Mark Metzstein, PhD

Research Interests

  • Drosophila
  • Drosophila melanogaster
  • Cytoplasmic Vesicles
  • Transport Vesicles
  • Drosophila tracheal development
  • Nonsense mediated m RNA decay


  • English

Academic Information

  • Departments: Human Genetics - Associate Professor

Academic Office Information

  • 801-585-9941
  • George and Dolores Eccles Institute of Human Genetics
    Human Genetics
    15 N 2030 E, Room: 6160A
    Salt Lake City, UT 84112

Education History

Type School Degree
Postdoctoral Fellowship Stanford University School of Medicine, Department of Biochemistry, Laboratory of Dr. Mark A Krasnow
Postdoctoral Fellow
Postdoctoral Training Massachusetts Institute of Technology, Department of Biology
Postdoctoral Training
Doctoral Training Massachusetts Institute of Technology, Department of Biology
Undergraduate Robinson College, University of Cambridge

Global Impact

Education History

Type School Degree Country
Undergraduate Robinson College, University of Cambridge
B.A. United Kingdom

Selected Publications

Journal Article

  1. Nikolova LS, Metzstein MM (2015). Intracellular lumen formation in Drosophila proceeds via a novel subcellular compartment. Development, 142, 3964-3973.
  2. Jones TA, Nikolova LS, Schjelderup A, Metzstein MM (2014). Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells. Dev Biol, 390(1), 41-50.
  3. Chapin A, Hu H, Rynearson SG, Hollien J, Yandell M, Metzstein MM (2014). In Vivo Determination of Direct Targets of the Nonsense Mediated Decay Pathway in Drosophila. G3 (Bethesda), 4, 485-496.
  4. Jones TA, Metzstein MM (2013). Examination of Drosophila Larval Tracheal Terminal Cells by Light Microscopy. J Vis Exp, 77, e50496.
  5. Frizzell KA, Rynearson SG, Metzstein MM (2012). Drosophila mutants show NMD pathway activity is reduced, but not eliminated, in the absence of Smg6. RNA, 18, 1475-1486.
  6. Ruiz OE, Nikolova LS, Metzstein MM (2012). Drosophila Zpr1 (Zinc Finger Protein 1) Is Required Downstream of Both EGFR And FGFR Signaling in Tracheal Subcellular Lumen Formation. PLoS ONE, 7(9), e45649.
  7. Jones TA, Metzstein MM (2011). A Novel Function for the PAR Complex in Subcellular Morphogenesis of Tracheal Terminal Cells in Drosophila melanogaster. Genetics, 189, 153-164.
  8. Chan AC, Drakos SG, Ruiz OE, Smith AC, Gibson CC, Ling J, Passi SF, Stratman AN, Sacharidou A, Revelo MP, Grossmann AH, Diakos NA, Davis GE, Metzstein MM, Whitehead KJ, Li DY (2011). Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest, 121(5), 1871-81.
  9. A Ashleigh Long, Cecon Mahapatra, E A Woodruff III, Jeff Rohrbough, Hung-Tat Leung, S Shino, L An, R W Doerge, Mark M Metzstein, William L Pak, Kendal Broadie (2010). The nonsense-mediated decay pathway is critical for maintaining synapse architecture and synaptic vesicle cycle efficacy. J Cell Sci, 123(19), 3303-3315.
  10. Metzstein MM, Krasnow M (2006). Functions of the Nonsense-Mediated RNA Decay Pathway in Drosophila Development. PLoS Genet, 2(12), 180.


  1. Ghabrial A, Luschnig S, Metzstein MM, Krasnow MA (2003). Branching morphogenesis of the Drosophila tracheal system. [Review]. Annu Rev cell Dev Biol, 19, 623-47.