Neklason, Deborah Wood, PhD

Research Interests

  • Genetics Colon Cancer

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Internal Medicine - Research Associate Professor
  • Divisions: Epidemiology
  • Cancer Center Programs: Cancer Control & Population Sciences

Academic Office Information

  • 801-587-9882
  • Huntsman Cancer Institute
    2000 Circle of Hope
    Salt Lake City, UT 84112

Academic Bio

Deborah Neklason, PhD, is a member of Huntsman Cancer Institute's colon cancer research team and research associate professor in the Department of Oncological Sciences at the University of Utah School of Medicine. She is also a member of the Cancer Control and Population Sciences Program.

Neklason's works focuses on the genetic basis of inherited forms of colon cancer. Scientists have identified the genes that account for about five percent of inherited cancer cases. The goal of Huntsman Cancer Institute's colon cancer research is to find the genes that lead to the rest of the cases and to identify targets for chemoprevention.

Neklason coordinates clinical and basic research projects originating from the Familial Colon Cancer Clinic. This clinic is for patients and family members who are at risk for inherited colon cancers. She is working to identify genes responsible for cancer in these families and to characterize the molecular consequences of the genetic mutations. She is also involved in the "Sibling Pair Project," which is the largest search ever launched for brothers and/or sisters with a common colon cancer gene. In this study, Huntsman Cancer Institute collaborates with 20 other major cancer centers in the United States to identify multiple genes that cause a predisposition to cancer.

Prior to joining Huntsman Cancer Institute, Neklason was manager for biochemical assay products at Echelon Biosciences in Salt Lake City. She received her PhD in human genetics from the University of Utah in 1999.

Education History

Type School Degree
Doctoral Training University of Utah, Department of Human Genetics, Laboratory of James Metherall, Ph.D
Human Genetics
Ph.D.
Other Training University of Utah, Department of Continuing Education
Management Certificate Program
Certificate
Undergraduate University of Washington
Microbiology
B.S.

