Lamb, Allen Newton, PhD

Research Interests

  • Clinical Cytogenetics Laboratory
  • Constitutional and Acquired Genetic Abnormalities
  • Submicroscopic Chromosomal Imbalances

Languages

  • English

Academic Information

  • Departments: Pathology - Professor (Clinical)
  • Divisions: Clinical Pathology

Board Certification

  • American Board of Medical Genetics (Clinical Cytogenetics)

Academic Office Information

  • 801-583-2787-Ext-3308
  • ARUP Laboratories
    Cyotgenetics
    500 S Chipeta Way
    Salt Lake City, UT 84108

Email: u0594958@utah.edu

Education History

Type School Degree
Fellowship Harvard Medical School
Clinical Molecular Genetics
Fellow
Fellowship University of North Carolina
Clinical Cytogenetics
Fellow
Doctoral Training Wesleyan University
Molecular Biology and Biochemistry
Ph.D.
Graduate Training University of Maine - Orono
Microbiology
M.S.
Undergraduate University of Maine - Orono
Biology
B.S.

Selected Publications

Journal Article

  1. Waggoner D, Wain KE, Dubuc AM, Conlin L, Hickey SE, Lamb AN, Martin CL, Morton CC, Rasmussen K, Schuette JL, Schwartz S, Miller DT (2018 Jun 18). Yield of additional genetic testing after chromosomal microarray for diagnosis of neurodevelopmental disability and congenital anomalies: a clinical practice resource of the American College of Medical Genetics and Genomics (ACMG).LID - 10.1038/s41436-018-0040-6 [doi]. (Epub ahead of print) Genet Med.
  2. Bhat G, LaGrave D, Millson A, Herriges J, Lamb AN, Matalon R (). Xq11.1-11.2 deletion involving ARHGEF9 in a girl with autism spectrum disorder. Eur J Med Genet, 59(9), 470-473.
  3. Rosenfeld JA, Fox JE, Descartes M, Brewer F, Stroud T, Gorski JL, Upton SJ, Moeschler JB, Monteleone B, Neill NJ, Lamb AN, Ballif BC, Shaffer LG, Ravnan JB (). Clinical features associated with copy number variations of the 14q32 imprinted gene cluster. Am J Med Genet A; Article first published online: 26 NOV 2014. Am J Med Genet A, 167(2), 345-353.
  4. Andersen EA, Baldwin EE, Ellingwood S, Smith R, Lamb AN (). Xq28 Duplication Overlapping the int22h-1/int22h-2 Region and Including Genes RAB39B and CLIC2 in a Family with Intellectual and Developmental Disability. 164(7):1795-801. PMID: 24700761. Am J Med Genet A, 164(7), 1795-1801.
  5. South ST, Lee C, Lamb AN, Higgins AW, Kearney HM (). ACMG Standards and Guidelines for constitutional cytogenomic microarray analysis, including postnatal and prenatal applications: revision. Genet Med, 15(11), 901-909.
  6. Shuvarikov A, Campbell IM, Dittwald P, Neill NJ, Bialer MG, Moore C, Wheeler PG, Wallace SE, Hannibal MC, Murray MF, Giovanni MA, Terespolsky D, Sodhi S, Cassina M, Viskochil D, Moghaddam B, Herman K, Brown C, Gambin A, Cheung SW, Patel A, Lamb AN, Shaffer LG, Ellison JW, Ravnan JB, Stankiewicz P, Rosenfeld JA (). Recurrent HERV-H-Mediated 3q13.2-q13.31 Deletions Cause a Syndrome of Hypotonia and Motor, Language, and Cognitive Delays. Hum Mutat, 34(10), 1415-1423.
  7. Paciorkowski AR, Traylor RN, Rosenfeld JA, Hoover JM, Harris CJ, Winter S, Lacassie Y, Bialer M, Lamb AN, Schultz RA, Berry-Kravis E, Porter BE, Falk M, Venkat A, Vanzo RJ, Cohen JS, Fatemi A, Dobyns WB, Shaffer LG, Ballif BC, Marsh ED (). MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways. Neurogenetics, 2013 Feb 7.
  8. Barber JCK, Rosenfeld JA, Foulds N, Laird S, Bateman MS, Thomas NS, Baker S, Maloney VK, Anilkumar A, Smith WE, Banks V, Ellingwood, Kharbutli Y, Mehta L, Eddleman KA, Marble M, Zambrano R, Crolla JA, Lamb AN (). 8p23.1 Duplication Syndrome: Common, Confirmed and Novel Features in Six Further Patients. Am J Med Genet, 161(3), 487-500.
  9. Wapner RJ, Martin CL, Levy B, Ballif BC, Eng CM, Zachary JM, Savage M, Platt LD, Saltzman D, Grobman WA, Klugman S, Scholl T, Simpson JL, McCall K, Aggarwal VS, Bunke B, Nahum O, Patel A, Lamb AN, Thom EA, Beaudet AL, Ledbetter DH, Shaffer LG, Jackson L (2012 Dec 6). Chromosomal microarray versus karyotyping for prenatal diagnosis. N Engl J Med, 367(23), 2175-84.
  10. Rosenfeld JA1, Traylor RN, Schaefer GB, McPherson EW, Ballif BC, Klopocki E, Mundlos S, Shaffer LG, Aylsworth AS, 1q211 Study Group Abuelo D, Anderson I, Angle B, Ardinger H, Asamoah A, Atkin JF, Axelrod J, Bader P, Blout C, Brasington C, Briere LC, Brock PL, Burton B, Chitayat D, Cushman LJ, Earl DL, El-Khechen D, Escobar LF, Hamati A, Harris DJ, Herman G, Hoover J, Jackson KE, Kaiser-Rogers KA, Kaplan LC, Klemsz A, Lacassie Y, Ladda R, Lamb AN, Lund MM, Lyon H, MacDonald GP, Madan-Khetarpal S, Marble M, Mark PR, Martin LS, Martin N, McConnell JS, McCracken E, McDonald M, McGuire M, Mendoza-Londono R, Miller AN, Moeschler J, Noyes AG, Platky K, Powell CM, Putnam A, Roberts V, Sanger WG, Schultz RA, Sell S, Senturias Y, Shashi V, Shur N, Siriwardena K, Sommer A, Spence JE, Stavropoulos J, Stevens CA, Strenk ME, Tarnopolsky M, Thomas E, Thomas MJ, Torchia BS, Venter A, Weaver DD, Wilson WG (). Proximal microdeletions and microduplications of 1q21.1 contribute to variable abnormal phenotypes. Eur J Hum Genet, 20(7), 754-61.
  11. Rosenfeld JA, Traylor RN, Schaefer GB, McPherson EW, Ballif BC, Klopocki E, Mundlos S, Shaffer LG, Aylsworth AS, 1q211 Study Group Lamb AN is listed as a member of the 1q211 study group (). Proximal microdeletions and microduplications of 1q21.1 contribute to variable abnormal phenotypes. Eur J Hum Genet, 20(7), 754-761.
  12. Lamb AN, Rosenfeld JA, Coppinger J, Dodge ET, Dabell MP, Torchia BS, Ravnan JB, Shaffer LG, Ballif BC (). Defining the impact of maternal cell contamination on the interpretation of prenatal microarray analysis. Genet Med, 14(11), 914-21.
