Jorge Isaac, MD

Languages

  • English
  • Spanish

Academic Information

  • Departments: Pathology - Adjunct Assistant Professor

Board Certification

  • American Board of Pathology (Anatomic & Clinical)

Academic Office Information

  • 801-585-2540
  • Huntsman Cancer Institute
    Surgical Pathology
    2000 Circle of Hope, Room: 3860
    Salt Lake City, UT 84112

Email: jorge.isaac@path.utah.edu

Education History

Type School Degree
Fellowship Louisiana State University at Shreveport School of Medicine
Pathology
Fellow
Residency Louisiana State University at Shreveport School of Medicine
Pathology
Resident
Residency University of Alabama - Birmingham
Pathology
Resident
Research Fellow Mayo Medical School
Research Fellow
Residency Hospital Universitario del Valle
Transfusion Medicine
Resident
Professional Medical La Pontificia Universidad Javeriana
M.D.
Undergraduate Colegio Biffi La Salle
B.S.

Global Impact

Education History

Type School Degree Country
Residency Hospital Universitario del Valle
Transfusion Medicine
Resident Colombia
Professional Medical La Pontificia Universidad Javeriana
M.D. Colombia
Undergraduate Colegio Biffi La Salle
B.S. Colombia

Selected Publications

Journal Article

  1. Togel F, Isaac J, Westenfelder C (2004). Hematopoeitic Stem cell mobilization-associated granulocytosis severely worsens acute renal failure. J Am Soc Nephrol, 15, 1261-7.
  2. Shihab FS, Bennett WM, Isaac J, Yi H, Andoh TF (2003 Feb). Nitric oxide modulates vascular endothelial growth factor and receptors in chronic cyclosporine nephrotoxicity. Kidney Int, 63(2), 522-33.
  3. Shihab FS, Bennett WM, Isaac J, Yi H, Andoh TF (2002 Aug). Angiotensin II regulation of vascular endothelial growth factor and receptors Flt-1 and KDR/Flk-1 in cyclosporine nephrotoxicity. Kidney Int, 62(2), 422-33.
  4. Isaac J, Herrara GA, Shihab FS (2001 Apr). De novo fibrillary glomerulopathy in the renal allograft of a patient with systemic lupus erythematosus. Nephron, 87(4), 365-8.
  5. Herrera GA, Russell WJ, Isaac J, Turbat-Herrera EA, Tagouri YM, Sanders PW, Picken MM, Dempsey S (1999 Mar-Apr). Glomerulopathic light chain-mesangial cell interactions modulate in vitro extracellular matrix remodeling and reproduce mesangiopathic findings documented in vivo. Ultrastruct Pathol, 23(2), 107-26.
  6. Isaac J, Kerby JD, Russell WJ, Dempsey SC, Sanders PW, Herrera GA (1998 Dec). In vitro modulation of AL-amyloid formation by human mesangial cells exposed to amyloidogenic light chains. Amyloid, 5(4), 238-46.
  7. Turbat-Herrera EA, Isaac J, Sanders PW, Truong LD, Herrera GA (1997 May). Integrated expression of glomerular extracellular matrix proteins and beta 1 integrins in monoclonal light chain-related renal diseases. Mod Pathol, 10(5), 485-95.
  8. Herrera GA, Isaac J, Turbat-Herrera EA (1997). The Role of Electron Microscopy in Transplant Renal Pathology. Ultrastruct Pathol, 21, 481-98.
  9. Isaac J, Berndt TJ, Knox FG (1995 Nov). Role of dopamine in the exaggerated phosphaturic response to parathyroid hormone in the remnant kidney. J Lab Clin Med, 126(5), 470-3.
  10. Berndt TJ, Isaac J, Kent P, Knox FG (1994). Role of Intrarenal Dopamine on Renal phosphate regulation. J Bone Miner Metab, Vol 12(Suppl 1), S49-S53.
  11. Isaac J, Berndt TJ, Thothathri V, Tyce GM, Knox FG (1993 May). Catecholamines and phosphate excretion by the remnant kidney. Kidney Int, 43(5), 1021-6.
  12. Isaac J, Berndt TJ, Knox FG (1992 Aug). Stimulation of alpha 2-adrenoreceptors blunts the phosphaturic response to parathyroid hormone. J Lab Clin Med, 120(2), 305-9.
  13. Isaac J, Glahn RP, Appel MM, Onsgard M, Dousa TP, Knox FG (1992 May). Mechanism of dopamine inhibition of renal phosphate transport. J Am Soc Nephrol, 2(11), 1601-7.
  14. Isaac J, Berndt TJ, Chinnow SL, Tyce GM, Dousa TP, Knox FG (1992 Mar). Dopamine enhances the phosphaturic response to parathyroid hormone in phosphate-deprived rats. J Am Soc Nephrol, 2(9), 1423-9.