Selected Publications

Journal Article

  1. Millar MM, Kinney AY, Camp NJ, Cannon-Albright LA, Hashibe M, Penson DF, Kirchhoff AC, Neklason DW, Gilsenan AW, Dieck GS, Stroup AM, Edwards SL, Bateman C, Carter ME, Sweeney C (2019 Jan 25). Predictors of Response Outcomes for Research Recruitment Through a Central Cancer Registry: Evidence From 17 Population-Based Studies.LID - 10.1093/aje/kwz011 [doi]. (Epub ahead of print) Am J Epidemiol.
  2. Kanth P, Hazel MW, Boucher KM, Yang Z, Wang L, Bronner MP, Boylan KE, Burt RW, Westover M, Neklason DW, Delker DA (2018 Sep 28). Small RNA sequencing of sessile serrated polyps identifies microRNA profile associated with colon cancer.LID - 10.1002/gcc.22686 [doi]. (Epub ahead of print) Genes Chromosomes Cancer.
  3. Sample DC, Samadder NJ, Pappas LM, Boucher KM, Samowitz WS, Berry T, Westover M, Nathan D, Kanth P, Byrne KR, Burt RW, Neklason DW (2018 Jul 16). Variables affecting penetrance of gastric and duodenal phenotype in familial adenomatous polyposis patients. BMC Gastroenterol, 18(1), 115.
  4. Young EL, Thompson BA, Neklason DW, Firpo MA, Werner T, Bell R, Berger J, Fraser A, Gammon A, Koptiuch C, Kohlmann WK, Neumayer L, Goldgar DE, Mulvihill SJ, Cannon-Albright LA, Tavtigian SV (2018 Jun 27). Pancreatic cancer as a sentinel for hereditary cancer predisposition. BMC Cancer, 18(1), 697.
  5. Samadder NJ, Kuwada SK, Boucher KM, Byrne K, Kanth P, Samowitz W, Jones D, Tavtigian SV, Westover M, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Burt RW, Neklason DW (2018 Feb 8). Association of Sulindac and Erlotinib vs Placebo With Colorectal Neoplasia in Familial Adenomatous Polyposis: Secondary Analysis of a Randomized Clinical Trial.LID - 10.1001/jamaoncol.2017.5431 [doi]. (Epub ahead of print) JAMA Oncol.
  6. Delker DA, Wood AC, Snow AK, Samadder NJ, Samowitz WS, Affolter KE, Boucher KM, Pappas LM, Stijleman IJ, Kanth P, Byrne KR, Burt RW, Bernard PS, Neklason DW (2018 Jan). Chemoprevention with Cyclooxygenase and Epidermal Growth Factor Receptor Inhibitors in Familial Adenomatous Polyposis Patients: mRNA Signatures of Duodenal Neoplasia. Cancer Prev Res (Phila), 11(1), 4-15.
  7. Moriwaki M, Moore B, Mosbruger T, Neklason DW, Yandell M, Jorde LB, Welt CK (2017 Mar 1). POLR2C Mutations Are Associated With Primary Ovarian Insufficiency in Women. J Endocr Soc, 1(3), 162-173.
  8. Gan M, Boothe D, Neklason DW, Samadder NJ, Frandsen J, Keener MB, Lloyd S (2017 Aug). Outcomes and complications of radiation therapy in patients with familial adenomatous polyposis. J Gastrointest Oncol, 8(4), 643-649.
  9. Al-Agha AE, Ahmed IA, Nuebel E, Moriwaki M, Moore B, Peacock KA, Mosbruger T, Neklason DW, Jorde LB, Yandell M, Welt CK (2017 Dec 12). Primary Ovarian Insufficiency and Azospermia in Carriers of a Homozygous PSMC3IP Stop Gain Mutation.LID - 10.1210/jc.2017-01966 [doi]. (Epub ahead of print) J Clin Endocrinol Metab.
  10. Abbott D, Brockmeyer D, Neklason DW, Teerlink C, Cannon-Albright LA (2017 Feb 03). Population-based description of familial clustering of Chiari malformation Type I. J Neurosurg, 1-6.
  11. Bong YS, Assefnia S, Tuohy T, Neklason DW, Burt RW, Ahn J, Jiang HJ, Byers SW (2016 Oct 19). A role for the vitamin D pathway in non-intestinal lesions in genetic and carcinogen models of colorectal cancer and in familial adenomatous polyposis.LID - 10.18632/oncotarget.12768 [doi]. (Epub ahead of print) Oncotarget.
