, (210), 225-38.
  51. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355.
  52. Rowley JW, Oler AJ, Tolley ND, Hunter BN, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (2011). Genome-wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11.
  53. Bosque A, Famiglietti M, Weyrich AS, Goulston C, Planelles V (2011). Homeostatic proliferation fails to efficiently reactivate HIV-1 latently infected central memory CD4+ T cells. PLoS Pathog, 7(10), e1002288.
  54. Cecchetti L, Tolley ND, Michetti N, Bury L, Weyrich AS, Gresele P (2011). Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood, 118(7), 1903-11.
  55. Kahr WH, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu GY, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J (2011). Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet, 43(8), 738-40.
  56. Smith TL, Weyrich AS (2011). Platelets as central mediators of systemic inflammatory responses. Thromb Res, 127(5), 391-4.
  57. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost, 9(4), 748-58.
  58. Schubert S, Schwertz H, Weyrich AS, Franks ZG, Lindemann S, Otto M, Behr H, Loppnow H, Schlitt A, Russ M, Presek P, Werdan K, Buerke M (2011). Staphylococcus aureus alpha-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins (Basel), 3(2), 120-33.
  59. Schubert S, Schwertz H, Weyrich AS, Franks ZG, Lindemann S, Otto M, Behr H, Loppnow H, Schlitt A, Russ M, Presek P, Werdan K, Buerke M (2011). Staphylococcus aureus α-toxin triggers the synthesis of B-cell lymphoma 3 by human platelets. Toxins (Basel), 3, 120-133.
  60. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost, 9, 748-758.
  61. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WHA, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of β-defensin 1 in human platelets: Suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355.
  62. Rowley JW, Oler A, Tolley ND, Hunter B, Low EN, Nix DA, Yost CC, Zimmerman GA, Weyrich AS (2011). Genome wide RNA-seq analysis of human and mouse platelet transcriptomes. Blood, 118(14), e101-11.
  63. Cecchetti L, Tolley ND, Michetti N, Bury L, Weyrich AS, Gresele P (2011). Megakaryocytes differentially sort mRNAs for matrix metalloproteinases and their inhibitors into platelets: a mechanism for regulating synthetic events. Blood, 118(7), 1903-11.
  64. Kahr WHA, Hinckley J, Li L, Schwertz H, Christensen H, Rowley JW, Pluthero FG, Urban D, Fabbro S, Nixon B, Gadzinski R, Storck M, Wang K, Ryu G-Y, Jobe SM, Schutte BC, Moseley J, Loughran NB, Parkinson J, Weyrich AS, Di Paola J (2011). Mutations in NBEAL2, encoding a BEACH protein, cause gray platelet syndrome. Nat Genet, 43(8), 738-40.
  65. Schwertz H, Weyrich AS (2010). Platelet precursors display bipolar behavior. J Cell Biol, 191(4), 699-700.
  66. Franks ZG, Campbell RA, Weyrich AS, Rondina MT (2010). Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. Ann N Y Acad Sci, 1207, 11-17.
  67. Pawlinski R, Wang JG, Owens AP 3rd, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N (2010). Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood, 116(5), 806-814.
  68. Pawlinski R, Wang JG, Owens AP 3rd, Williams J, Antoniak S, Tencati M, Luther T, Rowley JW, Low EN, Weyrich AS, Mackman N (2010). Hematopoietic and nonhematopoietic cell tissue factor activates the coagulation cascade in endotoxemic mice. Blood, 116(5), 806-14.
  69. Schwertz H, Koster S, Kahr WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, Weyrich AS (2010). Anucleate platelets generate progeny. Blood, 115(18), 3801-9.
  70. Zimmerman GA, Weyrich AS (2010). Immunology. Arsonists in rheumatoid arthritis. Science, 327(5965), 528-9.
  71. Schwertz H, Koster S, Kahr, WH, Michetti N, Kraemer BF, Weitz DA, Blaylock RC, Kraiss LW, Greinacher A, Zimmerman GA, Weyrich AS (2010). Anucleate platelets generate progeny. Blood, 115, 3801-3809.
