Kenneth M. Boucher, PhD

Research Interests

  • Biostatistics
  • Mathematical Modeling
  • Topology
  • Statistical Consulting
  • Grant Writing

Languages

  • English

Academic Information

  • Departments: Family & Preventive Medicine - Adjunct Associate Professor, Internal Medicine - Research Associate Professor, Population Health Sciences - Adjunct Associate Professor
  • Divisions: Biostatistics, Epidemiology, Public Health

Academic Office Information

  • 801-585-9544
  • Huntsman Cancer Hospital
    1950 Circle of Hope, Room: 1710
    Salt Lake City, UT 84112

Academic Bio

Dr. Kenneth Boucher is Co-Director of the Cancer Biostatistics Shared Resource at Huntsman Cancer Institute at the University of Utah. He is a Research Associate Professor in the Department of Internal Medicine and Adjunct Associate Professor in the Department of Family and Preventive Medicine and the Department of Population Health Sciences. He has been at the University of Utah since 1990 and at the Huntsman Cancer Institute since 1996. He is a member of the Cancer Control and Population Sciences Program at HCI.

Dr. Boucher has numerous research interests in the fields of cancer biostatistics and mathematical modeling. These interests include clinical trials, analysis high throughput genomics, carcinogenesis modeling, and cancer epidemiology.

Cancer Biostatistics Shared Resource webpage: https://uofuhealth.utah.edu/huntsman/shared-resources/cancer-biostatistics/

Education History

Type School Degree
Doctoral Training University of Michigan
Mathematics
Ph.D.
Graduate Training University of Notre Dame
Mathematics
M.S.
Undergraduate Washington University
Mathematics
B.S.

