Guilherme Del Fiol, MD, PhD

Research Interests

  • Clinical Decision Support Systems
  • Knowledge Management, Clinical
  • Health Information Standards Development and Use
  • Controlled Standard Terminologies


  • English
  • Italian
  • Portuguese

Academic Information

  • Departments: Biomedical Informatics - Associate Professor

Academic Office Information

  • 801-581-4080
  • Biomedical Informatics
    421 Wakara Way, Room: Suite 140
    Salt Lake City, UT 84108

Academic Bio

Dr. Guilherme Del Fiol earned his MD from the University of Sao Paulo, Brazil; his MS in Computer Science from the Catholic University of Parana, Brazil; and his PhD in Biomedical Informatics from the University of Utah. He is currently Associate Professor and Vice-Chair of Research in the University of Utah’s Department of Biomedical Informatics. Prior to the University of Utah, Dr. Del Fiol held positions in Clinical Knowledge Management at Intermountain Healthcare and as faculty at the Duke Community and Family Medicine Department. Since 2008, he has served as an elected co-chair of the Clinical Decision Support Work Group at Health Level International (HL7). He is also an elected Fellow of the American College of Medical Informatics (ACMI) and a member of the Comprehensive Cancer Center at Huntsman Cancer Institute.

Dr. Del Fiol's research interests are in the design, development, evaluation, and dissemination of standards-based clinical decision support interventions. He has been focusing particularly in clinical decision support for cancer prevention. He is the lead author of the HL7 Infobutton Standard and the project lead for OpenInfobutton, an open source suite of infobutton tools and Web services, which is in production use at several healthcare organizations throughout the United States, including Intermountain Healthcare, Duke University, and the Veterans Health Administration (VHA). His research has been funded by various sources including the National Library of Medicine (NLM), National Cancer Institute (NCI), AHRQ, CMS, and PCORI.

“Health informatics combines the two areas that appeal to me the most, health care and technology. I feel this combination provides me with greater potential to improve the quality of health care than through direct patient care. It is rewarding knowing that my research work has practical and direct implications in the daily routine of clinicians and ultimately in people’s health. This is a major motivation for me to come to work every day.”

Google Scholar:

My Bibliography in PubMed:

Twitter: @guilhermeDFiol

Research Statement

Dr. Del Fiol is interested in the design, development, evaluation and dissemination of standards-based clinical informatics and clinical decision support (CDS) interventions to improve the quality, safety, and value of health care. He is especially interested in clinical decision support interventions for cancer prevention and screening. He is also interested in the development and implementation of health IT standards to promote wide dissemination of CDS interventions across health care organizations and EHR platforms.

Education History

Type School Degree
Doctoral Training University of Utah, Department of Biomedical Informatics
Biomedical Informatics
Graduate Training Catholic University of Paraná, School of Computer Science
Information Systems
Other Training School of Public Health, University of São Paulo
Hospital Administration
Residency University of São Paulo
Resident, Medical Informatics
Professional Medical University of São Paulo

Global Impact

Education History

Type School Degree Country
Graduate Training Catholic University of Paraná, School of Computer Science
Information Systems
M.S. Brazil
Other Training School of Public Health, University of São Paulo
Hospital Administration
Certificate Brazil
Residency University of São Paulo
Resident, Medical Informatics
Resident Brazil
Professional Medical University of São Paulo
M.D. Brazil


Description Country
Clinical Decision Support in the Electronic Health Record. Pan American Health Organization (PAHO), Buenos Aires, Argentina. Latin America and the Caribbean
HL7 Infobutton Standard: Meeting Clinician's information needs. VII Jornadas Universitarias de Sistemas de Informaion en Salud, Hospital Italiano, Buenos Aires, Argentina. Argentina
Standards for Clinical Decision Support, Webinar presentation, Brazilian Society of Health Informatics Webinar Brazil
Clinical Decision Support Systems, National Hospital Association (ANAHP) Workshop, Sao Paulo, Brazil (Webinar) Brazil
Water everywhere and not a drop to drink: access to context-specific information at the point of care. Academic week seminar (Webinar presentation), Federal University of Parana, Brazil Brazil
Design and development of Apps Integrated with Electronic Health Record Systems using an Architecture based on SMART on FHIR. Brazilian Society of Health Informatics, Webinar, Brazil Brazil
CDS Hooks: a New Standard for Clinical Decision Support Systems Brazil

