David R. Shprecher, DO, MSCI


  • English
  • Japanese
  • Spanish

Academic Information

  • Departments: Neurology - Adjunct Associate Professor
  • Divisions: Sleep and Movement Disorders

Board Certification

  • American Board of Psychiatry & Neurology (Neurology)

Academic Office Information

  • 632-832-6500
  • 10515 W. Santa Fe Drive
    Sun City, AZ 85351

Academic Bio

David Shprecher, DO Msci has dedicated his career to improving treatment options for individuals with movement disorders. His work as a site investigator has been aimed at improving symptomatic and disease modifying pharmacological therapies for Parkinson's, Huntington's, Tourette sydrome, progressive supranuclear palsy, and tardive dyskinesia. He has maintained an adjunct appointment with the University of Utah in order to complete ongoing clinical trials, a validation study of colon biopsy for enteric alpha-synuclein pathology in Parkinson disease, and an epidemiological study on risk factors for parkinsonism. His primary appointment is now with the Banner Sun Health Research Institute in Sun City, Arizona, in order to participate in clinical-pathological correlation studies in prodromal and manifest neurodegenerative disease. The ultimate goal of this work is to guide the design of neuroprotection trials aimed at delaying or preventing onset of parkinsonian disorders.

Education History

Type School Degree
Graduate Training University of Rochester
Clinical Investigation
Fellowship University of Rochester
Movement Disorders
Residency University of Utah School of Medicine
Internship University of Utah School of Medicine
Internal Medicine
Professional Medical Lake Erie College of Osteopathic Medicine
Osteopathic Medicine
Undergraduate Cornell University College of Arts and Sciences

