Yang, Jun , PhD

Languages

  • English

Academic Information

  • Departments: Neurobiology & Anatomy - Adjunct Associate Professor, Ophthalmology/Visual Sciences - Associate Professor, Surgery - Adjunct Assistant Professor
  • Divisions: Otolaryngology-Head and Neck Surgery

Email: u0635305@utah.edu

Education History

Type School Degree
Research Fellow Harvard Medical School, Massachusetts Eye and Ear Infirmary
Study of Retinal Degenerations
Research Fellow
Doctoral Training University of Massachusetts
Molecular and Cellular Biology
Ph.D.
Undergraduate Nankai University
Biomedical Sciences
B.S.

Global Impact

Education History

Type School Degree Country
Undergraduate Nankai University
Biomedical Sciences
B.S. China

Selected Publications

Journal Article

  1. Zou J, Li R, Wang Z, Yang J (). Studies of the periciliary membrane complex in the Syrian hamster photoreceptor. Adv Exp Med Biol.
  2. Tadenev ALD, Akturk A, Devanney N, Mathur PD, Clark AM, Yang J, Tarchini B (). GPSM2-GNAI specify the tallest stereocilia and define hair bundle row identity. Curr Biol.
  3. Sharif AS, Yu D, Loertscher S, Austin R, Nguyen K, Mathur PD, Clark AM, Zou J, Lobanova ES, Arshavsky VY, Yang J (). C8ORF37 is required for photoreceptor outer segment disc morphogenesis by maintaining outer segment membrane protein homeostasis. J Neurosci, 38(13), 3160-3176.
  4. Almishaal A, Mathur P, Hillas E, Chen L, Zhang A, Yang J, Wang Y, Yokoyama WM, Firpo MA, Park AH (). Natural killer cells attenuate cytomegalovirus-induced hearing loss in mice. PLoS Pathog, 13(8), e1006599.
  5. Zou J, Chen Q, Almishaal A, Mathur PD, Zheng T, Tian C, Zheng QY, Yang J (). The roles of USH1 proteins and PDZ domain-containing USH proteins in USH2 complex integrity in cochlear hair cells. Hum Mol Genet, 26(3), 624-636.
  6. Ciardo MG, Andres-Borderia A, Cuesta N, Valente P, Camprubi-Robles M, Yang J, Planells-Cases R, Ferrer-Montiel A (). Whirlin increases TRPV1 channel expression and cellular stability. Biochim Biophys Acta Mol Cell Res, 1863(1), 115-127.
  7. Mathur P, Vijayakumar S, Vashist D, Jones SM, Jones TA, Yang J (). A study of whirlin isoforms in the mouse vestibular system suggests potential vestibular dysfunction in DFNB31-deficient patients. Hum Mol Genet, 24(24), 7017-7030.
  8. Zou J, Mathur P, Zheng T, Wang Y, Almishaal A, Park A, Yang J (). Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle. Hum Mol Genet, 24(24), 6944-6957.
  9. Mathur P, Zou J, Zheng T, Almishaal A, Wang Y, Chen Q, Wang L, Vashist D, Brown S, Park A, Yang J (). Distinct expression and function of whirlin isoforms in the inner ear and retina: an insight into pathogenesis of USH2D and DFNB31. Hum Mol Genet, 24(21), 6213-6228.
  10. Chen Q, Zou J, Shen Z, Zhang W, Yang J (). Whirlin and PDZ domain containing 7 (PDZD7) proteins are both required to form the quaternary protein complex associated with Usher syndrome type 2. J Biol Chem, 289(52), 36070-36088.
  11. Zou J, Zheng T, Ren C, Askew C, Liu X, Pan B, Holt JR, Wang Y, Yang J (). Deletion of PDZD7 disrupts the Usher syndrome type 2 protein complex in cochlear hair cells and causes hearing loss in mice. Hum Mol Genet, 23(9), 2374-2390.
  12. Green JA, Yang J, Grati M, Kachar B, Bhat MA (). Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. BMC Neurosci, 14, 96.
  13. Zou J, Lee A, Yang J (). The expression of whirlin and Ca(v)1.3alpha(1) is mutually independent in photoreceptors. Vision Res, 75, 53 - 59.
