Shami Kanekar, PhD

Education History

Global Impact

Education History

Selected Publications

Journal Article

1. Kanekar S, RE Ettaro, MD Hoffman, HJ Ombach, J Brown, C Lynch, CS Sheth and PF Renshaw (2021). Sex-based Impact of Dietary Creatine on Depressive Symptoms, Brain Serotonin and SSRI Efficacy in an Animal Model of Treatment-resistant Depression. Int J Mol Sci.
2. Kanekar S, Sheth C, Ombach H, Brown J, Hoffman M, Ettaro R, Renshaw P (2021). Sex-based changes in rat brain serotonin and behavior in a model of altitude-related vulnerability to treatment-resistant depression. (Epub ahead of print) Psychopharmacology (Berl).
3. A Prescot, R Huber, S Kanekar, D Kondo, J Prisciandaro, D Ongur and PF Renshaw (2021). Effect of moderate altitude on human cerebral metabolite levels: A preliminary, multi-site, proton magnetic resonance spectroscopy investigation. Psychiatry Res Neuroimaging, 314, 111314.
4. HJ Ombach, LS Scholl, AV Bakian, K Renshaw, YH Sung, PF Renshaw and S Kanekar (2/20/19). Association Between Altitude, Prescription Opioid Misuse, and Fatal Overdoses. Addict Behav Rep.
5. Kanekar S, Sheth CS, Olson PR, Bogdanova OV, Ombach H, M Petersen, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2018). Hypobaric Hypoxia Exposure in Rats Differentially Alters Antidepressant Efficacy of the Selective Serotonin Reuptake Inhibitors Fluoxetine, Paroxetine, Escitalopram and Sertraline. Pharmacol Biochem Behav, 170, 25-35.
6. CS Sheth, H Ombach, P Olson, S Kanekar, PF Renshaw (2018). Increased Anxiety And Anhedonia In Female Rats Following Exposure To Altitude. High Alt Med Biol, 19(1), 81-90.
7. Kanekar S, Bogdanova OV, Olson PR, Sung YH, DAnci KE, Renshaw PF (2015). Hypobaric Hypoxia induces Depression-like Behavior in Female Sprague Dawley Rats, but not in Males. High Alt Med Biol, 16(1), 52-60.
8. Bogdanova OV, Abdullah O, Kanekar S, Bogdanov VB, Prescot AP, Renshaw PF (2014). Neurochemical Alterations in the Frontal Cortex of the rat after one week of hypobaric hypoxia. Behav Brain Res, 263(263), 203-209.
9. Hartmann JS, Thompson H, Wang H, Kanekar S, Huang W, Budd SJ, Hartnett ME (2011). Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity. Mol Vis, 17, 1577-87.
10. Kanekar S, Gandham M, Lucero MT (2010). PACAP protects against TNFalpha-induced cell death in olfactory epithelium and olfactory placodal cell lines. Mol Cell Neurosci, 45(4), 345-54.
11. Kanekar S, Jia C, Hegg CC (2009). Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices. J Neurosci Res, 87(6), 1424-34.
12. Sun Y, Kanekar SL, Vetter ML, Gorski S, Jan YN, Glaser T, Brown NL (2003). Conserved and divergent functions of Drosophila atonal, amphibian, and mammalian Ath5 genes. Evol Dev, 5(5), 532-41.
13. Tucker P, Laemle L, Munson A, Kanekar S, Oliver ER, Brown N, Schlecht H, Vetter M, Glaser T (2001). The eyeless mouse mutation (ey1) removes an alternative start codon from the Rx/rax homeobox gene. Genesis, 31(1), 43-53.
14. Brown NL, Kanekar S, Vetter ML, Tucker PK, Gemza DL, Glaser T (1998). Math5 encodes a murine basic helix-loop-helix transcription factor expressed during early stages of retinal neurogenesis. Development, 125(23), 4821-33.
15. Perron M, Kanekar S, Vetter ML, Harris WA (1998). The genetic sequence of retinal development in the ciliary margin of the Xenopus eye. Dev Biol, 199(2), 185-200.
16. Kanekar S, Perron M, Dorsky R, Harris WA, Jan LY, Jan YN, Vetter ML (1997). Xath5 participates in a network of bHLH genes in the developing Xenopus retina. Neuron, 19(5), 981-94.
17. Kanekar SS, Ritchie TC, Coulter JD (1993). Spinal cord afferent systems containing the nerve terminal protein NT75. J Comp Neurol, 332(2), 198-212.