Selected Publications

Journal Article

  1. Maughan BL, Kessel A, McFarland TR, Sayegh N, Nussenzveig R, Hahn AW, Hoffman JM, Morton K, Sirohi D, Kohli M, Swami U, Boucher K, Haaland B, Agarwal N (2021). Radium-223 plus Enzalutamide versus Enzalutamide in Metastatic Castration-Refractory Prostate Cancer: Final Safety and Efficacy Results. (Epub ahead of print) Oncologist.
  2. Binneboese A, Covington MF, Horn KP, Archibald ZG, Boucher KM, Morton KA, Hoffman JM (2021). Correlation between FDG-PET uptake and survival in patients with primary brain tumors. Am J Nucl Med Mol Imaging, 11(3), 196-206.
  3. Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY (2021). Correction: Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Clin Cancer Res, 27(11), 3265.
  4. Kelley KC, Grossman KF, Brittain-Blankenship M, Thorne KM, Akerley WL, Terrazas MC, Kosak KM, Boucher KM, Buys SS, McGregor KA, Werner TL, Agarwal N, Weis JR, Sharma S, Ward JH, Kennedy TP, Sborov DW, Shami PJ (2021). A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker. BMC Cancer, 21(1), 510.
  5. Flint ND, Bishop MD, Smart TC, Strunck JL, Boucher KM, Grossman D, Secrest AM (2020). Low accuracy of self-reported family history of melanoma in high-risk patients. Fam Cancer, 20(1), 41-48.
  6. Rahman H, Kumar D, Liu T, Okwundu N, Lum D, Florell SR, Burd CE, Boucher KM, VanBrocklin MW, Grossman D (2020). Aspirin Protects Melanocytes and Keratinocytes against UVB-Induced DNA Damage In Vivo. J Invest Dermatol, 141(1), 132-141.e3.
  7. Stephens DM, Boucher K, Kander E, Parikh SA, Parry EM, Shadman M, Pagel JM, Cooperrider J, Rhodes J, Mato A, Winter A, Hill B, Gaballa S, Danilov A, Phillips T, Brander DM, Smith SM, Davids M, Rogers K, Glenn MJ, Byrd JC (2020). Hodgkin lymphoma arising in patients with chronic lymphocytic leukemia: outcomes from a large multi-center collaboration. Haematologica, Online ahead of print.
  8. Holowatyj AN, Haffa M, Lin T, Scherer D, Gigic B, Ose J, Warby CA, Himbert C, Abbenhardt-Martin C, Achaintre D, Boehm J, Boucher KM, Gicquiau A, Gsur A, Habermann N, Herpel E, Kauczor HU, Keski-Rahkonen P, Kloor M, von Knebel-Doeberitz M, Kok DE, Nattenmller J, Schirmacher P, Schneider M, Schrotz-King P, Simon T, Ueland PM, Viskochil R, Weijenberg MP, Scalbert A, Ulrich A, Bowers LW, Hursting SD, Ulrich CM (2020). Multi-omics Analysis Reveals Adipose-tumor Crosstalk in Patients with Colorectal Cancer. Cancer Prev Res (Phila), 13(10), 817-828.
  9. Tavtigian SV, Harrison SM, Boucher KM, Biesecker LG (2020). Fitting a naturally scaled point system to the ACMG/AMP variant classification guidelines. Hum Mutat, 41(10), 1734-1737.
  10. Rogers CR, Matthews P, Xu L, Boucher K, Riley C, Huntington M, Le Duc N, Okuyemi KS, Foster MJ (2020). Interventions for increasing colorectal cancer screening uptake among African-American men: A systematic review and meta-analysis. PLoS ONE, 15(9), e0238354.
  11. Cowman SJ, Fuja DG, Liu XD, Tidwell RSS, Kandula N, Sirohi D, Agarwal AM, Emerson LL, Tripp SR, Mohlman JS, Stonhill M, Garcia G, Conley CJ, Olalde AA, Sargis T, Ramirez-Torres A, Karam JA, Wood CG, Sircar K, Tamboli P, Boucher K, Maughan B, Spike BT, Ho TH, Agarwal N, Jonasch E, Koh MY (2020). Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer. Clin Cancer Res, 26(18), 4970-4982.
  12. Tward JD, ONeil B, Boucher K, Kokeny K, Lowrance WT, Lloyd S, Cannon D, Stephenson RA, Agarwal N, Farr T, Petragallo R, Sherar NZ, Kunz I, Hofer A, Courdy S, Shrieve DC, Dechet C (2020). Metastasis, Mortality, and Quality of Life for Men With NCCN High and Very High Risk Localized Prostate Cancer After Surgical and/or Combined Modality Radiotherapy. Clin Genitourin Cancer, 18(4), 274-283.e5.
  13. Cohen AL, Anker CJ, Johnson B, Burt LM, Shrieve DC, Salzman K, Jensen R, Boucher K, Colman H (2020). Repeat radiation with bevacizumab and minocycline in bevacizumab-refractory high grade gliomas: a prospective phase 1 trial. J Neurooncol, 148(3), 577-585.
  14. Li C, Liu T, Tavtigian SV, Boucher K, Kohlmann W, Cannon-Albright L, Grossman D (2019). Targeted germline sequencing of patients with three or more primary melanomas reveals high rate of pathogenic variants. Melanoma Res, 30(3), 247-251.
