Penelope J. Brockie, PhD

Languages

  • English

Academic Information

  • Departments: Neurobiology & Anatomy - Research Professor

Email: penny.brockie@neuro.utah.edu

Education History

Type School Degree
Doctoral Training University of Utah
Molecular Biology
Ph.D.
Undergraduate Monash University
Genetics
B.Sc. (Hons)

Selected Publications

Journal Article

  1. Lei N, Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2017). NRAP-1 Is a Presynaptically Released NMDA Receptor Auxiliary Protein that Modifies Synaptic Strength. Neuron, 96(6), 1303-1316.e6.
  2. Hoerndli FJ, Wang R, Mellem JE, Kallarackal A, Brockie PJ, Thacker C, Madsen DM, Maricq AV (2015). Neuronal Activity and CaMKII Regulate Kinesin-Mediated Transport of Synaptic AMPARs. Neuron, 86(2), 457-74.
  3. Hoerndli FJ, Maxfield DA, Brockie PJ, Mellem JE, Jensen E, Wang R, Madsen DM, Maricq AV (2013). Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors. Neuron, 80(6), 1421-37.
  4. Brockie PJ, Jensen M, Mellem JE, Jensen E, Yamasaki T, Wang R, Maxfield D, Thacker C, Hoerndli F, Dunn PJ, Tomita S, Madsen DM, Maricq AV (2013). Cornichons control ER export of AMPA receptors to regulate synaptic excitability. Neuron, 80(1), 129-42.
  5. Wang R, Mellem JE, Jensen M, Brockie PJ, Walker CS, Hoerndli FJ, Hauth L, Madsen DM, Maricq AV (2012). The SOL-2/Neto auxiliary protein modulates the function of AMPA-subtype ionotropic glutamate receptors. Neuron, 75(5), 838-50.
  6. Jensen M, Hoerndli FJ, Brockie PJ, Wang R, Johnson E, Maxfield D, Francis MM, Madsen DM, Maricq AV (2011). Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell, 149(1), 173-87.
  7. Brockie PJ, Maricq AV (2010). In a pickle: is cornichon just relish or part of the main dish? Neuron, 68(6), 1017-9.
  8. Walker CS, Jensen S, Ellison M, Matta JA, Lee WY, Imperial JS, Duclos N, Brockie PJ, Madsen DM, Isaac JT, Olivera B, Maricq AV (2009). A novel Conus snail polypeptide causes excitotoxicity by blocking desensitization of AMPA receptors. Curr Biol, 19(11), 900-8.
  9. Wang R, Walker CS, Brockie PJ, Francis MM, Mellem JE, Madsen DM, Maricq AV (2008). Evolutionary conserved role for TARPs in the gating of glutamate receptors and tuning of synaptic function. Neuron, 59(6), 997-1008.
  10. Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2008). Action potentials contribute to neuronal signaling in C. elegans. Nat Neurosci, 11(8), 865-7.
  11. Kano T, Brockie PJ, Sassa T, Fujimoto H, Kawahara Y, Iino Y, Mellem JE, Madsen DM, Hosono R, Maricq AV (2008). Memory in Caenorhabditis elegans is mediated by NMDA-type ionotropic glutamate receptors. Curr Biol, 18(13), 1010-5.
  12. Walker CS, Francis MM, Brockie PJ, Madsen DM, Zheng Y, Maricq AV (2006). Conserved SOL-1 proteins regulate ionotropic glutamate receptor desensitization. Proc Natl Acad Sci U S A, 103(28), 10787-92.
  13. Walker CS, Brockie PJ, Madsen DM, Francis MM, Zheng Y, Koduri S, Mellem JE, Strutz-Seebohm N, Maricq AV (2006). Reconstitution of invertebrate glutamate receptor function depends on stargazin-like proteins. Proc Natl Acad Sci U S A, 103(28), 10781-6.
  14. Brockie PJ, Maricq AV (2006). Building a synapse: genetic analysis of glutamatergic neurotransmission. Biochem Soc Trans, 34(Pt 1), 64-7.
  15. Zheng Y, Brockie PJ, Mellem JE, Madsen DM, Walker CS, Francis MM, Maricq AV (2006). SOL-1 is an auxiliary subunit that modulates the gating of GLR-1 glutamate receptors in Caenorhabditis elegans. Proc Natl Acad Sci U S A, 103(4), 1100-5.
  16. Brockie PJ, Maricq AV (2006). Ionotropic glutamate receptors: genetics, behavior and electrophysiology. WormBook, 1-16.
  17. Hills T, Brockie PJ, Maricq AV (2004). Dopamine and glutamate control area-restricted search behavior in Caenorhabditis elegans. J Neurosci, 24(5), 1217-25.
  18. Zheng Y, Mellem JE, Brockie PJ, Madsen DM, Maricq AV (2003). SOL-1 is a CUB-domain protein required for GLR-1 glutamate receptor function in C. elegans. Nature, 427(6973), 451-7.
  19. Brockie PJ, Maricq AV (2003). Ionotropic glutamate receptors in Caenorhabditis elegans. Neurosignals, 12(3), 108-25.
  20. Mellem JE, Brockie PJ, Zheng Y, Madsen DM, Maricq AV (2002). Decoding of polymodal sensory stimuli by postsynaptic glutamate receptors in C. elegans. Neuron, 36(5), 933-44.
  21. Brockie PJ, Mellem JE, Hills T, Madsen DM, Maricq AV (2001). The C. elegans glutamate receptor subunit NMR-1 is required for slow NMDA-activated currents that regulate reversal frequency during locomotion. Neuron, 31(4), 617-30.
  22. Brockie PJ, Madsen DM, Zheng Y, Mellem J, Maricq AV (2001). Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. J Neurosci, 21(5), 1510-22.
  23. Zheng Y, Brockie PJ, Mellem JE, Madsen DM, Maricq AV (1999). Neuronal control of locomotion in C. elegans is modified by a dominant mutation in the GLR-1 ionotropic glutamate receptor. Neuron, 24(2), 347-61.

Editorial

  1. Jensen M, Brockie PJ, Maricq AV (2012). Wnt signaling regulates experience-dependent synaptic plasticity in the adult nervous system. Cell Cycle, 11(14), 2585-6.