Richard Holubkov, PhD

Languages

  • Czech
  • English
  • German

Academic Information

  • Departments: Family & Preventive Medicine - Adjunct Professor, Pediatrics - Professor, Population Health Sciences - Adjunct Professor
  • Divisions: Biostatistics, Pediatric Critical Care, Public Health

Academic Office Information

  • 801-585-3237
  • Williams Building
    Pediatric Critical Care
    295 Chipeta Way
    Salt Lake City, UT 84108

Academic Bio

Dr. Holubkov has over 25 years of experience as an applied biostatistician, focusing on the design, execution and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. Dr. Holubkov received his Ph.D. in Biostatistics from the University of Washington in 1995, and was a faculty member at the University of Pittsburgh prior to joining the University of Utah in 2002. At the University of Pittsburgh, Dr. Holubkov was chief biostatistician for the NHLBI Registries of Percutaneous Coronary Interventions and the two NHLBI Bypass Angioplasty Revascularization Investigations (BARI), and he also directed the Coordinating Center for an industry-sponsored international randomized trial comparing two mechanical heart valves.

At the University of Utah, he is the Co-Principal Investigator and Chief Biostatistician for the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN) Coordinating Center since the network'e (CPCCRN) inception, Director of the Coordinating Center for the NHLBI-funded Hydrocephalus Research Network (HCRN), Co-Director of the Study Design and Biostatistics Center in the Center for Clinical Sciences (CCTS), and the chief biostatistician for the NHLBI’s Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials.

Dr. Holubkov also regularly teaches courses on the design and analysis of randomized clinical trials and mentors clinical investigators as well as students in the Masters of Statistics Program. Dr. Holubkov has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees.

Education History

Type School Degree
Doctoral Training University of Washington
Biostatistics
Ph.D.
Graduate Training University of Washington
Biostatistics
M.S.
Graduate Training Carnegie-Mellon University
Statistics
M.S.
Undergraduate University of Chicago
Statistics
B.S.