Selected Publications

Journal Article

  1. Khalifa A, Mason CC, Garvin JH, Williams MS, Del Fiol G, Jackson BR, Bleyl SB, Huff SM (2021). A qualitative study of prevalent laboratory information systems and data communication patterns for genetic test reporting. (Epub ahead of print) Genet Med.
  2. Morid MA, Lau M, Del Fiol G (2021). Predictive analytics for step-up therapy: Supervised or semi-supervised learning? J Biomed Inform, 119, 103842.
  3. Taber P, Staes CJ, Phengphoo S, Rocha E, Lam A, Del Fiol G, Maviglia SM, Rocha RA (2021). Developing a sampling method and preliminary taxonomy for classifying COVID-19 public health guidance for healthcare organizations and the general public. J Biomed Inform, 120, 103852.
  4. Douthit BJ, Staes CJ, Del Fiol G, Richesson RL (2021). A thematic analysis to examine the feasibility of EHR-based clinical decision support for implementing Choosing Wisely ® guidelines. JAMIA Open, 4(2), ooab031.
  5. Strasberg HR, Rhodes B, Del Fiol G, Jenders RA, Haug PJ, Kawamoto K (2021). Contemporary clinical decision support standards using Health Level Seven International Fast Healthcare Interoperability Resources. (Epub ahead of print) J Am Med Inform Assoc.
  6. Kaphingst KA, Kohlmann W, Chambers RL, Goodman MS, Bradshaw R, Chan PA, Chavez-Yenter D, Colonna SV, Espinel WF, Everett JN, Gammon A, Goldberg ER, Gonzalez J, Hagerty KJ, Hess R, Kehoe K, Kessler C, Kimball KE, Loomis S, Martinez TR, Monahan R, Schiffman JD, Temares D, Tobik K, Wetter DW, Mann DM, Kawamoto K, Del Fiol G, Buys SS, Ginsburg O, BRIDGE research team (2021). Comparing models of delivery for cancer genetics services among patients receiving primary care who meet criteria for genetic evaluation in two healthcare systems: BRIDGE randomized controlled trial. BMC Health Serv Res, 21(1), 542.
  7. Weir CR, Taber P, Taft T, Reese TJ, Jones B, Del Fiol G (2020). Feeling and thinking: can theories of human motivation explain how EHR design impacts clinician burnout? J Am Med Inform Assoc, 28(5), 1042-1046.
  8. Gibson B, Kramer H, Weir C, Del Fiol, G, Borbolla D, Schlechter C, Lam C, Nelson M, Bohner C, Schulthies S, Sieperas T, Pruhs A, Nahum-Shani I, Fernandez ME, Wetter D (2021). Workflow analysis for design of an electronic health record-based tobacco cessation intervention in community health centers. JAMIA Open.
  9. Oosterhoff JH, Thio QC, Groot OQ, Bongers ME, Ghaednia H, Karhade AV, Del Fiol G, Kawamoto K (2021). Integration of automated predictive analytics into electronic health records: can spine surgery applications lead the way using SMART on FHIR and CDS Hooks? Seminars in Spine Surgery, 100870.
  10. Liu S, Reese TJ, Kawamoto K, Del Fiol G, Weir C (2021). A systematic review of theoretical constructs in CDS literature. BMC Med Informat Decis Making, 21(1), 102.
  11. Rasmussen LV, Connolly JJ, Del Fiol G, Freimuth RR, Pet DB, Peterson JF, Shirts BH, Starren JB, Williams MS, Walton N, Taylor CO (2021). Infobuttons for Genomic Medicine: Requirements and Barriers. Appl Clin Inform, 12(2), 383-390.
  12. Tiase VL, Sward KA, Del Fiol G, Staes C, Weir C, Cummins MR (2021). Patient-Generated Health Data in Pediatric Asthma: Exploratory Study of Providers' Information Needs. JMIR Pediatr Parent, 4(1), e25413.
  13. Reese TJ, Schlechter CR, Potter LN, Kawamoto K, Del Fiol G, Lam CY, Wetter DW (2021). Evaluation of Revised US Preventive Services Task Force Lung Cancer Screening Guideline Among Women and Racial/Ethnic Minority Populations. JAMA Netw Open, 4(1), e2033769.
  14. Morid MA, Borjali A, Del Fiol G (2020). A scoping review of transfer learning research on medical image analysis using ImageNet. Comput Biol Med, 128, 104115.
  15. Tiase VL, Hull W, McFarland MM, Sward KA, Del Fiol G, Staes C, Weir C, Cummins MR (2020). Patient-generated health data and electronic health record integration: a scoping review. JAMIA Open, 3(4), 619-627.