Review

  1. Isaac J, Lowichik A, Cartwright P, Rohr R (2000 Oct). Inverted papilloma of the urinary bladder in children: case report and review of prognostic significance and biological potential behavior. [Review]. J Pediatr Surg, 35(10), 1514-6.
  2. Isaac J, Herrera GA (July/August 1998). Renal Biopsy as a primary diagnostic tool in plasma cell dyscrasias. [Review]. Pathol Case Rev, Vol 3(4), 183-9.

Book Chapter

  1. Isaac J, Herrera GA (2001). El rinon en el Myeloma y las enfermedades de cadena ligera. In Avendano H (Ed.), Nefrologia Clinica (2nd Edition). Editorial Medica PanAmericana.
  2. Isaac J, Herrera GA (1997). El rinon en el Myeloma y las enfermedades de cadena ligera. In Avendano H (Ed.), Nefrologia Clinica (pp. 328-37). Editorial Medica PanAmericana.

Case Report

  1. Isaac J, Shihab FS (2002 Dec). Recurrent lupus nephritis in the second allograft of a patient with systemic lupus erythematosus. Nephron, 92(4), 947-9.
  2. Isaac J, Shihab FS (2002 Oct). De novo C1q nephropathy in the renal allograft of a kidney pancreas transplant recipient: BK virus-induced nephropathy? Nephron, 92(2), 431-6.
  3. Isaac J, Herrera GA (2002 Jul). Cast nephropathy in a case of Waldenstrom's macroglobulinemia. Nephron, 91(3), 512-5.

Letter

  1. Isaac J, Clayton F, Rohr R, Herrera GA (2001 Jan-Feb). ANCA-associated necrotizing/granulomatous glomerulonephritis in an elderly patient; importance of the renal biopsy [Letter to the editor]. Rev Invest Clin, 53(1), 88-90.

