Karen A. Heichman, PhD

Research Interests

  • Cancer Therapeutic Development

Languages

  • English

Academic Information

  • Departments: Pathology - Adjunct Associate Professor
  • Divisions: Anatomic Pathology

Academic Office Information

  • 801-584-5068
  • ARUP
    500 Chipeta Way
    Salt Lake City, UT 84108

Email: karen.heichman@aruplab.com

Education History

Type School Degree
Postdoctoral Fellowship American Cancer Society
Postdoctoral Fellow
Postdoctoral Fellowship Fred Hutchinson Cancer Research Center
Genetics and Cell Biology
Postdoctoral Fellow
Doctoral Training UCLA School of Medicine
Biological Chemistry
Ph.D.
Undergraduate University of California at Berkeley
Genetics
B.S.

Selected Publications

Journal Article

  1. Grenache DG, Heichman KA, Werner TL, Vucetic Z (2015 Jan 1). Clinical performance of two multi-marker blood tests for predicting malignancy in women with an adnexal mass. Clin Chim Acta, 438, 358-63.
  2. Taber JM, Aspinwall LG, Heichman KA, Kinney AY (2014 May). Preferences for blood-based colon cancer screening differ by race/ethnicity. Am J Health Behav, 38(3), 351-61.
  3. Li X, Kuang J, Shen Y, Majer MM, Nelson CC, Parsawar K, Heichman KA, Kuwada SK (2012 Jun 29). The atypical histone macroH2A1.2 interacts with HER-2 protein in cancer cells. J Biol Chem, 287(27), 23171-83.
  4. Warren JD, Xiong W, Bunker AM, Vaughn CP, Furtado LV, Roberts WL, Fang JC, Samowitz WS, Heichman KA (2011). Septin 9 methylated DNA is a sensitive and specific blood test for colorectal cancer. BMC Medicine, 9, 133.
  5. McCoy EL, Iwanaga R, Jedlicka P, Abbey NS, Chodosh LA, Heichman KA, Welm AL, Ford HL (2009 Sep). Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest, 119(9), 2663-77.
  6. Micalizzi DS, Christensen KL, Jedlicka P, Coletta RD, Baron AE, Harrell JC, Horwitz KB, Billheimer D, Heichman KA, Welm AL, Schiemann WP, Ford HL (2009 Sep). The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling. J Clin Invest, 119(9), 2678-90.
  7. Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (1999 Jul 15). Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. Genomics, 59(2), 248-51.
  8. Wong AK, Chen Y, Lian L, Ha PC, Petersen K, Laity K, Carillo A, Emerson M, Heichman K, Gupte J, Tavtigian SV, Teng DH (1999). Genomic structure, chromosomal location, and mutation analysis of the human CDC14A gene. Genomics, 59(2), 248-251.
  9. Heichman KA, Roberts JM (1998 Feb). CDC16 controls initiation at chromosome replication origins. Mol Cell, 1(3), 457-63.
  10. Heichman KA, Roberts JM (1996 Apr 5). The yeast CDC16 and CDC27 genes restrict DNA replication to once per cell cycle. Cell, 85(1), 39-48.
  11. Moskowitz IP, Heichman KA, Johnson RC (1991 Sep). Alignment of recombination sites in Hin-mediated site-specific DNA recombination. Genes Dev, 5(9), 1635-45.
  12. Heichman KA, Moskowitz IP, Johnson RC (1991 Sep). Configuration of DNA strands and mechanism of strand exchange in the Hin invertasome as revealed by analysis of recombinant knots. Genes Dev, 5(9), 1622-34.
  13. Heichman KA, Johnson RC (1990 Aug 3). The Hin invertasome: protein-mediated joining of distant recombination sites at the enhancer. Science, 249(4968), 511-7.
  14. Treger JM, Heichman KA, McEntee K (1988 Mar). Expression of the yeast UB14 gene increases in response to DNA-damaging agents and in meiosis. Mol Cell Biol, 8(3), 1132-6.