  12. Li J, Woods SL, Healey S, Beesley J, Chen X, Lee JS, Sivakumaran H, Wayte N, Nones K, Waterfall JJ, Pearson J, Patch AM, Senz J, Ferreira MA, Kaurah P, Mackenzie R, Heravi-Moussavi A, Hansford S, Lannagan TR, Spurdle AB, Simpson PT, da Silva L, Lakhani SR, Clouston AD, Bettington M, Grimpen F, Busuttil RA, Di Costanzo N, Boussioutas A, Jeanjean M, Chong G, Fabre A, Olschwang S, Faulkner GJ, Bellos E, Coin L, Rioux K, Bathe OF, Wen X, Martin HC, Neklason DW, Davis SR, Walker RL, Calzone KA, Avital I, Heller T, Koh C, Pineda M, Rudloff U, Quezado M, Pichurin PN, Hulick PJ, Weissman SM, Newlin A, Rubinstein WS, Sampson JE, Hamman K, Goldgar D, Poplawski N, Phillips K, Schofield L, Armstrong J, Kiraly-Borri C, Suthers GK, Huntsman DG, Foulkes WD, Carneiro F, Lindor NM, Edwards SL, French JD, Waddell N, Meltzer PS, Worthley DL, Schrader KA, Chenevix-Trench G (2016 Apr 13). Point Mutations in Exon 1B of APC Reveal Gastric Adenocarcinoma and Proximal Polyposis of the Stomach as a Familial Adenomatous Polyposis Variant.LID - S0002-9297(16)30036-2 [pii]LID - 10.1016/j.ajhg.2016.03.001 [doi]. (Epub ahead of print) Am J Hum Genet.
  13. Samadder NJ, Neklason DW, Boucher KM, Byrne KR, Kanth P, Samowitz W, Jones D, Tavtigian SV, Done MW, Berry T, Jasperson K, Pappas L, Smith L, Sample D, Davis R, Topham MK, Lynch P, Strait E, McKinnon W, Burt RW, Kuwada SK (2016 Mar 22-29). Effect of Sulindac and Erlotinib vs Placebo on Duodenal Neoplasia in Familial Adenomatous Polyposis: A Randomized Clinical Trial. JAMA, 315(12), 1266-75.
  14. Kanth P, Bronner MP, Boucher KM, Burt R, Neklason DW, Hagedorn CH, Delker DA (2016 Mar 29). Gene Signature in Sessile Serrated Polyps Identifies Colon Cancer Subtype.LID - canprevres.0363.2015 [pii]. (Epub ahead of print) Cancer Prev Res (Phila).
  15. Neklason DW, VanDerslice J, Curtin K, Cannon-Albright LA (2016 Feb). Evidence for a heritable contribution to neuroendocrine tumors of the small intestine. Endocr Relat Cancer, 23(2), 93-100.
  16. Kalbfleisch T, Brock P, Snow A, Neklason D, Gowans G, Klein J (2015). Characterization of an APC Promoter 1B deletion in a Patient Diagnosed with Familial Adenomatous Polyposis via Whole Genome Shotgun Sequencing. F1000Res, 4, 170.
  17. Snow AK, Tuohy TM, Sargent NR, Smith LJ, Burt RW, Neklason DW (2015 Oct). APC promoter 1B deletion in seven American families with familial adenomatous polyposis. Clin Genet, 88(4), 360-5.
  18. Delker DA, McGettigan BM, Kanth P, Pop S, Neklason DW, Bronner MP, Burt RW, Hagedorn CH (2014). RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers. PLoS ONE, 9(2), e88367.
  19. Knight S, Abo RP, Abel HJ, Neklason DW, Tuohy TM, Burt RW, Thomas A, Camp NJ (2012 Nov). Shared genomic segment analysis: the power to find rare disease variants. Ann Hum Genet, 76(6), 500-9.
  20. Huff CD, Witherspoon DJ, Simonson TS, Xing J, Watkins WS, Zhang Y, Tuohy TM, Neklason DW, Burt RW, Guthery SL, Woodward SR, Jorde LB (2011 May). Maximum-likelihood estimation of recent shared ancestry (ERSA). Genome Res, 21(5), 768-74.
  21. Neklason DW, Done MW, Sargent NR, Schwartz AG, Anton-Culver H, Griffin CA, Ahnen DJ, Schildkraut JM, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Burt RW (2011). Activating mutation in MET oncogene in familial colorectal cancer. BMC Cancer, 11, 424.
  22. Jasperson KW, Vu TM, Schwab AL, Neklason DW, Rodriguez-Bigas MA, Burt RW, Weitzel JN (2010 Jun). Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis. Fam Cancer, 9(2), 99-107.
  23. Tuohy TM, Done MW, Lewandowski MS, Shires PM, Saraiya DS, Huang SC, Neklason DW, Burt RW (2010 Mar). Large intron 14 rearrangement in APC results in splice defect and attenuated FAP. Hum Genet, 127(3), 359-69.
  24. Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW (2010 Oct). Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer. J Med Genet, 47(10), 692-9.
  25. Neklason DW, Thorpe BL, Ferrandez A, Tumbapura A, Boucher K, Garibotti G, Kerber RA, Solomon CH, Samowitz WS, Fang JC, Mineau GP, Leppert MF, Burt RW, Kuwada SK (2008 Oct). Colonic adenoma risk in familial colorectal cancer--a study of six extended kindreds. Am J Gastroenterol, 103(10), 2577-84.