Review

1. Kanekar S and Renshaw PF (2019). The Impact of Living at Altitude on Depression and Antidepressant Function in Utah Women: The Need for Novel Antidepressants. [Review]. Utah's Health: An Annual Review.
2. Gould TD, Georgiou P, Brenner LA, Brundin L, Can A, Courtet P, Donaldson Z, Dwivedi Y, Guillaume S, Gottesman II, Kanekar S, Lowry C, Renshaw PF, Rujescu D, Smith E, Turecki G, Zanos P, Zarate CA, Zunszain PA, Postolache TT (04/11/2017). Animal Models to Improve our Understanding and Treatment of Suicidal Behavior. [Review]. Transl Psychiatry, 7(4), 1-22.
3. Bogdanova OV, Kanekar S, DAnci K, Renshaw PF (2013). Factors influencing behavior in the forced swim test. [Review]. Physiol Behav, 118, 227-239.

Abstract

1. S Kanekar, RE Ettaro, MD Hoffman and PF Renshaw (2021). Sex-based animal model studies identifying effective therapeutics for treatment-resistant depression at altitude [Abstract].
2. S Kanekar, RE Ettaro, MD Hoffman and PF Renshaw (2021). Methamphetamine rewards and brain dopamine may increase with housing at moderate altitude in females: sex-based animal model studies [Abstract].
3. S Kanekar (2020). An Animal Model for SSRI-Resistant Depression at Altitude: Brain Serotonin and Antidepressants Based on Bioenergetics. Talk for ACNP Meeting Panel on “Sex Differences in Depression: focus on factors that differentially affect females or males” session [Abstract]. 45, 1-67.
4. S Kanekar, HJ Ombach, J Brown, MD Hoffman, RE Ettaro, CS Sheth, YH Sung and PF Renshaw (2020). Therapeutics Targeting Brain Bioenergetics may be Effective as Antidepressants in Altitude-related Treatment-Resistant Depression: Sex-based Animal Model Studies [Abstract].
5. Kanekar S, Sheth CS, Ombach HJ, Olson PR, Bogdanova OV, Petersen M, Renshaw CE, Sung YH, DAnci KE, Renshaw PF (2019). Improving Brain Bioenergetics may Improve Altitude-related Depression: Animal Model Studies. [Abstract]. 44, M139.
6. SES Smith, S Kanekar, J Lee, AD Plante, PF Renshaw, MB Scholand (2019). Characterization of shared molecular pathways in depression and idiopathic pulmonary fibrosis [Abstract]. Meeting of the American Thoracic Society.
7. CS Sheth, HJ Ombach, J Brown, PF Renshaw, and S Kanekar (2018). Living at Moderate Altitude May Alter Brain Monoamines to Worsen Mood and Substance Use Disorders: A Sex-based Animal Model Study [Abstract]. Neuropsychopharmacology, 43, S69.
8. HJ Ombach1, LS Scholl, AV Bakian, KT Renshaw, YH Sung, PF Renshaw and S Kanekar (2018). Living at Altitude is an Independent Risk Factor for Increased Prescription Opioid Misuse and Fatal Overdose by Prescription Opioids [Abstract]. Neuropsychopharmacology, 43, S132.
9. SES Smith, S Kanekar, J Lee, AD Plante, PF Renshaw, MB Scholand (05/14/18). Characterization of shared molecular pathways in depression and idiopathic pulmonary fibrosis [Abstract]. American Thoracic Society, 2018 Meeting.
10. Kanekar S, Sheth CS, Olson PR, M Petersen, Bogdanova OV, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2016). Differential Effects of the SSRIs Fluoxetine, Paroxetine, Escitalopram and Sertraline in a Rodent Model of Hypobaric Hypoxia-related Depression. [Abstract]. Neuropsychopharmacology, 41, S163.
11. Kanekar S, Bogdanova OV, Olson PR, Renshaw CE, Sung YH, DAnci KE, Renshaw, PF (2015). Antidepressant Efficacy in a Rodent Model of Hypoxia-Related Depression: Do SSRIs Lose Efficacy at Altitude? [Abstract]. Neuropsychopharmacology, 40, S334.
12. Kanekar S, Bogdanova OV, Olson PR, Nizam H, Ombach HJ, Renshaw CE, Sung Y, DAnci KE, and Renshaw, PF (2015). Methamphetamine preference in female rats in the conditioned place preference test increases at altitude. [Abstract]. Neuropsychopharmacology, 40, S424.
13. Kanekar S, Bogdanova OV, Olson PR, DAnci KE, Sung YH, Renshaw PF (2014). Hypobaric hypoxia induces DLB and alters SSRI efficacy in female Sprague Dawley rats. [Abstract]. Society for Biological Psychiatry.

News

• Common Antidepressents Are Less Effective at High Altitudes, Rodent Study Suggests
• Study Links Thin Air, Higher Altitudes to Depression in Female Rats