Don A. Delker, PhD
- Translational Bioinformatics
- Computational Biology
- Gene Expression
- Cancer Biology
- Departments: Internal Medicine - Research Assistant Professor
- Divisions: Gastroenterology
Academic Office Information
School of Medicine
30 N 1900 E
Salt Lake City, UT 84132
Don A. Delker, Ph.D. is a Research Assistant Professor in the Division of Gastroenterology, Hepatology and Nutrition. As a nationally recognized genomics scientist, his research interests include the discovery of gene profiles predictive of chemical toxicity and human disease. He specializes in RNA sequencing analysis of human biospecimens to identify novel expression patterns predictive of cancer risk.
Dr. Delker’s research includes the characterization of gene expression profiles in sessile serrated colon polyps (SSA/Ps). Approximately 20-30% of colon cancers are thought to arise from SSA/Ps. He uses next generation sequencing technology and custom bioinformatics programs to develop gene signatures that distinguish SSA/Ps from other colon polyp types. The goal of this research is to develop improved diagnostics for SSA/Ps since histologically they are often difficult to distinguish from other more benign polyps.
Dr. Delker is a long time member of the Society of Toxicology and is a councilor for the Stem Cell Specialty Section. He also serves as an Investigator on an international research team studying the toxicity of bromate, a disinfection byproduct found in drinking water. Dr. Delker received his Ph.D. in Pharmaceutical Sciences from the University of Connecticut. Previously, Dr. Delker served as Branch Chief of the Molecular Toxicology Branch at the National Health and Environmental Research Laboratory located in Research Triangle Park, North Carolina.
|Postdoctoral Fellowship||The Dow Chemical Company
|Doctoral Training||University of Connecticut
|Undergraduate||Brigham Young University
- Delker DA, McGettigan BM, Kanth P, Pop S, Neklason DW, Bronner MP, Burt RW, Hagedorn CH (2014). RNA sequencing of sessile serrated colon polyps identifies differentially expressed genes and immunohistochemical markers. PLoS One, 9(2), e88367.
- McFarland AP, Horner SM, Jarret A, Joslyn RC, Bindewald E, Shapiro BA, Delker DA, Hagedorn CH, Carrington M, Gale M Jr, Savan R (2014). The favorable IFNL3 genotype escapes mRNA decay mediated by AU-rich elements and hepatitis C virus-induced microRNAs. Nat Immunol, 15(1), 72-9.
- Kolisetty N, Delker DA, Muralidhara S, Bull RJ, Cotruvo JA, Fisher JW, Cummings BS (2013). Changes in mRNA and protein expression in the renal cortex of male and female F344 rats treated with bromate. Arch Toxicol, 87(11), 1911-25.
- Negash AA, Ramos HJ, Crochet N, Lau DT, Doehle B, Papic N, Delker DA, Jo J, Bertoletti A, Hagedorn CH, Gale M Jr (2013). IL-1beta production through the NLRP3 inflammasome by hepatic macrophages links hepatitis C virus infection with liver inflammation and disease. PLoS Pathog, 9(4), e1003330.
- Smalling RL, Delker DA, Zhang Y, Nieto N, McGuiness MS, Liu S, Friedman SL, Hagedorn CH, Wang L (2013). Genome-wide transcriptome analysis identifies novel gene signatures implicated in human chronic liver disease. Am J Physiol Gastrointest Liver Physiol, 305(5), G364-74.
- Folkers ME, Delker DA, Maxwell CI, Nelson CA, Schwartz JJ, Nix DA, Hagedorn CH (2011). ENCODE tiling array analysis identifies differentially expressed annotated and novel 5' capped RNAs in hepatitis C infected liver. PLoS ONE, 6(2), e14697.
- Delker D, Hatch G, Allen J, Crissman B, George M, Geter D, Kilburn S, Moore T, Nelson G, Roop B, Slade R, Swank A, Ward W, DeAngelo A (2006). Molecular biomarkers of oxidative stress associated with bromate carcinogenicity. Toxicology, 221(2-3), 158-65.
- Delker DA, Wang QS, Papanikolaou A, Whiteley HE, Rosenberg DW (1999). Quantitative assessment of azoxymethane-induced aberrant crypt foci in inbred mice. Exp Mol Pathol, 65(3), 141-9.