Xinjian Chen, MD

Research Interests

  • Allergy and Immunology


  • Chinese
  • English

Academic Information

    Board Certification

    • American Board of Pathology (Anatomic)

    Academic Office Information

    • Huntsman Cancer Hospital
      Surgical Pathology
      1950 Circle of Hope, Room: N3245
      Salt Lake City, UT 84112

    Academic Bio

    Dr. Chen's scholarly emphasis is on mechanisms regulating immunity and immunological tolerance as well as mechanisms for immunodeficiency and autoimmune diseases.

    Education History

    Type School Degree
    Fellowship Emory University School of Medicine
    Residency Emory University School of Medicine
    Anatomical Pathology
    Fellowship Stanford University Medical Center
    Dermatology Research
    Internship/Residency University of Alabama at Birmingham
    Internal Medicine
    Doctoral Training University of Alabama at Birmingham
    Residency Hunan Medical College
    Professional Medical Hunan Medical College

    Global Impact

    Education History

    Type School Degree Country
    Residency Hunan Medical College
    Resident China
    Professional Medical Hunan Medical College
    M.D. China

    Selected Publications

    Journal Article

    1. Chen X corresponding author, Jensen P (2014). The Biological Function of HLA-DO (H2-O). Crit Rev Immunol, 34, 215-25.
    2. Bramwell K, Ma Y, Chen X, Weiss J, Zachary J, Teuscher C, Weiss J (2014). Lysosomal beta-Glucuronidase Regulates Lyme and Rhuematoid Arthritis Severity. J Clin Invest, 124, 311-320.
    3. Anker CJ, Ribas A, Grossmann AH, Chen X, Grossmann KF (2013). Severe liver and skin toxicity following radiation and vemurafenib in metastatic melanoma. J Clin Oncol, 31, e283-7.
    4. Gu Y, Jensen P, Chen X (2013). Immunodeficiency and autoimmunity in H2-O deficient mice. J Immunol, 1(190), 126-37.
    5. Wang Y, Chen X, Tsai S, Thomas A, Shizuru JA, Cao TM (2013). Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in non-myeloablated mice. Immunogenetics, 65, 585-96.
    6. Chen X, Wang Y, Tsai S, Thomas A, Shizurur JA, Cao TM (2013). Pathways analysis of differential gene expression induced by engrafting doses of total body irradiation for allogeneic bone marrow transplantation in mice. Immunogenetics, 65, 597-607.
    7. Li Q, Shakya A, Guo X, Zhang H, Tantin D, Jensen PE, Chen X (2012). Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activity. J Immunol, 188, 4268-77.
    8. Huffaker TB, Hu R, Runtsch MC, Bake E, Chen X, Zhao J, Round JL, Baltimore D, OConnell RM (2012). Epistasis between microRNAs 155 and 146a during T cell-mediated antitumor immunity. Cell Rep, 2, 1697-709.
    9. Chen LL, Chen X, Choi Haesun, Sang Hongxun, et al (2011). Exploiting antitumor immunity to overcome relapse and improve remission duration. Cancer Immunol Immunother, 61, 1113-1124.
    10. Chen X (2010). B Lymphocytes, potent Antigen presenting cells for preferential expansion of allo-reactive FoxP3+ CD4 Regulatory T Cells. Recent Patents on. Recent Pat Endocr Metab Immune Drug Discov, 4, 100-110.
    11. Chen LC, Deldado J, Jensen PE, Chen X (2009). Direct expansion of human allospecific FoxP3+CD4+ regulatory T cells with allogeneic B cells for therapeutic application. J Immunol, 183, 4094-4102.
    12. Chen X correspondence author, Jensen, PE (2008). MHC class II antigen presentation and immunological abnormalities due to deficiency of MHC class II and its associated genes. Exp Mol Pathol, 85, 40-4.
    13. Chen X, Jensen PE (2008). The role of B lymphocytes as antigen-presenting cells. Arch Immunol Ther Exp (Warsz), 56, 77-83.
    14. Chen X correspondence author and Jensen PE (2007). Cutting Edge: Primary B-lymphocytes preferentially expand allogeneic FoxP3+ CD4 T cells. J Immunol, 179, 2046-50.
    15. Chen X correspondence author Reed-Loisel LM, Karlsson L, Jensen PE (2006). H2-O expression in primary dendritic cells. J Immunol, 176, 3548-56.
    16. Chen X correspondence author, Jensen PE (2004). The Expression of HLA-DO (H2-O) in B Lymphocytes. Immunol Res, 29, 19-28.
    17. Chen X, Jensen PE, Li S (2003). A useful marker to distinguish florid follicular hyperplasia from follicular lymphoma by flow cytometry. Am J Clin Pathol, 119, 842-51.
    18. Nagarajan UM, Chen X, Beresford GW, Nilsen R, Jensen PE, Boss JM (2002). Class II transactivator is required for maximal expression of HLA-DOB in B cells. J Immunol, 168, 1780-6.
    19. Chen X, Laur O, Kambayashi T, Li S, Bray RA, Weber DA, Karlsson L, Jensen PE (2002). Regulated expression of human histocompatibility leukocyte antigen (HLA)-DO during antigen-dependent and antigen-independent phases of B cell development. Journal of Experimental Medical Sciences, 195, 1053.
    20. Robbins PB, Lin Q, Goodnough JB, Tian H, Chen, X and Khavari PA (2001). In vivo restoration of laminin 5 b3 expression and function in junctional epidermolysis bullosa. Proc Natl Acad Sci U S A, 24(98), 5193-8.
    21. Jensen, PE, Weber DA, Thayer WP, Chen X, Dao CT (1999). HLA-DM and the MHC class II antigen presentation pathway. Immunol Res, 20, 195-205.
    22. Martin F, Chen X, Kearney JF (1998). Development of VH81X transgene bearing B cells in fetus and adult: sites for expansion and deletion in conventional and CD5/B1 lineage cells. Int Immunol, 9, 493-505.
    23. Chen X, Martin F, Forbush KA, Perlmutter RM, Kearney JF (1997). Evidence for selection of a population of self-reactive B cells into the splenic marginal zone. Int Immunol, 9, 27-41.
    24. Chen X, Kearney JF (1996). Generation and function of natural self-reactive B lymphocytes. Semin Immunol, 8, 19-27.
    25. Chen X, Matsura Y, Kearney JF (1994). CD5 Transgenic mice. Curr Top Microbiol Immunol, 194, 209-217.
    26. Solvason N, Chen S, Shu F, Kearney JF (1992). The fetal momentum in mice and humans: A site enriched for precursors of CD5 B cells early in development. Ann N Y Acad Sci, 651, 10-20.
    27. Chen X, Lin C (1985). Lack of estrogen receptor on breast lymphoma. Hum Pathol, 18, 84-86.