  72. Rowley JW, Weyrich AS, Campbell RA (2009). TGFBIp: more than meets the eye? Blood, 114(25), 5113-4.
  73. Schwertz H, Zimmerman GA, Weyrich AS (2009). Fibrinogen selects selectins. Blood, 114(2), 234.
  74. Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich AS (2009). PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood, 113, 6699-706.
  75. Foulks JM, Marathe GK, Michetti N, Stafforini DM, Zimmerman GA, McIntyre TM, Weyrich AS (2009). PAF-acetylhydrolase expressed during megakaryocyte differentiation inactivates PAF-like lipids. Blood, 113(26), 6699-706.
  76. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (2009). Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. Blood, 113(25), 6419-27.
  77. Yost CC, Cody MJ, Harris ES, Thornton NL, McInturff AM, Martinez ML, Chandler NB, Rodesch CK, Albertine KH, Petti CA, Weyrich AS, Zimmerman GA (2009). Impaired neutrophil extracellular trap (NET) formation: A novel innate immune deficiency of human neonates. Blood, 113, 6419-27.
  78. Weyrich AS, Zimmerman GA (2009). Comparative genomics: fishing nets hemostatic catch. Blood, 113(19), 4479-80.
  79. Foulks JM, Weyrich AS, Zimmerman GA, McIntyre TM (2008). A yeast PAF acetylhydrolase ortholog suppresses oxidative death. Free Radic Biol Med, 45(4), 434-42.
  80. Miyazaki Y, Bunting M, Stafforini DM, Harris ES, McIntyre TM, Prescott SM, Frutuoso VS, Amendoeira FC, de Oliveira Nascimento D, Vieira-de-Abreu A, Weyrich AS, Castro-Faria-Neto HC, Zimmerman GA (2008). Integrin αDβ2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol, 180(1), 590-600.
  81. Foulks JM, Weyrich AS, Zimmerman GA, McIntyre TM (2008). A yeast PAF acetylhydrolase ortholog suppresses oxidative death. Free Radic Biol Med, 45(4), 434-442.
  82. Miyazaki Y, Bunting M, Stafforini DM, Harris ES, McIntyre TM, Prescott SM, Frutuoso VS, Amendoeira FC, de Oliveira Nascimento D, Vieira-de-Abreu A, Weyrich AS, Castro-Faria-Neto HC, Zimmerman GA (2008). Integrin alphaDbeta2 is dynamically expressed by inflamed macrophages and alters the natural history of lethal systemic infections. J Immunol, 180(1), 590-600.
  83. Chen J, Yang L, Foulks JM, Weyrich AS, Marathe GK, McIntyre TM (2007). Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. J Lipid Res, 48(11), 2365-76.
  84. Weyrich AS, Denis MM, Schwertz H, Tolley ND, Foulks J, Spencer E, Kraiss LW, Albertine KH, McIntyre TM, Zimmerman GA (2007). mTOR-dependent synthesis of Bcl-3 controls the retraction of fibrin clots by activated human platelets. Blood, 109, 1975-1983.
  85. Buerke M, Guckenbiehl M, Schwertz H, Buerke U, Hilker M, Platsch H, Richert J, Bomm S, Zimmerman GA, Lindemann S, Mueller-Werdan U, Werdan K, Darius H, Weyrich AS (2007). Intramural delivery of Sirolimus prevents vascular remodeling following balloon injury. Biochim Biophys Acta, 1774(1), 5-15.
  86. Chen J, Yang L, Foulks JM, Weyrich AS, Marathe GK, McIntyre TM (2007). Intracellular PAF catabolism by PAF acetylhydrolase counteracts continual PAF synthesis. J Lipid Res, 48(11), 2365-2376.
  87. Brant-Zawadski PB, Schmid DI, Jiang H, Weyrich AS, Zimmerman GA, Kraiss LW (2007). Translational control in endothelial cells. J Vasc Surg, 45 Suppl A, A8-14.
  88. Schwertz H, Tolley ND, Foulks JM, Denis MM, Risenmay BW, Buerke M, Tilley RE, Rondina MT, Harris EM, Kraiss LW, Mackman N, Zimmerman GA, Weyrich AS (2006). Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets. J Exp Med, 203(11), 2433-40.