  13. Ballif BC, Rosenfeld JA, Traylor R, Theisen A, Bader PI, Ladda RL, Sell SL, Steinraths M, Surti U, McGuire M, Williams S, Farrell SA, Filiano J, Schnur RE, Coffey LB, Tervo RC, Stroud T, Marble M, Netzloff M, Hanson K, Aylsworth AS, Bamforth JS, Babu D, Niyazov DM, Ravnan JB, Schultz RA, Lamb AN, Torchia BS, Bejjani BA, Shaffer LG (2012 Jan). High-resolution array CGH defines critical regions and candidate genes for microcephaly, abnormalities of the corpus callosum, and seizure phenotypes in patients with microdeletions of 1q43q44. Hum Genet, 131(1), 145-56.
  14. Rosenfeld JA, Amrom D, Andermann E, Andermann F, Veilleux M, Curry C, Fisher J, Deputy S, Aylsworth AS, Powell CM, Manickam K, Heese B, Maisenbacher M, Stevens C, Ellison JW, Upton S, Moeschler J, Torres-Martinez W, Stevens A, Marion R, Pereira EM, Babcock M, Morrow B, Sahoo T, Lamb AN, Ballif BC, Paciorkowski AR, Shaffer LG (2012 Feb). Genotype-phenotype correlation in interstitial 6q deletions: a report of 12 new cases. Neurogenetics, 13(1), 31-47.
  15. Lamb AN, Rosenfeld JA, Neill NJ, Talkowski ME, Blumenthal I, Girirajan S, Keelean-Fuller D, Fan Z, Pouncey J, Stevens C, Mackay-Loder L, Terespolsky D, Bader PI, Rosenbaum K, Vallee SE, Moeschler JB, Ladda R, Sell S, Martin J, Ryan S, Jones MC, Moran R, Shealy A, Madan-Khetarpal S, McConnell J, Surti U, Delahaye A, Heron-Longe B, Pipiras E, Benzacken B, Passemard S, Verloes A, Isidor B, Le Caignec C, Glew GM, Opheim KE, Descartes M, Eichler EE, Morton CC, Gusella JF, Schultz RA, Ballif BC, Shaffer LG (2012 Apr). Haploinsufficiency of SOX5 at 12p12.1 is associated with developmental delays with prominent language delay, behavior problems, and mild dysmorphic features. Hum Mutat, 33(4), 728-40.
  16. Mefford HC, Rosenfeld JA, Shur N, Slavotinek AM, Cox VA, Hennekam RC, Firth HV, Willatt L, Wheeler P, Morrow EM, Cook J, Sullivan R, Oh A, McEonald MT, Zonana J, Keller K, Hannibal MC, Ball S, Kussmann J, Gorski J, Zelewski S, Banks V, Smith W, Smith R, Paull L, Rosenbaum KN, Amor DJ, Silva J, Lamb A, Eichler EE (). Further clinical and molecular delineation of the 15q24 microdeletion syndrome. Epub 2011 Dec 17. J Med Genet, 49(2), 110-8.
  17. Neill NJ, Ballif BC, Lamb AN, Parikh S, Ravnan JB, Schultz RA, Torchia BS, Rosenfeld JA, Shaffer LG (2011 Apr). Recurrence, submicroscopic complexity, and potential clinical relevance of copy gains detected by array CGH that are shown to be unbalanced insertions by FISH. Genome Res, 21(4), 535-44.
  18. Sahoo T, Theisen A, Sanchez-Lara PA, Marble M, Schweitzer DN, Torchia BS, Lamb AN, Bejjani BA, Shaffer LG, Lacassie Y (2011 Jul). Microdeletion 20p12.3 involving BMP2 contributes to syndromic forms of cleft palate. Am J Med Genet A, 155A(7), 1646-53.
  19. Shaffer LG, Coppinger J, Morton SA, Alliman S, Burleson J, Traylor R, Walker C, Byerly S, Lamb AN, Schultz R, Ravnan JB, Kashork CD, Torchia BS, Sulpizio S, Sundin K, Schermer M, Adler K, Dallaire S, Ballif BC (2011 Aug). The development of a rapid assay for prenatal testing of common aneuploidies and microdeletion syndromes. Prenat Diagn, 31(8), 778-87.
  20. Rosenfeld JA, Drautz JM, Clericuzio CL, Cushing T, Raskin S, Martin J, Tervo RC, Pitarque JA, Nowak DM, Karolak JA, Lamb AN, Schultz RA, Ballif BC, Bejjani BA, Gajecka M, Shaffer LG (2011 Aug). Deletions and duplications of developmental pathway genes in 5q31 contribute to abnormal phenotypes. Am J Med Genet A, 155A(8), 1906-16.
  21. Sahoo T, Theisen A, Rosenfeld JA, Lamb AN, Ravnan JB, Schultz RA, Torchia BS, Neill N, Casci I, Bejjani BA, Shaffer LG (2011 Oct). Copy number variants of schizophrenia susceptibility loci are associated with a spectrum of speech and developmental delays and behavior problems. Genet Med, 13(10), 868-80.
  22. Kearney HM, South ST, Wolff DJ, Lamb A, Hamosh A, Rao KW, A Working Group of the American College of Medical Genetics (). American College of Medical Genetics recommendations for the design and performance expectations for clinical genomic copy number microarrays intended for use in the postnatal setting for detection of constitutional abnormalities. Genet Med, 13(7), 676-679.
  23. Theisen A, Theisen A, Rosenfeld JA, Shane K, McBride KL, Atkin JF, Gaba C, Hoo J, Kurczynski TW, Schnur RE, Coffey LB, Zackai EH, Schimmenti L, Friedman N, Zabukovec M, Ball S, Pagon R, Lucas A, Brasington CK, Spence JE, Sparks S, Banks V, Smith W, Friedberg T, Wyatt PR, Aust M, Tervo R, Crowley A, Skidmore D, Lamb AN, Ravnan B, Sahoo T, Schultz R, Torchia BS, Sgro M, Chitayat D, Shaffer LG (). Refinement of the region for split hand/foot malformation 5 on 2q31.1. Mol Syndromol, 1(5), 262-171.
  24. Theisen A, Rosenfeld JA, Shane K, McBride KL, Atkin JF, Gaba C, Hoo J, Kurczynski TW, Schnur RE, Coffey LB, Zackai EH, Schimmenti L, Friedman N, Zabukovec M, Ball S, Pagon R, Lucas A, Brasington CK, Spence JE, Sparks S, Banks V, Smith W, Friedberg T, Wyatt PR, Aust M, Tervo R, Crowley A, Skidmore D, Lamb AN, Ravnan B, Sahoo T, Schultz R, Torchia BS, Sgro M, Chitayat D, Shaffer LG (2010). Refinement of the Region for Split Hand/Foot Malformation 5 on 2q31.1. Mol Syndromol, 1(5), 262-271.
  25. Sahoo T, Theisen A, Rosenfeld JA, Torchia BS, Lamb AN, Schultz RA, Ravnan JB, Ballif BC, Bejjani BA, Shaffer LG (). Copy number variations of schizophrenia susceptibility loci are associated with a spectrum of neurodevelopmental impairments. American College of Medical Genetics Annual Clinical Genetics Meeting. Albuquerque, NM. Genet Med, 13(10), 868-80.
  26. Rosenfeld JA, Ballif BC, Torchia BS, Sahoo T, Ravnan JB, Schultz R, Lamb A, Bejjani BA, Shaffer LG (). Copy number variations associated with autism spectrum disorders contribute to a spectrum of neurodevelopmental disorders. Genet Med, 12, 694-702.
  27. Rosenfeld JA, Crolla JA, Tomkins S, Bader P, Morrow B, Gorski J, Troxell R, Forster-Gibson C, Cilliers D, Hislop RG, Lamb A, Torchia B, Ballif BC, Shaffer LG (2010 Aug). Refinement of causative genes in monosomy 1p36 through clinical and molecular cytogenetic characterization of small interstitial deletions. Am J Med Genet A, 152A(8), 1951-9.