  14. Wang L, Zou J, Shen Z, Song E, Yang J (). Whirlin interacts with espin and modulates its actin-regulatory function: an insight into the mechanism of Usher syndrome type II. Hum Mol Genet, 21(3), 692-710.
  15. Yang J, Wang L, Song H, Sokolov M (). Current understanding of Usher syndrome type II. Front Biosci, 17, 1165-1183.
  16. Zou JH, Luo L, Shen Z, Choido V, Ambati BK, Hauswirth WW, Yang J (In preparation). Whirlin replacement restores the formation of the USH2 protein complex in whirlin knockout photoreceptors. Invest Ophthalmol Vis Sci, 52, 2343-2351.
  17. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Sun X, McMillan DR, Liberman MC, Li T (In revision). Ablation of whirlin long isoform disrupts the USH2 protein complex and causes vision and hearing loss. PLoS Genet, 6(5), e1000955.
  18. Yang J, Pawlyk B, Wen X, Adamian M, Soloviev M, Michaud N, Zhao Y, Sandberg MA, Makino CL, Li T (2007). Mpp4 is required for proper localization of plasma membrane calcium ATPases and maintenance of calcium homeostasis at the rod photoreceptor synaptic terminals. Hum Mol Genet, 16, 1017-1029.
  19. Yang J, Adamian M, Li T (2006). Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells. Mol Biol Cell, 17, 1033-1040.
  20. Yang J, Li T (2005). The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Exp Cell Res, 309, 379-389.
  21. Yang J, Gao J, Adamian M, Wen X, Pawlyk B, Zhang L, Sanderson MJ, Zuo J, Makino CL, Li T (2005). The ciliary rootlet maintains long-term stability of the sensory cilia. Mol Cell Biol, 25, 4129-4137.
  22. Liu X, Bulgakov O, Wen X, Woodruff ML, Pawlyk B, Yang J, Fain GL, Sandberg MA, Makino CL, Li T (2004). AIPL1, the protein that is defective in Leber congenital amaurosis, is essential for the biosynthesis of retinal rod cGMP phosphodiesterase. Proc Natl Acad Sci U S A, 101, 13903-13908.
  23. Hong D, Pawlyk B, Sokolov M, Strissel KJ, Arshavsky VY, Yang J, Tulloch B, Wright AF, Li T (2003). RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia. Invest Ophthalmol Vis Sci, 44, 2413-2421.
  24. Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (2002). Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet. J Cell Biol, 159, 431-440.
  25. Yang J, Zoeller RT (2002). Differential display identifies neuroendocrine-specific protein-A (NSP-A) as an ethanol-responsive gene in the fetal rat brain. Brain Res Dev Brain Res, 138, 117-133.
  26. Zou X, Chen C, Yang J, Hu J, Hou Y (). Extraction of fructose 1,6-diphosphate from fermentation broth by ion-exchange process. Ion Exchange and Adsorption, 16(6), 528-533.
  27. Du H, Zou L, Ren R, Li N, Li J, Wang Y, Yang J, Xiong W, Xu Z (). PDZD7 long isoform is indispensable for stereocilia development and mechanotransduction in hair cells. Cell Rep.
  28. Almishaal AA, Sjogren P, Mathur PD, Hillas E, Johnson T, Price MS, Haller T, Yang J, Rajasekaran NS, Firpo MA, Park AH (). Reactive Oxygen Species and Hearing Loss in Murine CMV Labyrinthitis. Hear Res.

Review

  1. Mathur PD, Yang J (). Usher syndrome and non-syndromic deafness: functions of different whirlin isoforms in the cohclea, vestibular organs, and retina. [Review]. Hear Res, 375, 14-24.
  2. Mathur P, Yang J (). Usher syndrome: hearing loss, retinal degeneration and associated abnormalities. [Review]. BBA - Molecular Basis of Disease, 1852(3), 406-420.
  3. Yang J, Li T (2006). Rootletin. [Review]. Exp Eye Res, 83, 1-2.

