James Patterson (Pat) McAllister II, PhD

Research Interests

  • Hydrocephalus
  • Pediatric Traumatic Brain Injury
  • Neurobiology
  • Nervous System Diseases
  • Nervous System Malformations
  • Neural Tube Defects
  • Neuroanatomy
  • Neuroglia
  • Neurohistology and staining techniques
  • Neuronal Plasticity
  • Neuropathology
  • Neurosciences
  • Neurosurgery
  • Developmental Disabilities
  • Cerebrospinal Fluid Shunts
  • Cerebrospinal Fluid
  • Cerebrospinal Fluid Pressure
  • Cerebral Ventricles
  • Prostheses and Implants
  • Bioengineering
  • Recovery of Function
  • Gliosis
  • Neuroprotection
  • Neuroinflammation
  • Neural Regeneration

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Bioengineering - Adjunct Professor, Neurosurgery - Professor Emeritus
  • Divisions: Pediatric Neurosurgery

Academic Office Information

  • 314-747-8773
  • Department of Neurosurgery, Division of Pediatric Neurosurgery
    425 S. Euclid
    St. Louis, MO 63110

Academic Bio

As Professor and Director of Basic Hydrocephalus Research, Dr. Pat McAllister plays an integral role in the research activities of the Department of Neurosurgery and especially the Division of Pediatric Neurosurgery at Primary Children's Medical Center. With a joint appointment in the Department of Bioengineering, he is very active in guiding graduate students through doctoral and master’s studies in neuroscience and biomedical engineering, as well as neurosurgical residents in their basic research training. This interdisciplinary approach helps to "glue" a variety of basic research initiatives together with the clinical strengths of the Neurosurgery Department.
Dr. McAllister received his Ph.D. from Purdue University in 1976, and following postdoctoral training at the University of Vermont School of Medicine, has held staff positions at the UCLA Mental Retardation Research Center, Temple University School of Medicine, the Cleveland Clinic Foundation, and the Detroit Medical Center/Wayne State University prior to joining the University of Utah in July, 2007.
Dr. McAllister has dedicated 25 years to the study of hydrocephalus, and recently was given the Robert H. Pudenz Prize for Excellence Cerebrospinal Fluid Physiology and Hydrocephalus by the International Society for Pediatric Neurosurgery. In addition to advancing our understanding of the neuronal damage that occurs in the hydrocephalic brain, his introduction of shunting experiments in animals during the mid-eighties has contributed greatly to what is known about the potential for recovery after treatment. Most recently, he and his colleagues have developed a unique model of communicating (extraventricular) hydrocephalus that is very relevant clinically because it mimics the type of cerebrospinal fluid (CSF) obstruction found in children and older adults with hydrocephalus. By working closely with bioengineers and pediatric neurosurgeons, he has turned the current efforts in the lab towards approaches that could supplement surgical treatments (cerebrospinal fluid shunting) by protecting neurons or promoting regeneration in the hydrocephalic brain, understanding the role that intracranial pressure and pulsatility play in hydrocephalus, and developing shunt systems that resist cellular obstruction or function as “smart” drainage systems that monitor physiological changes. Finally, he consults with various neurosurgical instrumentation companies, has written FDA applications, and holds 4 patents.

Education History

Type School Degree
Postdoctoral Fellowship Univ. Vermont Coll. Med., Dept. Anat. & Neurobiol.
Developmental Neuroanatomy
Postdoctoral Fellow
Doctoral Training Purdue University
Neurobiology
Ph.D.
Undergraduate Earlham College
Biology
B.A.

Global Impact

Selected Provider Publications

Journal Article

  1. Habiyaremye G, Morales DM, Morgan CD, McAllister JP, CreveCoeur TS, Han RH, Gabir M, Baksh B, Mercer D, Limbrick DD Jr (2017). Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus. Fluids Barriers CNS, 14(1), 35.
    Global Impact: Global, Global, Global.