  28. Alliman S, Coppinger J, Marcadier J, Thiese H, Brock P, Shafer S, Weaver C, Asamoah A, Leppig K, Dyack S, Morash B, Schultz R, Torchia BS, Lamb AN, Bejjani BA (2010 Aug). Clinical and molecular characterization of individuals with recurrent genomic disorder at 10q22.3q23.2. Clin Genet, 78(2), 162-8.
  29. Duker AL, Ballif BC, Bawle EV, Person RE, Mahadevan S, Alliman S, Thompson R, Traylor R, Bejjani BA, Shaffer LG, Rosenfeld JA, Lamb AN, Sahoo T (2010 Nov). Paternally inherited microdeletion at 15q11.2 confirms a significant role for the SNORD116 C/D box snoRNA cluster in Prader-Willi syndrome. Eur J Hum Genet, 18(11), 1196-201.
  30. South ST, Lamb AN (). Detecting genomic imbalances in prenatal diagnosis: main hurdles and recent advances. Expert Opin Med Diagn, 3(3), 1-9.
  31. Coppinger J, Alliman S, Lamb AN, Torchia BS, Bejjani BA, Shaffer LG (2009 Dec). Whole-genome microarray analysis in prenatal specimens identifies clinically significant chromosome alterations without increase in results of unclear significance compared to targeted microarray. Prenat Diagn, 29(12), 1156-66.
  32. Rowe LR, Chandler B, Gray J, Chen Z, Lamb AN, South ST (June 2008). Optimization and validation of an automated metaphase harvester. J Assoc Genet Technol, 34(2), 58-60.
  33. South ST, Rope AF, Lamb AN, Aston E, Glaus N, Whitby H, Maxwell T, Zhu XL, Brothman AR (2008 Jun). Expansion in size of a terminal deletion: a paradigm shift for parental follow-up studies. J Med Genet, 45(6), 391-5.
  34. Ravnan JB, Tepperberg JH, Papenhausen P, Lamb AN, Hedrick J, Eash D, Ledbetter DH, Martin CL (2006 Jun). Subtelomere FISH analysis of 11 688 cases: an evaluation of the frequency and pattern of subtelomere rearrangements in individuals with developmental disabilities. J Med Genet, 43(6), 478-89.
  35. Roberts AE, Cox GF, Kimonis V, Lamb A, Irons M (2004 Aug 1). Clinical presentation of 13 patients with subtelomeric rearrangements and a review of the literature. Am J Med Genet A, 128(4), 352-63.
  36. Donnenfeld AE, Lamb AN (2003). Cytogenetics and molecular cytogenetics in prenatal diagnosis. Clin Lab Med, 23, 457-480.
  37. Donnenfeld AE, Lockwood D, Custer T, Lamb AN (2002 Nov-Dec). Prenatal diagnosis from fetal urine in bladder outlet obstruction: success rates for traditional cytogenetic evaluation and interphase fluorescence in situ hybridization. Genet Med, 4(6), 444-7.
  38. Donnenfeld AE, Lockwood D, Lamb AN (2001 Oct). Prenatal diagnosis from cystic hygroma fluid: the value of fluorescence in situ hybridization. Am J Obstet Gynecol, 185(4), 1004-8.
  39. Estabrooks L, Lamb AN (2000). Prenatal interphase flourescence in situ hybridization (FISH). Contemp Ob-Gyn, 45(7), 68-87.
  40. Frizzley JK, Stephan MJ, Lamb AN, Jonas PP, Hinson RM, Moffitt DR, Shkolny DL, McDermid HE (1999 Mar). Ring 22 duplication/deletion mosaicism: clinical, cytogenetic, and molecular characterisation. J Med Genet, 36(3), 237-41.
  41. Estabrooks LL, Hanna JS, Lamb AN (1999 Feb). Overwhelming maternal cell contamination in amniotic fluid samples from patients with oligohydramnios can lead to false prenatal interphase FISH results. Prenat Diagn, 19(2), 179-81.
  42. Huang B, Lamb A, Dorian A, Brumblay J, Powell B (1999 Jul 16). Small supernumerary ring X chromosome in a four-month-old girl. Am J Med Genet, 85(2), 191-3.
  43. Huang B, Wang S, Ning Y, Lamb AN, Bartley J (1999 Dec 3). Autosomal XX sex reversal caused by duplication of SOX9. Am J Med Genet, 87(4), 349-53.
  44. Haung B, Ning Y, Lamb AN, Sandlin CJ, Jamehdor M, Reid T, Bartley J (1998). Identification of an unusual marker chromosome by spectral karyotyping. Am J Med Genet, 80, 368-372.
  45. Estop AM, Munne S, Cieply KM, Vandermark KK, Lamb AN, Fisch H (1998 Jan). Meiotic products of a Klinefelter 47,XXY male as determined by sperm fluorescence in-situ hybridization analysis. Hum Reprod, 13(1), 124-7.
  46. Chen Z, Notohamiprodjo M, Guan XY, Paietta E, Blackwell S, Stout K, Turner A, Richkind K, Trent JM, Lamb A, Sandberg AA (1998 Aug). Gain of 9p in the pathogenesis of polycythemia vera. Genes Chromosomes Cancer, 22(4), 321-4.
  47. Lanphear N, Lamb A, Oppenheimer S, Soukup S (1995 Jul 3). Supernumerary chromosome marker (1) in a developmentally delayed child. Am J Med Genet, 57(3), 400-2.
  48. Estabrooks LL, Lamb AN, Aylsworth AS, Callanan NP, Rao KW (1994 Feb). Molecular characterisation of chromosome 4p deletions resulting in Wolf-Hirschhorn syndrome. J Med Genet, 31(2), 103-7.
  49. Estabrooks LL, Lamb AN, Kirkman HN, Callanan NP, Rao KW (1992 Nov). A molecular deletion of distal chromosome 4p in two families with a satellited chromosome 4 lacking the Wolf-Hirschhorn syndrome phenotype. Am J Hum Genet, 51(5), 971-8.
  50. Lamb A, Tibbetts M, Hammond CI (1991 Apr). The product of the KIN1 locus in Saccharomyces cerevisiae is a serine/threonine-specific protein kinase. Yeast, 7(3), 219-28.
  51. Lloyd JA, Lamb AN, Potter SS (1987 Mar). Phylogenetic screening of the human genome: identification of differentially hybridizing repetitive sequence families. Mol Biol Evol, 4(2), 85-98.
  52. Kushnick T, Rao KW, Lamb AN (1984 Nov). Familial 5p- syndrome. Clin Genet, 26(5), 472-6.
  53. Shick JM, Taylor WF, Lamb AN (1981). Reproduction and genetic variation in the deposit-feeding sea star Ctenodiscus crispatus. Mar Biol, 63, 51-66.
  54. Shick JM, Hoffman RJ, Lamb AN (1979). Asexual reproduction, population structure, and genotype-environment interactions in sea anemones. Am Zool, 19, 699-713.
  55. Shick JM, Lamb AN (1977). Asexual reproduction and genetic population structure in the colonizing sea anemone Hapliplanella luciae. Biol Bull, 153, 604-617.