  26. Neklason DW, Kerber RA, Nilson DB, Anton-Culver H, Schwartz AG, Griffin CA, Lowery JT, Schildkraut JM, Evans JP, Tomlinson GE, Strong LC, Miller AR, Stopfer JE, Finkelstein DM, Nadkarni PM, Kasten CH, Mineau GP, Burt RW (2008 Nov 1). Common familial colorectal cancer linked to chromosome 7q31: a genome-wide analysis. Cancer Res, 68(21), 8993-7.
  27. Schwab AL, Tuohy TM, Condie M, Neklason DW, Burt RW (2008). Gonadal mosaicism and familial adenomatous polyposis. Fam Cancer, 7(2), 173-7.
  28. Neklason DW, Stevens J, Boucher KM, Kerber RA, Matsunami N, Barlow J, Mineau G, Leppert MF, Burt RW (2008 Jan). American founder mutation for attenuated familial adenomatous polyposis. Clin Gastroenterol Hepatol, 6(1), 46-52.
  29. Tsai IC, Woolf M, Neklason DW, Branford WW, Yost HJ, Burt RW, Virshup DM (2007 Mar 1). Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism. Int J Cancer, 120(5), 1005-12.
  30. Kerber RA, Neklason DW, Samowitz WS, Burt RW (2005). Frequency of familial colon cancer and hereditary nonpolyposis colorectal cancer (Lynch syndrome) in a large population database. Fam Cancer, 4(3), 239-44.
  31. Neklason DW, Solomon CH, Dalton AL, Kuwada SK, Burt RW (2004). Intron 4 mutation in APC gene results in splice defect and attenuated FAP phenotype. Fam Cancer, 3(1), 35-40.
  32. Burt RW, Leppert MF, Slattery ML, Samowitz WS, Spirio LN, Kerber RA, Kuwada SK, Neklason DW, Disario JA, Lyon E, Hughes JP, Chey WY, White RL (2004 Aug). Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis. Gastroenterology, 127(2), 444-51.
  33. Prestwich GD, Chen Y, Feng L, Ozaki S, Ferguson CG, Drees BE, Neklason D, Mostert MJ, Porter-Gill PA, Kang V, Shope JC, Neilsen PO, DeWald DB (2002). In situ detection of phospholipid and phosphoinositide metabolism. Adv Enzyme Regul, 42, 19-38.
  34. Neklason DW, Andrews KM, Kelley RI, Metherall JE (1999 Aug 27). Biochemical variants of Smith-Lemli-Opitz syndrome. Am J Med Genet, 85(5), 517-23.
  35. Wilkinson DJ, Strong TV, Mansoura MK, Wood DL, Smith SS, Collins FS, Dawson DC (1997 Jul). CFTR activation: additive effects of stimulatory and inhibitory phosphorylation sites in the R domain. Am J Physiol, 273(1 Pt 1), L127-33.
  36. Debry P, Nash EA, Neklason DW, Metherall JE (1997 Jan 10). Role of multidrug resistance P-glycoproteins in cholesterol esterification. J Biol Chem, 272(2), 1026-31.
  37. Smit LS, Strong TV, Wilkinson DJ, Macek M Jr, Mansoura MK, Wood DL, Cole JL, Cutting GR, Cohn JA, Dawson DC, et al (1995 Feb). Missense mutation (G480C) in the CFTR gene associated with protein mislocalization but normal chloride channel activity. Hum Mol Genet, 4(2), 269-73.
  38. Brazas RM, Bhoite LT, Murphy MD, Yu Y, Chen Y, Neklason DW, Stillman DJ (1995 Dec 8). Determining the requirements for cooperative DNA binding by Swi5p and Pho2p (Grf10p/Bas2p) at the HO promoter. J Biol Chem, 270(49), 29151-61.
  39. Gregory PE, Gutmann DH, Mitchell A, Park S, Boguski M, Jacks T, Wood DL, Jove R, Collins FS (1993 May). Neurofibromatosis type 1 gene product (neurofibromin) associates with microtubules. Somat Cell Mol Genet, 19(3), 265-74.
  40. Strong TV, Smit LS, Nasr S, Wood DL, Cole JL, Iannuzzi MC, Stern RC, Collins FS (1992). Characterization of an intron 12 splice donor mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Hum Mutat, 1(5), 380-7.
  41. Gutmann DH, Wood DL, Collins FS (1991 Nov 1). Identification of the neurofibromatosis type 1 gene product. Proc Natl Acad Sci U S A, 88(21), 9658-62.
  42. Samadder, Neklason, Snow, Samowitz, Cessna, Rowe, Sandhu, Boucher, Pappas, Smith, Wong, Curtin, Provenzale, Burt (). Clinical and Molecular Features of Missed-Interval Colorectal Cancers A Population-based Study in Utah. Clin Gastroenterol Hepatol.

