Richard Holubkov, PhD

Languages

  • Czech
  • English
  • German

Academic Information

  • Departments: Pediatrics - Professor
  • Divisions: Biostatistics, Pediatric Critical Care, Public Health

Academic Office Information

  • 801-585-3237
  • Williams Building
    Pediatric Critical Care
    295 Chipeta Way
    Salt Lake City, UT 84108

Academic Bio

Dr. Holubkov has over 25 years of experience as an applied biostatistician, focusing on the design, execution, and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. Dr. Holubkov received his Ph.D. in Biostatistics from the University of Washington in 1995, and was a faculty member at the University of Pittsburgh prior to joining the University of Utah in 2002.

At the University of Pittsburgh, Dr. Holubkov was chief biostatistician for the NHLBI Registries of Percutaneous Coronary Interventions and the two NHLBI Bypass Angioplasty Revascularization Investigations (BARI), and he also directed the Coordinating Center for an industry-sponsored international randomized trial comparing two mechanical heart valves. At the University of Utah, he is the co-Principal Investigator and Chief Biostatistician for the NICHD’s Collaborative Pediatric Critical Care Research Network (CPCCRN) Coordinating Center since the network’s inception, Director of the Coordinating Center for the NHLBI-funded Hydrocephalus Research Network (HCRN) Co-Director of the Study Design and Biostatistics Center in the Center for Clinical &Translational Sciences (CCTS), and the chief biostatistician for the NHLBI’s Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials. Dr. Holubkov also regularly teaches courses on the design and analysis of randomized clinical trials, and mentors clinical investigators as well as students in the Masters of Statistics Program.

Dr. Holubkov has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology, and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees.Dr. Holubkov has over 25 years of experience as an applied biostatistician, focusing on the design, execution and analysis of prospective interventional studies, with a focus on pediatrics and cardiology. Dr. Holubkov received his Ph.D. in Biostatistics from the University of Washington in 1995, and was a faculty member at the University of Pittsburgh prior to joining the University of Utah in 2002. At the University of Pittsburgh, Dr. Holubkov was chief biostatistician for the NHLBI Registries of Percutaneous Coronary Interventions and the two NHLBI Bypass Angioplasty Revascularization Investigations (BARI), and he also directed the Coordinating Center for an industry-sponsored international randomized trial comparing two mechanical heart valves.

At the University of Utah, he is the Co-Principal Investigator and Chief Biostatistician for the NICHD Collaborative Pediatric Critical Care Research Network (CPCCRN) Coordinating Center since the network'e (CPCCRN) inception, Director of the Coordinating Center for the NHLBI-funded Hydrocephalus Research Network (HCRN), Co-Director of the Study Design and Biostatistics Center in the Center for Clinical Sciences (CCTS), and the chief biostatistician for the NHLBI’s Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials.

Dr. Holubkov also regularly teaches courses on the design and analysis of randomized clinical trials and mentors clinical investigators as well as students in the Masters of Statistics Program. Dr. Holubkov has authored or co-authored more than 100 publications in the areas of pediatrics, cardiology and statistical methodology. He serves on several Data Safety Monitoring Boards and protocol review committees.

Education History

Type School Degree
Doctoral Training University of Washington
Biostatistics
Ph.D.
Graduate Training University of Washington
Biostatistics
M.S.
Graduate Training Carnegie-Mellon University
Statistics
M.S.
Undergraduate University of Chicago
Statistics
B.S.

