Christopher P. Hill, DPhil

Research Interests

  • Structural Biology
  • Proteasome Activation and Regulation
  • Protein Quality Control
  • HIV Structure and Host Interactions
  • ESCRT Pathway
  • Nucleosome Remodeling and Reorganization


Lab Website


  • English

Academic Information

  • Departments: Biochemistry - Distinguished Professor

Academic Office Information

  • 801-585-5536
  • Biomedical Polymers Research Bldg
    20 S 2030 E
    Salt Lake City, UT 84112

Academic Bio

Christopher Hill, D.Phil., Vice Dean of Research for the School of Medicine, he is a distinguished professor in the Department of Biochemistry at the University of Utah School of Medicine. holds the H.A. and Edna Benning Medical Society Chair, and is a member of the Nuclear Control of Cell Growth and Differentiation Program. He served as department co-chair jointly with Wes Sundquist until 12/1/2019.

The Hill Lab uses structural and biochemical approaches to study how proteins function. This approach is applied to numerous targets that are relevant to cancer mechanisms. Studies on proteasome and protein quality control seek to understand mechanisms in a validated cancer therapeutic target. Studies of HIV-host interactions and the ESCRT pathway have led into mechanistic studies on how cells divide, and may inform new approaches to prevent the uncontrolled proliferation characteristic of cancers. Studies on nucleosome remodeling and reorganizing complexes advance understanding of mechanisms of gene expression, which may offer insights to the genetic defects that underlie progression toward cancer.

Hill received his BA and D.Phil. from the University of York, England. He then completed a postdoctoral fellowship at the University of California at Los Angles. Hill presents and publishes widely and has received numerous research fellowships and grants.

Education History

Type School Degree
Postdoctoral Fellowship University of California, Los Angeles
Structural Biology
Postdoctoral Fellow
Postdoctoral Fellowship University of York
Postdoctoral Fellow
Doctoral Training University of York
Undergraduate University of York

Global Impact

Education History

Type School Degree Country
Postdoctoral Fellowship University of York
Postdoctoral Fellow United Kingdom
Doctoral Training University of York
D.Phil. United Kingdom
Undergraduate University of York
B.A. United Kingdom