  89. Dixon DA, Tolley ND, Bemis-Standoli K, Martinez ML, Weyrich AS, Morrow JD, Prescott SM, Zimmerman GA (2006). Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest, 116(10), 2727-38.
  90. Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CM, Weyrich AS, Greene WC, Planelles V (2006). HIV-1 Vpr induces DNA replication stress in vitro and in vivo. J Virol, 80, 10407-10418.
  91. Denis MM, Tolley ND, Bunting M, Schwertz H, Jiang H, Lindemann S, Yost CC, Rubner FJ, Albertine KH, Swoboda KJ, Fratto CM, Tolley E, Kraiss LW, McIntyre TM, Zimmerman GA, Weyrich AS (2005). Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets. Cell, 122(3), 379-91.
  92. Weyrich AS, Denis MM, Kuhlmann-Eyre JR, Spencer ED, Dixon DA, Marathe GK, McIntyre TM, Zimmerman GA, Prescott SM (2005). Dipyridamole selectively inhibits inflammatory gene expression in platelet-monocyte aggregates. Circulation, 111(5), 633-42.
  93. Jiang H, Weyrich AS, Zimmerman GA, McIntyre TM (2004). Endothelial cell confluence regulates cyclooxygenase-2 and prostaglandin E2 production that modulate motility. J Biol Chem, 279(53), 55905-13.
  94. Yost CC, Denis MM, Lindemann S, Rubner FJ, Marathe GK, Buerke M, McIntyre TM, Weyrich AS, Zimmerman GA (2004). Activated polymorphonuclear leukocytes rapidly synthesize retinoic acid receptor-alpha: a mechanism for translational control of transcriptional events. J Exp Med, 200(5), 671-80.
  95. Lindemann, SW, Yost CC, Denis MM, McIntyre TY, Weyrich AS, Zimmerman GA (2004). Neutrophils alter the inflammatory milieu by signal-dependent translation of constitutive messenger RNAs. Proc Natl Acad Sci U S A, 101, 7076-7081.
  96. Watanabe J, Marathe GK, Neilsen PO, Weyrich AS, Harrison KA, Murphy RC, Zimmerman GA, McIntyre TM (2003). Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. J Biol Chem, 278(35), 33161-8.
  97. Kraiss LW, Alto NM, Dixon DA, McIntyre TM, Weyrich AS, Zimmerman GA (2003). Fluid flow regulates E-selectin protein levels in human endothelial cells by inhibiting translation. J Vasc Surg, 37(1), 161-8.
  98. Galt SW, Lindemann S, Allen L, Medd DJ, Falk JM, McIntyre TM, Prescott SM, Kraiss LW, Zimmerman GA, Weyrich AS (2002). Outside-in signals delivered by matrix metalloproteinase-1 regulate platelet function. Circ Res, 90(10), 1093-9.
  99. Feldhaus MJ, Weyrich AS, Zimmerman GA, McIntyre TM (2002). Ceramide generation in situ alters leukocyte cytoskeletal organization and beta 2-integrin function and causes complete degranulation. J Biol Chem, 277(6), 4285-93.
  100. Galt SW, Lindemann S, Medd D, Allen LL, Kraiss LW, Harris ES, Prescott SM, McIntyre TM, Weyrich AS, Zimmerman GA (2001). Differential regulation of matrix metalloproteinase-9 by monocytes adherent to collagen and platelets. Circ Res, 89(6), 509-16.
  101. Lindemann S, Tolley ND, Eyre JR, Kraiss LW, Mahoney TM, Weyrich AS (2001). Integrins regulate the intracellular distribution of eukaryotic initiation factor 4E in platelets. A checkpoint for translational control. J Biol Chem, 276(36), 33947-51.
  102. Mahoney TS, Weyrich AS, Dixon DA, McIntyre T, Prescott SM, Zimmerman GA (2001). Cell adhesion regulates gene expression at translational checkpoints in human myeloid leukocytes. Proc Natl Acad Sci U S A, 98(18), 10284-9.
