Yukio Saijoh, PhD

Research Interests

  • Left Right Asymmetry


  • English

Academic Information

  • Departments: Neurobiology & Anatomy - Research Associate Professor

Academic Office Information

  • 801-585-9887
  • Maxwell M. Wintrobe Research and Education Building
    Neurobiology and Anatomy
    26 N Medical Dr, Room: 417
    Salt Lake City, UT 84132

Email: y.saijoh@utah.edu

Academic Bio

Peer-Reviewed Original Publications

1. Hou, J., Wei, W., Saund, R.S., Xiang, P., Cunningham, T.J., Yi, Y., Alder, O., Lu, D.Y., Savory, J.G., Krentz, N.A., Montpetit, R., Cullum, R., Hofs, N., Lohnes, D., Humphries, R.K., Yamanaka, Y., Duester, G., Saijoh, Y., Hoodless, P.A.,(2014) A regulatory network controls nephrocan expression and midgut patterning. Development 141: 3772-3781.

2. Uemura, M., Ozawa A., Nagata T., Kurasawa K., Tsunekawa N., Nobuhisa I., Taga, T., Hara K., Kudo A., Kawakami H., Saijoh Y., Kurohmaru M., Kanai-Azuma M., and Kanai Y. (2013) “Sox17 haploinsufficiency results in perinatal biliary atresia and hepatitis in C57BL6 background mice”. Development. 140: 639-48.

3. Kosaka Y., Cieslik K A., Li L., Lezin G., Maguire C.T., Saijoh Y, Toyo-oka K., Gambello Ml J., Vatta M., Wynshaw-Boris A, Baldini A., Yost H. J and Brunelli L. (2012) “14-3-3ε has a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle” Mol Cell Biol, 32: 5089-2102

4. Nichol PF, Corliss R, Yamada S, Shiota K, and Saijoh Y. (2012) “Muscle patterning in mouse and human abdominal wall development and ompahlocele specimens of humans” Anat Rec, 295(12): 2129-40.

5. Saund, R.S., Kanai-Azuma, M., Kanai, Y., Kim, I., Lucero, M.T., and Saijoh, Y.,( 2012) Gut endoderm is involved in the transfer of left-right asymmetry from the node to the lateral plate mesoderm in the mouse embryo. Development.. 139 (13): 2426-35.

6. Nichol, P.F., Tyrrell, J.D., and Saijoh, Y.,( 2012) Retinaldehyde dehydrogenase 2 is down-regulated during duodenal atresia formation in Fgfr2IIIb-/- mice. J Surg Res, 175(1): 82-7.

7. Nichol, P.F. and Saijoh, Y., (2011) Pitx2 is a critical early regulatory gene in normal cecal development. J Surg Res. 170(1): 107-11.

8. Kwan, K.M., Otsuna, H., Kidokoro, H., Carney, K.R., Saijoh, Y., and Chien, C.B., (2012) A complex choreography of cell movements shapes the vertebrate eye. Development, 139(2): 359-72.

9. Nichol, P.F., Botham, R., Saijoh, Y., Reeder, A.L., and Zaremba, K.M., (2011) A more efficient method to generate null mutants using Hprt-Cre with floxed alleles. J Pediatr Surg, 46(9): 1711-9.

10. Nichol, P.F., Corliss, R.F., Tyrrell, J.D., Graham, B., Reeder, A., and Saijoh, Y., (2011) Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J Pediatr Surg.

46(1): 90-6.

11. Kawasumi, A., Nakamura, T., Iwai, N., Yashiro, K., Saijoh, Y., Belo, J.A., Shiratori, H., and Hamada, H., (2011) Left-right asymmetry in the level of active Nodal protein produced in the node is translated into left-right asymmetry in the lateral plate of mouse embryos. Dev Biol. 353(2): p. 321-30.

12. Nichol, P.F., Corliss, R.F., Tyrrell, J.D., Graham, B., Reeder, A., and Saijoh, Y., (2011) Conditional mutation of fibroblast growth factor receptors 1 and 2 results in an omphalocele in mice associated with disruptions in ventral body wall muscle formation. J Pediatr Surg.. 46(1): p. 90-6.