Book Chapter

  1. Yang J (). Usher Syndrome: Genes, Proteins, Models, Molecular Mechanisms, and Therapies. In Sadaf Naz (Ed.), Hearing Loss (pp. 293-328). Rijeka: Intech, ISBN: 978-953-51-0366-0.
  2. Zou J, Li R, Wang Z, Yang J (). Studies of the periciliary membrane complex in the Syrian hamster photoreceptor. In Rickman CB (Ed.), Advances in Experimental Medicine and Biology.

Abstract

  1. Almishaal A, Mathur PD, Franklin L, Martinovic AM, Sivas KS, Jennings S, Yang J, Firpo M, Park A (). Synaptopathy may precede hearing loss in mice and humans post congenital cytomegalovirus infection [Abstract]. 42nd ARO MidWinter Meeting.
  2. Tadenev A, Akturk A, Devanney N, Mathur PD, Clark A, Yang J, Tarchini B (). GPSM2-GNAI specify the tallest stereocilia and define row identity in the hair bundle [Abstract]. 42nd ARO MidWinter Meeting.
  3. Goldberg H, Asai Y, Pan B, Isgrig K, Yang J, Chien WW, Geleoc GS (). AAV mediatedd gene therapy restores partial auditory sensitivity in mouse models of autosomal recessive non-syndromic deafness DFNB31 and Usher syndrome type IID [Abstract]. 42nd ARO MidWinter Meeting.
  4. Yu D, Zou J, Yang J (). Functional studies on USH2A and ADGRV1 in photoreceptors [Abstract]. XVIII International Symposium on Retinal Degeneration.
  5. Mathur PD, Almishaal AA, Vijaykumar S, Jones TA, Jones SM, Yang J, Firpo MA, Park AH (). Murine congenital cytomegalovirus infection leads to vestibular dysfunction [Abstract]. 2018 Association for Research in Otolaryngology Abstract Book.
  6. Goldberg H, Asai Y, Pan B, Chien WW, Yang J, Holt JR, Geleoc GS (). AAV mediated gene therapy restores partial auditory sensitivity in mouse models of autosomal recessive non syndromic deafness DFNB31 and Usher syndrome type IID [Abstract]. International Symposium on Usher Syndrome Abstract Book.
  7. Zou J, Chen Q, Almishaal A, Mathur PD, Zheng T, Tian C, Zheng QY, Yang J (). Roles of USH1 proteins and PDZ domain-containing USH proteins in the USH2 complex integrity in cochlear hair cells [Abstract]. 2017 Association for Research in Otolaryngology Abstract Book.
  8. Zou J, Mathur PD, Zheng T, Wang Y, Almishaal A, Park AH, Yang J (). Individual USH2 proteins make distinct contributions to the ankle link complex during development of the mouse cochlear stereociliary bundle [Abstract]. 2016 Association for Research in Otolaryngology Abstract Book.
  9. Sharif AS, Yu D, Zou J, Loertscher S, Clark A, Mathur P, Nguyen K, Yang J (). C8orf37 knockout mice display abnormal photoreceptor outer segment morphogenesis and progressive photoreceptor degeneration [Abstract]. 2016 Association for Research in Vision and Ophthalmology Abstract Book.
  10. Sjogren PP, Almishaal A, Johnson TS, Mathur P, Yang J, Firpo MA, Park AH (). The role of reactive oxygen species in cytomegalovirus induced hearing loss [Abstract]. ASPO meeting.
  11. Mathur P, Vijayakumar S, Vashist D, Jones SM, Jones TA, Yang J (). Mutation studies in mice reveal a potential vestibular dysfunction in USH2D and DFNB31 patients [Abstract]. 2015 ASCB Annual Meeting Abstract Book.
  12. Mathur P, Zou J, Zheng T, Almishaal A, Vashist D, Wang Y, Park A, Yang J (). Whirlin different regions have unique functions in the inner ear and retina [Abstract]. 38th Midwinter ARO Meeting Abstract Book.
  13. Sharif A, Zou J, Chen Q, Zhang W, Nguyen K, Yang J (). Understanding the role of C8orf37 in photoreceptors [Abstract]. Biology and Chemistry of Vision FASEB 2015 Meeting.