  16. Humphreys BL, Del Fiol G, Xu H (2020). The UMLS knowledge sources at 30: indispensable to current research and applications in biomedical informatics. J Am Med Inform Assoc, 27(10), 1499-1501.
  17. Reese TJ, Segall N, Del Fiol G, Tonna JE, Kawamoto K, Weir C, Wright MC (2020). Iterative heuristic design of temporal graphic displays with clinical domain experts. (Epub ahead of print) J Clin Monit Comput.
  18. Reese TJ, Del Fiol G, Tonna JE, Kawamoto K, Segall N, Weir C, Macpherson BC, Kukhareva P, Wright MC (2020). Impact of integrated graphical display on expert and novice diagnostic performance in critical care. J Am Med Inform Assoc, 27(8), 1287-1292.
  19. Cummins MR, Del Fiol G, Crouch BI, Ranade-Kharkar P, Khalifa A, Iskander A, Mann D, Hoffman M, Thornton S, Allen TL, Bennett H (2019). Enabling health information exchange at a US Poison Control Center. J Am Med Inform Assoc, 27(7), 1000-1006.
  20. Karhade AV, Schwab JH, Del Fiol G, Kawamoto K (2020). SMART on FHIR in spine: integrating clinical prediction models into electronic health records for precision medicine at the point of care. (Epub ahead of print) Spine J.
  21. Penning ML, Blach C, Walden A, Wang P, Donovan KM, Garza MY, Wang Z, Frund J, Syed S, Syed M, Del Fiol G, Newby LK, Pieper C, Zozus M (2020). Near Real Time EHR Data Utilization in a Clinical Study. Stud Health Technol Inform, 270, 337-341.
  22. Haynes RB, Del Fiol G, Michelson M, Iorio A (2020). Context and Approach in Reporting Evaluations of Electronic Health Record-Based Implementation Projects. Ann Intern Med, 172(11 Suppl), S73-S78.
  23. Hanauer DA, Barnholtz-Sloan JS, Beno MF, Del Fiol G, Durbin EB, Gologorskaya O, Harris D, Harnett B, Kawamoto K, May B, Meeks E, Pfaff E, Weiss J, Zheng K (2020). Electronic Medical Record Search Engine (EMERSE): An Information Retrieval Tool for Supporting Cancer Research. JCO Clin Cancer Inform, 4, 454-463.
  24. Richesson RL, Staes CJ, Douthit BJ, Thoureen T, Hatch DJ, Kawamoto K, Del Fiol G (2019). Measuring implementation feasibility of clinical decision support alerts for clinical practice recommendations. J Am Med Inform Assoc, 27(4), 514-521.
  25. Morid MA, Sheng ORL, Del Fiol G, Facelli JC, Bray BE, Abdelrahman S (2020). Temporal Pattern Detection to Predict Adverse Events in Critical Care: Case Study With Acute Kidney Injury. JMIR Med Inform, 8(3), e14272.
  26. Fernandez ME, Schlechter CR, Del Fiol G, Gibson B, Kawamoto K, Siaperas T, Pruhs A, Greene T, Nahum-Shani I, Schulthies S, Nelson M, Bohner C, Kramer H, Borbolla D, Austin S, Weir C, Walker TW, Lam CY, Wetter DW (2020). QuitSMART Utah: an implementation study protocol for a cluster-randomized, multi-level Sequential Multiple Assignment Randomized Trial to increase Reach and Impact of tobacco cessation treatment in Community Health Centers. Implement Sci, 15(1), 9.
  27. Del Fiol G, Kohlmann W, Bradshaw RL, Weir CR, Flynn M, Hess R, Schiffman JD, Nanjo C, Kawamoto K (2020). Standards-Based Clinical Decision Support Platform to Manage Patients Who Meet Guideline-Based Criteria for Genetic Evaluation of Familial Cancer. JCO Clin Cancer Inform, 4, 1-9.
  28. Tiase VL, Hull W, McFarland MM, Sward KA, Del Fiol G, Staes C, Weir C, Cummins MR (2019). Patient-generated health data and electronic health record integration: protocol for a scoping review. BMJ Open, 9(12), e033073.
  29. Brooke BS, Beckstrom J, Slager SL, Weir CR, Del Fiol G (2019). Discordance in Information Exchange Between Providers During Care Transitions for Surgical Patients. J Surg Res, 244, 174-180.
  30. Colicchio TK, Del Fiol G, Cimino JJ (2019). Health information technology as a learning health system: Call for a national monitoring system. Learn Health Syst, 4(1), e10207.