Selected Publications

Journal Article

  1. Keenan HT, Clark AE, Holubkov R, Cox CS, Patel RP, Moore KR, Ewing-Cobbs L (2020). Latent Class Analysis to Classify Injury Severity in Pediatric Traumatic Brain Injury. J Neurotrauma, 37(13), 1512-1520.
  2. Pindrik J, Riva-Cambrin J, Kulkarni AV, Alvey JS, Reeder RW, Pollack IF, Wellons JC, Jackson EM, Rozzelle CJ, Whitehead WE, Limbrick DD, Naftel RP, Shannon C, McDonald PJ, Tamber MS, Hankinson TC, Hauptman JS, Simon TD, Krieger MD, Holubkov R, Kestle JRW, Hydrocephalus Clinical Research Network (2020). Surgical resource utilization after initial treatment of infant hydrocephalus: comparing ETV, early experience of ETV with choroid plexus cauterization, and shunt insertion in the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 1-9.
  3. Murphy LK, Palermo TM, Meert KL, Reeder R, Dean JM, Banks R, Berg RA, Carcillo JA, Chima R, McGalliard J, Haaland W, Holubkov R, Mourani PM, Pollack MM, Sapru A, Sorenson S, Varni JW, Zimmerman J (2020). Longitudinal Trajectories of Caregiver Distress and Family Functioning After Community-Acquired Pediatric Septic Shock. (Epub ahead of print) Pediatr Crit Care Med.
  4. Pollack MM, Banks R, Holubkov R, Meert KL, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (2021). Morbidity and Mortality in Critically Ill Children. I. Pathophysiologies and Potential Therapeutic Solutions. Crit Care Med, 48(6), 790-798.
  5. Morgan RW, Reeder RW, Meert KL, Telford R, Yates AR, Berger JT, Graham K, Landis WP, Kilbaugh TJ, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman D, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Sutton RM, Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentCollaborative Pediatric Critical Care Research Network CPCCRN Pediatric Intensive Care Quality of Cardio-Pulmonary Resuscitation PICqCPR Investigators (2020). Survival and Hemodynamics During Pediatric Cardiopulmonary Resuscitation for Bradycardia and Poor Perfusion Versus Pulseless Cardiac Arrest. Crit Care Med, 48(6), 881-889.
  6. Meert KL, Banks R, Holubkov R, Pollack MM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (2021). Morbidity and Mortality in Critically Ill Children. II. A Qualitative Patient-Level Analysis of Pathophysiologies and Potential Therapeutic Solutions. Crit Care Med, 48(6), 799-807.
  7. Mihalopoulos NL, Yap JT, Beardmore B, Holubkov R, Nanjee MN, Hoffman JM (2020). Cold-Activated Brown Adipose Tissue is Associated with Less Cardiometabolic Dysfunction in Young Adults with Obesity. Obesity (Silver Spring), 28(5), 916-923.
  8. Landis WP, Morgan RW, Reeder RW, Graham K, Siems A, Diddle JW, Pollack MM, Maa T, Fernandez RP, Yates AR, Tilford B, Ahmed T, Meert KL, Schneiter C, Bishop R, Mourani PM, Naim MY, Friess S, Burns C, Manga A, Franzon D, Tabbutt S, McQuillen PS, Horvat CM, Bochkoris M, Carcillo JA, Huard L, Federman M, Sapru A, Viteri S, Hehir DA, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Wolfe HA, Sutton RM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network CPCCRN Investigators the National Heart Lung and Blood Institute ICU-RESUScitation Project Investigators (2020). Variability in chest compression rate calculations during pediatric cardiopulmonary resuscitation. Resuscitation, 149, 127-133.
  9. Berger JT, Maddux AB, Reeder RW, Banks R, Mourani PM, Berg RA, Carcillo JA, Carpenter T, Hall MW, Meert KL, McQuillen PS, Pollack MM, Sapru A, Yates AR, Notterman DA, Holubkov R, Dean JM, Wessel DL, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (2020). Inhaled Nitric Oxide Use in Pediatric Hypoxemic Respiratory Failure. (Epub ahead of print) Pediatr Crit Care Med.
  10. Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Meert KL, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Wong H, Chima RS, Holubkov R, Coleman W, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock K, Dean JM, Reeder RW, Life After Pediatric Sepsis Evaluation LAPSE Investigators (2021). Critical Illness Factors Associated With Long-Term Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock. Crit Care Med, 48(3), 319-328.
  11. Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Meert KL, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Wong H, Chima RS, Holubkov R, Coleman W, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock K, Dean JM, Reeder RW, Life After Pediatric Sepsis Evaluation LAPSE Investigators (2021). Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock. Crit Care Med, 48(3), 329-337.
  12. Keenan HT, Clark AE, Holubkov R, Ewing-Cobbs L (2021). Changing Healthcare and School Needs in the First Year After Traumatic Brain Injury. J Head Trauma Rehabil, 35(1), E67-E77.
  13. Gildea MR, Moler FW, Page K, Meert K, Holubkov R, Dean JM, Christensen JR, Slomine BS (2021). Methods Used to Maximize Follow-Up: Lessons Learned From the Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials. Pediatr Crit Care Med, 21(1), 4-11.
  14. Siems A, Banks R, Holubkov R, Meert KL, Bauerfeld C, Beyda D, Berg RA, Bulut Y, Burd RS, Carcillo J, Dean JM, Gradidge E, Hall MW, McQuillen PS, Mourani PM, Newth CJL, Notterman DA, Priestley MA, Sapru A, Wessel DL, Yates AR, Zuppa AF, Pollack MM (2021). Structured Chart Review: Assessment of a Structured Chart Review Methodology. Hospital Pediatrics, 10(1), 61-69.
  15. Carcillo JA, Berg RA, Wessel D, Pollack M, Meert K, Hall M, Newth C, Lin JC, Doctor A, Shanley T, Cornell T, Harrison RE, Zuppa AF, Reeder RW, Banks R, Kellum JA, Holubkov R, Notterman DA, Dean JM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (2019). A Multicenter Network Assessment of Three Inflammation Phenotypes in Pediatric Sepsis-Induced Multiple Organ Failure. Pediatr Crit Care Med, 20(12), 1137-1146.
  16. Sutton RM, Reeder RW, Landis WP, Meert KL, Yates AR, Morgan RW, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network CPCCRN (2019). Ventilation Rates and Pediatric In-Hospital Cardiac Arrest Survival Outcomes. Crit Care Med, 47(11), 1627-1636.