Selected Publications

Journal Article

  1. Bluett B, Litvan I, Cheng S, Juncos J, Riley DE, Standaert DG, Reich SG, Hall DA, Kluger B, Shprecher D, Marras C, Jankovic J (2016). Understanding falls in progressive supranuclear palsy.LID - S1353-8020(16)30490-4 [pii]LID - 10.1016/j.parkreldis.2016.12.009 [doi]. (Epub ahead of print) Parkinsonism Relat Disord.
  2. Jankovic J, Jimenez-Shahed J, Budman C, Coffey B, Murphy T, Shprecher D, Stamler D (11/8/2016). Deutetrabenazine in tics associated with Tourette syndrome. Tremor Other Hyperkinet Mov (N Y), 6.
  3. Huntington Study Group, Frank S, Testa CM, Stamler D, Kayson E, Davis C, Edmondson MC, Kinel S, Leavitt B, Oakes D, ONeill C, Vaughan C, Goldstein J, Herzog M, Snively V, Whaley J, Wong C, Suter G, Jankovic J, Jimenez-Shahed J, Hunter C, Claassen DO, Roman OC, Sung V, Smith J, Janicki S, Clouse R, Saint-Hilaire M, Hohler A, Turpin D, James RC, Rodriguez R, Rizer K, Anderson KE, Heller H, Carlson A, Criswell S, Racette BA, Revilla FJ, Nucifora F Jr, Margolis RL, Ong M, Mendis T, Mendis N, Singer C, Quesada M, Paulsen JS, Brashers-Krug T, Miller A, Kerr J, Dubinsky RM, Gray C, Factor SA, Sperin E, Molho E, Eglow M, Evans S, Kumar R, Reeves C, Samii A, Chouinard S, Beland M, Scott BL, Hickey PT, Esmail S, Fung WL, Gibbons C, Qi L, Colcher A, Hackmyer C, McGarry A, Klos K, Gudesblatt M, Fafard L, Graffitti L, Schneider DP, Dhall R, Wojcieszek JM, LaFaver K, Duker A, Neefus E, Wilson-Perez H, Shprecher D, Wall P, Blindauer KA, Wheeler L, Boyd JT, Houston E, Farbman ES, Agarwal P, Eberly SW, Watts A, Tariot PN, Feigin A, Evans S, Beck C, Orme C, Edicola J, Christopher E (7/6/2016). Effect of Deutetrabenazine on Chorea Among Patients With Huntington Disease: A Randomized Clinical Trial. JAMA, 316(1), 40-50.
  4. Litvan I, Lees PS, Cunningham CR, Rai SN, Cambon AC, Standaert DG, Marras C, Juncos J, Riley D, Reich S, Hall D, Kluger B, Bordelon Y, Shprecher DR (2016). Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. Mov Disord, 31(5), 644-52.
  5. Kious BM, Jimenez-Shahed J, Shprecher DR (2016). Treatment-refractory Tourette Syndrome. Prog Neuropsychopharmacol Biol Psychiatry, 70, 227-36.
  6. Brody DM, Litvan I, Warner S, Riley DE, Hall DA, Kluger BM, Shprecher DR, Cunningham CR (2016). Relationship between uric acid levels and progressive supranuclear palsy. Mov Disord, 31(5), 663-7.
  7. Mata IF, Jang Y, Kim CH, Hanna DS, Dorschner MO, Samii A, Agarwal P, Roberts JW, Klepitskaya O, Shprecher DR, Chung KA, Factor SA, Espay AJ, Revilla FJ, Higgins DS, Litvan I, Leverenz JB, Yearout D, Inca-Martinez M, Martinez E, Thompson TR, Cholerton BA, Hu SC, Edwards KL, Kim KS, Zabetian CP (2015). The RAB39B p.G192R mutation causes X-linked dominant Parkinson's disease. Mol Neurodegener, 10(1), 50.
  8. Shprecher D, Rubenstein L, Gannon K, Frank S, Kurlan R (2014). Temporal Course of the Tourette Syndrome Clinical Triad. Tremor Other Hyperkinet Mov (N Y).
  9. Shprecher D, Grossmann K, Tward J (2014). Sustained remission of Parkinson disease associated melanoma with immunotherapy. Parkinsonism Relat Disord.
  10. Shprecher D, Schrock L, Himle M (2014). Neurobehavioral aspects, pathophysiology, and management of Tourette's syndrome. Curr Opin Neurol, 27(4), 484-92.
  11. Shprecher D, Gannon K, Agarwal N, Shi X, Anderson J (2014). Elucidating the mechanism of tic improvement in Tourette syndrome: a pilot study. Tremor Other Hyperkinet Mov (N Y).
  12. Duff K, Shprecher D, Litvan I, Gerstenecker A, Mast B on behalf of the ENGENE investigators (2013). Correcting for demographic variables on the modified Telephone Interview for Cognitive Status. Am J Geriatr Psychiatry.
  13. Shprecher D, Noyes Katia, Biglan Kevin, Wang Dongwen, Dorsey Ray E, Kurlan Roger, Adams Michael Jacob (2012). Willingness of Parkinson Disease Patients to Participate in Research Using Internet Based Technology. Telemed J E Health.
  14. Dorsey ER, Voss TS, Shprecher DR, Deuel LM, Beck CA, Gardiner IF, Coles MA, Burns RS, Marshall FJ, Biglan KM (2010). A U.S. survey of patients with Parkinson's disease: satisfaction with medical care and support groups. Mov Disord, 25(13), 2128-35.
  15. Shprecher D, Mehta L (2010). The syndrome of delayed post-hypoxic leukoencephalopathy. NeuroRehabilitation, 26(1), 65-72.
  16. Shprecher D, Kurlan R (2009). The management of tics. Mov Disord, 24(1), 15-24.
  17. Shprecher DR, Flanigan KM, Smith AG, Smith SM, Schenkenberg T, Steffens J (2008). Clinical and diagnostic features of delayed hypoxic leukoencephalopathy. J Neuropsychiatry Clin Neurosci, 20(4), 473-7.


  1. Lyon G, Shprecher D, Coffey B, Kurlan R (July 2010). Tourette’s Disorder. [Review]. Current Treatment Options in Neurology, 12(4), 274-286.
  2. Shprecher D, Schwalb J, Kurlan R (2008). Normal pressure hydrocephalus: diagnosis and treatment. [Review]. Curr Neurol Neurosci Rep, 8(5), 371-6.