Selected Publications

Journal Article

  1. Simon TD, Kronman MP, Whitlock KB, Browd SR, Holubkov R, Kestle JRW, Kulkarni AV, Langley M, Limbrick DD, Luerssen TG, Oakes WJ, Riva-Cambrin J, Rozzelle C, Shannon CN, Tamber M, Wellons JC, Whitehead WE, Mayer-Hamblett N (2019 Feb 15). Reinfection rates following adherence to Infectious Diseases Society of America guideline recommendations in first cerebrospinal fluid shunt infection treatment. J Neurosurg Pediatr, 1-9.
  2. Moler FW, Silverstein FS, Nadkarni VM, Meert KL, Shah SH, Slomine B, Christensen J, Holubkov R, Page K, Dean JM (2018 Dec 17). Pediatric out-of-hospital cardiac arrest: Time to goal target temperature and outcomes.LID - S0300-9572(18)31027-X [pii]LID - 10.1016/j.resuscitation.2018.12.012 [doi]. (Epub ahead of print) Resuscitation.
  3. Meert KL, Delius R, Slomine BS, Christensen JR, Page K, Holubkov R, Dean JM, Moler FW (2018 Dec 14). One-Year Survival and Neurologic Outcomes after Pediatric Open-Chest Cardiopulmonary Resuscitation.LID - S0003-4975(18)31825-3 [pii]LID - 10.1016/j.athoracsur.2018.11.028 [doi]. (Epub ahead of print) Ann Thorac Surg.
  4. Scholefield BR, Silverstein FS, Telford R, Holubkov R, Slomine BS, Meert KL, Christensen JR, Nadkarni VM, Dean JM, Moler FW (2018 Dec). Therapeutic hypothermia after paediatric cardiac arrest: Pooled randomized controlled trials. Resuscitation, 133, 101-107.
  5. Slomine BS, Silverstein FS, Christensen JR, Page K, Holubkov R, Dean JM, Moler FW (2018 Dec 1). Neuropsychological Outcomes of Children 1 Year After Pediatric Cardiac Arrest: Secondary Analysis of 2 Randomized Clinical Trials. JAMA Neurol, 75(12), 1502-1510.
  6. Basu S, Holubkov R, Dean JM, Meert KL, Berg RA, Carcillo J, Newth CJL, Harrison RE, Pollack MM (2018 Dec). PICU Autopsies: Rates, Patient Characteristics, and the Role of the Medical Examiner. Pediatr Crit Care Med, 19(12), 1137-1145.
  7. Berg RA, Reeder RW, Meert KL, Yates AR, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Sutton RM (2018 Dec). End-tidal carbon dioxide during pediatric in-hospital cardiopulmonary resuscitation. Resuscitation, 133, 173-179.
  8. Pollack MM, Holubkov R, Berg RA, Newth CJL, Meert KL, Harrison RE, Carcillo J, Dalton H, Wessel DL, Dean JM (2018 Dec). Predicting cardiac arrests in pediatric intensive care units. Resuscitation, 133, 25-32.
  9. Ahmed OZ, Holubkov R, Michael Dean J, Bennett TD, Meert KL, Berg RA, Newth CJL, Carcillo J, Burd RS, Pollack MM (2018 Nov 15). CHANGE IN FUNCTIONAL STATUS AMONG CHILDREN TREATED IN THE INTENSIVE CARE UNIT AFTER INJURY.LID - 10.1097/TA.0000000000002120 [doi]. (Epub ahead of print) J Trauma Acute Care Surg.
  10. Kahleova H, Fleeman R, Hlozkova A, Holubkov R, Barnard ND (2018 Nov 2). A plant-based diet in overweight individuals in a 16-week randomized clinical trial: metabolic benefits of plant protein. Nutr Diabetes, 8(1), 58.
  11. Ewing-Cobbs L, Cox CS Jr, Clark AE, Holubkov R, Keenan HT (2018 Nov). Persistent Postconcussion Symptoms After Injury.LID - e20180939 [pii]LID - 10.1542/peds.2018-0939 [doi]. Pediatrics, 142(5).
  12. Cornell TT, Selewski DT, Alten JA, Askenazi D, Fitzgerald JC, Topjian A, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM, Moler FW (2018 Oct). Acute kidney injury after out of hospital pediatric cardiac arrest. Resuscitation, 131, 63-68.
  13. Kahleova H, Dort S, Holubkov R, Barnard ND (2018 Sep 14). A Plant-Based High-Carbohydrate, Low-Fat Diet in Overweight Individuals in a 16-Week Randomized Clinical Trial: The Role of Carbohydrates.LID - E1302 [pii]LID - 10.3390/nu10091302 [doi]. Nutrients, 10(9).
  14. Sutton RM, Reeder RW, Landis W, Meert KL, Yates AR, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Notterman DA, Holubkov R, Dean JM, Nadkarni VM, Berg RA (2018 Sep). Chest compression rates and pediatric in-hospital cardiac arrest survival outcomes. Resuscitation, 130, 159-166.
  15. Ichord R, Silverstein FS, Slomine BS, Telford R, Christensen J, Holubkov R, Dean JM, Moler FW (2018 Jul 10). Neurologic outcomes in pediatric cardiac arrest survivors enrolled in the THAPCA trials. Neurology, 91(2), e123-e131.
  16. Meert K, Slomine BS, Christensen JR, Telford R, Holubkov R, Dean JM, Moler FW (2018 Jun). Burden of caregiving after a child's in-hospital cardiac arrest. Resuscitation, 127, 44-50.
  17. Simon TD, Kronman MP, Whitlock KB, Browd SR, Holubkov R, Kestle JRW, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon CN, Tamber M, Wellons Iii JC, Whitehead WE, Mayer-Hamblett N (2018 May 15). Patient and Treatment Characteristics by Infecting Organism in Cerebrospinal Fluid Shunt Infection.LID - 10.1093/jpids/piy035 [doi]. (Epub ahead of print) J Pediatric Infect Dis Soc.
  18. Berg RA, Sutton RM, Reeder RW, Berger JT, Newth CJ, Carcillo JA, McQuillen PS, Meert KL, Yates AR, Harrison RE, Moler FW, Pollack MM, Carpenter TC, Wessel DL, Jenkins TL, Notterman DA, Holubkov R, Tamburro RF, Dean JM, Nadkarni VM (2018 Apr 24). Association Between Diastolic Blood Pressure During Pediatric In-Hospital Cardiopulmonary Resuscitation and Survival. Circulation, 137(17), 1784-1795.
  19. Reeder RW, Girling A, Wolfe H, Holubkov R, Berg RA, Naim MY, Meert KL, Tilford B, Carcillo JA, Hamilton M, Bochkoris M, Hall M, Maa T, Yates AR, Sapru A, Kelly R, Federman M, Michael Dean J, McQuillen PS, Franzon D, Pollack MM, Siems A, Diddle J, Wessel DL, Mourani PM, Zebuhr C, Bishop R, Friess S, Burns C, Viteri S, Hehir DA, Whitney Coleman R, Jenkins TL, Notterman DA, Tamburro RF, Sutton RM (2018 Apr 3). Improving outcomes after pediatric cardiac arrest - the ICU-Resuscitation Project: study protocol for a randomized controlled trial. Trials, 19(1), 213.
  20. Simon TD, Kronman MP, Whitlock KB, Gove NE, Mayer-Hamblett N, Browd SR, Cochrane DD, Holubkov R, Kulkarni AV, Langley M, Limbrick DD, Luerssen TG, Oakes WJ, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC, Whitehead WE, Kestle JRW (2018 Apr). Reinfection after treatment of first cerebrospinal fluid shunt infection: a prospective observational cohort study. J Neurosurg Pediatr, 21(4), 346-358.
  21. Kulkarni AV, Riva-Cambrin J, Rozzelle CJ, Naftel RP, Alvey JS, Reeder RW, Holubkov R, Browd SR, Cochrane DD, Limbrick DD, Simon TD, Tamber M, Wellons JC, Whitehead WE, Kestle JRW (2018 Mar). Endoscopic third ventriculostomy and choroid plexus cauterization in infant hydrocephalus: a prospective study by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 21(3), 214-223.
  22. Meert K, Telford R, Holubkov R, Slomine BS, Christensen JR, Berger J, Ofori-Amanfo G, Newth CJL, Dean JM, Moler FW (2018 Mar). Paediatric in-hospital cardiac arrest: Factors associated with survival and neurobehavioural outcome one year later. Resuscitation, 124, 96-105.
  23. Slomine BS, Silverstein FS, Christensen JR, Holubkov R, Telford R, Dean JM, Moler FW (2018 Mar). Neurobehavioural outcomes in children after In-Hospital cardiac arrest. Resuscitation, 124, 80-89.
  24. Pollack MM, Holubkov R, Reeder R, Dean JM, Meert KL, Berg RA, Newth CJL, Berger JT, Harrison RE, Carcillo J, Dalton H, Wessel DL, Jenkins TL, Tamburro R (2018 Mar). PICU Length of Stay: Factors Associated With Bed Utilization and Development of a Benchmarking Model. Pediatr Crit Care Med, 19(3), 196-203.
  25. Kahleova H, Tura A, Hill M, Holubkov R, Barnard ND (2018 Feb 9). A Plant-Based Dietary Intervention Improves Beta-Cell Function and Insulin Resistance in Overweight Adults: A 16-Week Randomized Clinical Trial.LID - E189 [pii]LID - 10.3390/nu10020189 [doi]. Nutrients, 10(2).
  26. Berger JT, Villalobos ME, Clark AE, Holubkov R, Pollack MM, Berg RA, Carcillo JA, Dalton H, Harrison R, Meert KL, Newth CJL, Shanley TP, Wessel DL, Anand KJS, Zimmerman JJ, Sanders RC Jr, Liu T, Burr JS, Willson DF, Doctor A, Dean JM, Jenkins TL, Nicholson CE (2018 Feb). Cognitive Development One Year After Infantile Critical Pertussis. Pediatr Crit Care Med, 19(2), 89-97.
  27. Zinter MS, Holubkov R, Steurer MA, Dvorak CC, Duncan CN, Sapru A, Tamburro RF, McQuillen PS, Pollack MM (2018 Feb). Pediatric Hematopoietic Cell Transplant Patients Who Survive Critical Illness Frequently Have Significant but Recoverable Decline in Functional Status. Biol Blood Marrow Transplant, 24(2), 330-336.
  28. Topjian AA, Telford R, Holubkov R, Nadkarni VM, Berg RA, Dean JM, Moler FW (2018 Feb 1). Association of Early Postresuscitation Hypotension With Survival to Discharge After Targeted Temperature Management for Pediatric Out-of-Hospital Cardiac Arrest: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr, 172(2), 143-153.
  29. Keenan HT, Clark AE, Holubkov R, Cox CS, Ewing-Cobbs L (2018 Jan 15). Psychosocial and Executive Function Recovery Trajectories One Year after Pediatric Traumatic Brain Injury: The Influence of Age and Injury Severity. J Neurotrauma, 35(2), 286-296.
  30. Davila S, Halstead ES, Hall MW, Doctor A, Telford R, Holubkov R, Carcillo JA, Storch GA (2018 Jan). Viral DNAemia and Immune Suppression in Pediatric Sepsis. Pediatr Crit Care Med, 19(1), e14-e22.
  31. Newth CJL, Sward KA, Khemani RG, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Holubkov R, Doctor A, Dean JM, Jenkins TL, Nicholson CE (2017 Nov). Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? Pediatr Crit Care Med, 18(11), e521-e529.
  32. Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJS, Zimmerman JJ, Newth CJL, Harrison R, Burr J, Willson DF, Nicholson C, Bell MJ, Berg RA, Shanley TP, Heidemann SM, Dalton H, Jenkins TL, Doctor A, Webster A, Tamburro RF (2017 Nov). Interaction Between 2 Nutraceutical Treatments and Host Immune Status in the Pediatric Critical Illness Stress-Induced Immune Suppression Comparative Effectiveness Trial. JPEN J Parenter Enteral Nutr, 41(8), 1325-1335.
  33. Dalton HJ, Reeder R, Garcia-Filion P, Holubkov R, Berg RA, Zuppa A, Moler FW, Shanley T, Pollack MM, Newth C, Berger J, Wessel D, Carcillo J, Bell M, Heidemann S, Meert KL, Harrison R, Doctor A, Tamburro RF, Dean JM, Jenkins T, Nicholson C (2017 Sep 15). Factors Associated with Bleeding and Thrombosis in Children Receiving Extracorporeal Membrane Oxygenation. Am J Respir Crit Care Med, 196(6), 762-771.
  34. Berger JT, Holubkov R, Reeder R, Wessel DL, Meert K, Berg RA, Bell MJ, Tamburro R, Dean JM, Pollack MM (2017 Aug). Morbidity and mortality prediction in pediatric heart surgery: Physiological profiles and surgical complexity. J Thorac Cardiovasc Surg, 154(2), 620-628.e6.
  35. Wellons JC 3rd, Shannon CN, Holubkov R, Riva-Cambrin J, Kulkarni AV, Limbrick DD Jr, Whitehead W, Browd S, Rozzelle C, Simon TD, Tamber MS, Oakes WJ, Drake J, Luerssen TG, Kestle J (2017 Jul). Shunting outcomes in posthemorrhagic hydrocephalus: results of a Hydrocephalus Clinical Research Network prospective cohort study. J Neurosurg Pediatr, 20(1), 19-29.
  36. Slomine BS, Nadkarni VM, Christensen JR, Silverstein FS, Telford R, Topjian A, Koch JD, Sweney J, Fink EL, Mathur M, Holubkov R, Dean JM, Moler FW (2017 Jun). Pediatric cardiac arrest due to drowning and other respiratory etiologies: Neurobehavioral outcomes in initially comatose children. Resuscitation, 115, 178-184.
  37. Whitehead WE, Riva-Cambrin J, Kulkarni AV, Wellons JC 3rd, Rozzelle CJ, Tamber MS, Limbrick DD Jr, Browd SR, Naftel RP, Shannon CN, Simon TD, Holubkov R, Illner A, Cochrane DD, Drake JM, Luerssen TG, Oakes WJ, Kestle JR (2017 Feb). Ventricular catheter entry site and not catheter tip location predicts shunt survival: a secondary analysis of 3 large pediatric hydrocephalus studies. J Neurosurg Pediatr, 19(2), 157-167.
  38. Said AS, Spinella PC, Hartman ME, Steffen KM, Jackups R, Holubkov R, Wallendorf M, Doctor A (2017 Feb). RBC Distribution Width: Biomarker for Red Cell Dysfunction and Critical Illness Outcome? Pediatr Crit Care Med, 18(2), 134-142.