  103. Lindemann S, Tolley ND, Dixon DA, McIntyre TM, Prescott SM, Zimmerman GA, Weyrich AS (2001). Activated platelets mediate inflammatory signaling by regulated interleukin 1beta synthesis. J Cell Biol, 154(3), 485-90.
  104. Kraiss LW, Weyrich AS, Alto NM, Dixon DA, Ennis TM, Modur V, McIntyre TM, Prescott SM, Zimmerman GA (2000). Fluid flow activates a regulator of translation, p70/p85 S6 kinase, in human endothelial cells. Am J Physiol Heart Circ Physiol, 278(5), H1537-44.
  105. Pabla R, Weyrich AS, Dixon DA, Bray PF, McIntyre TM, Prescott SM, Zimmerman GA (1999). Integrin-dependent control of translation: engagement of integrin alphaIIbbeta3 regulates synthesis of proteins in activated human platelets. J Cell Biol, 144(1), 175-84.
  106. Kessel JM, Hayflick J, Weyrich AS, Hoffman PA, Gallatin M, McIntyre TM, Prescott SM, Zimmerman GA (1998). Coengagement of ICAM-3 and Fc receptors induces chemokine secretion and spreading by myeloid leukocytes. J Immunol, 160(11), 5579-87.
  107. Weyrich AS, Dixon DA, Pabla R, Elstad MR, McIntyre TM, Prescott SM, Zimmerman GA (1998). Signal-dependent translation of a regulatory protein, Bcl-3, in activated human platelets. Proc Natl Acad Sci U S A, 95(10), 5556-61.
  108. Hidari KI, Weyrich AS, Zimmerman GA, McEver RP (1997). Engagement of P-selectin glycoprotein ligand-1 enhances tyrosine phosphorylation and activates mitogen-activated protein kinases in human neutrophils. J Biol Chem, 272(45), 28750-6.
  109. Modur V, Feldhaus MJ, Weyrich AS, Jicha DL, Prescott SM, Zimmerman GA, McIntyre TM (1997). Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. J Clin Invest, 100(1), 158-68.
  110. Lehr HA, Weyrich AS, Saetzler RK, Jurek A, Arfors KE, Zimmerman GA, Prescott SM, McIntyre TM (1997). Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking. J Clin Invest, 99(10), 2358-64.
  111. Weyrich AS, Elstad MR, McEver RP, McIntyre TM, Moore KL, Morrissey JH, Prescott SM, Zimmerman GA (1996). Activated platelets signal chemokine synthesis by human monocytes. J Clin Invest, 97(6), 1525-34.
  112. Weyrich AS, McIntyre TM, McEver RP, Prescott SM, Zimmerman GA (1995). Monocyte tethering by P-selectin regulates monocyte chemotactic protein-1 and tumor necrosis factor-alpha secretion. Signal integration and NF-kappa B translocation. J Clin Invest, 95(5), 2297-303.
  113. Weyrich AS, Buerke M, Albertine KH, Lefer AM (1995). Time course of coronary vascular endothelial adhesion molecule expression during reperfusion of the ischemic feline myocardium. J Leukoc Biol, 57(1), 45-55.
  114. Weyrich AS, Ma XL, Buerke M, Murohara T, Armstead VE, Lefer AM, Nicolas JM, Thomas AP, Lefer DJ, Vinten-Johansen J (1994). Physiological concentrations of nitric oxide do not elicit an acute negative inotropic effect in unstimulated cardiac muscle. Circ Res, 75(4), 692-700.
  115. Buerke M, Weyrich AS, Murohara T, Queen C, Klingbeil CK, Co MS, Lefer AM (1994). Humanized monoclonal antibody DREG-200 directed against I-selectin protects in feline myocardial reperfusion injury. J Pharmacol Exp Ther, 271(1), 134-42.
  116. Albertine KH, Weyrich AS, Ma XL, Lefer DJ, Becker LC, Lefer AM (1994). Quantification of neutrophil migration following myocardial ischemia and reperfusion in cats and dogs. J Leukoc Biol, 55(5), 557-66.
  117. Buerke M, Weyrich AS, Zheng Z, Gaeta FC, Forrest MJ, Lefer AM (1994). Sialyl Lewisx-containing oligosaccharide attenuates myocardial reperfusion injury in cats. J Clin Invest, 93(3), 1140-8.