Review

  1. Lamb AN (2011 Dec). Laboratory aspects of prenatal microarray analysis. [Review]. Clin Lab Med, 31(4), 615-30, ix.
  2. Rodriguez-Revenga L, Mila M, Rosenberg C, Lamb AN, Lee C (September 2007). Structural variation in the human genome: the impact of copy number variants (CNV's) on clinical diagnosis. [Review]. Genet Med, 9(9), 600-606.

Book Chapter

  1. Hussong JW, Kjeldberg CR, eds (). : Laboratory Methods - Cytogenetics and Amniotic Fluid – Prenatal Diagnosis of chromosome abnormalities. In Hussong JW, Kjeldberg CR (Eds.), Kjeldberg’s Body Fluid Analysis (2nd, Chapter 2 and Chapter 3, pp. 26-28 and 39-40). American Society for Clinical Pathology.
  2. Donnenfeld AE, Lamb AN (2006). Cytogenetics and molecular cytogenetics. In Evans IM, Johnson MP, Yaron Y, Drugan A (Eds.), Prenatal Diagnosis (Ch 41, pp. 475-484). New York: McGraw-Hill.
  3. Lamb AN, Miller WA (2000). Prenatal Chromosome Diagnosis. In Mark HFL (Ed.), Medical Cytogenetics (8, pp. 191-211). New York: Marcel Dekker.

Case Report

  1. Shen W, Young BA, Bosworth M, Wright KE, Lamb AN, Ji Y (). Prenatal detection of uniparental disomy of chromosome 2 carrying a CHRND pathogenic variant that causes lethal multiple pterygium syndrome. Clin Genet, 93(6), 1248-1249.
  2. Richkind KE, Lamb A, Lytle C, Velasco J (). A third case of apparent t(2;4)(p23;q25) represents ins(2;4) with deletion of 2p. Leukemia. Leukemia, 10(11), 1847.
  3. David KL, Puno C, Rubenstein C, Lytle C, Lamb A (1994 Jun). Pathological case of the month. The use of fluorescence in situ hybridization technique to confirm an interchromosomal insertion. Arch Pediatr Adolesc Med, 148(6), 613-4.