  39. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Browning B, Pemberton VL, Page K, Gildea MR, Scholefield BR, Shankaran S, Hutchison JS, Berger JT, Ofori-Amanfo G, Newth CJ, Topjian A, Bennett KS, Koch JD, Pham N, Chanani NK, Pineda JA, Harrison R, Dalton HJ, Alten J, Schleien CL, Goodman DM, Zimmerman JJ, Bhalala US, Schwarz AJ, Porter MB, Shah S, Fink EL, McQuillen P, Wu T, Skellett S, Thomas NJ, Nowak JE, Baines PB, Pappachan J, Mathur M, Lloyd E, van der Jagt EW, Dobyns EL, Meyer MT, Sanders RC Jr, Clark AE, Dean JM (2017 Jan 26). Therapeutic Hypothermia after In-Hospital Cardiac Arrest in Children. N Engl J Med, 376(4), 318-329.
  40. Simon TD, Kronman MP, Whitlock KB, Gove N, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Luerssen TG, Oakes J, Riva-Cambrin J, Rozzelle C, Shannon C, Tamber M, Wellons JC 3rd, Whitehead WE, Mayer-Hamblett N (2016 Dec). Variability in Management of First Cerebrospinal Fluid Shunt Infection: A Prospective Multi-Institutional Observational Cohort Study. J Pediatr, 179, 185-191.e2.
  41. Meert K, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW (2016 Dec). Exploring the safety and efficacy of targeted temperature management amongst infants with out-of-hospital cardiac arrest due to apparent life threatening events. Resuscitation, 109, 40-48.
  42. Meert KL, Telford R, Holubkov R, Slomine BS, Christensen JR, Dean JM, Moler FW (2016 Dec). Pediatric Out-of-Hospital Cardiac Arrest Characteristics and Their Association With Survival and Neurobehavioral Outcome. Pediatr Crit Care Med, 17(12), e543-e550.
  43. Silverstein FS, Slomine BS, Christensen J, Holubkov R, Page K, Dean JM, Moler FW (2016 Dec). Functional Outcome Trajectories After Out-of-Hospital Pediatric Cardiac Arrest. Crit Care Med, 44(12), e1165-e1174.
  44. Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Burr J, Willson DF, Nicholson C, Bell MJ, Berg RA, Shanley TP, Heidemann SM, Dalton H, Jenkins TL, Doctor A, Webster A (2016 Nov). Inherent Risk Factors for Nosocomial Infection in the Long Stay Critically Ill Child Without Known Baseline Immunocompromise: A Post Hoc Analysis of the CRISIS Trial. Pediatr Infect Dis J, 35(11), 1182-1186.
  45. Kulkarni AV, Riva-Cambrin J, Holubkov R, Browd SR, Cochrane DD, Drake JM, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE, Kestle JR (2016 Oct). Endoscopic third ventriculostomy in children: prospective, multicenter results from the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 18(4), 423-429.
  46. Moler FW, Hutchison JS, Nadkarni VM, Silverstein FS, Meert KL, Holubkov R, Page K, Slomine BS, Christensen JR, Dean JM (2016 Aug). Targeted Temperature Management After Pediatric Cardiac Arrest Due To Drowning: Outcomes and Complications. Pediatr Crit Care Med, 17(8), 712-20.
  47. Meert KL, Slomine BS, Christensen JR, Telford R, Holubkov R, Dean JM, Moler FW (2016 Jun). Family Burden After Out-of-Hospital Cardiac Arrest in Children. Pediatr Crit Care Med, 17(6), 498-507.
  48. Berg RA, Nadkarni VM, Clark AE, Moler F, Meert K, Harrison RE, Newth CJ, Sutton RM, Wessel DL, Berger JT, Carcillo J, Dalton H, Heidemann S, Shanley TP, Zuppa AF, Doctor A, Tamburro RF, Jenkins TL, Dean JM, Holubkov R, Pollack MM (2016 Apr). Incidence and Outcomes of Cardiopulmonary Resuscitation in PICUs. Crit Care Med, 44(4), 798-808.
  49. Slomine BS, Silverstein FS, Christensen JR, Holubkov R, Page K, Dean JM, Moler FW (2016 Apr). Neurobehavioral Outcomes in Children After Out-of-Hospital Cardiac Arrest.LID - 10.1542/peds.2015-3412 [doi]LID - e20153412 [pii]. Pediatrics, 137(4).
  50. Kestle JR, Holubkov R, Douglas Cochrane D, Kulkarni AV, Limbrick DD Jr, Luerssen TG, Jerry Oakes W, Riva-Cambrin J, Rozzelle C, Simon TD, Walker ML, Wellons JC 3rd, Browd SR, Drake JM, Shannon CN, Tamber MS, Whitehead WE (2016 Apr). A new Hydrocephalus Clinical Research Network protocol to reduce cerebrospinal fluid shunt infection. J Neurosurg Pediatr, 17(4), 391-6.
  51. Riva-Cambrin J, Kestle JR, Holubkov R, Butler J, Kulkarni AV, Drake J, Whitehead WE, Wellons JC 3rd, Shannon CN, Tamber MS, Limbrick DD Jr, Rozzelle C, Browd SR, Simon TD (2016 Apr). Risk factors for shunt malfunction in pediatric hydrocephalus: a multicenter prospective cohort study. J Neurosurg Pediatr, 17(4), 382-90.
  52. Eissa MA, Mihalopoulos NL, Holubkov R, Dai S, Labarthe DR (2016 Mar). Changes in Fasting Lipids during Puberty. J Pediatr, 170, 199-205.
  53. Browning B, Page KE, Kuhn RL, DiLiberto MA, Deschenes J, Taillie E, Tomanio E, Holubkov R, Dean JM, Moler FW, Meert K, Pemberton VL (2016 Mar). Nurses' Attitudes Toward Clinical Research: Experience of the Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials. Pediatr Crit Care Med, 17(3), e121-9.
  54. Keele L, Meert KL, Berg RA, Dalton H, Newth CJ, Harrison R, Wessel DL, Shanley T, Carcillo J, Morrison W, Funai T, Holubkov R, Dean JM, Pollack M (2016 Feb). Limiting and Withdrawing Life Support in the PICU: For Whom Are These Options Discussed? Pediatr Crit Care Med, 17(2), 110-20.
  55. Pollack MM, Holubkov R, Funai T, Dean JM, Berger JT, Wessel DL, Meert K, Berg RA, Newth CJ, Harrison RE, Carcillo J, Dalton H, Shanley T, Jenkins TL, Tamburro R (2016 Jan). The Pediatric Risk of Mortality Score: Update 2015. Pediatr Crit Care Med, 17(1), 2-9.
  56. Meert KL, Keele L, Morrison W, Berg RA, Dalton H, Newth CJ, Harrison R, Wessel DL, Shanley T, Carcillo J, Clark A, Holubkov R, Jenkins TL, Doctor A, Dean JM, Pollack M (2015 Sep). End-of-Life Practices Among Tertiary Care PICUs in the United States: A Multicenter Study. Pediatr Crit Care Med, 16(7), e231-8.
  57. Moler FW, Silverstein FS, Holubkov R, Slomine BS, Christensen JR, Nadkarni VM, Meert KL, Clark AE, Browning B, Pemberton VL, Page K, Shankaran S, Hutchison JS, Newth CJ, Bennett KS, Berger JT, Topjian A, Pineda JA, Koch JD, Schleien CL, Dalton HJ, Ofori-Amanfo G, Goodman DM, Fink EL, McQuillen P, Zimmerman JJ, Thomas NJ, van der Jagt EW, Porter MB, Meyer MT, Harrison R, Pham N, Schwarz AJ, Nowak JE, Alten J, Wheeler DS, Bhalala US, Lidsky K, Lloyd E, Mathur M, Shah S, Wu T, Theodorou AA, Sanders RC Jr, Dean JM (). Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. N Engl J Med, 372(20), 1898-908.
  58. Dalton HJ, Garcia-Filion P, Holubkov R, Moler FW, Shanley T, Heidemann S, Meert K, Berg RA, Berger J, Carcillo J, Newth C, Harrison R, Doctor A, Rycus P, Dean JM, Jenkins T, Nicholson C (2015 Feb). Association of bleeding and thrombosis with outcome in extracorporeal life support. Pediatr Crit Care Med, 16(2), 167-74.
  59. Morales DM, Holubkov R, Inder TE, Ahn HC, Mercer D, Rao R, McAllister JP 2nd, Holtzman DM, Limbrick DD Jr (2015). Cerebrospinal fluid levels of amyloid precursor protein are associated with ventricular size in post-hemorrhagic hydrocephalus of prematurity. PLoS ONE, 10(3), e0115045.
  60. Holubkov R, Clark AE, Moler FW, Slomine BS, Christensen JR, Silverstein FS, Meert KL, Pollack MM, Dean JM (2015 Jan). Efficacy outcome selection in the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med, 16(1), 1-10.
  61. Stanley RM, Hoyle JD Jr, Dayan PS, Atabaki S, Lee L, Lillis K, Gorelick MH, Holubkov R, Miskin M, Holmes JF, Dean JM, Kuppermann N (2014 Dec). Emergency department practice variation in computed tomography use for children with minor blunt head trauma. J Pediatr, 165(6), 1201-1206.e2.
  62. Pollack MM, Holubkov R, Funai T, Clark A, Berger JT, Meert K, Newth CJ, Shanley T, Moler F, Carcillo J, Berg RA, Dalton H, Wessel DL, Harrison RE, Doctor A, Dean JM, Jenkins TL (2014 Nov). Pediatric intensive care outcomes: development of new morbidities during pediatric critical care. Pediatr Crit Care Med, 15(9), 821-7.
  63. Kulkarni AV, Riva-Cambrin J, Browd SR, Drake JM, Holubkov R, Kestle JR, Limbrick DD, Rozzelle CJ, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE (2014 Sep). Endoscopic third ventriculostomy and choroid plexus cauterization in infants with hydrocephalus: a retrospective Hydrocephalus Clinical Research Network study. J Neurosurg Pediatr, 14(3), 224-9.
  64. Whitehead WE, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Browd S, Limbrick D, Rozzelle C, Tamber MS, Simon TD, Shannon CN, Holubkov R, Oakes WJ, Luerssen TG, Walker ML, Drake JM, Kestle JR (2014 Aug). Factors associated with ventricular catheter movement and inaccurate catheter location: post hoc analysis of the hydrocephalus clinical research network ultrasound-guided shunt placement study. J Neurosurg Pediatr, 14(2), 173-8.
  65. Pollack MM, Holubkov R, Funai T, Clark A, Moler F, Shanley T, Meert K, Newth CJ, Carcillo J, Berger JT, Doctor A, Berg RA, Dalton H, Wessel DL, Harrison RE, Dean JM, Jenkins TL (2014 Jul). Relationship between the functional status scale and the pediatric overall performance category and pediatric cerebral performance category scales. JAMA Pediatr, 168(7), 671-6.
  66. Simon TD, Butler J, Whitlock KB, Browd SR, Holubkov R, Kestle JR, Kulkarni AV, Langley M, Limbrick DD Jr, Mayer-Hamblett N, Tamber M, Wellons JC 3rd, Whitehead WE, Riva-Cambrin J (2014 Jun). Risk factors for first cerebrospinal fluid shunt infection: findings from a multi-center prospective cohort study. J Pediatr, 164(6), 1462-8.e2.
  67. King M, Barnhart DC, OGorman M, Downey EC, Jackson D, Mundorff M, Holubkov R, Feola P, Srivastava R (2014 Apr). Effect of gastrojejunal feedings on visits and costs in children with neurologic impairment. J Pediatr Gastroenterol Nutr, 58(4), 518-24.
  68. Harvill ET, Goodfield LL, Ivanov Y, Meyer JA, Newth C, Cassiday P, Tondella ML, Liao P, Zimmerman J, Meert K, Wessel D, Berger J, Dean JM, Holubkov R, Burr J, Liu T, Brinkac L, Kim M, Losada L (2013 Dec 19). Genome Sequences of 28 Bordetella pertussis U.S. Outbreak Strains Dating from 2010 to 2012.LID - 10.1128/genomeA.01075-13 [doi]LID - e01075-13 [pii]. Genome Announcements, 1(6).
  69. Whitehead WE, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Holubkov R, Illner A, Oakes WJ, Luerssen TG, Walker ML, Drake JM, Kestle JR (2013 Dec). No significant improvement in the rate of accurate ventricular catheter location using ultrasound-guided CSF shunt insertion: a prospective, controlled study by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 12(6), 565-74.
  70. Berg RA, Sutton RM, Holubkov R, Nicholson CE, Dean JM, Harrison R, Heidemann S, Meert K, Newth C, Moler F, Pollack M, Dalton H, Doctor A, Wessel D, Berger J, Shanley T, Carcillo J, Nadkarni VM (2013 Oct). Ratio of PICU versus ward cardiopulmonary resuscitation events is increasing. Crit Care Med, 41(10), 2292-7.
  71. Kulkarni AV, Riva-Cambrin J, Butler J, Browd SR, Drake JM, Holubkov R, Kestle JR, Limbrick DD, Simon TD, Tamber MS, Wellons JC 3rd, Whitehead WE (2013 Oct). Outcomes of CSF shunting in children: comparison of Hydrocephalus Clinical Research Network cohort with historical controls: clinical article. J Neurosurg Pediatr, 12(4), 334-8.
  72. Moler FW, Silverstein FS, Meert KL, Clark AE, Holubkov R, Browning B, Slomine BS, Christensen JR, Dean JM (2013 Sep). Rationale, timeline, study design, and protocol overview of the therapeutic hypothermia after pediatric cardiac arrest trials. Pediatr Crit Care Med, 14(7), e304-15.
  73. Pollack MM, Dean JM, Butler J, Holubkov R, Doctor A, Meert KL, Newth CJ, Berg RA, Moler F, Dalton H, Wessel DL, Berger J, Harrison RE, Carcillo JA, Shanley TP, Nicholson CE (2013 Jun). The ideal time interval for critical care severity-of-illness assessment. Pediatr Crit Care Med, 14(5), 448-53.
  74. Heidemann SM, Holubkov R, Meert KL, Dean JM, Berger J, Bell M, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Willson DF, Nicholson C, Carcillo J (2013 May). Baseline serum concentrations of zinc, selenium, and prolactin in critically ill children. Pediatr Crit Care Med, 14(4), e202-6.