  15. Agarwal N, Nussenzveig R, Hahn AW, Hoffman JM, Morton K, Gupta S, Batten J, Thorley J, Hawks J, Santos VS, Nachaegari G, Wang X, Boucher K, Haaland B, Maughan BL (2020). Prospective Evaluation of Bone Metabolic Markers as Surrogate Markers of Response to Radium-223 Therapy in Metastatic Castration-resistant Prostate Cancer. Clin Cancer Res, 26(9), 2104-2110.
  16. Drost M, Tiersma Y, Glubb D, Kathe S, van Hees S, Callja F, Zonneveld JBM, Boucher KM, Ramlal RPE, Thompson BA, Rasmussen LJ, Greenblatt MS, Lee A, Spurdle AB, Tavtigian SV, de Wind N (2020). Two integrated and highly predictive functional analysis-based procedures for the classification of MSH6 variants in Lynch syndrome. Genet Med, 22(5), 847-856.
  17. Strunck JL, Smart TC, Boucher KM, Secrest AM, Grossman D (2020). Improved melanoma outcomes and survival in patients monitored by total body photography: A natural experiment. J Dermatol, 47(4), 342-347.
  18. Varedi A, Rahman H, Kumar D, Catrow JL, Cox JE, Liu T, Florell SR, Boucher KM, Okwundu N, Burnett WJ, VanBrocklin MW, Grossman D (2020). ASA Suppresses PGE2 in Plasma and Melanocytic Nevi of Human Subjects at Increased Risk for Melanoma. Pharmaceuticals (Basel), 13(1).
  19. Wu YP, Boucher K, Hu N, Hay J, Kohlmann W, Aspinwall LG, Bowen DJ, Parsons BG, Nagelhout ES, Grossman D, Mooney K, Leachman SA, Tercyak KP (2019). A pilot study of a telehealth family-focused melanoma preventive intervention for children with a family history of melanoma. Psychooncology, 29(1), 148-155.
  20. Kohli DR, Smith KR, Wong J, Yu Z, Boucher K, Faigel DO, Pannala R, Burt RW, Curtin K, Samadder NJ (2019). Familial pancreatic cancer risk: a population-based study in Utah. J Gastroenterol, 54(12), 1106-1112.
  21. Kanth P, Boylan KE, Bronner MP, Boucher KM, Hazel MW, Yao R, Pop S, Bernard PS, Delker DA (2019). Molecular Biomarkers of Sessile Serrated Adenoma/Polyps. Clin Transl Gastroenterol, 10(12), e00104.
  22. Kircher DA, Trombetti KA, Silvis MR, Parkman GL, Fischer GM, Angel SN, Stehn CM, Strain SC, Grossmann AH, Duffy KL, Boucher KM, McMahon M, Davies MA, Mendoza MC, VanBrocklin MW, Holmen SL (2019). AKT1E17K Activates Focal Adhesion Kinase and Promotes Melanoma Brain Metastasis. Mol Cancer Res, 17(9), 1787-1800.
  23. Chalmers AW, Patel S, Boucher K, Cannon L, Esplin M, Luckart J, Graves N, Van Duren T, Akerley W (2019). Phase I Trial of Targeted EGFR or ALK Therapy with Ipilimumab in Metastatic NSCLC with Long-Term Follow-Up. Target Oncol, 14(4), 417-421.
  24. Weldon Gilcrease G, Stenehjem DD, Wade ML, Weis J, McGregor K, Whisenant J, Boucher KM, Thorne K, Orgain N, Garrido-Laguna I, Sharma S (2018). Phase I/II study of everolimus combined with mFOLFOX-6 and bevacizumab for first-line treatment of metastatic colorectal cancer. Invest New Drugs, 37(3), 482-489.
  25. Cohen AL, Neumayer L, Boucher K, Factor RE, Shrestha G, Wade M, Lamb JG, Arbogast K, Piccolo SR, Riegert J, Schabel M, Bild AH, Werner TL (2017). Window-of-Opportunity Study of Valproic Acid in Breast Cancer Testing a Gene Expression Biomarker. JCO Precis Oncol, 1.
  26. Pulsipher MA, Wall DA, Grimley M, Goyal RK, Boucher KM, Hankins P, Grupp SA, Bunin N (2009). A phase I/II study of the safety and efficacy of the addition of sirolimus to tacrolimus/methotrexate graft versus host disease prophylaxis after allogeneic haematopoietic cell transplantation in paediatric acute lymphoblastic leukaemia (ALL). Br J Haematol, 147(5), 691-9.
  27. Yakovlev AY, Tsodikov AD, Boucher K, Kerber R (1999). The shape of the hazard function in breast carcinoma: curability of the disease revisited. Cancer, 85(8), 1789-98.
  28. Yakovlev A, Boucher K, DiSario J (1999). Modeling insight into spontaneous regression of tumors. Math BioSci, 155(1), 45-60.

Letter

  1. Varedi A, Bishop MD, Boucher KM, Kim CC, Grossman D (2019). Powering a prospective melanoma chemoprevention trial in high-risk cohorts. [Letter to the editor]. Int J Dermatol, 58(11), e232-e234.

Patent

  1. Szabo A, Boucher K, Jones D, L. Klebanov Tsodikov A, Yakovlev A (2002). Methods for identifying large subsets of differentially expressed genes based on multivariate microarray data.
  2. Szabo A, . Yakovlev A, Boucher K, Tsodikov A, Jones D, Klebanov L (2001). Methods for identifying differentially expressed genes by multivariate analysis of microarray data.