Review

  1. Heichman KA (2014 Apr). Blood-based testing for colorectal cancer screening. [Review]. Mol Diagn Ther, 18(2), 127-35.
  2. Heichman KA, Warren JD (2012 Oct 1). DNA methylation biomarkers and their utility for solid cancer diagnostics. [Review]. Clin Chem Lab Med, 50(10), 1707-21.
  3. Heichman KA (1996 Nov). Cdc6 and DNA replication: limited to humble origins. [Review]. BioEssays, 18(11), 859-62.
  4. Heichman KA, Roberts JM (1994 Nov 18). Rules to replicate by. [Review]. Cell, 79(4), 557-62.

Conference Proceedings

  1. Taber JM, Aspinwall LG, Heichman KA, Kinney AY (). American Society of Preventive Oncology Annual Meeting. Preferences for a methylated DNA blood test for colorectal cancer among a multiethnic sample of screened and unscreened adults (poster presentation).
  2. Taber JM, Aspinwall LG, Heichman KA, Kinney AY (). American Society of Preventive Oncology Annual Meeting. Blood-based colorectal cancer screening. Elliciting attitudes and determining predictors of interest in multiethnic sample (poster presentation).
  3. Heichman KA at al (). ASCO-NCI-EORTC Meeting on Molecular Markers in Cancer. Use of Septin 9 methylated DNA biomarker to detect cancer in the blood of colorectal cancer patients (poster presentation selected for oral presentatio by meeting organizers).
  4. Heichman KA (01-01-2007). Women in Government Legislative Training Sessions (Confernece presentations from 2007 to present). Women in Government Legislative Training Sessions.
  5. Heichman KA (12-31-2004). Industrial Presentations, Agriculture/Nutrition: DuPont/Pioneer Hi-Bred (US), Torrey Mesa Research Institute (US), Wheat Consortium (US).
  6. Heichman KA (12-31-2004). Industrial Presentations, European Biotech/Pharma: AstraZeneca (UK), Aventis (France), Biovitrum (Sweden), Boehringer Ingelheim (Germany), GlaxoSmithKline (UK), Lipha (France), Lundbeck (Denmark), Novo Nordisk (Denmark), Oxagen (UK), Roche (Switzerland), Sanofi-Synthelabo (France), Serono (Switzerland).
  7. Heichman KA (12-31-2004). Industrial Presentations, Agriculture/Nutrition: Nestle (Switzerland), Syngenta (Switzerland).
  8. Heichman KA (12-31-2004). Industrial Presentations, Government Institutions: NCI (National Cancer Institute), NHLBI (National Heart, Lung, and Blood Institute), NIAID (National Institute of Allergy and Infectious Disease), NIAMS (National Institute of Arthritis and Musculoskeletal and Skin Diseases), NIDDK (National Institute of Diabetes & Digestive & Kidney Diseases), NIMH (National Institute of Mental Health).
  9. Heichman KA (12-31-2004). Industrial Presentations, Japanese Biotech/Pharma: Hitachi Life Sciences, Kyorin Pharmaceutical Company, Takeda Pharmaceutical Company.
  10. Heichman KA (12-31-2004). Industrial Presentations, US Biotech/Pharma: Abbott Laboratories, Amgen, ArQule, Inc., Aventis, Bristol-Meyers Squibb, Johnson & Johnson, Eli Lilly and Company, Merck and Company, Millenium, Monsanto, Novartis, Pfizer, Pharmacia, Procter & Gamble, Searle, Silicon Genetics.
  11. Heichman KA (01-01-2001). New Genomic Technologies: Accelerating Drug Discovery. Strategic Research Institute Symposium.
  12. Heichman KA (01-01-2001). Proteomics: From Proteins to Drugs (Conference presentations from 2001 to present). Cambridge Healthtech Institute Symposium.
  13. Heichman KA (01-01-2000). Yeast Molecular Biology for Therapeutics (Conference Presentations from 2000-Present). Cambridge Healthtech Institute Symposium, Cambridge, MA.

Commentary

  1. Heichman KA (). The Future of Colorectal Cancer Screening. Adv Adm Lab.