Awards & Honors

Description Country
President Elect, Society for Research into Hydrocephalus and Spina Bifida Global

Selected Publications

Journal Article

  1. Habiyaremye G, Morales DM, Morgan CD, McAllister JP, CreveCoeur TS, Han RH, Gabir M, Baksh B, Mercer D, Limbrick DD Jr (2017). Chemokine and cytokine levels in the lumbar cerebrospinal fluid of preterm infants with post-hemorrhagic hydrocephalus. Fluids Barriers CNS, 14(1), 35.
  2. Adam A, Robison J, Lu J, Jose R, Badran N, Vivas-Buitrago T, Rigamonti D, Sattar A, Omoush O, Hammad M, Dawood M, Maghaslah M, Belcher T, Carson K, Hoffberger J, Jusue Torres I, Foley S, Yasar S, Thai QA, Wemmer J, Klinge P, Al-Mutawa L, Al-Ghamdi H, Carson KA, Asgari M, de Zelicourt D, Kurtcuoglu V, Garnotel S, Salmon S, Baledent O, Lokossou A, Page G, Balardy L, Czosnyka Z, Payoux P, Schmidt EA, Zitoun M, Sevestre MA, Alperin N, Baudracco I, Craven C, Matloob S, Thompson S, Haylock Vize P, Thorne L, Watkins LD, Toma AK, Bechter K, Pong AC, Juge L, Bilston LE, Cheng S, Bradley W, Hakim F, Ramon JF, Cardenas MF, Davidson JS, Garcia C, Gonzalez D, Bermudez S, Useche N, Mejia JA, Mayorga P, Cruz F, Martinez C, Matiz MC, Vallejo M, Ghotme K, Soto HA, Riveros D, Buitrago A, Mora M, Murcia L, Bermudez S, Cohen D, Dasgupta D, Curtis C, Dominguez L, Remolina AJ, Grijalba MA, Whitehouse KJ, Edwards RJ, Eleftheriou A, Lundin F, Fountas KN, Kapsalaki EZ, Smisson HF, Robinson JS, Fritsch MJ, Arouk W, Garzon M, Kang M, Sandhu K, Baghawatti D, Aquilina K, James G, Thompson D, Gehlen M, Schmid Daners M, Eklund A, Malm J, Gomez D, Guerra M, Jara M, Flores M, Vio K, Moreno I, Rodriguez S, Ortega E, Rodriguez EM, McAllister JP, Guerra MM, Morales DM, Sival D, Jimenez A, Limbrick DD, Ishikawa M, Yamada S, Yamamoto K, Junkkari A, Hayrinen A, Rauramaa T, Sintonen H, Nerg O, Koivisto AM, Roine RP, Viinamaki H, Soininen H, Luikku A, Jaaskelainen JE, Leinonen V, Kehler U, Lilja-Lund O, Kockum K, Larsson EM, Riklund K, Soderstrom L, Hellstrom P, Laurell K, Kojoukhova M, Sutela A, Vanninen R, Vanha KI, Timonen M, Rummukainen J, Korhonen V, Helisalmi S, Solje E, Remes AM, Huovinen J, Paananen J, Hiltunen M, Kurki M, Martin B, Loth F, Luciano M, Luikku AJ, Hall A, Herukka SK, Mattila J, Lotjonen J, Alafuzoff I, Jurjevic I, Miyajima M, Nakajima M, Murai H, Shin T, Kawaguchi D, Akiba C, Ogino I, Karagiozov K, Arai H, Reis RC, Teixeira MJ, Valencio CG, da Vigua D, Almeida-Lopes L, Mancini MW, Pinto FCG, Maykot RH, Calia G, Tornai J, Silvestre SSS, Mendes G, Sousa V, Bezerra B, Dutra P, Modesto P, Oliveira MF, Petitto CE, Pulhorn H, Chandran A, McMahon C, Rao AS, Jumaly M, Solomon D, Moghekar A, Relkin N, Hamilton M, Katzen H, Williams M, Bach T, Zuspan S, Holubkov R, Rigamonti A, Clemens G, Sharkey P, Sanyal A, Sankey E, Rigamonti K, Naqvi S, Hung A, Schmidt E, Ory-Magne F, Gantet P, Guenego A, Januel AC, Tall P, Fabre N, Mahieu L, Cognard C, Gray L, Buttner-Ennever JA, Takagi K, Onouchi K, Thompson SD, Thorne LD, Tully HM, Wenger TL, Kukull WA, Doherty D, Dobyns WB, Moran D, Vakili S, Patel MA, Elder B, Goodwin CR, Crawford JA, Pletnikov MV, Xu J, Blitz A, Herzka DA, Guerrero-Cazares H, Quinones-Hinojosa A, Mori S, Saavedra P, Trevino H, Maitani K, Ziai WC, Eslami V, Nekoovaght-Tak S, Dlugash R, Yenokyan G, McBee N, Hanley DF (2017). Abstracts from Hydrocephalus 2016. Fluids Barriers CNS, 14(Suppl 1), 15.