Selected Publications

Journal Article

  1. Liu L, Tang M, Pragani R, Whitby FG, Zhang YQ, Balakrishnan B, Fang Y, Karavadhi S, Tao D, LeClair CA, Hall MD, Marugan JJ, Boxer M, Shen M, Hill CP, Lai K, Patnaik S (2021). Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors. J Med Chem.
  2. Kessler JL, Kang G, Qin Z, Kang H, Whitby FG, Cheatham TE 3rd, Hill CP, Li Y, Yu SM (2021). Peptoid Residues Make Diverse, Hyperstable Collagen Triple-Helices. J Am Chem Soc, 143(29), 10910-10919.
  3. Zheng Y, Schubert HL, Singh PK, Martins LJ, Engelman AN, DOrso I, Hill CP, Planelles V (2021). Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal. mBio, 12(3), e0109821.
  4. Sarabia I, Novis CL, Macedo AB, Takata H, Nell R, Kakazu JC, Furler RL, Shakya B, Schubert HL, Hill CP, DePaula-Silva AB, Spivak AM, Trautmann L, Planelles V, Bosque A (2021). Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS. Front Immunol, 12, 682182.
  5. Tsai FTF, Hill CP (2020). Same structure, different mechanisms? Elife, 9.
  6. Han H, Schubert HL, McCullough J, Monroe N, Purdy MD, Yeager M, Sundquist WI, Hill CP (2019). Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation. J Biol Chem, 295(2), 435-443.
  7. Xiong X, Blakely A, Karra P, VandenBerg MA, Ghabash G, Whitby F, Zhang YW, Webber MJ, Holland WL, Hill CP, Chou DH (2019). Novel four-disulfide insulin analog with high aggregation stability and potency. Chem Sci, 11(1), 195-200.
  8. Smith AR, Weinstock MT, Siglin AE, Whitby FG, Francis JN, Hill CP, Eckert DM, Root MJ, Kay MS (2019). Characterization of resistance to a potent D-peptide HIV entry inhibitor. Retrovirology, 16(1), 28.
  9. Cooney I, Han H, Stewart MG, Carson RH, Hansen DT, Iwasa JH, Price JC, Hill CP, Shen PS (2019). Structure of the Cdc48 segregase in the act of unfolding an authentic substrate. Science, 365(6452), 502-505.
  10. Strenge KB, DiPaola CP, Miller LE, Hill CP, Whitmore RG (2019). Multicenter study of lumbar discectomy with Barricaid annular closure device for prevention of lumbar disc reherniation in US patients: A historically controlled post-market study protocol. Medicine (Baltimore), 98(35), e16953.
  11. Chun Y, Joo YJ, Suh H, Batot G, Hill CP, Formosa T, Buratowski S (2019). Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo. Mol Cell Biol, 39(15).
  12. Hemmis CW, Heard SC, Hill CP (2019). Phosphorylation of Tyr-950 in the proteasome scaffolding protein RPN2 modulates its interaction with the ubiquitin receptor RPN13. J Biol Chem, 294(25), 9659-9665.
  13. Han H, Fulcher JM, Dandey VP, Iwasa JH, Sundquist WI, Kay MS, Shen PS, Hill CP (2019). Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases. Elife, 8.
  14. Han H, Hill CP (2019). Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4. Biochem Soc Trans, 47(1), 37-45.
  15. Zurita Rendn O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J (2018). Vms1p is a release factor for the ribosome-associated quality control complex. Nat Commun, 9(1), 2197.
  16. Han H, Monroe N, Sundquist WI, Shen PS, Hill CP (2017). The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets. Elife, 6.
  17. Nielson JR, Fredrickson EK, Waller TC, Rendn OZ, Schubert HL, Lin Z, Hill CP, Rutter J (2017). Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria. Mol Cell, 68(4), 673-685.e6.
  18. Sdano MA, Fulcher JM, Palani S, Chandrasekharan MB, Parnell TJ, Whitby FG, Formosa T, Hill CP (2017). A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription. Elife, 6.
  19. VanderLinden RT, Hemmis CW, Yao T, Robinson H, Hill CP (2017). Structure and energetics of pairwise interactions between proteasome subunits RPN2, RPN13, and ubiquitin clarify a substrate recruitment mechanism. J Biol Chem, 292(23), 9493-9504.
  20. Monroe N, Han H, Shen PS, Sundquist WI, Hill CP (2017). Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase. Elife, 6.
  21. Monroe N, Hill CP (2015). Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines. J Mol Biol, 428(9 Pt B), 1897-911.
  22. Kemble DJ, McCullough LL, Whitby FG, Formosa T, Hill CP (2015). FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs. Mol Cell, 60(2), 294-306.
  23. Han H, Monroe N, Votteler J, Shakya B, Sundquist WI, Hill CP (2015). Binding of Substrates to the Central Pore of the Vps4 ATPase Is Autoinhibited by the Microtubule Interacting and Trafficking (MIT) Domain and Activated by MIT Interacting Motifs (MIMs). J Biol Chem, 290(21), 13490-9.
  24. Clinton TR, Weinstock MT, Jacobsen MT, Szabo-Fresnais N, Pandya MJ, Whitby FG, Herbert AS, Prugar LI, McKinnon R, Hill CP, Welch BD, Dye JM, Eckert DM, Kay MS (2015). Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets. Protein Sci, 24(4), 446-63.
  25. Vander Linden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (2015). Structural basis for the activation and inhibition of the UCH37 deubiquitylase. Mol Cell, 57(5), 901-911.
  26. Monroe N, Han H, Gonciarz MD, Eckert DM, Karren MA, Whitby FG, Sundquist WI, Hill CP (2014). The oligomeric state of the active Vps4 AAA ATPase. J Mol Biol, 426(3), 510-25.
  27. Kemble DJ, Whitby FG, Robinson H, McCullough LL, Formosa T, Hill CP (2013). Structure of the Spt16 middle domain reveals functional features of the histone chaperone FACT. J Biol Chem, 288(15), 10188-94.
  28. Hill CP, Sundquist WI (2013). Building a super elongation complex for HIV. Elife, 2, e00577.
  29. Schubert HL, Wittmeyer J, Kasten MM, Hinata K, Rawling DC, Hroux A, Cairns BR, Hill CP (2013). Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler. Proc Natl Acad Sci U S A, 110(9), 3345-50.
  30. Kish-Trier E, Hill CP (2013). Structural biology of the proteasome. Annu Rev Biophys, 42, 29-49.
  31. Stadtmueller BM, Kish-Trier E, Ferrell K, Petersen CN, Robinson H, Myszka DG, Eckert DM, Formosa T, Hill CP (2012). Structure of a proteasome Pba1-Pba2 complex: implications for proteasome assembly, activation, and biological function. J Biol Chem, 287(44), 37371-82.
  32. Hill CP, Babst M (2012). Structure and function of the membrane deformation AAA ATPase Vps4. Biochim Biophys Acta, 1823(1), 172-81.
  33. Tian G, Park S, Lee MJ, Huck B, McAllister F, Hill CP, Gygi SP, Finley D (2011). An asymmetric interface between the regulatory and core particles of the proteasome. Nat Struct Mol Biol, 18(11), 1259-67.
  34. Zhai Q, Landesman MB, Chung HY, Dierkers A, Jeffries CM, Trewhella J, Hill CP, Sundquist WI (2011). Activation of the retroviral budding factor ALIX. J Virol, 85(17), 9222-6.
  35. Hill CP, Damodaran O, Walsh P, Jevon GP, Blyth CC (2010). Balamuthia amebic meningoencephalitis and mycotic aneurysms in an infant. Pediatr Neurol, 45(1), 45-8.
  36. Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W (2011). UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci, 14(7), 874-80.
  37. Zhang H, Constantine R, Vorobiev S, Chen Y, Seetharaman J, Huang YJ, Xiao R, Montelione GT, Gerstner CD, Davis MW, Inana G, Whitby FG, Jorgensen EM, Hill CP, Tong L, Baehr W (2011). UNC119 is required for G protein trafficking in sensory neurons. Nat Neurosci, 14(7), 874-80.
  38. Close D, Johnson SJ, Sdano MA, McDonald SM, Robinson H, Formosa T, Hill CP (2011). Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain. J Mol Biol, 408(4), 697-713.
  39. Stadtmueller BM, Hill CP (2011). Proteasome activators. Mol Cell, 41(1), 8-19.
  40. Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (2011). Identification and structural characterization of the ALIX-binding late domains of simian immunodeficiency virus SIVmac239 and SIVagmTan-1. J Virol, 85(1), 632-7.
  41. Zhai Q, Landesman MB, Robinson H, Sundquist WI, Hill CP (2011). Structure of the Bro1 domain protein BROX and functional analyses of the ALIX Bro1 domain in HIV-1 budding. PLoS One, 6(12), e27466.
  42. Ragab AA, Hodges FS, Hill CP, McGuire RA, Tucci M (2013). Dynamic anterior cervical plating for multi-level spondylosis: Does it help? Evid Based Spine Care J, 1(1), 41-6.
  43. Dagan Y, Qazilbash MM, Hill CP, Kulkarni VN, Greene RL (2004). Evidence for a quantum phase transition in Pr2-xCe(x)CuO4-delta from transport measurements. Phys Rev Lett, 92(16), 167001.