  118. Lefer AM, Weyrich AS, Buerke M (1994). Role of selectins, a new family of adhesion molecules, in ischaemia-reperfusion injury. Cardiovasc Res, 28(3), 289-94.
  119. Buerke M, Weyrich AS, Lefer AM (1994). Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. Am J Physiol, 266(1 Pt 2), H128-36.
  120. Ma XL, Weyrich AS, Lefer DJ, Buerke M, Albertine KH, Kishimoto TK, Lefer AM (1993). Monoclonal antibody to L-selectin attenuates neutrophil accumulation and protects ischemic reperfused cat myocardium. Circulation, 88(2), 649-58.
  121. Weyrich AS, Ma XY, Lefer DJ, Albertine KH, Lefer AM (1993). In vivo neutralization of P-selectin protects feline heart and endothelium in myocardial ischemia and reperfusion injury. J Clin Invest, 91(6), 2620-9.
  122. Ma XL, Weyrich AS, Lefer DJ, Lefer AM (1993). Diminished basal nitric oxide release after myocardial ischemia and reperfusion promotes neutrophil adherence to coronary endothelium. Circ Res, 72(2), 403-12.
  123. Lefer AM, Ma XL, Weyrich AS, Scalia R (1993). Mechanism of the cardioprotective effect of transforming growth factor beta 1 in feline myocardial ischemia and reperfusion. Proc Natl Acad Sci U S A, 90(3), 1018-22.
  124. Carey C, Siegfried MR, Ma XL, Weyrich AS, Lefer AM (1992). Antishock and endothelial protective actions of a NO donor in mesenteric ischemia and reperfusion. Circ Shock, 38(3), 209-16.
  125. Weyrich AS, Solis GA, Li KS, Tulenko TN, Santamore WP (1992). Platelet amplification of vasospasm. Am J Physiol, 263(2 Pt 2), H349-58.
  126. Weyrich AS, Ma XL, Lefer AM (1992). The role of L-arginine in ameliorating reperfusion injury after myocardial ischemia in the cat. Circulation, 86(1), 279-88.
  127. Weyrich AS, Rejeski WJ, Brubaker PH, Parks JS (1992). The effects of testosterone on lipids and eicosanoids in cynomolgus monkeys. Med Sci Sports Exerc, 24(3), 333-8.
  128. Ma XL, Weyrich AS, Krantz S, Lefer AM (1992). Mechanisms of the cardioprotective actions of WEB-2170, bepafant, a platelet activating factor antagonist, in myocardial ischemia and reperfusion. J Pharmacol Exp Ther, 260(3), 1229-36.
  129. Berry MJ, Stoneman JV, Weyrich AS, Burney B (1991). Dissociation of the ventilatory and lactate thresholds following caffeine ingestion. Med Sci Sports Exerc, 23(4), 463-9.
  130. Solis GA, Kutcher MA, Weyrich AS, Santamore WP (1991). Albumin prevents platelet deposition following angioplasty. J Interv Cardiol, 3, 265-271.
  131. Santamore WP, Weyrich AS, Iskandrian AS (1991). Coronary artery spasm revisited. Coron Artery Dis, 2, 259-266.
  132. Berry MJ, Puntenney PJ, Weyrich AS, Robergs RA (1990). Stride frequency as a determinant of the ventilatory threshold. J Hum Mov Stud, 19, 129-142.
  133. Weyrich AS, Messier SP, Ruhmann BS, Berry MJ (1989). Effects of bat composition, grip firmness, and impact location on postimpact ball velocity. Med Sci Sports Exerc, 21(2), 199-205.
  134. Berry MJ, Weyrich AS, Robergs RA, Krause KM, Ingalls CP (1989). Ratings of perceived exertion in individuals with varying fitness levels during walking and running. Eur J Appl Physiol Occup Physiol, 58(5), 494-9.
  135. Berry MJ, Robergs RA, Weyrich AS, Puntenney PJ (1988). Ventilatory responses of trained and untrained subjects during running and walking. Int J Sports Med, 9(5), 325-9.