13. Bleyl SB, Saijoh Y, Bax AM, Gittenberger-de Groot AC, Wisse LJ, Chapman SC, Hunter J, Shiratori H, Hamada H, Shiota K, Klewer SE, Leppert MF, Schoenwolf GC. (2010) Dysregulation of the PDGF RA gene causes inflow tract anomalies including TAPVR: Integrating evidence from human genetics and model organisms. Hum Mol Genet. 19(7): 1286-1301

14. Yun, S, Saijoh, Y., Hirokawa KE, Kopinke D, Murtaugh CL, Monuki ES, and Levine EM. Lhx2 links the intrinsic and extrinsic factors controlling optic cup formation Development. 2009 36, 3895-3906.

15. Park, E.J., Sun, X., Nichol, P., Saijoh, Y., Martin, J.F., and Moon, A.M. (2008). System for tamoxifen-inducible expression of cre-recombinase from the Foxa2 locus in mice. Dev Dyn. 237(2): 447-53.

16. Kelly, G.M., Saijoh, Y., Finkielsztein, A., and Mangos, S. (2008). Mouse G-protein gamma3 expression in the developing CNS and neural crest cell derivatives. Int J Dev Biol. 52(8): 1143-50.

17. Tsunoda, I., Tanaka, T., Saijoh, Y., and Fujinami, R.S. (2007). Targeting inflammatory demyelinating lesions to sites of wallerian degeneration. Am J Pathol. 171(5): 1563-75.

18. Tanaka, C., Sakuma, R., Nakamura, T., Hamada, H., and Saijoh, Y. (2007). Long-range action of Nodal requires interaction with GDF1. Genes Dev. 21(24): 3272-82.

19. Sakamoto, Y., Hara, K., Kanai-Azuma, M., Matsui, T., Miura, Y., Tsunekawa, N., Kurohmaru, M., Saijoh, Y., Koopman, P., and Kanai, Y. (2007). Redundant roles of Sox17 and Sox18 in early cardiovascular development of mouse embryos. Biochem Biophys Res Commun. 360(3): 539-44.

20. Oki, S., Hashimoto, R., Okui, Y., Shen, M.M., Mekada, E., Otani, H., Saijoh, Y., and Hamada, H. (2007). Sulfated glycosaminoglycans are necessary for Nodal signal transmission from the node to the left lateral plate in the mouse embryo. Development. 134(21): 3893-904.

21. Frank, D.U., Elliott, S.A., Park, E.J., Hammond, J., Saijoh, Y., and Moon, A.M. (2007). System for inducible expression of cre-recombinase from the Foxa2 locus in endoderm, notochord, and floor plate. Dev Dyn. 236(4): 1085-92.

22. Bleyl, S.B., Moshrefi, A., Shaw, G.M., Saijoh, Y., Schoenwolf, G.C., Pennacchio, L.A., and Slavotinek, A.M. (2007). Candidate genes for congenital diaphragmatic hernia from animal models: sequencing of FOG2 and PDGFRalpha reveals rare variants in diaphragmatic hernia patients. Eur J Hum Genet. 15(9): 950-8.

23. Takaoka, K., Yamamoto, M., Shiratori, H., Meno, C., Rossant, J., Saijoh, Y., and Hamada, H. (2006). The mouse embryo autonomously acquires anterior-posterior polarity at implantation. Dev Cell. 10(4): 451-9.

24. Decastro, M., Saijoh, Y., and Schoenwolf, G.C. (2006). Optimized cationic lipid-based gene delivery reagents for use in developing vertebrate embryos. Dev Dyn. 235(8): 2210-9.

25. Saijoh, Y., Oki, S., Tanaka, C., Nakamura, T., Adachi, H., Yan, Y.T., Shen, M.M., and Hamada, H. (2005). Two nodal-responsive enhancers control left-right asymmetric expression of Nodal. Dev Dyn. 232(4): 1031-6.

26. Yashiro, K., Zhao, X., Uehara, M., Yamashita, K., Nishijima, M., Nishino, J., Saijoh, Y., Sakai, Y., and Hamada, H. (2004). Regulation of retinoic acid distribution is required for proximodistal patterning and outgrowth of the developing mouse limb. Dev Cell. 6(3): 411-22.