Abstract

  1. Kishore BK, Isaac J, Fuster M, Tripp SR, Hemmert A, Bollen M (2004). Cellular localization of Nucleotide Pyrophosphatases/Phosphodiesterases (NPPs) in Rat Kidney [Abstract]. Meeting of Experimental Biology.
  2. Westenfelder C, Toegel FE, Hu Z, Isaac J (2003). Stem Cell nephroplasty, a potentially novel strategy for the treatment of acute renal failure [Abstract]. J Am Soc Nephrol, 14, 570A, SU-PO158.
  3. Kishore BK, Isaac J, Tripp SR, Shi H, Baranowsky RL, Westenfelder C (2003). A Novel Method of Induction of Erythropoietin(EPO)-producing Peritubular Cells in Rat Kidney [Abstract]. J Am Soc Nephrol, 14, 626A, SU-PO424.
  4. Isaac J (2002). Interesting and Challenging cases in renal Pathology [Abstract]. Ann Clin Lab Sci, Vol 32(3).
  5. Shihab FS, Bennett WM, Isaac J, Yi H, Ando TF (2002). Modulation by Nitric Oxide of Endothelial Growth Factor and Receptors FLT-1 and KDR/FKL in Chronic Cyclosporine Nephrotoxicity [Abstract]. J Am Soc Nephrol, 13, 143A, F-P0413.
  6. Kishore B, Isaac J, Tripp SR, Sevigy J, Robson SC (2002). Localization of CD39/Vascular NTP Diphosphohydrolase (NTPDase) In Rat Kidney [Abstract]. J Am Soc Nephrol, 13, 335A, SA-P0353.
  7. Westenfelder C, Isaac J, Tripp SR, Joseph A, Hu Z, Baranowsky RL (2002). Ischemic Acute Renal Failure (ARF) in Rats causes Upregulation and Cellular Redistribution of tubular Erythropoietin Receptors (EPOR), an Adaptation that facilitates the Renoprotective Effects of EPO treatment [Abstract]. J Am Soc Nephrol, 13, 142A, F-P0406.
  8. Kishore B, Isaac J, Sevigy J, Robson S (2002). Localization of CD39L1/Vascular NTP Diphosphohydrolase (NTPDase2) in Murine Kidney [Abstract]. J Am Soc Nephrol, 13, 335A, SA-P0352.
  9. Isaac J, Shihab FS (2001). Specific immunohistochemical staining patterns for transforming growth factor beta 1(TGF-Beta 1) in renal allograft rejection, formalin fixed biopsies [Abstract]. USCAP Abstracts, 188A, 1107.
  10. Russell WJ, Isaac J, Dempsey SC, Herrera GA (1999). FK-506 Inhibits TGF-B mediated increase in Fibronectin production by Human Mesangial Cells exposed to Light Chain Deposition Disease-Light Chain [Abstract]. USCAP Meeting.
  11. Russell WJ, Isaac J, Herrera GA (1999). Signaling Events in Light-Chain Mediated Glomerular Damage [Abstract]. J Am Soc Nephrol, 10(A2442), 483A.
  12. Russell WJ, Isaac J, Dempsey S, Harris E, Cardelli J, Herrera GA (1998). In vitro mesangial cells culture model to study AL amyloidosis and light chain-mesangial cell interactions [Abstract]. VIII International Symposium on amyloidosis.
  13. Isaac J, Russell WJ, Dempsey SC, Herrera GA (1998). Tenascin (TN) is an important extracellular matrix (ECM) protein in the pathogenesis of nodular glomerulosclerosis in light chain deposition disease (LCDD) [Abstract]. J Am Soc Nephrol, 9, 518A.
  14. Herrera GA, Russell WJ, Isaac J, Turbat-Herrera EA, Dempsey S (1998). Pathology of light chain mesangial injury in an in vitro model [Abstract]. Abstract Book. 1998 Stohlman Scholar Symposium, Leukemia Society of America, 19.
  15. Russell WJ, Isaac J, Harris EN, Cardelli LA, Dempsey SC, Herrera GA (1998). Glomerulopathic Light chains (LCs) induce human mesangial cells (HMCs) membrane ruffling [Abstract]. J Am Soc Nephrol, 9, 526A.
  16. Harris EN, Cardelli JA, Russell WJ, Isaac J, Herrera GA (1998). Human Mesangial Cells in multiple Myeloma patients. LSUMC-S Cancer Center Barlow Conference [Abstract]. Conference Pamphlet, 36.
  17. Isaac J, Dempsey SC, Russell WJ, Herrera GA (1997). Human Mesangial Cells (HMCs) interactions with an amyloidogenic light chain (AL-LC) are accompanied by cytoskeletal rearrangements and Endocytosis [Abstract]. J Am Soc Nephrol, Vol 8(A2314), 498A.