  31. Kawamoto K, Kukhareva P, Shakib JH, Kramer H, Rodriguez S, Warner PB, Shields D, Weir C, Del Fiol G, Taft T, Stipelman CH (2019). Association of an Electronic Health Record Add-on App for Neonatal Bilirubin Management With Physician Efficiency and Care Quality. JAMA Netw Open, 2(11), e1915343.
  32. Williams MS, Taylor CO, Walton NA, Goehringer SR, Aronson S, Freimuth RR, Rasmussen LV, Hall ES, Prows CA, Chung WK, Fedotov A, Nestor J, Weng C, Rowley RK, Wiesner GL, Jarvik GP, Del Fiol G (2019). Genomic Information for Clinicians in the Electronic Health Record: Lessons Learned From the Clinical Genome Resource Project and the Electronic Medical Records and Genomics Network. Front Genet, 10, 1059.
  33. Aakre CA, Maggio LA, Fiol GD, Cook DA (2019). Barriers and facilitators to clinical information seeking: a systematic review. J Am Med Inform Assoc, 26(10), 1129-1140.
  34. Wright MC, Borbolla D, Waller RG, Del Fiol G, Reese T, Nesbitt P, Segall N (2019). Critical care information display approaches and design frameworks: A systematic review and meta-analysis. J Biomed Inform X, 3.
  35. Maggio LA, Aakre CA, Del Fiol G, Shellum J, Cook DA (2019). Impact of Clinicians' Use of Electronic Knowledge Resources on Clinical and Learning Outcomes: Systematic Review and Meta-Analysis. J Med Internet Res, 21(7), e13315.
  36. Colicchio TK, Cimino JJ, Del Fiol G (2019). Unintended Consequences of Nationwide Electronic Health Record Adoption: Challenges and Opportunities in the Post-Meaningful Use Era. J Med Internet Res, 21(6), e13313.
  37. Colicchio TK, Borbolla D, Colicchio VD, Scammon DL, Del Fiol G, Facelli JC, Bowes WA 3rd, Narus SP (2019). Looking Behind the Curtain: Identifying Factors Contributing to Changes on Care Outcomes During a Large Commercial EHR Implementation. EGEMS (Wash DC), 7(1), 21.
  38. Mowery DL, Kawamoto K, Bradshaw R, Kohlmann W, Schiffman JD, Weir C, Borbolla D, Chapman WW, Del Fiol G (2019). Determining Onset for Familial Breast and Colorectal Cancer from Family History Comments in the Electronic Health Record. AMIA Jt Summits Transl Sci Proc, 2019, 173-181.
  39. Colicchio TK, Del Fiol G, Scammon DL, Facelli JC, Bowes WA 3rd, Narus SP (2018). Comprehensive methodology to monitor longitudinal change patterns during EHR implementations: a case study at a large health care delivery network. J Biomed Inform, 83, 40-53.
  40. Bian J, Weir C, Unni P, Borbolla D, Reese T, Wan YJ, Del Fiol G (2018). Interactive Visual Displays for Interpreting the Results of Clinical Trials: Formative Evaluation With Case Vignettes. J Med Internet Res, 20(6), e10507.
  41. Del Fiol G, Michelson M, Iorio A, Cotoi C, Haynes RB (2018). A Deep Learning Method to Automatically Identify Reports of Scientifically Rigorous Clinical Research from the Biomedical Literature: Comparative Analytic Study. J Med Internet Res, 20(6), e10281.
  42. Ranade-Kharkar P, Weir C, Norlin C, Collins SA, Scarton LA, Baker GB, Borbolla D, Taliercio V, Del Fiol G (2017). Information needs of physicians, care coordinators, and families to support care coordination of children and youth with special health care needs (CYSHCN). J Am Med Inform Assoc, 24(5), 933-941.
  43. Cook DA, Teixeira MT, Heale BS, Cimino JJ, Del Fiol G (2017). Context-sensitive decision support (infobuttons) in electronic health records: a systematic review. J Am Med Inform Assoc, 24(2), 460-468.
  44. Morid MA, Fiszman M, Raja K, Jonnalagadda SR, Del Fiol G (2016). Classification of clinically useful sentences in clinical evidence resources. J Biomed Inform, 60, 14-22.
  45. Del Fiol G, Mostafa J, Pu D, Medlin R, Slager S, Jonnalagadda SR, Weir CR (2016). Formative evaluation of a patient-specific clinical knowledge summarization tool. Int J Med Inform, 86, 126-34.
  46. Del Fiol G, Crouch BI, Cummins MR (2015). Data standards to support health information exchange between poison control centers and emergency departments. J Am Med Inform Assoc, 22(3), 519-28.
