Timothy G. Formosa, PhD
- DNA Packaging
- Histone Chaperones
- Chromatin Assembly and Disassembly
- Cell Division
- Departments: Biochemistry - Professor
- Cancer Center Programs: Nuclear Control of Cell Growth & Differentiation
Academic Office Information
Emma Eccles Jones Research Building
15 North Medical Drive East, Room: 5700A
Salt Lake City, UT 84112
Tim Formosa, PhD, is a professor in the Department of Biochemistry at the University of Utah and a member of the Nuclear Control of Cell Growth and Differentiation Program at Huntsman Cancer Institute.
Formosa studies how genetic material (DNA) is packaged and copied so that daughter cells each receive an accurate copy of the genetic instructions. Mistakes in this process are responsible for human cancers, but the machinery is common to many species. Formosa therefore uses single-celled yeasts to study the universal parts of the copying machinery because this allows the use of many experimental approaches that cannot be applied to larger animals, revealing the important principles that can then be tested in humans.
Topics of study include
--How histone chaperones participate in organizing and disassembling DNA packaging
--How DNA is copied and assembled into chromatin, the stable form of DNA found in cells
--How the packaging of DNA affects its accurate replication during cell division
Formosa received a bachelor's degree from the University of California, Davis, and a PhD from the University of California, San Francisco.
|Postdoctoral Fellowship||University of Washington
|Doctoral Training||University of California at San Francisco
Biochemistry & Biophysics
|Undergraduate||University of California at Davis
- Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S (2019). Selective kinase inhibition shows that Bur1 (Cdk9) phosphorylates the Rpb1 linker in vivo. (Epub ahead of print) Mol Cell Biol.
- McCullough LL, Pham TH, Parnell TJ, Connell Z, Chandrasekharan MB, Stillman DJ, Formosa T (2019). Establishment and Maintenance of Chromatin Architecture Are Promoted Independently of Transcription by the Histone Chaperone FACT and H3-K56 Acetylation in Saccharomyces cerevisiae. Genetics, 211(3), 877-892.
- Nune M, Morgan MT, Connell Z, McCullough L, Jbara M, Sun H, Brik A, Formosa T, Wolberger C (2019). FACT and Ubp10 collaborate to modulate H2B deubiquitination and nucleosome dynamics. eLife, 8.
- McCullough L, Poe B, Connell Z, Xin H, Formosa T (2013). The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae. Genetics, 195(1), 101-13.
- Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP (2013). Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. J Biol Chem, 288(15), 10188-94.
- Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP (2012). Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. J Biol Chem, 287(44), 37371-82.
- McCullough L, Rawlins R, Olsen A, Xin H, Stillman DJ, Formosa T (2011). Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone. Genetics, 188(4), 835-46.
- Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP (2011). Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J Mol Biol, 408(4), 697-713.