Alisa Knowlton, MD


  • English

Academic Information

  • Departments: Family & Preventive Medicine - Adjunct Instructor
  • Divisions: Family Medicine

Academic Office Information

  • 801-294-1041
  • 390 North Main
    Bountiful, UT 84010

Selected Publications

Journal Article

  1. Howell MD, Geraci JM, Knowlton AA (2001 Aug). Congestive heart failure and outpatient risk of venous thromboembolism: a retrospective, case-control study. J Clin Epidemiol, 54(8), 810-6.
  2. Cornelussen RN, Gupta S, Knowlton AA (2001 Aug). Regulation of prostaglandin A1-induced heat shock protein expression in isolated cardiomyocytes. J Mol Cell Cardiol, 33(8), 1447-54.
  3. Chang J, Wasser JS, Cornelussen RN, Knowlton AA (2001 Jul 10). Activation of heat-shock factor by stretch-activated channels in rat hearts. Circulation, 104(2), 209-14.
  4. Chang J, Knowlton AA, Xu F, Wasser JS (2001 Jan). Activation of the heat shock response: relationship to energy metabolites. A (31)P NMR study in rat hearts. Am J Physiol Heart Circ Physiol, 280(1), H426-33.
  5. Knowlton AA, Sun L (2001 Jan). Heat-shock factor-1, steroid hormones, and regulation of heat-shock protein expression in the heart. Am J Physiol Heart Circ Physiol, 280(1), H455-64.
  6. Knowlton AA (2001 Jan). Mutation of amino acids 566-572 (KKKVLDK) inhibits nuclear accumulation of heat shock protein 72 after heat shock. J Mol Cell Cardiol, 33(1), 49-55.
  7. Knowlton AA, Grenier M, Kirchhoff SR, Salfity M (2000 Jun). Phosphorylation at tyrosine-524 influences nuclear accumulation of HSP72 with heat stress. Am J Physiol Heart Circ Physiol, 278(6), H2143-9.
  8. Sun L, Chang J, Kirchhoff SR, Knowlton AA (2000 Apr). Activation of HSF and selective increase in heat-shock proteins by acute dexamethasone treatment. Am J Physiol Heart Circ Physiol, 278(4), H1091-7.
  9. Chang J, Knowlton AA, Wasser JS (2000 Jan). Expression of heat shock proteins in turtle and mammal hearts: relationship to anoxia tolerance. Am J Physiol Regul Integr Comp Physiol, 278(1), R209-14.
  10. Wang Y, Knowlton AA, Christensen TG, Shih T, Borkan SC (1999 Jun). Prior heat stress inhibits apoptosis in adenosine triphosphate-depleted renal tubular cells. Kidney Int, 55(6), 2224-35.
  11. Knowlton AA (1999 Mar). Mutation of amino acids 246-251 alters nuclear accumulation of human heat shock protein (HSP) 72 with stress, but does not reduce viability. J Mol Cell Cardiol, 31(3), 523-32.
  12. Nakano M, Knowlton AA, Dibbs Z, Mann DL (1998 Apr 14). Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte. Circulation, 97(14), 1392-400.
  13. Knowlton AA, Kapadia S, Torre-Amione G, Durand JB, Bies R, Young J, Mann DL (1998 Apr). Differential expression of heat shock proteins in normal and failing human hearts. J Mol Cell Cardiol, 30(4), 811-8.
  14. Nakano M, Mann DL, Knowlton AA (1997 Mar 18). Blocking the endogenous increase in HSP 72 increases susceptibility to hypoxia and reoxygenation in isolated adult feline cardiocytes. Circulation, 95(6), 1523-31.
  15. Nakano M, Knowlton AA, Yokoyama T, Lesslauer W, Mann DL (1996 Apr). Tumor necrosis factor-alpha-induced expression of heat shock protein 72 in adult feline cardiac myocytes. Am J Physiol, 270(4 Pt 2), H1231-9.
  16. Latkin C, Mandell W, Oziemkowska M, Celentano D, Vlahov D, Ensminger M, Knowlton A (1995 Apr). Using social network analysis to study patterns of drug use among urban drug users at high risk for HIV/AIDS. Drug Alcohol Depend, 38(1), 1-9.