  47. Mishra R, Bian J, Fiszman M, Weir CR, Jonnalagadda S, Mostafa J, Del Fiol G (2014). Text summarization in the biomedical domain: a systematic review of recent research. J Biomed Inform, 52, 457-67.
  48. Del Fiol G, Weber AI, Brunker CP, Weir CR (2014). Clinical questions raised by providers in the care of older adults: a prospective observational study. BMJ Open, 4(7), e005315.
  49. Del Fiol G, Workman TE, Gorman PN (2014). Clinical questions raised by clinicians at the point of care: a systematic review. JAMA Intern Med, 174(5), 710-8.
  50. Jonnalagadda SR, Del Fiol G, Medlin R, Weir C, Fiszman M, Mostafa J, Liu H (2013). Automatically extracting sentences from Medline citations to support clinicians' information needs. J Am Med Inform Assoc, 20(5), 995-1000.
  51. Strasberg HR, Del Fiol G, Cimino JJ (2013). Terminology challenges implementing the HL7 context-aware knowledge retrieval ('Infobutton') standard. J Am Med Inform Assoc, 20(2), 218-23.
  52. Del Fiol G, Curtis C, Cimino JJ, Iskander A, Kalluri AS, Jing X, Hulse NC, Long J, Overby CL, Schardt C, Douglas DM (2013). Disseminating context-specific access to online knowledge resources within electronic health record systems. Stud Health Technol Inform, 192, 672-6.
  53. Del Fiol G, Huser V, Strasberg HR, Maviglia SM, Curtis C, Cimino JJ (2012). Implementations of the HL7 Context-Aware Knowledge Retrieval ("Infobutton") Standard: challenges, strengths, limitations, and uptake. J Biomed Inform, 45(4), 726-35.
  54. Kawamoto K, Del Fiol G, Lobach DF, Jenders RA (2010). Standards for scalable clinical decision support: need, current and emerging standards, gaps, and proposal for progress. Open Med Inform J, 4, 235-44.
  55. Kawamoto K, Del Fiol G, Orton C, Lobach DF (2010). System-agnostic clinical decision support services: benefits and challenges for scalable decision support. Open Med Inform J, 4, 245-54.
  56. Del Fiol G, Haug PJ, Cimino JJ, Narus SP, Norlin C, Mitchell JA (2008). Effectiveness of topic-specific infobuttons: a randomized controlled trial. J Am Med Inform Assoc, 15(6), 752-9.
  57. Del Fiol G, Haug PJ (2008). Infobuttons and classification models: a method for the automatic selection of on-line information resources to fulfill clinicians' information needs. J Biomed Inform, 41(4), 655-66.
  58. Del Fiol G, Haug PJ (2007). Use of classification models based on usage data for the selection of infobutton resources. AMIA Annu Symp Proc, 171-5.
  59. Del Fiol G, Rocha RA, Clayton PD (2007). Infobuttons at Intermountain Healthcare: utilization and infrastructure. AMIA Annu Symp Proc, 180-4.
  60. Del Fiol G, Rocha RA, Bradshaw RL, Hulse NC, Roemer LK (2005). An XML model that enables the development of complex order sets by clinical experts. IEEE Trans Inf Technol Biomed, 9(2), 216-28.
  61. Hulse NC, Del Fiol G, Rocha RA (2006). Development and validation of XML-based calculations within order sets. AMIA Annu Symp Proc, 360-4.
  62. Del Fiol G, Rocha RA, Washburn J, Rhodes J, Hulse N, Bradshaw RL, Roemer LK (2007). "On-demand" access to a multi-purpose collection of best practice standards. IEEE Engineering in Medicine and Biology Society. Conference Proceedings, 2004, 3342-5.
  63. Hulse NC, Rocha RA, Del Fiol G, Bradshaw RL, Hanna TP, Roemer LK (2007). The knowledge authoring tool: an XML-based knowledge acquisition environment. IEEE Engineering in Medicine and Biology Society. Conference Proceedings, 2004, 3350-3.

Conference Proceedings

  1. Borbolla DA, Del Fiol G, Norlin C, Taft TE, Cornia R, Warner P, Iskander A, Kramer H, Weir C, Kawamoto K, Shields D (2021). Design and Development of an Electronic Health Record Add-on App to Support the Care of Children and Youth with Special Health Care Needs. Pediatrics, American Academy of Pediatrics, 147(3), 8-9.


  1. Hall LK, Del Fiol G, Lenert L (09/18/2014). Using Health Information Technology to Support Shared Decision Making.. Washington, DC: Institute of Medicine.