  18. Isaac J, Russell WJ, Herrera GA (1997). In Vitro AL-amyloid formation by human mesangial cells (HMCs) Is attenuated by chloroquine Renal Pathology Society Young Investigator Award. United States and Canadian Academy of Pathology [Abstract]. Lab Invest, 76, 178A.
  19. Isaac J, Sanders PW, Murphy-Ullrich JE, Picken MM, Kerby JD, Pallero MA, Herrera GA (1996). In Vitro Al-amyloid formation is associated with low TGF-B activity [Abstract]. FASEB J, 10(6), A1425.
  20. Isaac J, Sanders PW, Murphy-Ullrich JE, Picken MM, Kerby JD, Pallero MA, Herrera GA (1996). Light Chain-Amyloid (AL) formation in vitro is enhanced by Thrombospondin and inhibited by TGF-B. Certificate of merit, The Stowell-Orbison Award [Abstract]. United States and Canadian Academy of Pathology.
  21. Isaac J, Sanders PW, Murphy-Ullrich JE, Picken MM, Kerby JD, Pallero MA, Herrera GA (1996). Light Chain-Amyloid (AL) formation in vitro is enhanced by Thrombospondin and inhibited by TGF-B. Certificate of merit, The Stowell-Orbison Award [Abstract]. Lab Invest, 74, 167A.
  22. Isaac J, Sanders PW, Murphy-Ullrich JE, Picken MM, Kerby JD, Pallero MA, Herrera GA (1996). Light Chain-Amyloid (AL) formation in vitro is enhanced by Thrombospondin and inhibited by TGF-B. Certificate of merit, The Stowell-Orbison Award [Abstract]. Mod Path, 9, 167A.
  23. Turbat-Herrera EA, Isaac J, Shultz JJ, Harkins L, Herrera GA (1996). Distribution of Alpha-B1 integrins in monoclonal light chain-related (MLCR) glomerulopathies. United States and Canadian Academy of Pathology [Abstract]. Lab Invest, 74, 169A.
  24. Turbat-Herrera EA, Isaac J, Shultz JJ, Harkins L, Herrera GA (1996). Distribution of Alpha-B1 integrins in monoclonal light chain-related (MLCR) glomerulopathies. United States and Canadian Academy of Pathology [Abstract]. Mod Path, 9, 169A.
  25. Knox FG member, Isaac J, Berndt TJ (1993). Role of dopamine in the exaggerated phosphaturic response to parathyroid hormone in the remnant kidney [Abstract]. Am Soc Renal Biochem Met.
  26. Thothathri V, Isaac J, Knox FG (1993). Effect of dopamine-1 receptor blockade on the phosphaturic response to dopamine in the rat [Abstract]. Meeting of Experimental Biology.
  27. Isaac J, Berndt TJ, Knox FG (1992). Abnormal response to alpha-adrenoreceptor stimulation in the phosphaturic response to parathyroid hormone by the remnant kidney [Abstract]. J Am Soc Nephrol, 3(3), 684.
  28. Berndt TJ, Isaac J, Dousa TP, Tyce GM, Knox FG (1992). Effect of changes in dietary phosphate intake on Urinary dopamine excretion [Abstract]. Fourth International conference on peripheral dopamine.
  29. Isaac J, Chinnow SL, Tyce GM, Knox FG (1992). Decrease sympathetic nerve activity and increased Dopamine synthesis enhance fractional excretion of phosphate in the remnant kidney [Abstract]. FASEB J, 6(4), A1548.
  30. Isaac J, Berndt TJ, Tyce GM, Dousa TP (1991). Dopamine as a paracrine regulator of renal phosphate transport [Abstract]. Fourth Biannual Meeting of the American Society of Renal Biochemistry and Metabolism.
  31. Isaac J, Appel M, Knox FG (1991). Dopamine decreases the maximum tubular capacity for phosphate reabsorption in rats [Abstract]. FASEB J, 5(5), A1407.
  32. Isaac J, Berndt TJ, Knox FG (1990). Dopamine enhances the Phosphaturic effect of parathyroid hormone in phosphate deprived rats [Abstract]. J Am Soc Nephrol, 1(4), 586.
  33. Isaac J, Berndt TJ, Knox FG (1990). Effect of alpha-adrenoreceptor stimulation on the phosphaturic response to parathyroid hormone [Abstract]. FASEB J, 4(4), A972.

Other

  1. Isaac J (2004). Granulomatous Interstitial Nephritis in a case of Systemic Sarcoidosis. ARUP Elec J.
  2. Morirs D, Isaac J (2003). Psoriasis associated IgM mesangialproliferative glomerulonephritis. ARUP Elec J.
  3. Isaac J, Gregory M (2003). Quinine induced Acute renal failure secondary to Acute Tubulo-Interstitial Nephritis. ARUP Elec J.