Paul A. House, MD

Research Interests

  • Epilepsy
  • Electrophysiology
  • Movement Disorders

Languages

  • English

Academic Information

  • Departments: Neurosurgery - Adjunct Assistant Professor
  • Divisions: Adult Neurosurgery

Board Certification

  • American Board of Neurological Surgery (Neurosurg)

Academic Office Information

  • 801-581-6908
  • Clinical Neurosciences Center
    Neurosurgery
    175 North Medical Drive East
    Salt Lake City, UT 84132

Academic Bio

My research, performed in collaboration with colleagues in Bioengineering and Neurology, is focused in two areas, both utilizing electrocorticography recording techniques. One overarching goal is to provide more detailed descriptions of seizure origination and propagation in neocortical epilepsy. We have performed semi-chronic recordings in human patients at several orders of spatial resolution by using penetrating and non-penetrating microelectrodes in addition to more traditional recording techniques. These recordings have allowed for analysis of seizure propagation from the scale of single unit activity to lobar involvement. The second overarching goal is to provide descriptions of information content, again across several orders of scale, that can be recorded with these interface devices. Some of these descriptions have been published in regards to their possible utility in brain-machine interface devices.

Education History

Type School Degree
Fellowship University of California - San Francisco
Neurosurgery
Fellow
Residency University of Utah School of Medicine
Neurosurgery
Resident
Internship University of Utah School of Medicine
General Surgery
Intern
Professional Medical Washington University School of Medicine
Medicine
M.D.
Undergraduate University of Iowa
Biochemistry
B.S.

Selected Publications

Journal Article

  1. Christie BP, Ashmont KR, House PA, Greger B (2016). Approaches to a cortical vision prosthesis: implications of electrode size and placement. J Neural Eng, 13(2), 025003.
  2. Smith EH, Liou JY, Davis TS, Merricks EM, Kellis SS, Weiss SA, Greger B, House PA, McKhann Ii GM, Goodman RR, Emerson RG, Bateman LM, Trevelyan AJ, Schevon CA (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nat Commun, 7, 11098.
  3. Kellis S, Sorensen L, Darvas F, Sayres C, ONeill K 3rd, Brown RB, House P, Ojemann J, Greger B (2016). Multi-scale analysis of neural activity in humans: Implications for micro-scale electrocorticography. Clin Neurophysiol, 127(1), 591-601.
  4. Seyedhosseini M, Shushruth S, Davis T, Ichida JM, House PA, Greger B, Angelucci A, Tasdizen T (2015). Informative features of local field potential signals in primary visual cortex during natural image stimulation. J Neurophysiol, 113(5), 1520-32.
  5. Fernandez E, Greger B, House PA, Aranda I, Botella C, Albisua J, Soto-Sanchez C, Alfaro A, Normann RA (2014). Acute human brain responses to intracortical microelectrode arrays: challenges and future prospects. Front Neuroeng, 7, 24.
  6. Smith E, Duede S, Hanrahan S, Davis T, House P, Greger B (2013). Seeing is Believing: Neural Representations of Visual Stimuli in Human Auditory Cortex Correlate with Illusory Auditory Perceptions. PLoS ONE, 8(9), e73148.
  7. Smith E, Kellis S, House P, Greger B (2013). Decoding stimulus identity from multi-unit activity and local field potentials along the ventral auditory stream in the awake primate: implications for cortical neural prostheses. J Neural Eng, 10(1), 016010.

Video