  75. Holubkov R, Casper TC, Dean JM, Anand KJ, Zimmerman J, Meert KL, Newth CJ, Berger J, Harrison R, Willson DF, Nicholson C (2013 May). The role of the Data and Safety Monitoring Board in a clinical trial: the CRISIS study. Pediatr Crit Care Med, 14(4), 374-83.
  76. Berger JT, Carcillo JA, Shanley TP, Wessel DL, Clark A, Holubkov R, Meert KL, Newth CJ, Berg RA, Heidemann S, Harrison R, Pollack M, Dalton H, Harvill E, Karanikas A, Liu T, Burr JS, Doctor A, Dean JM, Jenkins TL, Nicholson CE (2013 May). Critical pertussis illness in children: a multicenter prospective cohort study. Pediatr Crit Care Med, 14(4), 356-65.
  77. Garg A, Hegmann KT, Moore JS, Kapellusch J, Thiese MS, Boda S, Bhoyr P, Bloswick D, Merryweather A, Sesek R, Deckow-Schaefer G, Foster J, Wood E, Sheng X, Holubkov R (2013 Mar 7). Study protocol title: a prospective cohort study of low back pain. BMC Musculoskelet Disord, 14, 84.
  78. Wellons JC 3rd, Holubkov R, Browd SR, Riva-Cambrin J, Whitehead W, Kestle J, Kulkarni AV (2013 Jan). The assessment of bulging fontanel and splitting of sutures in premature infants: an interrater reliability study by the Hydrocephalus Clinical Research Network. J Neurosurg Pediatr, 11(1), 12-4.
  79. Anand KJ, Clark AE, Willson DF, Berger J, Meert KL, Zimmerman JJ, Harrison R, Carcillo JA, Newth CJ, Bisping S, Holubkov R, Dean JM, Nicholson CE (2013 Jan). Opioid analgesia in mechanically ventilated children: results from the multicenter Measuring Opioid Tolerance Induced by Fentanyl study. Pediatr Crit Care Med, 14(1), 27-36.
  80. Newth CJ, Meert KL, Clark AE, Moler FW, Zuppa AF, Berg RA, Pollack MM, Sward KA, Berger JT, Wessel DL, Harrison RE, Reardon J, Carcillo JA, Shanley TP, Holubkov R, Dean JM, Doctor A, Nicholson CE (2012 Aug). Fatal and near-fatal asthma in children: the critical care perspective. J Pediatr, 161(2), 214-21.e3.
  81. Bratton SL, Newth CJ, Zuppa AF, Moler FW, Meert KL, Berg RA, Berger J, Wessel D, Pollack M, Harrison R, Carcillo JA, Shanley TP, Liu T, Holubkov R, Dean JM, Nicholson CE (2012 Jul). Critical care for pediatric asthma: wide care variability and challenges for study. Pediatr Crit Care Med, 13(4), 407-14.
  82. Garg A, Hegmann KT, Wertsch JJ, Kapellusch J, Thiese MS, Bloswick D, Merryweather A, Sesek R, Deckow-Schaefer G, Foster J, Wood E, Kendall R, Sheng X, Holubkov R (2012 Jun 6). The WISTAH hand study: a prospective cohort study of distal upper extremity musculoskeletal disorders. BMC Musculoskelet Disord, 13, 90.
  83. Simon TD, Whitlock KB, Riva-Cambrin J, Kestle JR, Rosenfeld M, Dean JM, Holubkov R, Langley M, Hamblett NM (2012 Jun). Revision surgeries are associated with significant increased risk of subsequent cerebrospinal fluid shunt infection. Pediatr Infect Dis J, 31(6), 551-6.
  84. Riva-Cambrin J, Shannon CN, Holubkov R, Whitehead WE, Kulkarni AV, Drake J, Simon TD, Browd SR, Kestle JR, Wellons JC 3rd (2012 May). Center effect and other factors influencing temporization and shunting of cerebrospinal fluid in preterm infants with intraventricular hemorrhage. J Neurosurg Pediatr, 9(5), 473-81.
  85. Lemoine TJ, Swoboda KJ, Bratton SL, Holubkov R, Mundorff M, Srivastava R (2012 May). Spinal muscular atrophy type 1: are proactive respiratory interventions associated with longer survival? Pediatr Crit Care Med, 13(3), e161-5.
  86. Carcillo JA, Dean JM, Holubkov R, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Burr J, Willson DF, Nicholson C (2012 Mar). The randomized comparative pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. Pediatr Crit Care Med, 13(2), 165-73.
  87. Corneli HM, Zorc JJ, Holubkov R, Bregstein JS, Brown KM, Mahajan P, Kuppermann N (2012 Feb). Bronchiolitis: clinical characteristics associated with hospitalization and length of stay. Pediatr Emerg Care, 28(2), 99-103.
  88. Alessandrini EA, Alpern ER, Chamberlain JM, Shea JA, Holubkov R, Gorelick MH (2012 Jan). Developing a diagnosis-based severity classification system for use in emergency medical services for children. Acad Emerg Med, 19(1), 70-8.
  89. Simon TD, Whitlock KB, Riva-Cambrin J, Kestle JR, Rosenfeld M, Dean JM, Holubkov R, Langley M, Mayer-Hamblett N (2012 Jan). Association of intraventricular hemorrhage secondary to prematurity with cerebrospinal fluid shunt surgery in the first year following initial shunt placement. J Neurosurg Pediatr, 9(1), 54-63.
  90. Kestle JR, Riva-Cambrin J, Wellons JC 3rd, Kulkarni AV, Whitehead WE, Walker ML, Oakes WJ, Drake JM, Luerssen TG, Simon TD, Holubkov R (2011 Jul). A standardized protocol to reduce cerebrospinal fluid shunt infection: the Hydrocephalus Clinical Research Network Quality Improvement Initiative. J Neurosurg Pediatr, 8(1), 22-9.
  91. Chen Q, Reis SE, Kammerer C, Craig W, McNamara DM, Holubkov R, Sharaf BL, Sopko G, Pauly DF, Merz CN, Kamboh MI (2011 Apr). Association of anti-oxidized LDL and candidate genes with severity of coronary stenosis in the Women's Ischemia Syndrome Evaluation study. J Lipid Res, 52(4), 801-7.
  92. Hawkins JA, Kaza AK, Burch PT, Lambert LM, Holubkov R, Witte MK (2010 Oct). Simple versus complex truncus arteriosus: neutralization of risk but with increased resource utilization. World J Pediatr Congenit Heart Surg, 1(3), 285-91.
  93. Burch PT, Kaza AK, Lambert LM, Holubkov R, Shaddy RE, Hawkins JA (2010 Oct). Clinical performance of decellularized cryopreserved valved allografts compared with standard allografts in the right ventricular outflow tract. Ann Thorac Surg, 90(4), 1301-5; discussion 1306.
  94. Mihalopoulos NL, Holubkov R, Young P, Dai S, Labarthe DR (2010 Oct). Expected changes in clinical measures of adiposity during puberty. J Adolesc Health, 47(4), 360-6.
  95. Petko C, Minich LL, Everitt MD, Holubkov R, Shaddy RE, Tani LY (2010 Aug). Echocardiographic evaluation of children with systemic ventricular dysfunction treated with carvedilol. Pediatr Cardiol, 31(6), 780-4.
  96. Jou CJ, Etheridge SP, Minich LL, Saarel EV, Lambert LM, Kouretas PC, Holubkov R, Hawkins JA (2010 Apr). Long-term Outcome and Risk of Heart Block After Surgical Treatment of Subaortic Stenosis. World J Pediatr Congenit Heart Surg, 1(1), 15-9.
  97. Willson DF, Dean JM, Meert KL, Newth CJ, Anand KJ, Berger J, Harrison R, Zimmerman J, Carcillo J, Pollack M, Holubkov R, Jenkins TL, Nicholson C (2010 Jan). Collaborative pediatric critical care research network: looking back and moving forward. Pediatr Crit Care Med, 11(1), 1-6.
  98. Mahajan P, Alpern ER, Grupp-Phelan J, Chamberlain J, Dong L, Holubkov R, Jacobs E, Stanley R, Tunik M, Sonnett M, Miller S, Foltin GL (2009 Nov). Epidemiology of psychiatric-related visits to emergency departments in a multicenter collaborative research pediatric network. Pediatr Emerg Care, 25(11), 715-20.
  99. Kuppermann N, Holmes JF, Dayan PS, Hoyle JD Jr, Atabaki SM, Holubkov R, Nadel FM, Monroe D, Stanley RM, Borgialli DA, Badawy MK, Schunk JE, Quayle KS, Mahajan P, Lichenstein R, Lillis KA, Tunik MG, Jacobs ES, Callahan JM, Gorelick MH, Glass TF, Lee LK, Bachman MC, Cooper A, Powell EC, Gerardi MJ, Melville KA, Muizelaar JP, Wisner DH, Zuspan SJ, Dean JM, Wootton-Gorges SL (2009 Oct 3). Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort study. Lancet, 374(9696), 1160-70.
  100. Burch PT, Cowley CG, Holubkov R, Null D, Lambert LM, Kouretas PC, Hawkins JA (2009 Sep). Coarctation repair in neonates and young infants: is small size or low weight still a risk factor? J Thorac Cardiovasc Surg, 138(3), 547-52.
  101. Carcillo J, Holubkov R, Dean JM, Berger J, Meert KL, Anand KJ, Zimmerman J, Newth CJ, Harrison R, Willson DF, Nicholson C (2009 Jul-Aug). Rationale and design of the pediatric critical illness stress-induced immune suppression (CRISIS) prevention trial. JPEN J Parenter Enteral Nutr, 33(4), 368-74.
  102. Pollack MM, Holubkov R, Glass P, Dean JM, Meert KL, Zimmerman J, Anand KJ, Carcillo J, Newth CJ, Harrison R, Willson DF, Nicholson C (2009 Jul). Functional Status Scale: new pediatric outcome measure. Pediatrics, 124(1), e18-28.
  103. Holubkov R, Dean JM, Berger J, Anand KJ, Carcillo J, Meert K, Zimmerman J, Newth C, Harrison R, Willson DF, Nicholson C (2009 Jul). Is "rescue" therapy ethical in randomized controlled trials? Pediatr Crit Care Med, 10(4), 431-8.
  104. Blackburn MK, Lamb RD, Digre KB, Smith AG, Warner JE, McClane RW, Nandedkar SD, Langeberg WJ, Holubkov R, Katz BJ (2009 May). FL-41 tint improves blink frequency, light sensitivity, and functional limitations in patients with benign essential blepharospasm. Ophthalmology, 116(5), 997-1001.
  105. Holmes JF, Holubkov R, Kuppermann N (2009 Jan). Guardian availability in children evaluated in the emergency department for blunt head trauma. Acad Emerg Med, 16(1), 15-20.
  106. Srivastava R, Downey EC, OGorman M, Feola P, Samore M, Holubkov R, Mundorff M, James BC, Rosenbaum P, Young PC, Dean JM (2009 Jan). Impact of fundoplication versus gastrojejunal feeding tubes on mortality and in preventing aspiration pneumonia in young children with neurologic impairment who have gastroesophageal reflux disease. Pediatrics, 123(1), 338-45.
  107. Gorelick MH, Atabaki SM, Hoyle J, Dayan PS, Holmes JF, Holubkov R, Monroe D, Callahan JM, Kuppermann N (2008 Sep). Interobserver agreement in assessment of clinical variables in children with blunt head trauma. Acad Emerg Med, 15(9), 812-8.
  108. Guthery SL, Dong L, Dean JM, Holubkov R (2008 Sep). US estimates of hospitalized pediatric patients with ulcerative colitis: implications for multicenter clinical studies. Inflamm Bowel Dis, 14(9), 1253-8.
  109. Li Z, Knight S, Cook LJ, Hyde LK, Holubkov R, Olson LM (2008 Mar). Modeling motor vehicle crashes for street racers using zero-inflated models. Accid Anal Prev, 40(2), 835-9.
  110. Shaddy RE, Boucek MM, Hsu DT, Boucek RJ, Canter CE, Mahony L, Ross RD, Pahl E, Blume ED, Dodd DA, Rosenthal DN, Burr J, LaSalle B, Holubkov R, Lukas MA, Tani LY (2007 Sep 12). Carvedilol for children and adolescents with heart failure: a randomized controlled trial. JAMA, 298(10), 1171-9.
  111. Corneli HM, Zorc JJ, Mahajan P, Shaw KN, Holubkov R, Reeves SD, Ruddy RM, Malik B, Nelson KA, Bregstein JS, Brown KM, Denenberg MN, Lillis KA, Cimpello LB, Tsung JW, Borgialli DA, Baskin MN, Teshome G, Goldstein MA, Monroe D, Dean JM, Kuppermann N (2007 Jul 26). A multicenter, randomized, controlled trial of dexamethasone for bronchiolitis. N Engl J Med, 357(4), 331-9.
  112. Hawkins JA, Kouretas PC, Holubkov R, Williams RV, Tani LY, Su JT, Lambert LM, Mart CR, Puchalski MD, Minich LL (2007 May). Intermediate-term results of repair for aortic, neoaortic, and truncal valve insufficiency in children. J Thorac Cardiovasc Surg, 133(5), 1311-7.
  113. Srivastava R, Downey EC, Feola P, Samore M, Coburn L, Holubkov R, Mundorff M, Nkoy F, Desrochers D, James BC, Rosenbaum P, Young PC, Dean JM, OGorman M (2007 May). Quality of life of children with neurological impairment who receive a fundoplication for gastroesophageal reflux disease. J Hosp Med, 2(3), 165-73.
  114. Goulet CJ, Disario JA, Emerson L, Hilden K, Holubkov R, Fang JC (2007 Mar). In vivo evaluation of argon plasma coagulation in a porcine model. Gastrointest Endosc, 65(3), 457-62.
  115. Murtaugh MA, Curtin K, Sweeney C, Wolff RK, Holubkov R, Caan BJ, Slattery ML (2007 Mar). Dietary intake of folate and co-factors in folate metabolism, MTHFR polymorphisms, and reduced rectal cancer. Cancer Causes Control, 18(2), 153-63.
