Heidi L. Schubert, PhD

Research Interests

  • Crystallography, X-Ray
  • Cryogenic Electron Microscopy and Three-Dimensional Reconstruction (cryo-EM)
  • Nucleosome Remodeling and Reorganization
  • HIV

Languages

  • English

Academic Information

  • Departments: Biochemistry - Research Associate Professor

Academic Office Information

  • 801-585-9776
  • Emma Eccles Jones Research Building
    Biochemistry
    15 North Medical Drive East, Room: 3600B
    Salt Lake City, UT 84112

Academic Bio

My research addresses two fundamental problems in human biology. Physical interactions between HIV and human proteins are critical for infection and can be defined at the atomic level by X-ray crystallography. I also study the mechanism of large chromatin remodeling complexes required for fundamental regulation of a cellular genome. My research involves recombinant protein expression and purification studies with the goal of solving a crystal structure using molecular replacement, anomalous scattering, or isomorphous replacement. As manager of the Macromolecule Crystallography Core Facility I assist with the planning of many projects, advise students/postdocs from many laboratories on best approaches to protein expression and purification, and train users requiring our crystallization robot and imagers.

Research Statement

My research addresses two fundamental problems in human biology. Physical interactions between HIV and human proteins are critical for infection and can be defined at the atomic level by X-ray crystallography. I also study the mechanism of large chromatin remodeling complexes required for fundamental regulation of a cellular genome. My research involves recombinant protein expression and purification studies with the goal of solving a crystal structure using molecular replacement, anomalous scattering, or isomorphous replacement. As manager of the Macromolecule Crystallography Core Facility I assist with the planning of many projects, advise students/postdocs from many laboratories on best approaches to protein expression and purification, and train users requiring our crystallization robot and imagers.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Structural Biology
Postdoctoral Fellow
Postdoctoral Fellowship University of York
Structural Biology
Postdoctoral Fellow
Doctoral Training University of Michigan
Biological Chemistry
Ph.D.
Undergraduate Miami University
Chemistry
B.S.

Global Impact

Education History

Type School Degree Country
Postdoctoral Fellowship University of York
Structural Biology
Postdoctoral Fellow United Kingdom