Review

  1. Gammon A, Neklason DW (2015 Oct). Confidentiality & the Risk of Genetic Discrimination: What Surgeons Need to Know. [Review]. Surg Oncol Clin N Am, 24(4), 667-81.
  2. Jasperson KW, Tuohy TM, Neklason DW, Burt RW (2010 Jun). Hereditary and familial colon cancer. [Review]. Gastroenterology, 138(6), 2044-58.
  3. Burt R, Neklason DW (2005 May). Genetic testing for inherited colon cancer. [Review]. Gastroenterology, 128(6), 1696-716.

Book Chapter

  1. Pho L, Solomon CH, Neklason DW, Burt RW (). Genetic Counseling for Gastrointestinal Patients in Yamada T(ed) Textbook of Gastroenterology. In Textbook of Gastroenterology (4, Chapter 54). Lippilcott Williams & Wilkins.
  2. Kuwada SK, Neklason DW, Burt RW (). Biology and Molecular Genetics of Colorectal Cancer. In Saltz (Ed.), Colorectal Cancer: Multimodality Management (2002, pp. 3-21). Totowa, NJ: Humana Press Inc.

Editorial

  1. Neklason, DW (). Gaps in our knowledge of genetics underlying common familial cancer (doi: 10.4172/2161-1041.S2-e001). Hereditary Genetics (omicsonline.org/hereditary-genetics.php), 2013(S2), e001.

Letter

  1. Samadder NJ, Neklason DW, Burt RW (2016 Aug 2). Sulindac and Erlotinib for Familial Adenomatous Polyposis--Reply [Letter to the editor]. JAMA, 316(5), 545.

