Jonathan E. Constance, PhD
- Departments: Pediatrics - Research Assistant Professor, Pharmaceutics and Pharmaceutical Chemistry - Adjunct Assistant Professor, Pharmacology and Toxicology - Adjunct Assistant Professor
- Divisions: Pediatric Clinical Pharmacology
Academic Office Information
295 Chipeta Way
Salt Lake City, UT 84108
Jonathan Constance, Ph.D., is a Research Assistant Professor in the Division of Clinical Pharmacology.
Dr. Constance’s research seeks to better understand patient level factors, such as genetics, stage of development, pathophysiologic states, and polypharmacy that influence drug efficacy and risk in neonatal and pediatric populations. Of special interest are the pharmacokinetic and pharmacodynamic relationships between concomitant antineoplastic therapy and non-anticancer medications related to altered chemotherapeutic activity and efficacy among pediatric patients with cancer. This encompasses interests in the ontogeny of xenobiotic metabolizing enzymes and transporters, patterns of drug use, and targeted therapies such as tyrosine kinase inhibitors and peptide/protein drugs. Using clinical data, including genetic characteristics, to inform in vitro drug-drug interaction models with the aim of understanding the consequences of interpatient variability on drug efficacy and toxicity.
Teaching and training professional and graduate students in Pharmacology and Toxicology and Pediatric Clinical Pharmacology.
|Doctoral Training||University of Utah
Pharmacology & Toxicology
|Undergraduate||University of Utah
|Fellowship||University of Utah