  3. McAllister JP, Guerra MM, Ruiz LC, Jimenez AJ, Dominguez-Pinos D, Sival D, den Dunnen W, Morales DM, Schmidt RE, Rodriguez EM, Limbrick DD (2017). Ventricular Zone Disruption in Human Neonates With Intraventricular Hemorrhage. J Neuropathol Exp Neurol, 76(5), 358-375.
  4. Limbrick DD Jr, Castaneyra-Ruiz L, Han RH, Berger D, McAllister JP, Morales DM (2017). Cerebrospinal Fluid Biomarkers of Pediatric Hydrocephalus. Pediatr Neurosurg, 52(6), 426-435.
  5. Limbrick DD Jr, Baksh B, Morgan CD, Habiyaremye G, McAllister JP 2nd, Inder TE, Mercer D, Holtzman DM, Strahle J, Wallendorf MJ, Morales DM (2017). Cerebrospinal fluid biomarkers of infantile congenital hydrocephalus. PLoS ONE, 12(2), e0172353.
  6. Morales DM, Silver SA, Morgan CD, Mercer D, Inder TE, Holtzman DM, Wallendorf MJ, Rao R, McAllister JP, Limbrick DD Jr (2017). Lumbar Cerebrospinal Fluid Biomarkers of Posthemorrhagic Hydrocephalus of Prematurity: Amyloid Precursor Protein, Soluble Amyloid Precursor Protein alpha, and L1 Cell Adhesion Molecule. Neurosurgery, 80(1), 82-90.
  7. Bradley NK, Liakos AM, McAllister JP 2nd, Magram G, Kinsman S, Bradley MK (1998). Maternal shunt dependency: implications for obstetric care, neurosurgical management, and pregnancy outcomes and a review of selected literature. Neurosurgery, 43(3), 448-60; discussion 460-1.
  8. Harris NG, McAllister JP 2nd, Conaughty JM, Jones HC (1996). The effect of inherited hydrocephalus and shunt treatment on cortical pyramidal cell dendrites in the infant H-Tx rat. Exp Neurol, 141(2), 269-79.
  9. Kriebel RM, Shah AB, McAllister JP 2nd (1993). The microstructure of cortical neuropil before and after decompression in experimental infantile hydrocephalus. Exp Neurol, 119(1), 89-98.
  10. Hale PM, McAllister JP 2nd, Katz SD, Wright LC, Lovely TJ, Miller DW, Wolfson BJ, Salotto AG, Shroff DV (1992). Improvement of cortical morphology in infantile hydrocephalic animals after ventriculoperitoneal shunt placement. Neurosurgery, 31(6), 1085-96; discussion 1096.
  11. Williamson EC, Pearson HE, McAllister JP 2nd (1992). Gliosis and ganglion cell death in the developing cat retina during hydrocephalus and after decompression. Brain Res Dev Brain Res, 70(1), 47-52.

Patent

  1. Naik R, Ng S, Abrams G, McAllister JPII, Iezzi R (2002). Self-Assembled Nanobump Array Structures and A Method To Fabricate Such Structures. U.S. Patent No. 20040145053. Washington, D.C.:U.S. Patent and Trademark Office.
  2. Auner GW, Abrams GW, Iezzi R, McAllister JPII (2001). Method and Apparatus for Activating Molecules to Stimulate Neurological Tissue. U.S. Patent No. 09/881-549. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Iezzi R, Auner G, Abrams GW, McAllister JPII (2000). Method and Apparatus for Activating Caged Molecules for Visual Prosthesis. U.S. Patent No. 60/212,214. Washington, D.C.:U.S. Patent and Trademark Office.
  4. Iezzi R, Auner GW, McAllister JPII, Abrams GW (2000). Method and Device for Optically Activating Caged Molecules for Visual Prosthesis. U.S. Patent No. 60/212,214. Washington, D.C.:U.S. Patent and Trademark Office.