Abstract

  1. Snow AS, Thompson BA, Bell R, Teerlink CC, Nguyen KN, Sargent NR, Kohlmann WK, Cannon-Albright LA, Tavtigian SV, and Neklason DW (). Genetic Analysis of Familial Colorectal Cancer [Abstract]. Colloaborative Group of Americas on Inherited Colorectal Cancer, October 2018, San Diego, CA USA.
  2. Priyanka Kanth, Mark W Hazel, John C Schell, Jared Rutter, Deborah W Neklason, Alyssa P Mills, Don A Delker (). Effects of EGFR and COX pathway inhibitors in human colon organoid growth and differentiation across high risk colon cancer syndromes, Digestive Disease Week, Washington, DC [Abstract]. Gastroenterology.
  3. N Jewel Samadder, Deborah Neklason, Angela Snow, Wade Samowitz, Kenneth Boucher, Lisa Pappas, Ken Robert Smith, Jathine Wong, Karen Curtin, Dawn Provenzale, Randall W Burt (). Clinical and Molecular Features of Missed-Interval Colorectal Cancers:A Population-based Study in Utah, Digestive Disease Week, Washington, DC [Abstract]. Gastroenterology.
  4. N Jewel Samadder, Deborah W Neklason, Kenneth Boucher, Priyanka Kanth, Kathryn Byrne, Wade Samowitz, Tom Greene, Lisa Pappas, Sean Tavtigian, Michelle Done, Therese Berry, Laurel Smith, Danielle Sample, Elena Strait, Wendy McKinnon, Patrick Lynch, Randall W Burt, Scott K Kuwada (). Effect of COX and EGFR Inhibition on Colorectal Neoplasia in Familial Adenomatous Polyposis: A Randomized Placebo-Controlled Trial, Digestive and Disease Week, Chicago, IL [Abstract]. Gastroenterology, 152(5), S140.
  5. Deborah Neklason, Angela Snow, Bryony Thompson, Lisa Pappas, Lisa Cannon-Albright, Sean Tavtigian, Randy Burt (). SEMA4A genetic variant (p.P682S) segregating through large multigeneration colorectal cancer family [Abstract]. Collaborative Group of Americas on Inherited Colorectal Cancer, Orlando, FL.
  6. Deborah Neklason, Kim Herget, Austin Wood, Angela Snow, Lisa Cannon-Albright, James VanDerslice, Carol Sweeney, Rachael Hemmert, Marissa Taddie, Karen Curtin (). Incidence and Familial Etiology of Small Intestinal Neuroendocrine Tumors from Utah Population [Abstract]. Collaborative Group of Americas on Inherited Colorectal Cancer, Orlando, FL.
  7. Neklason DW, Delker DA, Samadder NJ, Wood A, Burt RW, Bernard P (). Molecular pathways impacted in FAP patients treated with COX and EGFR combined inhibition: Collaborative Group of Americas on Inherited Colorectal Cancer, Anaheim, CA [Abstract]. Familial Cancer, 14(1), 175-209.
  8. N Jewel Samadder, Deborah W Neklason, Kenneth Boucher, Priyanka Kanth, Kathryn Byrne, Wade Samowitz, Tom Greene, Lisa Pappas, Sean Tavtigian, Michelle Done, Therese Berry, Laurel Smith, Danielle Sample, Elena Strait, Wendy McKinnon, Patrick Lynch, Randall W Burt and Scott K Kuwada (). Effect of COX and EGFR Inhibition on Colorectal Neoplasia in Familial Adenomatous Polyposis: A Randomized Placebo-Controlled Trial [Abstract]. Digestive Disease Week, Chicago, IL 2017.
  9. Sample D, Done M, Edwards S, Keener M, Edwards R, Burt R, Samadder NJ, Neklason D (). Perceived benefits and barriers of clinical trial participants with familial adenomatous polyposis [Abstract]. Collaborative Group of Americas for Inherited Colorectal Cancer, Seattle, Wa.
  10. Deborah W Neklason, Don A Delker, Kenneth M Boucher, Priyanka Kanth, Kathryn Byrne, Philip Bernard, Wade Samowitz, Michelle W Done, Therese Berry, Lisa Pappas, Laurel Smith, Danielle Sample, Rian Davis, Matthew K Topham, Randall W Burt, Scott K Kuwada, N Jewel Samadder (). Regression of Duodenal Neoplasia in Familial Adenomatous Polyposis Patients using COX and EGFR Inhibition: A Randomized Placebo-controlled Trial [Abstract]. Late Breaking Minisymposium: AACR, New Orleans, LA, Oral Presentation, (#7926).