27. Yamamoto, M., Saijoh, Y., Perea-Gomez, A., Shawlot, W., Behringer, R.R., Ang, S.L., Hamada, H., and Meno, C. (2004). Nodal antagonists regulate formation of the anteroposterior axis of the mouse embryo. Nature. 428(6981): 387-92.

28. Hou, J., Yashiro, K., Okazaki, Y., Saijoh, Y., Hayashizaki, Y., and Hamada, H. (2004). Identification of a novel left-right asymmetrically expressed gene in the mouse belonging to the BPI/PLUNC superfamily. Dev Dyn. 229(2): 373-9.

29. Yamamoto, M., Mine, N., Mochida, K., Sakai, Y., Saijoh, Y., Meno, C., and Hamada, H. (2003). Nodal signaling induces the midline barrier by activating Nodal expression in the lateral plate. Development. 130(9): 1795-804.

30. Watanabe, D., Saijoh, Y., Nonaka, S., Sasaki, G., Ikawa, Y., Yokoyama, T., and Hamada, H. (2003). The left-right determinant Inversin is a component of node monocilia and other 9+0 cilia. Development. 130(9): 1725-34.

31. Takeuchi, J.K., Ohgi, M., Koshiba-Takeuchi, K., Shiratori, H., Sakaki, I., Ogura, K., Saijoh, Y., and Ogura, T. (2003). Tbx5 specifies the left/right ventricles and ventricular septum position during cardiogenesis. Development. 130: 5953-5964.

32. Saijoh, Y., Oki, S., Ohishi, S., and Hamada, H. (2003). Left-right patterning of the mouse lateral plate requires nodal produced in the node. Dev Biol. 256(1): 160-72.

33. Krebs, L.T., Iwai, N., Nonaka, S., Welsh, I.C., Lan, Y., Jiang, R., Saijoh, Y., O'Brien, T.P., Hamada, H., and Gridley, T. (2003). Notch signaling regulates left-right asymmetry determination by inducing Nodal expression. Genes Dev. 17(10): 1207-12.

34. Nonaka, S., Shiratori, H., Saijoh, Y., and Hamada, H. (2002). Determination of left-right patterning of the mouse embryo by artificial nodal flow. Nature. 418(6893): 96-9.

35. Yamamoto, M., Meno, C., Sakai, Y., Shiratori, H., Mochida, K., Ikawa, Y., Saijoh, Y., and Hamada, H. (2001). The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse. Genes Dev. 15(10): 1242-56.

36. Shiratori, H., Sakuma, R., Watanabe, M., Hashiguchi, H., Mochida, K., Sakai, Y., Nishino, J., Saijoh, Y., Whitman, M., and Hamada, H. (2001). Two-step regulation of left-right asymmetric expression of Pitx2: initiation by nodal signaling and maintenance by Nkx2. Mol Cell. 7(1): 137-49.

37. Sakai, Y., Meno, C., Fujii, H., Nishino, J., Shiratori, H., Saijoh, Y., Rossant, J., and Hamada, H. (2001). The retinoic acid-inactivating enzyme CYP26 is essential for establishing an uneven distribution of retinoic acid along the anterio-posterior axis within the mouse embryo. Genes Dev. 15(2): 213-25.

38. Meno, C., Takeuchi, J., Sakuma, R., Koshiba-Takeuchi, K., Ohishi, S., Saijoh, Y., Miyazaki, J., ten Dijke, P., Ogura, T., and Hamada, H. (2001). Diffusion of nodal signaling activity in the absence of the feedback inhibitor Lefty2. Dev Cell. 1(1): 127-38.

39. Yashiro, K., Saijoh, Y., Sakuma, R., Tada, M., Tomita, N., Amano, K., Matsuda, Y., Monden, M., Okada, S., and Hamada, H. (2000). Distinct transcriptional regulation and phylogenetic divergence of human LEFTY genes. Genes Cells. 5(5): 343-57.