  136. Weyrich AS, Herb RA, Berry MJ (1987). The influence of diet and exercise on lipoproteins. N C Med J, 23, 10-13.

Review

  1. Campbell RA, Tolley ND, Schwertz H, Weyrich AS (2011). Platelet protein synthesis and translational control. [Review]. Curr Proteomics, 8, 200-207.

Book Chapter

  1. Smith MC, Schwertz H, Zimmerman GA, Weyrich AS (2013). The Platelet Proteome. In A. D. Michelson (Ed.), Platelets (Third Edition, pp. 103-116). London: Elsevier.
  2. Vieira-de-Abreu A, Rondina MT, Weyrich AS, Zimmerman GA (2013). Platelets in Disease: Inflammation. In A. D. Michelson (Ed.), Platelets (Third Edition, pp. 733-766). London: Elsevier.
  3. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich AS (2012). Assessing Protein Synthesis by Platelets. In J. M. Gibbins, M. P. Mahaut-Smith (Eds.), Methods in Molecular Biology: Platelets and Megakaryocytes (3, pp. 141-153). New York: Humana Press.
  4. Harris ES, Rondina MT, Schwertz H, Weyrich AS, Zimmerman GA (2010). Pathogenesis of sepsis and sepsis-induced acute lung injury. In A.M.K. Choi (Ed.), Acute Respiratory Distress Syndrome, Second Edition (pp. 369-419). New York: Informa Healthcare.
  5. Schwertz H, Weyrich AS, Zimmerman GA (2007). Interacoes entre plaquetas, leucocitos e endotelia na resposta inflamatoria sistemica e na sepse. (Cellular interactions of platelets, leukocytes and endothelum in systemic inflammatory responses and sepsis). In H. Caire de Castro Faria Neto, C Marcus David (Eds.), Sepse: Da Bancada a Beira Do Leto (pp. 107-120). Rio de Janeiro: Revinter Press.
  6. Lindemann SW, McIntyre TM, Prescott SM, Zimmerman GA, Weyrich AS (2005). Expanding the functional repertoire of platelets in thrombosis and inflammation: signal-dependent protein synthesis. In DJ Fitzgerald, MJ Quinn (Eds.), Platelet Function: Assessment, Diagnosis and Treatment (pp. 149-174).
  7. Zimmerman GA, Dixon DA, McIntyre TM, Prescott SM, Weyrich AS (2003). Molecular Mechanisms of Juxtacrine Cell Signaling in Microvascular Responses and Inflammation. In G.W. Schmid-Schonbein and D.N. Granger (Eds.), Molecular Basis for Microcirculatory Disorders (pp. 203-217).
  8. Weyrich AS, Zimmerman GA (2002). Selectins. In Encyclopedia of Molecular Medicine (5, pp. 2876-2880).
  9. Zimmerman GA, Elstad MR, Lorant DE, McIntyre TM, Prescott SM, Topham MK, Weyrich AS, Whatley RE (1997). Platelet-activating factor (PAF): Signaling and adhesion in cell-cell interactions. In Nigams; Kunkel G; Prescott SM; Vargaftig BB (Ed.), Platelet-Activating Factor and Related Lipid Mediators 2. Roles in Health and Disease (416, pp. 297-304). Advances in Experimental Medicine and Biology.
  10. Lefer AM, Ma XL, Weyrich AS, Lefer DJ (1993). Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury. In Bonney (Ed.), Inflammatory Disease Therapy: Preclinical and Clinical Developments (41, pp. 127-135).

Editorial

  1. Weyrich AS, Kraiss LK, Zimmerman GA (2008). Trading places: mRNA transfer between cells. Blood, 110(7), 2219.
  2. Bozza FA, Weyrich AS (2008). Mitochondria push platelets past their prime. Blood, 111(5), 2496-2497.
  3. Weyrich AS, Schwertz H, Mackman N (2007). Platelet tissue factor comes of age. Blood, 109(12), 5069-5070.
  4. Weyrich AS, Prescott SM, Zimmerman GA (2002). Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. Circulation, 106(12), 1433-5.

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