  17. Wolfe HA, Sutton RM, Reeder RW, Meert KL, Pollack MM, Yates AR, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Eunice Kennedy Shriver National Institute of Child Health, Human Development Collaborative Pediatric Critical Care Research Network, Pediatric Intensive Care Quality of Cardiopulmonary Resuscitation Investigators (2019). Functional outcomes among survivors of pediatric in-hospital cardiac arrest are associated with baseline neurologic and functional status, but not with diastolic blood pressure during CPR. Resuscitation, 143, 57-65.
  18. Topjian AA, Telford R, Holubkov R, Nadkarni VM, Berg RA, Dean JM, Moler FW, Therapeutic Hypothermia after Pediatric Cardiac Arrest THAPCA Trial Investigators (2019). The association of early post-resuscitation hypotension with discharge survival following targeted temperature management for pediatric in-hospital cardiac arrest. Resuscitation, 141, 24-34.
  19. Topjian AA, Sutton RM, Reeder RW, Telford R, Meert KL, Yates AR, Morgan RW, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network CPCCRN Investigators, Zuppa AF, Graham K, Twelves C, Diliberto MA, Landis WP, Tomanio E, Kwok J, Bell MJ, Abraham A, Sapru A, Alkhouli MF, Heidemann S, Pawluszka A, Hall MW, Steele L, Shanley TP, Weber M, Dalton HJ, Bell A, Mourani PM, Malone K, Locandro C, Coleman W, Peterson A, Thelen J, Doctor A (2019). The association of immediate post cardiac arrest diastolic hypertension and survival following pediatric cardiac arrest. Resuscitation, 141, 88-95.
  20. Flaherty BF, Jackson ML, Cox CS Jr, Clark A, Ewing-Cobbs L, Holubkov R, Moore KR, Patel RP, Keenan HT (2019). Ability of the PILOT score to predict 6-month functional outcome in pediatric patients with moderate-severe traumatic brain injury. (Epub ahead of print) J Pediatr Surg.
  21. Christensen JR, Slomine BS, Silverstein FS, Page K, Holubkov R, Dean JM, Moler FW, Therapeutic Hypothermia after Pediatric Cardiac Arrest THAPCA Trial Investigators (2019). Cardiac Arrest Outcomes in Children With Preexisting Neurobehavioral Impairment. Pediatr Crit Care Med, 20(6), 510-517.
  22. Meert K, Slomine BS, Silverstein FS, Christensen J, Ichord R, Telford R, Holubkov R, Dean JM, Moler FW, Therapeutic Hypothermia after Paediatric Cardiac Arrest THAPCA Trial Investigatorss (2019). One-year cognitive and neurologic outcomes in survivors of paediatric extracorporeal cardiopulmonary resuscitation. Resuscitation, 139, 299-307.
  23. Slomine BS, Silverstein FS, Page K, Holubkov R, Christensen JR, Dean JM, Moler FW, Therapeutic Hypothermia after Pediatric Cardiac Arrest THAPCA Trial Investigators (2019). Relationships between three and twelve month outcomes in children enrolled in the therapeutic hypothermia after pediatric cardiac arrest trials. Resuscitation, 139, 329-336.
  24. Gildea MR, Moler FW, Page K, Pemberton VL, Holubkov R, Nadkarni VM, Dean JM, Olson LM (2018). Practice Patterns after the Therapeutic Hypothermia After Pediatric Cardiac Arrest Out-of-Hospital Trial: A Survey of Pediatric Critical Care Physicians. J Pediatr Intensive Care, 8(2), 71-77.
  25. Riva-Cambrin J, Kestle JRW, Rozzelle CJ, Naftel RP, Alvey JS, Reeder RW, Holubkov R, Browd SR, Cochrane DD, Limbrick DD, Shannon CN, Simon TD, Tamber MS, Wellons JC, Whitehead WE, Kulkarni AV, Hydrocephalus Clinical Research Network (2019). Predictors of success for combined endoscopic third ventriculostomy and choroid plexus cauterization in a North American setting: a Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr, 1-11.
  26. Williams MA, Nagel SJ, Luciano MG, Relkin N, Zwimpfer TJ, Katzen H, Holubkov R, Moghekar A, Wisoff JH, McKhann GM, Golomb J, Edwards RJ, Hamilton MG (2019). The clinical spectrum of hydrocephalus in adults: report of the first 517 patients of the Adult Hydrocephalus Clinical Research Network registry. J Neurosurg, 1-12.
  27. Kahleova H, Hlozkova A, Fleeman R, Fletcher K, Holubkov R, Barnard ND (2019). Fat Quantity and Quality, as Part of a Low-Fat, Vegan Diet, Are Associated with Changes in Body Composition, Insulin Resistance, and Insulin Secretion. A 16-Week Randomized Controlled Trial. Nutrients, 11(3).
  28. Bennett EE, VanBuren J, Holubkov R, Bratton SL (2018). Presence of Invasive Devices and Risks of Healthcare-Associated Infections and Sepsis. J Pediatr Intensive Care, 7(4), 188-195.
  29. Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJS, Zimmerman JJ, Newth CJL, Harrison R, Burr J, Willson DF, Nicholson C, Bell MJ, Berg RA, Shanley TP, Heidemann SM, Dalton H, Jenkins TL, Doctor A, Webster A, Tamburro RF (2017). Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. JPEN J Parenter Enteral Nutr, 41(8), 1325-1335.
  30. Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC 3rd, Whitehead WE, Mayer-Hamblett N (2016). Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study. J Pediatr, 179, 185-191.e2.
  31. Pollack MM, Holubkov R, Funai T, Berger JT, Clark AE, Meert K, Berg RA, Carcillo J, Wessel DL, Moler F, Dalton H, Newth CJ, Shanley T, Harrison RE, Doctor A, Jenkins TL, Tamburro R, Dean JM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (2015). Simultaneous Prediction of New Morbidity, Mortality, and Survival Without New Morbidity From Pediatric Intensive Care: A New Paradigm for Outcomes Assessment. Crit Care Med, 43(8), 1699-709.
  32. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM, THAPCA Trial Investigators (2015). Therapeutic hypothermia after out-of-hospital cardiac arrest in children. N Engl J Med, 372(20), 1898-908.
  33. Cress M, Kestle JR, Holubkov R, Riva-Cambrin J (2013). Risk factors for pediatric arachnoid cyst rupture/hemorrhage: a case-control study. Neurosurgery, 72(5), 716-22; discussion 722.
  34. Sharaf BL, Pepine CJ, Kerensky RA, Reis SE, Reichek N, Rogers WJ, Sopko G, Kelsey SF, Holubkov R, Olson M, Miele NJ, Williams DO, Merz CN, WISE Study Group (2001). Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study Angiographic Core Laboratory). Am J Cardiol, 87(8), 937-41; A3.