Abstract

  1. Preston M, Torchia BS, Schultz RA, Ravnan JB, Sahoo T, Bejjani BA, Shaffer LG, Lamb AN (). Inherited large CNVs detected by microarray analysis: benign or clinically relevant? American College of Medical Genetics Annual Clinical Genetics Meeting. Albuquerque, NM [Abstract].
  2. Lamb AN, Coppinger J, Hall E, Thompson R, Bejjani BA, Shaffer LG, Ballif BC (). Defining the reisk for MCC interference with the interpretation of microarray results in a prenatal diagnostic setting. American College of Medical Genetics Annual Clinical Genetics Meeting. Albuquerque, NM [Abstract].
  3. Schultz RA, Rosenfeld JA, Bejjani BA, Shaffer LG, Lamb AN, Torchia BS, Ballif BC, Sulpizio S, Byerly S, McDaniel LD, Ma Q, Mitui M, Rogers B, Wilson KS, Pascual JM (). Array CGH is a useful diagnostic tool in the investigation and molecular classification of epilepsy. American College of Medical Genetics Annual Clinical Genetics Meeting. Albuquerque, NM [Abstract].
  4. Ballif BC, Torchia BS, Lamb AN, Schultz RA, Ravnan JB, Sahoo T, Bejjani BA, Shaffer LG (). The use of microarrays for the genotype-first approach to identification of novel microdeletion/microduplication syndromes and causative genes. American College of Medical Genetics Annual Clinical Genetics Meeting. Albuquerque, NM [Abstract].
  5. Lamb AN, Rosenfeld J, Keelean-Fuller D, Fan Z, Pouncey J, Stevens K, Mackay-Loder L, Terespolsky D, Rosenbaum K, Vallee S, Moeschler J, Dineen R, Hoganson G, Girirajan S, Eichler EE, Torchia BA, Shaffer LG (). Deletion of the SOX5 gene at 12p12.1 is associated with autistic-like behavior and severe language delays. American Society of Human Genetics Annual Meeting. Honolulu, HI [Abstract].
  6. Shaffer LG, Bejjani BA, Torchia BA, Schultz R, Sahoo T, Lamb A, Neill N, Ballif BC (). Uncovering complexity by microarray-based cytogenetics and FISH visualization: What have we been missing? American Society of Human Genetics Annual Meeting. Honolulu, HI [Abstract].
  7. Torchia BA, Bejjani BA, Schultz R, Lamb A, Shaffer LG (). Evaluation and interpretation of copy number variations identified by array CGH. American College of Medical Genetics Annual Clinical Genetics Meeting. Tampa, FL [Abstract].
  8. Coppinger J, Bejjani BA, Schultz R, Shaffer LG, Torchia BA, Lamb AN (). Array CGH characterizes abnormal prenatal karyotypes and identifies chromosome imbalances missed by conventional cytogenetics.
    Poster session, Am Soc Hum Genet, Honolulu, Hawaii
    [Abstract].
  9. Alliman S, Bejjani BA, Torchia B, Schultz R, Shaffer LG, Lamb AN, Coppinger J (). Array CGH has a 13% yield for clinically significant chromosome imbalances in prenatal samples of pregnancies that eventually resulted in loss or therapeutic termination. Poster session. Am Soc Hum Genet, Honolulu, Hawaii [Abstract].
  10. Rowe LR, Rector LS, Lamb AN, Brothman AR, South ST (). Validation of Fluorescence in Situ Hybridization Assays: BETAINV Versus Mean Plus 3 Standard Deviations for Calculation of Normal Cut-Off Values, American Cytogenetics Conference (ACC), Monterey, CA [Abstract].
  11. Rowe LR, Chandler B, Gray J, Chen Z, Lamb AN, South ST (June 2008). Optimization and Validation of an Automated Metaphase Harvester, 33rd Annual Meeting, Houston, TX [Abstract]. The Journal of the Association of Genetic Technologists, 34(2), 58-60.
  12. Sirko-Osadsa DA, Faulkner N, Rosenblum-Vos L, Lamb AN, Hallam S (March 17-20, 2005). Pathway to resolve apparent sex discrepancies for Fragile X specimens [Abstract]. ACMG/MOD Annual Clinical Genetics Meeting, Dallas, TX.
  13. Huang B, Lamb AN (2003). Refined risk of UPD associated with prenatally-detected inv dup(15) chromsomes [Abstract]. AJHG, 73(#879), 320.
  14. Roberts AE, Cox GF, Kimonis V, Lamb A, Irons MB (2003). Subtelomeric FISH testing: are we casting the net wide enough? [Abstract]. ACMG/MOD Annual Clinical Genetics Meeting, March 13-16, 2003, San Diego, CA. Genetics in Medicine, 5(#91), 223.
  15. Weinblatt VJ, Hansen J, Donnenfeld AE, Lamb AN, Wapner RJ (2002). Comparison of the efficacy of direct chromosome preparations to interphase fluorescence in situ hybridization (FISH) for rapid results in chorionic villus specimens (CVS) [Abstract]. ACMG.
  16. Donnenfeld AE, Lockwood DH, Custer T, Lamb AN (2001). Prenatal diagnosis from fetal urine in fetuses with bladder outlet obstruction [Abstract]. Am. J. Hum. Genet, Supplement, 69(#2883), 671.
  17. He M, Lytle C, Challinor P, Sapeta M, Ravnan B, Irons M, Lamb A (2001). A de novo 9q terminal deletion detected by subtelomere FISH analysis in a mildly affected child [Abstract]. Am. J. Hum. Genet, Supplement, 69(#702), 303.
  18. Battaglia A, Lewin SO, Bamshad M, Chen Z, Lamb AN, Plumbos JP, Berkhiem L, Carey JC (2001). 1p deletion syndrome: a common, important, and often missed cause of developmental delay/mental retardation [Abstract]. Am. J. Hum. Genet, Supplement, 69(#90), 193.
  19. Donnenfeld AE, Lockwood D, Lamb AN (March 1-4, 2001). Prenatal diagnosis from cystic hygroma fluid: the value of fluorescence in situ hybridization [Abstract]. ACMG/MOD, Miami, FL.