40. Saijoh, Y., Adachi, H., Sakuma, R., Yeo, C.Y., Yashiro, K., Watanabe, M., Hashiguchi, H., Mochida, K., Ohishi, S., Kawabata, M., Miyazono, K., Whitman, M., and Hamada, H. (2000). Left-right asymmetric expression of lefty2 and nodal is induced by a signaling pathway that includes the transcription factor FAST2. Mol Cell. 5(1): 35-47.

41. Osada, S.I., Saijoh, Y., Frisch, A., Yeo, C.Y., Adachi, H., Watanabe, M., Whitman, M., Hamada, H., and Wright, C.V. (2000). Activin/nodal responsiveness and asymmetric expression of a Xenopus nodal-related gene converge on a FAST-regulated module in intron 1. Development. 127(11): 2503-14.

42. Saijoh, Y., Adachi, H., Mochida, K., Ohishi, S., Hirao, A., and Hamada, H. (1999). Distinct transcriptional regulatory mechanisms underlie left-right asymmetric expression of lefty-1 and lefty-2. Genes Dev. 13(3): 259-69.

43. Okada, Y., Nonaka, S., Tanaka, Y., Saijoh, Y., Hamada, H., and Hirokawa, N. (1999). Abnormal nodal flow precedes situs inversus in iv and inv mice. Mol Cell. 4(4): 459-68.

44. Nishino, J., Mochida, K., Ohfuji, Y., Shimazaki, T., Meno, C., Ohishi, S., Matsuda, Y., Fujii, H., Saijoh, Y., and Hamada, H. (1999). GFR alpha3, a component of the artemin receptor, is required for migration and survival of the superior cervical ganglion. Neuron. 23(4): 725-36.

45. Adachi, H., Saijoh, Y., Mochida, K., Ohishi, S., Hashiguchi, H., Hirao, A., and Hamada, H. (1999). Determination of left/right asymmetric expression of nodal by a left side-specific enhancer with sequence similarity to a lefty-2 enhancer. Genes Dev. 13(12): 1589-600.

46. Mochizuki, T., Saijoh, Y., Tsuchiya, K., Shirayoshi, Y., Takai, S., Taya, C., Yonekawa, H., Yamada, K., Nihei, H., Nakatsuji, N., Overbeek, P.A., Hamada, H., and Yokoyama, T. (1998). Cloning of inv, a gene that controls left/right asymmetry and kidney development. Nature. 395(6698): 177-81.

47. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K., Mochida, K., Ohishi, S., Noji, S., Kondoh, H., and Hamada, H. (1998). lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Cell. 94(3): 287-97.

48. Ito, Y., Ando, A., Ando, H., Ando, J., Saijoh, Y., Inoko, H., and Fujimoto, H. (1998). Genomic structure of the spermatid-specific hsp70 homolog gene located in the class III region of the major histocompatibility complex of mouse and man. J Biochem (Tokyo). 124(2): 347-53.

49. Hagino-Yamagishi, K., Saijoh, Y., Yamazaki, Y., Yazaki, K., and Hamada, H. (1998). Transcriptional regulatory region of Brn-2 required for its expression in developing olfactory epithelial cells. Brain Res Dev Brain Res. 109(1): 77-86.

50. Meno, C., Ito, Y., Saijoh, Y., Matsuda, Y., Tashiro, K., Kuhara, S., and Hamada, H. (1997). Two closely-related left-right asymmetrically expressed genes, lefty-1 and lefty-2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos. Genes Cells. 2(8): 513-24.

51. Hagino-Yamagishi, K., Saijoh, Y., Ikeda, M., Ichikawa, M., Minamikawa-Tachino, R., and Hamada, H. (1997). Predominant expression of Brn-2 in the postmitotic neurons of the developing mouse neocortex. Brain Res. 752(1-2): 261-8.

52. Saijoh, Y., Fujii, H., Meno, C., Sato, M., Hirota, Y., Nagamatsu, S., Ikeda, M., and Hamada, H. (1996). Identification of putative downstream genes of Oct-3, a pluripotent cell-specific transcription factor. Genes Cells. 1(2): 239-52.

