Douglas R. Mackay, PhD

Research Interests

  • Cytokinesis
  • Abscission Checkpoint
  • Nuclear Pore Complex
  • DNA Damage
  • Cell Biology
  • Cell Cycle Regulation

Languages

  • English

Academic Information

  • Departments: Oncological Sciences - Research Assistant Professor

Academic Office Information

  • 801-585-5441
  • Huntsman Cancer Institute
    2000 Circle of Hope
    Salt Lake City, UT 84112

Research Statement

I have been involved in research aimed at understanding the molecular regulation of abscission timing for 13 years, playing an integral role in key findings that demonstrate a link between nuclear pore reassembly and the abscission checkpoint. My research was also instrumental in uncovering a novel connection between postmitotic genome surveillance and the abscission checkpoint, which allowed me to characterize both Chk1 and ATR as factors upstream of Aurora B in abscission checkpoint signaling. Together, my contributions represent two previously uncharacterized physiological conditions where the abscission checkpoint is sustained, as well as the only known factors upstream of Aurora B in this context. I am currently collaborating with the Wes Sundquist Lab in the Department of Biochemistry to understand the function of novel proteins thought to be involved in the process of abscission and the abscission checkpoint. Connections between DNA damage signaling and abscission have fueled a parallel, yet synergistic interest in exploring how the nuclear pore components Nup153 and Nup50 are involved in the canonical DNA damage response.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Cell Biology
Postdoctoral Fellow
Doctoral Training University of California, Irvine
Biological Sciences
Ph.D.
Undergraduate University of Utah
Biology
B.S.