  20. Lamb AN, Lytle CL, Challinor P, Norvell P, Martinez L, Crenshaw D, Estabrooks LL (March 1-4, 2001). Subtelomere FISH analysis in a clinical referral population [Abstract]. ACMG/MOD, Miami, FL.
  21. Huang B, Wang S, Ning Y, Lamb AN, Bartley J (1999). Autosomal XX sex reversal caused by duplication of SOX9 [Abstract]. Am. J. Hum. Genet, Supplement, 65(#20), A6.
  22. Estabrooks LL, SAPETA M, Lytle C, Challinor P, Dietrich-Cook H, Crenshaw D, Norvell P, Shadoan P, McKnight R, Hunter N, Ravnan B, Mowery-Rushton P, Suri V, Lamb AN (1999). Prenatal interphase FISH using the Aneuvysion Probe set in over 10,000 samples [Abstract]. Am. J. Hum. Genet, Supplement, 65(#882), A162.
  23. Lamb AN, Lytle CH, Aylsworth AS, Powell, CM, Rao KW, Carey JC, Opitz JM, Viskochil DH, Brothman AR, Stephan M, Bartley JA, Hackbarth M, McCarthy D, Proffitt J (1999). Low proportion of subtelomeric rearrangements in a population of patients with mental retardation and dysmorphic features [Abstract]. Am. J. Hum. Genet, Supplement, 65(#924), A169.
  24. Wang Y-M, Fang W, Lee M-H, Morrison L, Legator M, Sepeta M, Wang B, Lamb A (1998). Identification of a de novo der(14) by multicolor FISH analysis [Abstract]. Am. J. Hum. Genet, Supplement, 63(#876), A143.
  25. Wang B-T, Fernandez M, Takacs J, Sapeta M, Challinor P, Estabrooks L, Barringer S, Lamb A (1998). Prenatal identification of multiple extra marker chromosomes by FISH in an infant with mild congenital anomalies [Abstract]. Am. J. Hum. Genet, Supplement, 63(#875), A154.
  26. Lamb AN, Estabrooks LL, Legator MS, Ramakrishnan R, Poole I, Piper J, Morrison LE (1998). Combinatorial 24 chromosome FISH for the identification of constitutional abnormalities: unbalanced translocations and analphoid marker chromosomes [Abstract]. Am. J. Hum. Genet, Supplement, 63, A142.
  27. Richkind KE, Chen Z, Lamb A, Estabrooks L, Velasco, Roherty S, Lytle C (1997). Clinical application of interphase FISH when diagnostic cytogenetic study is normal [Abstract]. ASH.
  28. Huang B, Ning Y, Sandlin C, Lamb A, Jamehdor M, Reid T, Bartley J (1997). Identification of a marker chromosome without detectable alpha satellite sequences by spectral karyotyping [Abstract]. Am. J. Hum. Genet, Supplement, 61, A2178.
  29. Sandlin CJ, Lamb AN, Kershberg HB, Precht KS, Lese CM, Ledbetter DH, Huang B (1997). Jumping translocations involving the Y chromosome in a family [Abstract]. Am. J. Hum. Genet, Supplement, 61, A793.
  30. Chen Z, NotohamiprodjoM, Guam XY, Blackwell, Stout K, Turner A, Richkind K, Trent J, Lamb A, Sanberg AA (1997). Amplification of 9p in the pathogenesis of polycythemia vera [Abstract]. Am. J. Hum. Genet, Supplement, 61, A680.
  31. Richkind KE, Lamb AN, Velasco J, Roherty S, Lytle C (1996). Significance of nonclonal abnormalities in cancer cytogenetics - evaluation of clonality by interphase cytogenetics [Abstract]. Am. J. Hum. Genet, Supplement, 59, A423.
  32. Wu BL, Scheider GH, Boles RG, Armfield K, Lamb A, Weremowicz S, Sandstrom M, Korf B (1996). Characterization of NF1 mutations by FISH: Large deletions, somatic mosaicism, and translocation identified in sporadic or familial cases of NF1 [Abstract]. Am. J. Hum. Genet, Supplement, 59, A764.
  33. Estabrooks LL, Lytle CH, Sapeta M, Sandow JM, Takacs JE, Hanna JS, Neu RN, Weiser JJ, Ward BE, Rao KW, Lamb AN (1996). Partial aneuploidy detected by prenatal interphase FISH analysis [Abstract]. Am. J. Hum. Genet, Supplement, 59, A2090.
  34. Carelli MP, Lamb AN, Estabrooks LL, Ward BE (1995). Prenatal interphase FISH analysis of amniocytes: Longitudinal study of accuracy and detection rates [Abstract]. Am. J. Hum. Genet, Supplement, 57, A50.
  35. Sandlin CI, Dodd BS, Dunman KW, Bartley JA, Bernstein R, Lamb A (1995). Phenotypes associated with terminal deletion of the short arm of chromosome 1 [Abstract]. Am. J. Hum. Genet, Supplement, 57, A125.
  36. Lamb AN, Pettenati M, Hanna J, Krasikov N, Neu R, Rao N, Weinstein M, Weiser J, Estabrooks L (1995). Six cases of satellited long arm of chromosome 2 detected during prenatal chromosome diagnosis [Abstract]. Am. J. Hum. Genet, Supplement, 57, A282.
  37. Olney PN, Korotkin J, Sanford Hanna J, Lamb A, Allitto BA, Hirsch R, Kupke K (1995). Prenatal diagnosis of a 46, XX male with SRY probe and FISH [Abstract]. Am. J. Hum. Genet, 5, A286.
  38. David KL, Rubenstein CT, Puno-Cocuzza C, Lamb A (1995). Long term follow-up of a prenatally diagnosed mosaic inv dup(15):clinical implications [Abstract]. Am. J. Hum. Genet, 57, A343.
  39. Richkind KE, Lamb AN, Wason D, Lytle C, Velasco J (1995). Prospective evaluation of FISH analysis for hematologic malignancies [Abstract]. Blood, 86(Suppl 1), 777a.
