Jeanne M. Frederick, PhD

Languages

  • English

Academic Information

  • Departments: Ophthalmology/Visual Sciences - Research Associate Professor

Academic Office Information

  • 801-585-3573
  • John A. Moran Eye Center
    Ophthalmology & Visual Sciences
    65 N Mario Capecchi
    Salt Lake City, UT 84132

Research Statement

I have performed retina histology since the early 1980s, initially studying the circuitry of human dopaminergic amacrine/interplexiform cells in freshly-acquired (<2hr postmortem) donor eyes. Since moving to the University of Utah, we have been first to show: a) mutant rhodopsin on a null background aggregates and is retained in the ER, identified by calnexin colabeling (2001), where it initiates an unfolded protein response; b) guanylate cyclases 1/2 participate in transport of photoreceptor peripheral membrane proteins (2007); c) heterotrimeric kinesin-II is required for the trafficking of membrane proteins in cones, but not rods (2009); and d) lutein- and zeaxanthin-binding proteins, as well as lipase C, are expressed in neurons of the primate retina (2009-10). Continuing studies are directed toward elucidating protein function in healthy photoreceptors, and reasons for dysfunction in the disease state.

Education History

Type School Degree
Postdoctoral Fellowship Baylor College of Medicine
Retinal Development
Postdoctoral Fellow
Doctoral Training University of Wisconsin-Madison
Anatomy/Developmental Biology
Ph.D.
Undergraduate Marquette University
Biology
B.S.