Jonathan E. Constance, PhD

Languages

  • English

Academic Information

  • Departments: Pediatrics - Research Assistant Professor, Pharmaceutics and Pharmaceutical Chemistry - Adjunct Assistant Professor, Pharmacology and Toxicology - Adjunct Assistant Professor
  • Divisions: Pediatric Clinical Pharmacology

Academic Office Information

  • 801-213-3745
  • Williams Building
    295 Chipeta Way
    Salt Lake City, UT 84108

Academic Bio

Jonathan Constance, Ph.D., is a Research Assistant Professor in the Division of Clinical Pharmacology.

Dr. Constance’s research seeks to better understand patient level factors, such as genetics, stage of development, pathophysiologic states, and polypharmacy that influence drug efficacy and risk in neonatal and pediatric populations. Of special interest are the pharmacokinetic and pharmacodynamic relationships between concomitant antineoplastic therapy and non-anticancer medications related to altered chemotherapeutic activity and efficacy among pediatric patients with cancer. This encompasses interests in the ontogeny of xenobiotic metabolizing enzymes and transporters, patterns of drug use, and targeted therapies such as tyrosine kinase inhibitors and peptide/protein drugs. Using clinical data, including genetic characteristics, to inform in vitro drug-drug interaction models with the aim of understanding the consequences of interpatient variability on drug efficacy and toxicity.

Teaching and training professional and graduate students in Pharmacology and Toxicology and Pediatric Clinical Pharmacology.

Education History

Type School Degree
Doctoral Training University of Utah
Pharmacology & Toxicology
Ph.D.
Undergraduate University of Utah
Chemistry
B.S.
Fellowship University of Utah
Clinical Pharmacology
Clinical Fellow