  17. Sun JZ, Tang XL, Knowlton AA, Park SW, Qiu Y, Bolli R (1995 Jan). Late preconditioning against myocardial stunning. An endogenous protective mechanism that confers resistance to postischemic dysfunction 24 h after brief ischemia in conscious pigs. J Clin Invest, 95(1), 388-403.
  18. Latkin C, Mandell W, Vlahov D, Oziemkowska M, Knowlton A, Celentano D (1994 Jun). My place, your place, and no place: behavior settings as a risk factor for HIV-related injection practices of drug users in Baltimore, Maryland. Am J Community Psychol, 22(3), 415-30.
  19. Knowlton AA, Connelly CM, Romo GM, Mamuya W, Apstein CS, Brecher P (1992 Apr). Rapid expression of fibronectin in the rabbit heart after myocardial infarction with and without reperfusion. J Clin Invest, 89(4), 1060-8.
  20. Knowlton AA, Eberli FR, Brecher P, Romo GM, Owen A, Apstein CS (1991 Dec). A single myocardial stretch or decreased systolic fiber shortening stimulates the expression of heat shock protein 70 in the isolated, erythrocyte-perfused rabbit heart. J Clin Invest, 88(6), 2018-25.
  21. Mai DH, Peschel RE, Portlock C, Knowlton A, Farber L (1991 Oct 1). Stage I and II subdiaphragmatic Hodgkin's disease. Cancer, 68(7), 1476-81.
  22. Peschel RE, Hou-Wun Mai D, Dowling S, Knowlton A, Farber L, Fischer JJ (1991 Aug). Pathologic stage I and II Hodgkin's disease. Long-term results at three Connecticut hospitals. Conn Med, 55(8), 449-52.
  23. Knowlton AA, Brecher P, Apstein CS (1991 Jan). Rapid expression of heat shock protein in the rabbit after brief cardiac ischemia. J Clin Invest, 87(1), 139-47.
  24. Knowlton AA, Falk RH (1990 Apr 1). Paradoxical increase in heart rate before conversion to sinus rhythm in patients with recent-onset atrial fibrillation. Am J Cardiol, 65(13), 930-2.
  25. Knowlton AA, Burrier RE, Brecher P (1989 Oct). Rabbit heart fatty acid-binding protein. Isolation, characterization, and application of a monoclonal antibody. Circ Res, 65(4), 981-8.
  26. Knowlton AA, Apstein CS, Saouf R, Brecher P (1989 Jun). Leakage of heart fatty acid binding protein with ischemia and reperfusion in the rat. J Mol Cell Cardiol, 21(6), 577-83.
  27. Wiegers SE, Plehn JF, Rajail-Khorasani A, Knowlton AA (1988 Dec). Purulent pericarditis and ventricular pseudoaneurysm in an intravenous drug abuser. Am Heart J, 116(6 Pt 1), 1635-7.
  28. Falk RH, Knowlton AA, Battinelli NJ (1988 Oct). The effect of propranolol and verapamil on external pacing threshold: a placebo-controlled study. Pacing Clin Electrophysiol, 11(10), 1439-43.


  1. Knowlton AA (1995 Jan). Current concepts in transcription, translation, and the regulation of gene expression. A primer for the clinician. [Review]. Chest, 107(1), 241-8.
  2. Knowlton AA (1995 Jan). The role of heat shock proteins in the heart. [Review]. J Mol Cell Cardiol, 27(1), 121-31.
  3. Knowlton AA (1994 Jun 17). Heat-shock proteins, stress, and the heart. [Review]. Ann N Y Acad Sci, 723, 128-37.
  4. Urdaneta N, Fischer JJ, Knowlton A (1988 Dec). Olfactory neuroblastoma. Observations on seven patients treated with radiation therapy and review of the literature. [Review]. Am J Clin Oncol, 11(6), 672-8.


  1. Geraci JM, Knowlton AA (2000 Dec). Spironolactone for heart failure: spiraling out of control. Chest, 118(6), 1522-3.


  1. Cornelussen RN, van Nieuwenhoven FA, Snoeckx LH, Knowlton AA (2001 Nov 27). Presence of heat shock protein 72 in cardiomyocytes after heat stress [Letter to the editor]. Circulation, 104(22), E123.