  40. Neu RL, Lamb AN, Allitto BA, Speer JW, Stiller RJ (March 6-9, 1995). Prenatal diagnosis of a 45,X,- 15,+der(15)t(Y;15)(q12;p11) fetus initially reported as 45,X,15p+ [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  41. Ward BE, Carelli MP, Lamb AN, Bryndorf T (March 6-9, 1995). Multicenter laboratory experience using Fluorescence In Situ Hybridization (FISH) for rapid detection of chromosomal aneuploidies in uncultured amniotic fluid cells [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  42. Lytle CH, Wright M, Courtwright J, Sapeta M, Takacs J, Ward BE, Lamb AN (March 6-9, 1995). Differences in the level of mosaicism in uncultured and cultured amniocytes as detected by Interphase FISH and cytogenetic analysis [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  43. Lytle CH, Wright M, Courtwright J, Sapeta M, Takacs J, Ward BE, Lamb AN (March 6-9, 1995). Differences in the level of mosaicism in uncultured and cultured amniocytes as detected by Interphase FISH and cytogenetic analysis [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  44. Hanna JS, Allitto BA, St Amant M, Coleman FH, Lamb AN (March 6-9, 1995). Prenatal diagnosis of satellited Yp: clinical significance and report of two cases [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  45. Estabrooks LL, Lytle CH, Cole J, Wagner S, Lamb AN (March 6-9, 1995). An inherited distal 9p+ chromosome without apparent clinical consequence [Abstract]. 2nd Joint Clinical Genetics Meeting, The 26th Annual March of Dimes Clinical Genetics Conference and The American College of Medical Genetics 2nd Annual Meeting. Los Angeles, California.
  46. Puder KS, Humes R, Gold RB, Bawle E, Lamb AN, Goyert GL (1994). Prenatal diagnosis of interrupted aortic arch prompting familial diagnosis of DiGeorge/velocardiofacial syndrome utilizing FISH techniques [Abstract]. Am. J. Hum. Genet, Supplement, 55, A285.
  47. Ward BE, Wright M, Lytle C, Theve R, Lamb A (1994). Prenatal aneuploidy detection by fluorescence in situ hybridization (FISH) in 1,068 second trimester pregnancies with fetal ultrasound abnormalities [Abstract]. Am. J. Hum. Genet, Supplement, 55, A289.
  48. Ward BE, Wright M, Lytle C, Theve R, Lamb A (1994). Prenatal aneuploidy detection by fluorescence in situ hybridization (FISH) in 1,068 second trimester pregnancies with fetal ultrasound abnormalities [Abstract]. Am. J. Hum. Genet, Supplement, 55, A289.
  49. Hajianpour MJ, Lamb A, Coyle M (1994). Intrafamilial and interfamilial variability of phenotype in familial velo-cardio-facial syndrome [Abstract]. Am. J. Hum. Genet, 5, A308.
  50. Travers H, Shapiro A, Bitran M, Lamb A, Ward BE, Weinstein ME (1994). Prenatal detection of rec(21)(p11q22) utilizing FISH [Abstract]. Am. J. Hum. Genet. Supplement, 55, A121.
  51. Lamb AN, Sapeta MJ, Portereiko MF, Courtright JS, Roherty SL, Lytle CH (March 13-17, 1994). Interphase FISH analysis for aneuploidy detection in uncultured amniocytes: clinical trial with 1000 specimens [Abstract]. March of Dimes 25th Clinical Genetics Conference/American College of Medical Genetics First Annual Meeting, Kissimmee, Florida.
  52. Simpson E, Randolph LM, Tom W, Lamb A (March 13-17, 1994). Apparently normal phenotype outcome of de novo 21qs detected prenatally [Abstract]. March of Dimes 25th Clinical Genetics Conference/American College of Medical Genetics First Annual Meeting, Kissimmee, Florida.
  53. Lamb AN, Lytle CH, Roherty SL (February 8-11, 1994). Identification of marker chromosomes detected prenatally and postnatally [Abstract]. FISH: Clinical Application in Cancer and Genetics, Lake Tahoe, California.
  54. Richkind K, Lytle C, Lamb AN, Wormsley S, Lemons R (February 8 11, 1994). Complex translocation involving chromosomes 4, 15, 17, and 19 in acute promyelocytic leukemia undetected by (15;17) cosmid probes [Abstract]. FISH: clinical Application in Cancer and Genetics; Lake Tahoe, California.
  55. Bonnet G, Lytle C, Wason D, Richkind KE, Lamb A (February 8-11, 1994). Use of bcr/abl probes and chromosome paints to confirm CML in patients with variant translocations or normal karyotypes [Abstract]. FISH: Clinical Applications in Cancer & Genetics; Lake Tahoe, California.
  56. Lamb AN, Lytle CH, Roherty SL, Sapeta M, Theves R, Ward BE (1993). Aneuploidy detection in uncultured amniocytes: Intersite transfer of interphase FISH technology [Abstract]. Am. J. Hum. Genet, Supplement, 53, 1802.
  57. Krasikov N, Lamb AN, Ventrano L, Hansen LE, Menges D, Lytle CH, Roherty SL, Davenport MB, Pauker S, Dolkart L, Davis G (1993). Benign variant 8p23.1? [Abstract]. Am. J. Hum. Genet, Supplement, 53, 568.
  58. Roherty S, Lytle CH, Lamb AN (1993). Discrepancy between cytogenetic and FISH analysis for deletion detection in Prader-Willi and Angelman syndromes [Abstract]. Am. J. Hum. Genet, Supplement, 53, 594.
  59. Randolph LM, Lamb AN (1993). Molecular confirmation of cytogenetic deletions is vital in Prader-Willi syndrome and Angelman syndrome [Abstract]. Am. J. Hum. Genet, Supplement, 53, 1752.
  60. David K, Rubenstein C, Lamb A, Naylor S (1993). Use of molecular technology to examine the cause of differing phenotypic expression within a family having an interchromosomal insertion [Abstract]. Am. J. Hum. Genet, Supplement, 53, 1726.
  61. Benn P, Craffey A, Ciarleglio L, Lamb A, Sanford-Hanna J, Krasikov N (1993). Maternal serum screening for Down Syndrome (DS) may also preferentially identify some fetuses with supernumerary "marker" chromosomes (SMCs [Abstract]. Am. J. Hum. Genet, Supplement, 53, 1382.