  116. Lyon JL, Alder SC, Stone MB, Scholl A, Reading JC, Holubkov R, Sheng X, White GL Jr, Hegmann KT, Anspaugh L, Hoffman FO, Simon SL, Thomas B, Carroll R, Meikle AW (2006 Nov). Thyroid disease associated with exposure to the Nevada nuclear weapons test site radiation: a reevaluation based on corrected dosimetry and examination data. Epidemiology, 17(6), 604-14.
  117. Kinney AY, Simonsen SE, Baty BJ, Mandal D, Neuhausen SL, Seggar K, Holubkov R, Bloor L, Smith K (2006 Aug). Risk reduction behaviors and provider communication following genetic counseling and BRCA1 mutation testing in an African American kindred. J Genet Couns, 15(4), 293-305.
  118. Grunkemeier GL, Jin R, Im K, Holubkov R, Kennard ED, Schaff HV (2006 Jul). Time-related risk of the St. Jude Silzone heart valve. Eur J Cardiothorac Surg, 30(1), 20-7.
  119. Kinney AY, Simonsen SE, Baty BJ, Mandal D, Neuhausen SL, Seggar K, Holubkov R, Smith K (2006 Apr 15). Acceptance of genetic testing for hereditary breast ovarian cancer among study enrollees from an African American kindred. Am J Med Genet A, 140(8), 813-26.
  120. Statler KD, Alexander H, Vagni V, Holubkov R, Dixon CE, Clark RS, Jenkins L, Kochanek PM (2006 Mar 3). Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injury. Brain Res, 1076(1), 216-24.
  121. Marcello PW, Roberts PL, Rusin LC, Holubkov R, Schoetz DJ (2006 Feb). Vascular pedicle ligation techniques during laparoscopic colectomy. A prospective randomized trial. Surg Endosc, 20(2), 263-9.
  122. Gorelick MH, Alpern ER, Singh T, Snowdon D, Holubkov R, Dean JM, Kuppermann N (2005 Dec). Availability of pediatric emergency visit data from existing data sources. Acad Emerg Med, 12(12), 1195-200.
  123. Kinney AY, Bloor LE, Mandal D, Simonsen SE, Baty BJ, Holubkov R, Seggar K, Neuhausen S, Smith K (2005 Dec 1). The impact of receiving genetic test results on general and cancer-specific psychologic distress among members of an African-American kindred with a BRCA1 mutation. Cancer, 104(11), 2508-16.
  124. Englberger L, Schaff HV, Jamieson WR, Kennard ED, Im KA, Holubkov R, Carrel TP (2005 Dec). Importance of implant technique on risk of major paravalvular leak (PVL) after St. Jude mechanical heart valve replacement: a report from the Artificial Valve Endocarditis Reduction Trial (AVERT). Eur J Cardiothorac Surg, 28(6), 838-43.
  125. Fang JC, Hilden K, Holubkov R, DiSario JA (2005 Nov). Transnasal endoscopy vs. fluoroscopy for the placement of nasoenteric feeding tubes in critically ill patients. Gastrointest Endosc, 62(5), 661-6.
  126. Sheppard R, Bedi M, Kubota T, Semigran MJ, Dec W, Holubkov R, Feldman AM, Rosenblum WD, McTiernan CF, McNamara DM (2005 Sep 20). Myocardial expression of fas and recovery of left ventricular function in patients with recent-onset cardiomyopathy. J Am Coll Cardiol, 46(6), 1036-42.
  127. Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA (2005 Mar 14). Hormone therapy, lipoprotein subclasses, and coronary calcification: the Healthy Women Study. Arch Intern Med, 165(5), 510-5.
  128. Curtin K, Slattery ML, Holubkov R, Edwards S, Holden JA, Samowitz WS (2004 Dec). p53 alterations in colon tumors: a comparison of SSCP/sequencing and immunohistochemistry. Appl Immunohistochem Mol Morphol, 12(4), 380-6.
  129. McNamara DM, Holubkov R, Postava L, Janosko K, MacGowan GA, Mathier M, Murali S, Feldman AM, London B (2004 Nov 16). Pharmacogenetic interactions between angiotensin-converting enzyme inhibitor therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. J Am Coll Cardiol, 44(10), 2019-26.
  130. Davila-Roman VG, Waggoner AD, Kennard ED, Holubkov R, Jamieson WR, Englberger L, Carrel TP, Schaff HV (2004 Oct 6). Prevalence and severity of paravalvular regurgitation in the Artificial Valve Endocarditis Reduction Trial (AVERT) echocardiography study. J Am Coll Cardiol, 44(7), 1467-72.
  131. OBrien SH, Holubkov R, Reis EC (2004 Aug). Identification, evaluation, and management of obesity in an academic primary care center. Pediatrics, 114(2), e154-9.
  132. Bedi M, Postava LA, Murali S, MacGowan GA, Mathier M, Shears L, Kormos R, Holubkov R, London B, McNamara DM (2004 Jun). Effect of the TNF-alpha-promoter polymorphism on cardiac allograft rejection. J Heart Lung Transplant, 23(6), 696-700.
  133. Slattery ML, Levin TR, Ma K, Goldgar D, Holubkov R, Edwards S (2003 Nov). Family history and colorectal cancer: predictors of risk. Cancer Causes Control, 14(9), 879-87.
  134. Reis EC, Roth EK, Syphan JL, Tarbell SE, Holubkov R (2003 Nov). Effective pain reduction for multiple immunization injections in young infants. Arch Pediatr Adolesc Med, 157(11), 1115-20.
  135. Cohen HA, Williams DO, Holmes DR Jr, Selzer F, Kip KE, Johnston JM, Holubkov R, Kelsey SF, Detre KM (2003 Sep). Impact of age on procedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI Dynamic Registry. Am Heart J, 146(3), 513-9.
  136. Lawson WE, Kennard ED, Hui JC, Holubkov R, Kelsey SF (2003 Aug 15). Analysis of baseline factors associated with reduction in chest pain in patients with angina pectoris treated by enhanced external counterpulsation. Am J Cardiol, 92(4), 439-43.
  137. Slattery ML, Edwards S, Curtin K, Ma K, Edwards R, Holubkov R, Schaffer D (2003 Aug 1). Physical activity and colorectal cancer. Am J Epidemiol, 158(3), 214-24.
  138. Chen Q, Reis SE, Kammerer CM, McNamara DM, Holubkov R, Sharaf BL, Sopko G, Pauly DF, Bairey Merz CN, Kamboh MI (2003 Jul). APOE polymorphism and angiographic coronary artery disease severity in the Women's Ischemia Syndrome Evaluation (WISE) study. Atherosclerosis, 169(1), 159-67.
  139. Chen Q, Reis SE, Kammerer C, Craig WY, LaPierre SE, Zimmer EL, McNamara DM, Pauly DF, Sharaf B, Holubkov R, Bairey Merz CN, Sopko G, Bontempo F, Kamboh MI (2003 Jul 1). Genetic variation in lectin-like oxidized low-density lipoprotein receptor 1 (LOX1) gene and the risk of coronary artery disease. Circulation, 107(25), 3146-51.
  140. Holmes DR, Selzer F, Johnston JM, Kelsey SF, Holubkov R, Cohen HA, Williams DO, Detre KM (2003 Apr 15). Modeling and risk prediction in the current era of interventional cardiology: a report from the National Heart, Lung, and Blood Institute Dynamic Registry. Circulation, 107(14), 1871-6.
  141. Marroquin OC, Holubkov R, Edmundowicz D, Rickens C, Pohost G, Buchthal S, Pepine CJ, Sopko G, Sembrat RC, Meltzer CC, Reis SE (2003 Apr). Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: implications for clinical practice. Am Heart J, 145(4), 628-35.
  142. McNamara DM, Holubkov R, Postava L, Ramani R, Janosko K, Mathier M, MacGowan GA, Murali S, Feldman AM, London B (2003 Apr 1). Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure. Circulation, 107(12), 1598-602.
  143. Chen Q, Reis SE, Kammerer CM, McNamara DM, Holubkov R, Sharaf BL, Sopko G, Pauly DF, Merz CN, Kamboh MI (2003 Jan). Association between the severity of angiographic coronary artery disease and paraoxonase gene polymorphisms in the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) study. Am J Hum Genet, 72(1), 13-22.
  144. Holubkov R, Pepine CJ, Rickens C, Reichek N, Rogers WJ, Sharaf BL, Sopko G, Merz CN, Kelsey SF, Olson M, Smith KM, Reis SE (2002 Dec). Electrocardiogram abnormalities predict angiographic coronary artery disease in women with chest pain: results from the NHLBI WISE Study. Clin Cardiol, 25(12), 553-8.
  145. Holubkov R, Laskey WK, Haviland A, Slater JC, Bourassa MG, Vlachos HA, Cohen HA, Williams DO, Kelsey SF, Detre KM (2002 Nov). Angina 1 year after percutaneous coronary intervention: a report from the NHLBI Dynamic Registry. Am Heart J, 144(5), 826-33.
  146. Soran O, Kennard ED, Kelsey SF, Holubkov R, Strobeck J, Feldman AM (2002 Nov-Dec). Enhanced external counterpulsation as treatment for chronic angina in patients with left ventricular dysfunction: a report from the International EECP Patient Registry (IEPR). Congest Heart Fail, 8(6), 297-302.
  147. Mackey RH, Kuller LH, Sutton-Tyrrell K, Evans RW, Holubkov R, Matthews KA (2002 Oct 17). Lipoprotein subclasses and coronary artery calcium in postmenopausal women from the healthy women study. Am J Cardiol, 90(8A), 71i-76i.
  148. Bourassa MG, Detre KM, Johnston JM, Vlachos HA, Holubkov R (2002 Oct). Effect of prior revascularization on outcome following percutaneous coronary intervention; NHLBI Dynamic Registry. Eur Heart J, 23(19), 1546-55.
  149. Reis SE, Olson MB, Fried L, Reeser V, Mankad S, Pepine CJ, Kerensky R, Merz CN, Sharaf BL, Sopko G, Rogers WJ, Holubkov R (2002 Jun 18). Mild renal insufficiency is associated with angiographic coronary artery disease in women. Circulation, 105(24), 2826-9.
  150. Lakshmi MV, Kennard ED, Kelsey SF, Holubkov R, Michaels AD (2002 Jun 1). Relation of the pattern of diastolic augmentation during a course of enhanced external counterpulsation (EECP) to clinical benefit (from the International EECP Patient Registry [IEPR]). Am J Cardiol, 89(11), 1303-5.
  151. Holubkov R, Kennard ED, Foris JM, Kelsey SF, Soran O, Williams DO, Holmes DR (2002 May 15). Comparison of patients undergoing enhanced external counterpulsation and percutaneous coronary intervention for stable angina pectoris. Am J Cardiol, 89(10), 1182-6.
  152. Holubkov R, Karas RH, Pepine CJ, Rickens CR, Reichek N, Rogers WJ, Sharaf BL, Sopko G, Merz CN, Kelsey SF, McGorray SP, Reis SE (2002 May). Large brachial artery diameter is associated with angiographic coronary artery disease in women. Am Heart J, 143(5), 802-7.
  153. Schaff HV, Carrel TP, Jamieson WR, Jones KW, Rufilanchas JJ, Cooley DA, Hetzer R, Stumpe F, Duveau D, Moseley P, van Boven WJ, Grunkemeier GL, Kennard ED, Holubkov R (2002 Mar). Paravalvular leak and other events in silzone-coated mechanical heart valves: a report from AVERT. Ann Thorac Surg, 73(3), 785-92.
  154. Sutton-Tyrrell K, Kuller LH, Matthews KA, Holubkov R, Patel A, Edmundowicz D, Newman A (2002 Feb). Subclinical atherosclerosis in multiple vascular beds: an index of atherosclerotic burden evaluated in postmenopausal women. Atherosclerosis, 160(2), 407-16.
  155. Detre KM, Holubkov R (2002 Jan). Coronary revascularization on balance: Robert L. Frye lecture. Mayo Clin Proc, 77(1), 72-82.
  156. Englberger L, Carrel T, Schaff HV, Kennard ED, Holubkov R (2001 Sep). Differences in heart valve procedures between North American and European centers: a report from the Artificial Valve Endocarditis Reduction Trial (AVERT). J Heart Valve Dis, 10(5), 562-71.
  157. Barsness G, Feldman AM, Holmes DR Jr, Holubkov R, Kelsey SF, Kennard ED (2001 Jun). The International EECP Patient Registry (IEPR): design, methods, baseline characteristics, and acute results. Clin Cardiol, 24(6), 435-42.
  158. Michaels AD, Kennard ED, Kelsey SE, Holubkov R, Soran O, Spence S, Chou TM (2001 Jun). Does higher diastolic augmentation predict clinical benefit from enhanced external counterpulsation?: Data from the International EECP Patient Registry (IEPR). Clin Cardiol, 24(6), 453-8.
  159. McNamara DM, Holubkov R, Starling RC, Dec GW, Loh E, Torre-Amione G, Gass A, Janosko K, Tokarczyk T, Kessler P, Mann DL, Feldman AM (2001 May 8). Controlled trial of intravenous immune globulin in recent-onset dilated cardiomyopathy. Circulation, 103(18), 2254-9.
  160. Sutton-Tyrrell K, Mackey RH, Holubkov R, Vaitkevicius PV, Spurgeon HA, Lakatta EG (2001 May). Measurement variation of aortic pulse wave velocity in the elderly. Am J Hypertens, 14(5 Pt 1), 463-8.
  161. Reis SE, Holubkov R, Conrad Smith AJ, Kelsey SF, Sharaf BL, Reichek N, Rogers WJ, Merz CN, Sopko G, Pepine CJ (2001 May). Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: results from the NHLBI WISE study. Am Heart J, 141(5), 735-41.
  162. McNamara DM, Holubkov R, Janosko K, Palmer A, Wang JJ, MacGowan GA, Murali S, Rosenblum WD, London B, Feldman AM (2001 Mar 27). Pharmacogenetic interactions between beta-blocker therapy and the angiotensin-converting enzyme deletion polymorphism in patients with congestive heart failure. Circulation, 103(12), 1644-8.
