David R. Shprecher, DO, MSCI


  • English
  • Japanese
  • Spanish

Academic Information

  • Departments: Neurology - Adjunct Associate Professor
  • Divisions: Sleep and Movement Disorders

Board Certification

  • American Board of Psychiatry & Neurology (Neurology)

Academic Office Information

  • 632-832-6500
  • 10515 W. Santa Fe Drive
    Sun City, AZ 85351

Academic Bio

David Shprecher, DO Msci has dedicated his career to improving treatment options for individuals with movement disorders. His work as a site investigator has been aimed at improving symptomatic and disease modifying pharmacological therapies for Parkinson's, Huntington's, Tourette sydrome, progressive supranuclear palsy, and tardive dyskinesia. He has maintained an adjunct appointment with the University of Utah in order to complete ongoing clinical trials, a validation study of colon biopsy for enteric alpha-synuclein pathology in Parkinson disease, and an epidemiological study on risk factors for parkinsonism. His primary appointment is now with the Banner Sun Health Research Institute in Sun City, Arizona, in order to participate in clinical-pathological correlation studies in prodromal and manifest neurodegenerative disease. The ultimate goal of this work is to guide the design of neuroprotection trials aimed at delaying or preventing onset of parkinsonian disorders.

David Shprecher, DO Msci has dedicated his career to improving treatment options for individuals with movement disorders including ataxia, dystonia, essential tremor, Huntington disease, multiple system atrophy, progressive supranuclear palsy, tardive dyskinesia, tics and Tourette syndrome, Lewy body dementia and Parkinson disease. This includes use of botulinum toxin injections and deep brain stimulation to treat movement disorders.

He has maintained an adjunct position with the University of Utah for clinical trials. His primary practice is now located at the Cleo Roberts Clinic in Sun City, Arizona.

Education History

Type School Degree
Graduate Training University of Rochester
Clinical Investigation
Fellowship University of Rochester
Movement Disorders
Residency University of Utah School of Medicine
Internship University of Utah School of Medicine
Internal Medicine
Professional Medical Lake Erie College of Osteopathic Medicine
Osteopathic Medicine
Undergraduate Cornell University College of Arts and Sciences

Selected Publications

Journal Article

  1. Gerstenecker A, Roberson ED, Schellenberg GD, Standaert DG, Shprecher DR, Kluger BM, Litvan I (2017 Dec). Genetic influences on cognition in progressive supranuclear palsy. Mov Disord, 32(12), 1764-1771.
  2. Bluett B, Litvan I, Cheng S, Juncos J, Riley DE, Standaert DG, Reich SG, Hall DA, Kluger B, Shprecher D, Marras C, Jankovic J, ENGENE PSP study (2017 Feb). Understanding falls in progressive supranuclear palsy. Parkinsonism Relat Disord, 35, 75-81.
  3. Jankovic J, Jimenez-Shahed J, Budman C, Coffey B, Murphy T, Shprecher D, Stamler D (). Deutetrabenazine in tics associated with Tourette syndrome. Tremor Other Hyperkinet Mov (N Y), 6.
  4. Kious BM, Jimenez-Shahed J, Shprecher DR (2016 Oct 3). Treatment-refractory Tourette Syndrome. Prog Neuropsychopharmacol Biol Psychiatry, 70, 227-36.
  5. Huntington Study Group, Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, ONeill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F Jr, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E (2016 Jul 5). Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA, 316(1), 40-50.
  6. Brody DM, Litvan I, Warner S, Riley DE, Hall DA, Kluger BM, Shprecher DR, Cunningham CR (2016 May). Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord, 31(5), 663-7.
  7. Litvan I, Lees PS, Cunningham CR, Rai SN, Cambon AC, Standaert DG, Marras C, Juncos J, Riley D, Reich S, Hall D, Kluger B, Bordelon Y, Shprecher DR, for ENGENE-PSP (2016 May). Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. Mov Disord, 31(5), 644-52.
  8. Mata IF, Jang Y, Kim CH, Hanna DS, Dorschner MO, Samii A, Agarwal P, Roberts JW, Klepitskaya O, Shprecher DR, Chung KA, Factor SA, Espay AJ, Revilla FJ, Higgins DS, Litvan I, Leverenz JB, Yearout D, Inca-Martinez M, Martinez E, Thompson TR, Cholerton BA, Hu SC, Edwards KL, Kim KS, Zabetian CP (2015 Sep 24). The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease. Mol Neurodegener, 10, 50.
  9. Shprecher D, Rubenstein L, Gannon K, Frank S, Kurlan R (). Temporal Course of the Tourette Syndrome Clinical Triad. Tremor Other Hyperkinet Mov (N Y).
  10. Shprecher D, Schrock L, Himle M (). Neurobehavioral aspects, pathophysiology, and management of Tourette's syndrome. Curr Opin Neurol, 27(4), 484-92.
  11. Shprecher D, Gannon K, Agarwal N, Shi X, Anderson J (). Elucidating the mechanism of tic improvement in Tourette syndrome: a pilot study. Tremor Other Hyperkinet Mov (N Y).
  12. Duff K, Shprecher D, Litvan I, Gerstenecker A, Mast B on behalf of the ENGENE investigators (). Correcting for demographic variables on the modified Telephone Interview for Cognitive Status. Am J Geriatr Psychiatry.
  13. Shprecher D, Noyes Katia, Biglan Kevin, Wang Dongwen, Dorsey Ray E, Kurlan Roger, Adams Michael Jacob (). Willingness of Parkinson Disease Patients to Participate in Research Using Internet Based Technology. Telemed J E Health.
  14. Dorsey ER, Voss TS, Shprecher DR, Deuel LM, Beck CA, Gardiner IF, Coles MA, Burns RS, Marshall FJ, Biglan KM (2010 Oct 15). A U.S. survey of patients with Parkinson's disease: satisfaction with medical care and support groups. Mov Disord, 25(13), 2128-35.
  15. Shprecher D, Mehta L (2010). The syndrome of delayed post-hypoxic leukoencephalopathy. NeuroRehabilitation, 26(1), 65-72.
  16. Shprecher D, Kurlan R (2009 Jan 15). The management of tics. Mov Disord, 24(1), 15-24.
  17. Shprecher D, Schwalb J, Kurlan R (2008 Sep). Normal pressure hydrocephalus: diagnosis and treatment. Curr Neurol Neurosci Rep, 8(5), 371-6.
  18. Shprecher DR, Flanigan KM, Smith AG, Smith SM, Schenkenberg T, Steffens J (2008 Fall). Clinical and diagnostic features of delayed hypoxic leukoencephalopathy. J Neuropsychiatry Clin Neurosci, 20(4), 473-7.


  1. Lyon G, Shprecher D, Coffey B, Kurlan R (). Tourette’s Disorder. [Review]. Curr Treat Options Neurol, 12(4), 274-286.

Case Report

  1. Shprecher D, Grossmann K, Tward J (). Sustained remission of Parkinson disease associated melanoma with immunotherapy. Parkinsonism Relat Disord.


  1. Shprecher DR, Majersik JJ (2017 Sep 12). The virtual house call: A 21st-century innovation in the care of patients with Parkinson disease. 89(11), 1103-1104.