  62. Crandall BF, Lamb AN, Estabrooks LL (1993). A girl with an inverted duplicated Xq and an abnormal phenotype [Abstract]. Am. J. Hum. Genet, 53, 539.
  63. Towner J, Carvajal MV, Moscatello D, Lytle C, Gallagher T, Neu RL, Lacassie Y, Lamb AN (1993). Abnormal phenotype associated with an inherited and with a de novo inv dup(15)marker chromosome: Detection of euchromatic sequences using probes from the PWS/AS deletion regions [Abstract]. Am. J. Hum. Genet, Supplement, 53, 612.
  64. Towner J, Carvajal MV, Moscatello D, Lytle CH, Neu RL, Lamb AN, Lacassie Y (July 8-10, 1993). Abnormal phenotype associated with an inherited inv dup(15) marker chromosome: Detection of euchromatic sequences using probes from the PWS/AS deletion region [Abstract]. Southern Genetics Group, 16th Summer Meeting, Hilton Head, South Carolina.
  65. Saxon EH, Sliverstein M, Weinstein ME, Lytle CH, Roherty SL, Neu RL, Lamb AN (May 22 25, 1993). FISH as an adjunct to traditional cytogenetics in the prenatal diagnosis of supernumerary marker chromosomes [Abstract]. Association of Cytogenetic Technologists, 18th Annual Meeting, Boston, MA.
  66. Neu RL, Lytle CH, Ryan SL, Weinstein ME, Lamb AN (March 28-31, 1993). Examples of the practical application of FISH technology in the diagnostic cytogenetic laboratory [Abstract]. American Cytogenetics Conference, Port Ludlow, WA.
  67. Dowman AC, Lockwood DH, Lamb AN, Neu RL (1992). A survey of pericentric inversions of chromosomes 1, 2, 10, and Y and satellited Yq in prenatal cytogenetic studies: Frequencies and pregnancy outcomes [Abstract]. American Journal of Human Genetics, supplement 51, A288.
  68. Lytle C, Estabrooks L, Lamb A (July 12-15, 1992). Use of Flourescent in situ hybridization to determine the origin of the extra material in prenatally detected 15p+ chromosomes. Clinical and Molecular Cytogenetics of Developmental Disorders [Abstract]. 24th Annual March of Dimes Clinical Genetics Conference, Stanford University, Stanford, CA.
  69. Estabrooks L, Lamb A, Rao K (February 5-8, 1992). Detection of deletions and characterization of a de novo derivative chromosome by flourescent in situ hybridization (FISH) in patients with chromosome 4p16.3 rearrangements [Abstract]. International Symposium on Molecular Cytogenetics, Lake Tahoe, CA.
  70. Estabrooks, Lamb A, Aylsworth, Callanan, Farber, Vo, Carlock, Bengtsson, Wasmuth, Altherr, Rao (1991). Characterization of chromosome 4p deletions and rearrangements [Abstract]. American Journal of Human Genetics, Supplement 49, 297.
  71. Kepten, Highsmith, Friedman, Perry, Lamb A, Silverman (1991). A protocol for DNA based linkage analysis in Fragile X syndrome [Abstract]. Clinical Chemistry, 37, 1058.
  72. Lamb AN, Roche M, Kirkman N, Rao K, Aylsworth A (1990). A patient with a minute terminal deletion of chromosome 2 long arm [Abstract]. American Journal of Human Genetics, 47, 120.
  73. Lamb A, Estabrooks, Callanan, Friedman, Rao (1989). A satellited chromosome 4 in two families [Abstract]. American Journal of Human Genetics, 45, 310.
  74. Aylsworth, Horton, Ellison, Lamb A, Rao (May, 1989). Dysmorphogenesis in three constitutional diseases of bone: achondrogenesis, camptomelic dysplasia, and spondylocostal. (Platform Presentation) [Abstract]. David W. Smith Workshop on Malformations and Morphogenesis. Madrid, Spain.
  75. Potter, Bourekas, Lamb A, Lloyd, MdNeish, Pine, Smyth-Templeton (May, 1986). Phylogenetic screening for transposable elements, insertion of Drosophilia transposable elements into transgenic mice, and the nucleotide sequence of the loop of a complete foldback element [Abstract]. Eukaryotic Transposable Elements. Cold Spring Harbor, 40.
  76. Potter, Bourekas, Lamb A, Lloyd, MdNeish, Pine and Smyth-Templeton (May 1986). Phylogenetic screening for transposable elements, insertion of Drosophilia transposable elements into transgenic mice, and the nucleotide sequence of the loop of a complete foldback element [Abstract]. Eukaryotic Transposable Elements, Cold Spring Harbor, 40.
  77. Lamb AN, Rao KR (June 1982). An objective comparison of commercially available tissue culture media for amniotic fluid cell culture [Abstract]. 1982 Birth Defects Conference Program, 222.
  78. Beauregard LJ, Lamb AN (1979). Experiences with prenatal diagnosis of genetic disorders at Eastern Maine Medical Center [Abstract]. J. Maine Med. Assoc, 70, 286.
  79. Lamb AN, Beauregard LG (1978). The morphology of amniotic fluid cells and colonies in culture [Abstract]. Fourth Maine Biomedical Science Symposium, Orono, H6-7.
  80. Beauregard LJ, Lamb AN, Lamarche PH (1978). Clinical implications of fragile sites on human chromosomes [Abstract]. Fourth Maine Biomedical Science Symposium, Orono, H6-2.

Other

  1. Lamb AN (1988). The Characterization of the yeast KIN1 Gene Product. Ph.D. Dissertation, Wesleyan University, Middletown, CT, Department of Molecular Biology and Biochemistry (p. 77).
  2. Lamb AN (1982). A comparison of commercially available tissue culture media for the growth of amniotic fluid cells. M.S. Thesis, University of Maine at Orono (p. 53).