Sarah Franklin, PhD
- Departments: Biochemistry - Adjunct Assistant Professor, Internal Medicine - Assistant Professor
- Divisions: Cardiovascular Medicine
Academic Office Information
Nora Eccles and Richard A. Harrison Building
95 S 2000 E
Salt Lake City, UT 84112
Sarah Franklin, PhD, is an Assistant Professor at the University of Utah with a research laboratory in the Nora Eccles Harrison Cardiovascular Research and Training Institute. She received her PhD from Brigham Young University and then received postdoctoral training at UCLA in the department of Anesthesiology.
Her research interests focus on understanding how the packaging of DNA around nucleosomes influences specific patterns of gene expression and how this packaging is modulated during disease to alter transcriptional activity. Specifically her research is aimed at understanding the mechanistic basis for how remodeling of chromatin induces the re-expression of fetal genes in the heart during the development of hypertrophy and failure. She has utilized a mouse model of pressure overload hypertrophy, a novel method for isolation and fractionation of cardiac nuclei and state-of-the-art mass spectrometry to characterize the protein constituents of chromatin from normal and diseased hearts. This work has allowed her to identify a number of novel chromatin binding proteins whose abundance is differentially regulated during heart failure progression. Her laboratory has now begun to evaluate the specific role of these proteins on chromatin structure and heart morphology and physiology using isolated cell and animal models.
|Fellowship||University of California, Department of Anesthesiology
|Doctoral Training||Brigham Young University
|Undergraduate||Brigham Young University
|Undergraduate||College of Eastern Utah