  1. Forest KT, Hill CP (2015). Editorial overview: Macromolecular machines and assemblies: Rise and fall at the molecular level. Curr Opin Struct Biol, 31, vii-viii.


  1. VanderLinden RT, Hemmis CW, Schmitt B, Ndoja A, Whitby FG, Robinson H, Cohen RE, Yao T, Hill CP (2016). Structural Basis for the Activation and Inhibition of the UCH37 Deubiquitylase. Mol Cell (61(3), p. 487). United States.


  1. Christopher Hill, Kent Lai, Manshu Tang, Francis Whitby (2018). X-ray Co-Crystal Structure of human GALK1 and a small molecule GALK1 inhibitors.
  2. Bijina Balakrishnan, Matthew Boxer, Matthew Hall, Christopher Hill, Surendra Karavadhi, Kent Lai, Tobie Lee, Li Liu, Rajan Pragani, Min Shen, Manshu Tang, Francis Whitby, Ya-qin Zhang (2018). New Generation of Small Molecule Human GALK1 inhibitors.
  3. Christopher P. Hill, Casey W. Hemmis, Ryan T. VanderLinden (2017). Novel Cancer Therapeutic Involving the 26S Proteosome Subcomplex.
  4. Wesley I. Sundquist, Hui Wang, Christopher P. Hill, Timothy L. Stemmler, Darrell R. Davis, Steven L. Alam (2002). In Vitro Assays for Inhibitors of HIV Capsid Conformational Changes and for HIV Capsid Formation.
  5. Wesley I. Sundquist, Christopher P. Hill, Hui Wang (2000). The HIV-1 CA Protein Dimer as a Therapeutic Target Against HIV/AIDS.
  6. Christopher P. Hill, Keith D. Wilkinson, Steven C. Johnston, Christopher N. Larsen, William J. Cook (1998). Methods and Compositions for a Deubiquitinating Enzyme and Variants Thereof.
  7. Christopher P. Hill, Theresa R. Gamble, Felix F. Vajdos, Sanghee Yoo, David K. Worthylake, Megan Houseweart, Wesley I. Sundquist (1996). Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid.
  8. Daniel Bancroft, Allyson Christensen, Christopher P. Hill, Wesley I. Sundquist, David K. Worthylake (1995). CRYSTAL STRUCTURE OF THE TRIMERIC HIV-1 MATRIX PROTEIN.