  163. Sutton-Tyrrell K, Kuller LH, Edmundowicz D, Feldman A, Holubkov R, Givens L, Matthews KA (2001 Mar 1). Usefulness of electron beam tomography to detect progression of coronary and aortic calcium in middle-aged women. Am J Cardiol, 87(5), 560-4.
  164. Lawson WE, Kennard ED, Holubkov R, Kelsey SF, Strobeck JE, Soran O, Feldman AM (2001). Benefit and safety of enhanced external counterpulsation in treating coronary artery disease patients with a history of congestive heart failure. Cardiology, 96(2), 78-84.
  165. Sharaf BL, Pepine CJ, Kerensky RA, Reis SE, Reichek N, Rogers WJ, Sopko G, Kelsey SF, Holubkov R, Olson M, Miele NJ, Williams DO, Merz CNB (2001). Detailed angiographic analysis of women with suspected ischemic chest pain (pilot phase data from the NHLBI-sponsored Women's Ischemia Syndrome Evaluation [WISE] Study angiographic core laboratory). Am J Cardiol, 87, 937-941.
  166. Williams DO, Holubkov R, Yeh W, Bourassa MG, Al-Bassam M, Block PC, Coady P, Cohen H, Cowley M, Dorros G, Faxon D, Holmes DR, Jacobs A, Kelsey SF, King SB 3rd, Myler R, Slater J, Stanek V, Vlachos HA, Detre KM (2000 Dec 12). Percutaneous coronary intervention in the current era compared with 1985-1986: the National Heart, Lung, and Blood Institute Registries. Circulation, 102(24), 2945-51.
  167. Kubota T, Miyagishima M, Alvarez RJ, Kormos R, Rosenblum WD, Demetris AJ, Semigran MJ, Dec GW, Holubkov R, McTiernan CF, Mann DL, Feldman AM, McNamara DM (2000 Sep). Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failure. J Heart Lung Transplant, 19(9), 819-24.
  168. Reis SE, Holubkov R, Young JB, White BG, Cohn JN, Feldman AM (2000 Aug). Estrogen is associated with improved survival in aging women with congestive heart failure: analysis of the vesnarinone studies. J Am Coll Cardiol, 36(2), 529-33.
  169. Detre KM, Lombardero MS, Brooks MM, Hardison RM, Holubkov R, Sopko G, Frye RL, Chaitman BR (2000 Apr 6). The effect of previous coronary-artery bypass surgery on the prognosis of patients with diabetes who have acute myocardial infarction. Bypass Angioplasty Revascularization Investigation Investigators. N Engl J Med, 342(14), 989-97.
  170. Alderman EL, Brooks MM, Bourassa M, Califf RM, Chaitman BR, Detre K, Faxon D, Frye R, Hardison RM, Hlatky M, Holubkov R, Jones RH, Kelsey SF, Schaff H, Shemin RJ, Sopko G, Sutton-Tyrrell K, Williams DO (2000). Seven-year outcome in the Bypass Angioplasty Revascularization Investigation (BARI) by treatment and diabetic status. J Am Coll Cardiol, 35, 1122-9.
  171. Wilhelm CR, Ristich J, Knepper LE, Holubkov R, Wisniewski SR, Kormos RL, Wagner WR (1999 Dec). Measurement of hemostatic indexes in conjunction with transcranial doppler sonography in patients with ventricular assist devices. Stroke, 30(12), 2554-61.
  172. Soran O, Young JD, Holubkov R, Loftus S, Bourge R, Carson P, Jaski B, White BG, Feldman AM (1999 Sep). Effect of inotrope withdrawal on morbidity and mortality in patients with chronic heart failure: results of the vesnarinone trial withdrawal substudy. Vest Withdrawal Substudy Group. J Card Fail, 5(3), 195-200; discussion 201-2.
  173. Holubkov R, Detre KM, Sopko G, Sutton-Tyrrell K, Kelsey SF, Frye RL (1999 Jul 15). Trends in coronary revascularization 1989 to 1997: the Bypass Angioplasty Revascularization Investigation (BARI) survey of procedures. Am J Cardiol, 84(2), 157-61.
  174. Bozkurt B, Villaneuva FS, Holubkov R, Tokarczyk T, Alvarez RJ Jr, MacGowan GA, Murali S, Rosenblum WD, Feldman AM, McNamara DM (1999 Jul). Intravenous immune globulin in the therapy of peripartum cardiomyopathy. J Am Coll Cardiol, 34(1), 177-80.
  175. Reis SE, Holubkov R, Lee JS, Sharaf B, Reichek N, Rogers WJ, Walsh EG, Fuisz AR, Kerensky R, Detre KM, Sopko G, Pepine CJ (1999 May). Coronary flow velocity response to adenosine characterizes coronary microvascular function in women with chest pain and no obstructive coronary disease. Results from the pilot phase of the Women's Ischemia Syndrome Evaluation (WISE) study. J Am Coll Cardiol, 33(6), 1469-75.
  176. Lewis JF, Lin L, McGorray S, Pepine CJ, Doyle M, Edmundowicz D, Holubkov R, Pohost G, Reichek N, Rogers W, Sharaf BL, Sopko G, Merz CN (1999 May). Dobutamine stress echocardiography in women with chest pain. Pilot phase data from the National Heart, Lung and Blood Institute Women's Ischemia Syndrome Evaluation (WISE). J Am Coll Cardiol, 33(6), 1462-8.
  177. Schaff H, Carrel T, Steckelberg JM, Grunkemeier GL, Holubkov R (1999). Artificial Valve Endocarditis Reduction Trial (AVERT): protocol of a multicenter randomized trial. J Heart Valve Dis, 8(2), 131-9.
  178. Detre KM, Guo P, Holubkov R, Califf RM, Sopko G, Bach R, Brooks MM, Bourassa MG, Shemin RJ, Rosen AD, Krone RJ, Frye RL, Feit F (1999 Feb 9). Coronary revascularization in diabetic patients: a comparison of the randomized and observational components of the Aypass Angioplasty Revascularization Investigation (BARI). Circulation, 99(5), 633-40.
  179. Reis SE, Holubkov R, Zell KA, Smith AJ, Cohen HA, Feldman MD, Blumenthal RS (1998 Dec). Estrogen acutely abolishes abnormal cold-induced coronary constriction in men. Chest, 114(6), 1556-61.
  180. Zenati M, Cohen HA, Holubkov R, Smith AJ, Boujoukos AJ, Caldwell J, Firestone L, Griffith BP (1998 Oct). Preoperative risk models for minimally invasive coronary bypass: a preliminary study. J Thorac Cardiovasc Surg, 116(4), 584-9.
  181. Holubkov R, Zenati M, Akin JJ, Erb L, Courcoulas A (1998 Oct). MIDCAB characteristics and results: the CardioThoracic Systems (CTS) registry. Eur J Cardiothorac Surg, 14 Suppl 1, S25-30.
  182. Holubkov R, Holt VL, Connell FA, LoGerfo JP (1998 Aug). Analysis, assessment, and presentation of risk-adjusted statewide obstetrical care data: the StORQS II study in Washington State. Statewide Obstetrics Review and Quality System. Health Serv Res, 33(3 Pt 1), 531-48.
  183. George CJ, Baim DS, Brinker JA, Fischman DL, Goldberg S, Holubkov R, Kennard ED, Veltri L, Detre KM (1998 Apr 1). One-year follow-up of the Stent Restenosis (STRESS I) Study. Am J Cardiol, 81(7), 860-5.
  184. King SB 3rd, Yeh W, Holubkov R, Baim DS, Sopko G, Desvigne-Nickens P, Holmes DR Jr, Cowley MJ, Bourassa MG, Margolis J, Detre KM (1998 Mar 1). Balloon angioplasty versus new device intervention: clinical outcomes. A comparison of the NHLBI PTCA and NACI registries. J Am Coll Cardiol, 31(3), 558-66.
  185. Reis SE, Holubkov R, Zell KA, Edmundowicz D, Shapiro AH, Feldman AM (1998 Mar). Unstable angina: specialty-related disparities in implementation of practice guidelines. Clin Cardiol, 21(3), 207-10.
  186. Bourassa MG, Yeh W, Holubkov R, Sopko G, Detre KM (1998 Jan). Long-term outcome of patients with incomplete vs complete revascularization after multivessel PTCA. A report from the NHLBI PTCA Registry. Eur Heart J, 19(1), 103-11.
  187. Cohen Reis E, Holubkov R (1997 Dec). Vapocoolant spray is equally effective as EMLA cream in reducing immunization pain in school-aged children. Pediatrics, 100(6), E5.
  188. Reis SE, Holubkov R, Edmundowicz D, McNamara DM, Zell KA, Detre KM, Feldman AM (1997 Sep). Treatment of patients admitted to the hospital with congestive heart failure: specialty-related disparities in practice patterns and outcomes. J Am Coll Cardiol, 30(3), 733-8.
  189. The BARI Investigators Writing Group of 22 including Holubkov R (1997). Influence of diabetes on 5-year mortality and morbidity in a randomized trial comparing PTCA and CABG in patients with multivessel disease. The Bypass Angioplasty Revascularization Investigation (BARI). Circulation, 96, 1761-9.
  190. Breslow NE, Holubkov R (1997 Jan 15-Feb 15). Weighted likelihood, pseudo-likelihood and maximum likelihood methods for logistic regression analysis of two-stage data. Stat Med, 16(1-3), 103-16.
  191. Breslow NE, Holubkov R (1997). Maximum likelihood estimation of logistic regression parameters under two-phase, outcome-dependent sampling. J Roy Stat Soc B Stat Meth, 59, 447-61.
  192. Detre KM, Rosen AD, Bost JE, Cooper ME, Sutton-Tyrrell K, Holubkov R, Shemin RJ, Frye RL (1996 Sep). Contemporary practice of coronary revascularization in U.S. hospitals and hospitals participating in the bypass angioplasty revascularization investigation (BARI). J Am Coll Cardiol, 28(3), 609-15.
  193. Temkin NR, Holubkov R, Machamer JE, Winn HR, Dikmen SS (1995 May). Classification and regression trees (CART) for prediction of function at 1 year following head trauma. J Neurosurg, 82(5), 764-71.
  194. Omiecinski CJ, Aicher L, Holubkov R, Checkoway H (1993 Jun). Human peripheral lymphocytes as indicators of microsomal epoxide hydrolase activity in liver and lung. Pharmacogenetics, 3(3), 150-8.
  195. Kelsey SF, James M, Holubkov AL, Holubkov R, Cowley MJ, Detre KM (1993 Mar). Results of percutaneous transluminal coronary angioplasty in women. 1985-1986 National Heart, Lung, and Blood Institute's Coronary Angioplasty Registry. Circulation, 87(3), 720-7.
  196. Bourassa MG, Holubkov R, Yeh W, Detre KM (1992 Jul 15). Strategy of complete revascularization in patients with multivessel coronary artery disease (a report from the 1985-1986 NHLBI PTCA Registry). Am J Cardiol, 70(2), 174-8.
  197. Ruocco NA Jr, Ring ME, Holubkov R, Jacobs AK, Detre KM, Faxon DP (1992 Jan 1). Results of coronary angioplasty of chronic total occlusions (the National Heart, Lung, and Blood Institute 1985-1986 Percutaneous Transluminal Angioplasty Registry). Am J Cardiol, 69(1), 69-76.
  198. Bentivoglio LG, Holubkov R, Kelsey SF, Holmes DR Jr, Sopko G, Cowley MJ, Myler RK (1991 Aug). Short and long term outcome of percutaneous transluminal coronary angioplasty in unstable versus stable angina pectoris: a report of the 1985-1986 NHLBI PTCA Registry. Cathet Cardiovasc Diagn, 23(4), 227-38.
  199. Titus-Ernstoff L, Ernstoff MS, Duray PH, Barnhill RL, Holubkov R, Kirkwood JM (1991 May). A relation between childhood sun exposure and dysplastic nevus syndrome among patients with nonfamilial melanoma. Epidemiology, 2(3), 210-4.
  200. Kelsey SF, Miller DP, Holubkov R, Lu AS, Cowley MJ, Faxon DP, Detre KM (1990 Nov 1). Results of percutaneous transluminal coronary angioplasty in patients greater than or equal to 65 years of age (from the 1985 to 1986 National Heart, Lung, and Blood Institute's Coronary Angioplasty Registry). Am J Cardiol, 66(15), 1033-8.
  201. Detre KM, Holmes DR Jr, Holubkov R, Cowley MJ, Bourassa MG, Faxon DP, Dorros GR, Bentivoglio LG, Kent KM, Myler RK (1990 Sep). Incidence and consequences of periprocedural occlusion. The 1985-1986 National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry. Circulation, 82(3), 739-50.
  202. Detre K, Holubkov R, Kelsey S, Bourassa M, Williams D, Holmes D Jr, Dorros G, Faxon D, Myler R, Kent K, et al (1989 Sep). One-year follow-up results of the 1985-1986 National Heart, Lung, and Blood Institute's Percutaneous Transluminal Coronary Angioplasty Registry. Circulation, 80(3), 421-8.
  203. Holmes DR Jr, Holubkov R, Vlietstra RE, Kelsey SF, Reeder GS, Dorros G, Williams DO, Cowley MJ, Faxon DP, Kent KM, et al (1988 Nov). Comparison of complications during percutaneous transluminal coronary angioplasty from 1977 to 1981 and from 1985 to 1986: the National Heart, Lung, and Blood Institute Percutaneous Transluminal Coronary Angioplasty Registry. J Am Coll Cardiol, 12(5), 1149-55.
  204. Detre K, Holubkov R, Kelsey S, Cowley M, Kent K, Williams D, Myler R, Faxon D, Holmes D Jr, Bourassa M, et al (1988 Feb 4). Percutaneous transluminal coronary angioplasty in 1985-1986 and 1977-1981. The National Heart, Lung, and Blood Institute Registry. N Engl J Med, 318(5), 265-70.