  14. Zou J, Zheng T, Ren C, Askew C, Liu X, Pan B, Holt JR, Wang Y, Yang J (). Deletion of PDZD7 disrupts the USH2 protein complex in cochlear hair cells and causes hearing loss in mice, Boston Massachusetts, USA [Abstract]. Usher Syndrome Coalition Interantional Symposium Program and Abstracts.
  15. Zou J, Zheng T, Yang J (). A study of PDZD7 in the mouse retina, 2014 ARVO meeting, Orlando, Florida, USA [Abstract]. 2014 ARVO meeting program.
  16. Chen Q, Vachali P, Shen Z, Yang J (). Understanding the formation of the USH2 complex using biochemical assays, Society for Neuroscience 2013 annual meeting, San Diego, California, USA [Abstract].
  17. Wang L, Zou J, Shen Z, Yang J (). Interaction of whirlin and espin provides a potential link between the USH2 complex and actin filaments [Abstract]. Investigative Ophthalmology & Visual Science, 52.
  18. Zou JH, Luo L, Chiodo V, Ambati BK, Hauswirth WW, Yang J (2010). AAV-mediated gene replacement therapy in a mouse model of Usher syndrome type II lacking whirlin [Abstract]. Investigative Ophthalmology & Visual Science, 51.
  19. Yang J, Liu X, Adamian M, Pawlyk BS, Sun X, McMillan DR, White PC, Liberman MC, Li T (2008). N-terminal mutation of whirlin disrupts the Usher Syndrome II (USH2) protein complex and causes retinal and inner ear defects in mice [Abstract]. Investigative Ophthalmology & Visual Science , 49, 4405.
  20. Yang J, Pawlyk B, Wen X-H, Adamian M, Zhao Y, Sandberg MA, Makino CL, Li T (2007). Mpp4 at the photoreceptor synaptic terminals: anchoring plasma membrane calcium ATPases and modulating calcium homeostasis [Abstract]. Investigative Ophthalmology & Visual Science, 48, 3069.
  21. Yang J, Liu X, Zhao Y, Adamian M, Pawlyk B, Li T (2006). Subcellular localization of whirlin and its interaction with Ush2A in the photoreceptors [Abstract]. Investigative Ophthalmology & Visual Science, 47, 2848.
  22. Yang J, Gao J, Adamian M, Wen X-H, Pawlyk B, Zuo J, Makino CL, Li T (2005). The ciliary rootlet provides structural support for photoreceptor outer segments [Abstract]. Investigative Ophthalmology & Visual Science, 46, 3974.
  23. Yang J, Li T (2003). Interaction of kinesin with rootletin recruits flotillin 1 and amyloid precursor protein along rootletin fibers [Abstract]. Molecular Biology of the Cell, 14, 426A.
  24. Yang J, Liu X, Adamian M, Bulgakov O, Li T (2002). Rootletin is the structural component of the vertebrate ciliary rootlet. Molecular Biology of the Cell [Abstract]. 13, 328A.
  25. Yang J, Zoeller RT (2000). Limited changes in patterns of gene expression in alcohol-treated rat fetal brain revealed by differential display and cDNA array. Society for Neuroscience 30th Annual Meeting. New Orleans, LA [Abstract].
  26. Yang J, Dowling ALS, Fletcher DL, Zoeller RT (1998). Identification of genes expressed in fetal cortex during cortical development that are affected by maternal ethanol consumption. Alcoholism: Clinical and Experimental Research [Abstract]. 22 , P55A.
  27. Zoeller RT, Fletcher D, Martz G, Dowling A, Yang J, Christie S, Crofton K (1998). Perinatal exposure to polychlorinated biphenyls increases circulating levels of T4, and TSH, and affects the expression of multiple genes in the brain of 200-day old rats [Abstract]. Thyroid, 8, 65.
  28. Dowling ALS, Yang J, Leonard J, Zoeller RT (1997). Identification of thyroid hormone regulated genes in the developing brain [Abstract]. Thyroid , 7, S-114.

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