53. Meno, C*., Saijoh, Y*., Fujii, H., Ikeda, M., Yokoyama, T., Yokoyama, M., Toyoda, Y., and Hamada, H. (1996). Left-right asymmetric expression of the TGF beta-family member lefty in mouse embryos. Nature. 381(6578): 151-5. *equal contribution

54. Hirose, K., Morita, M., Ema, M., Mimura, J., Hamada, H., Fujii, H., Saijo, Y., Gotoh, O., Sogawa, K., and Fujii-Kuriyama, Y. (1996). cDNA cloning and tissue-specific expression of a novel basic helix-loop- helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol Cell Biol. 16(4): 1706-13.

55. Ema, M., Suzuki, M., Morita, M., Hirose, K., Sogawa, K., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., and Fujii-Kuriyama, Y. (1996). cDNA cloning of a murine homologue of Drosophila single-minded, its mRNA expression in mouse development, and chromosome localization. Biochem Biophys Res Commun. 218(2): 588-94.

56. Ema, M., Morita, M., Ikawa, S., Tanaka, M., Matsuda, Y., Gotoh, O., Saijoh, Y., Fujii, H., Hamada, H., Kikuchi, Y., and Fujii-Kuriyama, Y. (1996). Two new members of the murine Sim gene family are transcriptional repressors and show different expression patterns during mouse embryogenesis. Mol Cell Biol. 16(10): 5865-75.

57. Saijoh, Y. and Takeuchi, T. (1992). Action site of the lethal Ay gene in the mouse embryo. Jpn J Genet. 67(5): 357-70.

58. Esashi, Y., Saijoh, Y., Ishida, S., Oota, H., and Ishizawa, K. (1986). Reversal of ethylene action on cocklebur seed germination in relation to duration of pre-treatment soaking and temperatures. Plant, Cell and Environment. 9: 121-126.

59. Esashi, Y., Saito, H., Saijoh, Y., Ishida, S., and Kodama, H. (1985). Light actions in the germnation of cocklebur seeds II. Possible origin of the diversity of light responses in seed germnation. Plant Cell Physiol. 26(2): 361-370.

60. Esashi, Y., Saijoh, Y., Saito, H., Ishida, S., and Satoh, S. (1985). CO2 enhancement of aerobic and hypoxic C2H4 production in the tissues of cocklebur seeds at different donrmant states. Aust. J. Plant Physiol. 12: 59-68.

Review articles

1. Saijoh, Y., Viotti, M., Hadjantonakis, A.K., 2014. Follow your gut: relaying information from the site of left-right symmetry breaking in the mouse. Genesis 52, 503-514.

  1. Nichol P.F, Byrne J.L, Dodgion C, Saijoh Y. (2008). Clinical considerations in gastroschisis: incremental advances against a congenital anomaly with severe secondary effects. Am J Med Genet C Semin Med Genet. 148 C(3):231-40.
  2. Saijoh, Y. (2008). Flexibility in determination of left-right asymmetry. Science Journal Kagaku 78 (4) 429-430. (Japanese)
  3. Hamada, H., Meno, C., Watanabe, D., and Saijoh, Y. (2002). Establishment of vertebrate left-right asymmetry. Nat Rev Genet. 3(2): 103-13.
  4. Hamada, H., Meno, C., Saijoh, Y., Adachi, H., Yashiro, K., Sakuma, R., and Shiratori, H. (2001). Role of asymmetric signals in left-right patterning in the mouse. Am J Med Genet. 101(4): 324-7.
  5. Takeuchi, T., Tamate, H., and Saijoh, Y. (1995). A pleiotropic gene which controls coat color and lethality in early development in the mouse. Zool Sci. 12(6):675-81.

Education History

Type School Degree
Doctoral Training Tohoku University Graduate School of Science
Developmental Biology
Graduate Training Tohoku University Graduate School of Science
Developmental Biology
Undergraduate Tohoku University

Global Impact

Education History

Type School Degree Country
Doctoral Training Tohoku University Graduate School of Science
Developmental Biology
Ph.D. Japan
Graduate Training Tohoku University Graduate School of Science
Developmental Biology
M.S. Japan
Undergraduate Tohoku University
B.A. Japan