  11. Clark, E, Esplin, MS, Manuck, T, Neklason, D, Wu, W, Jorde, L, Camp, N, Varner, M (). Mapping genetic susceptibility to preterm birth: Analysis of Utah pedigrees using shared genomic segment analysis [Abstract]. American Jorunal of Obstetrics and Gynecology, 214(1), S218-219.
  12. Neklason DW, Delker DA, Samadder NJ, Wood A, Burt RW, Bernard P (). Molecular pathways impacted in FAP patients treated with COX and EGFR combined inhibition [Abstract]. Collaborative Group of Americas on Inherited Colorectal Cancer, Baltimore MD *Selected as best podium presentation.
  13. E L Young 1, D W Neklason 1, 2, A K Snow 1, B A Thompson 1, M A Firpo 7, S J Mulvihill 7, T L Werner 8, R Bell 1, K R Smith 5, A Fraser 1, W K Kohlmann 1, L A Neumayer 6, L A Cannon-Albright 2, 3, S V Tavtigian 1 (). PgmNr 2787: Multi-gene panel testing in breast, ovarian, and pancreatic cancer cases: Prevalence and unintended screening recommendations [Abstract]. American Society of Human Genetics Annual Meeting, Baltimore, MD.
  14. B A Thompson 1, D W Neklason 1, 2, A K Snow 1, E L Young 1, R Bell 1, N R Sargent 1, W K Kohlmann 1, L A Cannon-Albright 2, 3, S V Tavtigian 1, 4 (). PgmNr 2791: Majority of familial colorectal cancer unexplained by known cancer susceptibility genes [Abstract]. American Society of Human Genetics Annual Meeting, Baltimore, MD.
  15. G Chenevix-Trench 1, J Li 1, S Healey 1, H Sivakumaran 1, J French 1, S Edwards 1, K Nones 1, N Waddell 1, P Pichurin 2, P Hulick 3, K J Hamman 4, U Rudloff 5, K Calzone 5, J J Waterfall 5, D Huntsman 6, P Meltzer 5, D Neklason 7, D Goldgar 8, F Carneiro 9, C Kiraly-Borri 10, L Schofield 10, D Worthley 11, N Lindor 12, G Suthers 13, I Schrader (). PgmNr 236: Mutations in a promoter of APC cause a syndrome of gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS) without colorectal involvement [Abstract]. American Society of Human Genetics Annual Meeting, Baltimore, MD.
  16. Neklason DW, Delker DA, Samadder NJ, Bernard P (). Chemoprevention with COX2 and EGFR inhibition in familial adenomatous polyposis patients: mRNA signatures of duodenal neoplasia [Abstract]. AACR: Integrating Clinical Genomics and Cancer Therapy, Salt Lake City, UT.
  17. Samadder NJ, Neklason DW, Kanth P, Byrne K, Samowitz W, Jasperson K, Kohlmann W, Gammon A, Champine M, Nathan D, Boucher K, Greene T, Pappas L, Fang J, Valentine J, Hagedorn C, Jones D, Tavtigian S, Done M, Berry T, Smith L, Larson M, Martineau L, Sample D, Christenson C, Keener M, Strait E, McKinnon W, Greenblatt M, Lynch P, Burt RW, Kuwada SK (). Effect of COX and EGFR Inhibition on Duodenal Neoplasia in Familial Adenomatous Polyposis [Abstract]. Gastroenterology, 148(4 Suppl 1), S-93-4.
  18. Kanth P, Bronner MP, Neklason D, Burt RW, Hagedorn C, Delker D (). RNA sequencing identifies unique and commonly expressed genes in sessile serrated and hyperplastic colon polyps and demonstrates molecular overlap between syndromic and sporadic sessile serrated polyps [Abstract]. Gastroenterology, 148(4 Suppl 1), S-363.
  19. Neklason, DW, Hanson, HA, Schaefer, C, Mineau, G, Leppert, MF, Burt, RW, Smith, KR (). Impact of genetic on reducing colorectal cancer - Oral Presentation [Abstract]. American Society of Human Genetics, San Diego, CA 2014.
  20. Snow, AK, Tuohy, TMF, Sargent NR, Smith, LJ, Burt, RW, Neklason, DW (). APC promoter 1B deletion in seven American families with familial adenomatous polyposis [Abstract]. American Society of Human Genetics, San Diego, CA 2014.
  21. Neklason, DW, Gilcrease, GW, Sargent, NR, Snow, A, Teerlink, C, Bailey, M, Burt, RW (). Exome sequencing of family with carcinoid cancers [Abstract]. American Society of Human Genetics, Boston, MA 2013.