Review

  1. Frye RL, Bell MR, Schaff HV, Holubkov R, Detre KM (2002 Feb). The role of PCI and CABG in the management of coronary artery disease in patients with diabetes. [Review]. Curr Diab Rep, 2(1), 16-20.
  2. Reis SE, Zell KA, Holubkov R (1997). Women's hearts are different. [Review]. Curr Probl Obstet Gynecol Fertil, 20, 69-92.

Book Chapter

  1. Holubkov R, Kennard E, Kelsey S, Soran O (2001). A report from the International Enhanced External Counterpulsation Registry (IEPR). In Lewis BS, Halon DA, Flugelman MY, Hradec J (Eds.), ADVANCES IN CORONARY ARTERY DISEASE: PROCEEDINGS OF THE 4TH INTERNATIONAL CONGRESS ON CORONARY ARTERY DISEASE (pp. 387-391). Bologna, Italy: Monduzzi Editore S.p.A.
  2. Holubkov R, Reis SE (2000). The diagnosis and treatment of heart disease in women. In Goldman MB, Hatch MC (Eds.), WOMEN & HEALTH (pp. 771-81). San Diego, CA: Academic Press.
  3. Kent KM, Kelsey SF, James M, Holubkov AL, Holubkov R, Detre K (1993). Percutaneous transluminal coronary angioplasty in women: 1985-86 National Heart, Lung and Blood Institute PTCA Registry. In Wenger NK, Speroff L, Packard B (Eds.), LONG-TERM CARDIOVASCULAR HEALTH AND DISEASE IN WOMEN: PROCEEDINGS OF AN NHLBI CONFERENCE. Greenwich, CT: Le Jacq Communications, Inc.
  4. Bourassa MG, David PR, Bonan R, Williams DO, Holubkov R, Kelsey SF, Detre KM (1987). Percutaneous transluminal coronary angioplasty after myocardial infarction. In Kappagoda CT, Greenwood PV (Eds.), LONG-TERM MANAGEMENT OF PATIENTS AFTER MYOCARDIAL INFARCTION. Boston, MA: Martinus Nijhoff Publishing.

Editorial

  1. McNamara DM, Bedi M, Holubkov R, et al (2003). Effect of the Asp298 variant of endothelial nitric oxide synthase on survival for patients with congestive heart failure (Response to Letter). Circulation, 108, E112.
  2. Frye R, Sopko G, Holubkov R, Detre KM (1997). Angioplasty vs bypass surgery in patients with multivessel coronary artery disease (Reply to Letter). Journal of the American Medical Association, 278(2), 115.
  3. Detre K, Holubkov R, Kelsey S, Williams D, Robertson T (1988). Coronary angioplasty in 1985-86 and 1977-1981 (Reply to Letter). N Engl J Med, 319(5), 310.

Letter

  1. Moler FW, Holubkov R, Dean JM (2015 Sep 3). Therapeutic Hypothermia in Children [Letter to the editor]. N Engl J Med, 373(10), 980.
  2. Holubkov R, Detre KM (1996 Jul 4). Coronary-artery stenting [Letter to the editor]. N Engl J Med, 335(1), 61.
  3. Burkhard-Meir C, Staeblein A, von Poelnitz A, Hoefling B, Holubkov R, Detre KM (1990 Jan 6). Coronary angioplasty: a German/US comparison [Letter to the editor]. Lancet, 335(8680), 58.