  22. Nathan, D, Sample, D, Berry, T, Done, M, Pappas, L, Samadder, NJ, Byrne, K, Burt, R, Neklason, D (). Report of upper GI phenotype in individuals with Familial Adenomatous Polyposis (FAP) and Attenuated FAP (AFAP) The proceedings of the collaborative group of americas on inherited colorectal cancer, Anaheim, CA [Abstract]. The proceedings of the collaborative group of americas on inherited colorectal cancer, Anaheim, CA, 2013.
  23. Berry T, Done M, Sample D, Kuwada S, Boucher K, Tuohy T, Samadder JN, Bryne K, Neklason D, and Burt R (). A Clinical Trial of COX and EGFRInhibition in Familial Adenomatous Polyposis Patients, The proceedings of the collaborative group of americas on inherited colorectal cancer [Abstract]. fam cancer, 12(4), 779-809.
  24. Delker DA, McGettigan BM, Kanth P, Neklason DW, Bronner M, Burt RW, Hagedorn CH (). Next Generation Sequencing Alanysis of 5' Capped RNAs Identifies Novel Differentially Expressed Genes in Sessile Serrated Colon Polyps [Abstract]. Digestive Disease Week, May 19-21, 2013, 2013(01/01/2013).
  25. Kohlmann W, Pappas LM, Jasperson K, Neklason DW, Burt RW, Weitzel JN, Stoffel EM (). Effect of smoking on urothelial cancer risk in individuals with Lynch syndrome [Abstract]. Hered Cancer Clin Pract, 8(Suppl 1), O6.
  26. Condie MW, Tuohy TMF, Shires P, Burt RW, Neklason, DW (). Mutation-negative FAP patients with mRNA defects of APC [Abstract]. Hered Cancer Clin Pract, 8(Suppl1), O1.
  27. Neklason DW, Tuohy TM, Stevens J, Otterud B, Baird L, Kerber RA, Samowitz WS, Kuwada SK, Leppert MF, Burt RW (). Colorectal adenomas and cancer link to chromosome 13q22.1-13q31.3 in a large family with excess colorectal cancer [Abstract]. Hered Cancer Clin Pract, 8(Suppl1), O4.
  28. Lewandowski MS, Day TM, Christensen J, Tuohy TMF, Kohlmann W, Neklason DW, Burt RW (). Evolution of a High-Risk Cancer Registry: past, present and future [Abstract]. Hered Cancer Clin Pract, 8(Suppl1), P11.
  29. Neklason DW, Milash BA, Tuohy TM, Lilley J and Burt RW (). Differential gene expression in primary colonic tissue from control, FAP and AFAP patients reveals unique signatures with diagnostic potential [Abstract]. Hered Cancer Clin Pract, 8(supl1), P13.
  30. Condie, MW, Boucher, KM, Burt, RW, Neklason, DW (). Evaluation of ODC1 genotype as a modifier of adenoma number in attenuated FAP [Abstract]. Am. J. Hum. Genet.
  31. Warner, J, Neklason, D, Schwab, A, Cox, J, Kuwada, S, Dechet, C, Burt, R (November, 2006). Population-based analysis of cancers in large Utah families, with known mismatch repair gene mutations [Abstract]. Hereditary Cancer in Clinical Practice.
  32. Jasperson, K, Lowstuter, K, Vu, T, Schwab, A, Bredthauer, L, Neklason, D, Rodriguez-Bigas, M, Burt, R, Weitzel, J (November, 2006). Evaluating Lynch syndrome in very early onset colorectal cancer probands without apparent polyposis [Abstract]. Hereditary Cancer in Clinical Practice.
  33. Condie, M, Burt, RW, Neklason, DW (November, 2006). Optimizing PCR-based assay for MSH2delta1-6 American founder mutation [Abstract]. Hereditary Cancer in Clinical Practice.
  34. Schwab, A, Tuohy, T, Condie, M, Neklason, D, Burt, RW (November, 2006). Gonadal mosaicism in a family with familial adenomatous polyposis [Abstract]. Hereditary Cancer in Clinical Practice.
  35. Neklason, DW, Kerber, R, Nilson, D, Mineau, G, Burt, RW (November, 2006). Common familial colorectal cancer linked to chromosome 7q32.33: a sibpair study [Abstract]. Hereditary Cancer in Clinical Practice.
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