Abstract

  1. Mihalopoulos N, Young P, Holubkov R, Hoffman JM (2009). Brown adipose tissue, body mass index, and glucose in humans [Abstract]. Circulation, 119(10), E275.
  2. Petko C, Minich L, Everitt M, Holubkov R, Shaddy R, Tani L (2009). Echocardiographic predictors of outcome in children with systematic venticular dysfunction and heart failure [Abstract]. Journal of the American College of Cardiology, 53(10), A355.
  3. Mihalopoulos NL, Holubkov R, Young P (2008). Relationship between waist circumference and adipokines during puberty [Abstract]. Circulation, 117(11).
  4. Kelly LA, Holubkov R, Campbell MA, Herlevi KS, Taylor T, Hull C, Gleich GJ, Zone JJ, Leiferman KM (2007). Serum IgE concentrations in bullous pemphigoid correlate with disease activity [Abstract]. Journal of Allergy and Clinical Immunology, 119(1), S204.
  5. Holubkov R, Knight S, Dean JM, Kuppermann N, Corneli H (May 2007). Unscheduled interim analysis due to underenrollment in a "seasonal" pediatric study [Abstract]. Controlled Clinical Trials.
  6. Donaldson A, Knight S, Holubkov R (2006). Randomly selecting days of the week [Abstract]. Clinical Trials, 3, 226.
  7. Holubkov R, Curtin K, Sheng X, Ma K, Slattery ML (2006). Assessing significance of additive interaction between categorical variables using a logistic model [Abstract]. Clinical Trials, 3, 218.
  8. Donaldson A, Cook L, Zimmerman J, Holubkov R (2006). Power simulations for bounded outcomes [Abstract]. Clinical Trials, 2, 225.
  9. Gorelick M, Alpern E, Singh T, Snowdon D, Holubkov R, Dean JM (2004). Availability of pediatric emergency visit data from existing data sources [Abstract]. Pediatric Research, 55, 120A.
  10. Kinney AY, Bloor LE, Simonsen SE, Baty BJ, Holubkov R, Mandal D, Seggar K, Smith K (2004). Impact of culturally-targeted BRCA1 counseling and testing on screening and prevention among high-risk African American women [Abstract]. Cancer Epidemiology Biomarkers & Prevention, 13, 1828S.
  11. Lawson WE, Kennard ED, Hui JC, Holubkov R, Kelsey SF (2003). Factors predicting one year outcomes in patients treated with enhanced external counterpulsation [Abstract]. Journal of Investigative Medicine, 51, S360.
  12. Shami PJ, Saavedra JE, Holubkov R, Wang LY, Keefer LK (2003). JS-K, a novel nitric oxide (NO) generator, shows potent anti-leukemic efficacy in a systemic human leukemia xenograft model [Abstract]. Blood, 102[Suppl 1], 626a.
  13. Im K, Kennard E, Holubkov R (2003). Assessing treatment-specific reporting bias in the follow-up phase of a stopped multicenter randomized trial [Abstract]. Controlled Clinical Trials, 24, 136S-137S.
  14. Olson MB, Holubkov R, Fried L, et al (2003). Mildly reduced creatinine clearance is associated with coronary artery disease in women: the NHLBI-sponsored WISE study [Abstract]. Journal of the American College Of Cardiology, 41, A326.
  15. Holubkov R, Schaff HV, Carrell TP, et al (2003). Heparinization early after valve replacement is associated with reduced risk of long-term thromboembolic events: a report from AVERT [Abstract]. Circulation, 108[Suppl S], 2009.
  16. McNamara DM, Holubkov R, Postava LA, et al (2002). Polygenic Risk Assessment Improves Usefulness of Genotyping in Heart-Failure Populations - Additive Effects of ACE and Enos Polymorphisms [Abstract]. Journal of the American College Of Cardiology, 39, A134-A135.
  17. Mahlab DS, Postava LA, Holubkov R, et al (2002). Beta(2) adrenergic-receptor variant Ile64 - effect on heart-failure survival and impact of beta-blockade [Abstract]. Journal of the American College Of Cardiology, 39, A135.
  18. Lawson WE, Kennard E, Linnemeier G, Holubkov R, Mehra M (2002). Do women with refractory angina respond as well as men to treatment with enhanced external counterpulsation? [Abstract]. Journal of the American College Of Cardiology, 39, A154.
  19. Postava L, Mahlab D, Holubkov R, et al (2002). B1 and B2 adrenergic receptor polymorphisms and heart failure survival. Interaction with beta blockade [Abstract]. Circulation, 106[Suppl S], 3019.
  20. Johnson BE, Holubkov R, Merz CNB, et al (2002). HRT modulates brachial artery diameter and flow-mediated dilation. The NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) study [Abstract]. Journal of the American College Of Cardiology, 39, A220.
  21. Zahid M, Murali S, Holubkov R, Sade E, Jacques D, Gorcsan J (2002). Which echo/Doppler index is most predictive of adverse outcome in patients with severe heart failure referred for transplantation? [Abstract]. Journal of the American College Of Cardiology, 39, A383.
  22. McNamara DM, Postava L, Holubkov R, et al (2002). Asp298 variant of endothelial nitric oxide synthase and heart failure survival: Comparison of ischemic and nonischemic cardiomyopathy [Abstract]. Circulation, 106[Suppl S], 1641.
  23. Reis EC, Roth EK, Syphan JL, Tarbell SE, Holubkov R (2002). Effective pain reduction for multiple immunization injections in young infants [Abstract]. Pediatric Research, 51, 967.
  24. Chen Q, Reis SE, Kammerer C, Luedecking-Zimmer E, McNamara DM, Pauly DF, Sharaf B, Holubkov R, Merz NB, Sopko G, Kamboh MI (2002). Genetic variation in the oxidized LDL-receptor-1 (OLR1) gene and the risk of coronary artery disease [Abstract]. American Journal of Human Genetics, 71[Suppl S], 1031.
  25. Chen Q, Reis SE, Pauly D, Sharaf B, McNamara D, Holubkov R (2001). Association between the apolipoprotein E polymorphism and the severity of coronary artery disease in the NHLBI-sponsored Women's Ischemia Syndrome Evaluation (WISE) Study [Abstract]. American Journal of Human Genetics, 69[Suppl 1], 1283.
  26. Fitzgerald CP, Kennard ED, Lawson WE, Holubkov R (2001). Primary utilization to improve myocardial perfusion with enhanced external counterpulsation revascularization (PUMPER) [Abstract]. Heart, 85[Suppl I], P41.
  27. Lawson WE, Hui JKC, Kennard ED, Holubkov R, Kelsey SF (2001). Are the initial benefits of enhanced external counterpulsation sustained at one year? [Abstract]. JACC, 37[Suppl A], 328A.
  28. Linnemeier G, Lawson W, Kennard ED, Holubkov R (2001). Enhanced external counterpulsation for the treatment of angina in the elderly: safety response, and durability of benefit [Abstract]. European Heart Journal, 22[Suppl S], 642.
  29. Holubkov R, Karas RH, Pepine CJ, et al (2001). Large brachial artery diameter is associated with angiographic CAD in women: a report from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) [Abstract]. JACC, 37[Suppl A], 367A.
  30. Mackey RH, Kuller LH, Sutton-Tyrrell K, Matthews KA, Evans RW, Holubkov R, Otvos JD (2001). LDL subclass distribution is associated with coronary calcification in postmenopausal women [Abstract]. Circulation, 103(9), 30.
  31. Linnemeier G, Kennard ED, Lawson WE, Holubkov R (2001). EECP produces angina relief in diabetic patients comparable to non-diabetic patients - A six-month follow-up study [Abstract]. Diabetes, 50[Suppl 2], A159.
  32. Postava LA, Holubkov R, Janosko KM, et al (2001). The aldosterone synthase promoter polymorphism modulates the effect of the ACE D-allele on heart failure survival [Abstract]. Circulation, 104[Suppl S], 9.
  33. Johnson BD, Merz CNB, Reis SE, Holubkov R, Bittner V, Pepine CJ, Rogers WJ, Reichek N, Sharaf BL, Kerensky RA, Kelsey SF, Sopko G (2001). The differential influence of current HRT and age on vascular function in women: The NHLBI-sponsored WISE study [Abstract]. JACC, 37[Suppl A], 251A.
  34. Sutton-Tyrrell K, Newman AB, Holubkov R, Liebenauer L, Simkin-Silverman L, Kuller LH (2001). Effects of dietary and exercise intervention on progression of carotid Intima-Media Thickness [Abstract]. Circulation, 103(9), P96.
  35. McNamara DM, Starling RC, Dec GWW, Loh E, Torre-Amione G, Gass A, Villanueva FS, Janosko KM, Holubkov R (2001). Left ventricular diameter at presentation predicts subsequent recovery for patients with recent-onset dilated cardiomyopathy: Results from the IMAC trial [Abstract]. Circulation, 104[Suppl S], 3108.
  36. Bazaz S, Kennard ED, Holubkov R, Dwyer N, Crawford L (2001). Patients with non-cardiac vascular disease and chronic angina benefit from enhanced external counterpulsation [Abstract]. JACC, 37[Suppl A], 255A.
  37. Chen Q, Reis SE, McNamara D, Holubkov R, Kamboh MI (2001). Analysis of association between the severity of coronary disease and paraoxonase gene polymorphism in the Women's Ischemia Syndrome Evaluation (WISE) study [Abstract]. Arterioscler Thromb Vas Biol, 21, 679.
  38. Holubkov R, Kennard ED, Kelsey SF, Soran O, Holmes DR Jr (2001). Intervention for stable angina: a multicenter comparison of consecutive patients undergoing enhanced external counterpulsation (EECP) and PCI [Abstract]. JACC, 37[Suppl A], 328A.
  39. Michaels AD, Kelsey S, Holubkov R, Kennard ED (2001). Efficacy of enhanced external counterpulsation (EECP) for patients who are not candidates for coronary revascularization: Immediate and 1-year clinical outcomes from the international EECP patient registry [Abstract]. American Journal of Cardiology, 88[Suppl S], TCT265.
  40. McNamara DM, Holubkov R, Postava LA, et al (2001). Pharmacogenetic interaction of the ACE deletion polymorphism and high dose ACE inhibitor therapy in heart failure survival [Abstract]. Circulation, 104[Suppl S], 2809.
  41. Kubota T, Miyagishima M, Alvarez RJ, Kormos RL, Rosenblum WD, Semigran MJ, Dec GW, Holubkov R, McTiernan CF, Feldman AM, McNamara DM (2000). Expression of proinflammatory cytokines in the failing human heart: Comparison of recent-onset and end-stage cardiomyopathy [Abstract]. Circulation, [Suppl S];102, 2015.
  42. McNamara DM, Starling R, Dec GW, Loh E, Torre-Amione G, Tokarczyk TR, Janosko KM, Holubkov R (2000). Plasma cytokines in acute cardiomyopathy: Evolution over time, correlations with functional studies, and potential role in recovery [Abstract]. Circulation, [Suppl S];102, 2020.
  43. Soran O, Kennard ED, Holubkov R, Strobeck J, Feldman AM (2000). Six month outcome of patients with left ventricular dysfunction treated with enhanced external counterpulsation for chronic angina [Abstract]. European Heart Journal, 21 [Suppl S], 3261.
  44. McNamara DM, Holubkov R, Janosko KM, et al (2000). Pharmacogenetic interaction of the ACE deletion polymorphism and beta blocker therapy in heart failure survival [Abstract]. Circulation, [Suppl S]; 102, 1844.
  45. Sutton-Tyrrell K, Edmundowicz D, Kuller LH, Feldman AH, Holubkov R, Givens L, Matthews KA (2000). Progression of coronary and aortic calcification in women at 8 years post-menopause [Abstract]. Circulation, 101, P6.
  46. Michaels AD, Kennard ED, Kelsey S, Holubkov R, Spence S, Chou TM (2000). Does optimal diastolic augmentation predict clinical benefit from enhanced external counterpulsation (EECP)? Data from the International Enhanced ExternalCounterpulsation Patient Registry [Abstract]. European Heart Journal, 21 [Suppl S], P1043.
  47. Lawson WE, Kennard ED, Hui JCK, Holubkov R, Kelsey SF (2000). Predictors of successful response to enhanced external counterpulsation as treatment of angina pectoris [Abstract]. Circulation, [Suppl S]; 102, 3332.
  48. Ramani RN, Tokarczyk TR, Palmer AD, Janosko KM, Rosenblum WD, Macgowan GA, Murali S, Holubkov R, Wang JJ, McNamara DM (2000). Asp(298) variant of endothelial nitric oxide synthase (eNOS) and functional capacity in patients with heart failure [Abstract]. Circulation, [Suppl S]; 102, 1842.
  49. Edmundowicz D, Sutton-Tyrrell K, Kuller LH, Feldman AH, Holubkov R, Givens L, Matthews KA (2000). Progression of coronary and aortic calcification in middle-aged women as measured by electron beam tomography [Abstract]. JACC, 35 [Suppl A], 433A.
  50. Izzo MR, Holubkov R, Cropcho L, et al (1999). Homocysteine levels are not associated with coronary artery disease or endothelial dysfunction in women: results from the NHLBI WISE study [Abstract]. Circulation, 100, I-869.
  51. Sharaf B, Pepine CJ, Reis SE, Reichek N, Rogers WJ, Sopko G, Holubkov R, Olson M, Miele NJ, Kerensky R (1999). A detailed angiographic analysis of women presenting with suspected ischemic chest pain: pilot phase data from the NHLBI Women's Ischemia Syndrome Evaluation (WISE) study angiographic core laboratory [Abstract]. Circulation, 100, I-185.
  52. McNamara D, Holubkov R, Wang JJ, et al (1999). The Asp298 variant of endothelial nitric oxide synthase (eNOS) improves survival in patients with heart failure [Abstract]. Circulation, 100, I-507.
  53. McNamara D, Holubkov R, Wang JJ, et al (1999). The eNOS Asp298 variant is not associated with atherosclerosis or endothelial dysfunction in women: results from the NHLBI WISE study [Abstract]. Circulation, 100, I-718-19.
  54. McNamara D, Starling RC, Dec GW, Loh E, Torre-Amione G, Gass A, Janosko K, Tokarczyk T, Holubkov R, Feldman AM (1999). Intervention in myocarditis and acute cardiomyopathy with immune globulin: results from the randomized placebo controlled IMAC trial [Abstract]. Circulation, 100, I-21.
  55. Reis SE, Reichek N, Holubkov R, et al (1998). Sex hormone and atherosclerotic risk factor profiles are not determinants of coronary miscrovascular reserve in women with chest pain: pilot phase results from WISE [Abstract]. JACC, 3[suppl A], 359A.
  56. Holubkov R, McGorray P, Reis SE, et al (1998). Determinants of brachial artery endothelial function in women: pilot phase results from the WISE clinical centers [Abstract]. JACC, 31[suppl A], 321A.
  57. Reis EC, Holubkov R (1997). Vapocoolant spray is as effective as EMLA cream in reducing immunization pain in school-aged children [Abstract]. Ambulatory Child Health, 3[part2], 167.
  58. Holubkov R, Yeh W, Kelsey SF, Detre KM (1996). A dynamic approach to recruiting patients in a registry of coronary interventions [Abstract]. Controlled Clinical Trials, 17(2S), 90S.
  59. Breslow NE, Holubkov R (1996). Maximum likelihood estimation of logistic regression parameters under two-phase, outcome dependent sampling [Abstract]. The XVIIth International Biometrics Conference, Contributed Papers, 69.
  60. Holubkov R, Holt VL, Connell FA, LoGerfo JP (1995). Analysis, comparison, and presentation of sparse outcome data by institution [Abstract]. The 1995 International Conference on Health Policy Research, Contributed Papers.