Tim Jenkins, PhD

Research Interests

  • Sperm Epigenetic Research
  • Effect of Age on the Sperm Epigenome
  • Germline Aging Calculator

Languages

  • English

Academic Information

  • Departments: Surgery - Assistant Professor
  • Divisions: Urology

Academic Bio

Beyond his clinical studies, Dr. Jenkins brings extensive experience in epigenetic research. Since joining the Division of Urology he has specifically made significant strides in the field of sperm epigenetic research. Dr. Jenkins, in collaboration with Dr. Ki Aston and Dr. Douglas Carrell, has recently developed an algorithm using epigenetic signatures in the sperm to predict an individuals age. This novel tool has important basic science and clinical relevance as older men have been shown to father offspring with an increased likelihood of developing various neuropsychiatric disorders (autism, schizophrenia, bipolar disorder, etc.). Dr. Jenkins has also been recognized as an expert in the field of aging and epigenetic alterations associated with various forms of infertility. In fact, Dr. Jenkins received First Place honors from the American Urological Association in the 2016 ‘Early Career Investigator Showcase’ for his work on ‘Aging and the Male Gamete.'

Tim Jenkins received his B.S. in Physiology and Developmental Biology from Brigham Young University in 2008. He received his Ph.D. in Physiology from the University of Utah in 2013. Tim’s dissertation research evaluated the impact of age on male fertility and offspring health. Following completion of his Ph.D. he was offered a fellowship at the University of Utah and soon thereafter a faculty position with the Division of Urology. Tim’s research efforts as a faculty member at the University of Utah have been focussed on improving reproductive outcomes in patients with male factor infertility by optimizing clinical treatment options for couples seeking fertility care. One key project has been the improvement of sperm preparation procedures for intrauterine insemination with the use of microfluidic technology. This line of study is designed to improve the reliability of sperm preparation methods while decreasing exposures and stresses to sperm cells. As a result, the procedures being assessed have the capacity to increase success rates of commonly utilized assisted reproductive therapies. In his free time, he loves to spend time with his wife and three kids, fly fish, and mountain bike.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah School of Medicine
Postdoctoral Fellow
Doctoral Training University of Utah
Physiology
Ph.D.
Undergraduate Brigham Young University
Physiology and Developmental Biology
B.S.

Selected Publications

Journal Article

  1. Zhou J, Jenkins TG, Jung AM, Jeong KS, Zhai J, Jacobs ET, Griffin SC, Dearmon-Moore D, Littau SR, Peate WF, Ellis NA, Lance P, Chen Y, Burgess JL (2019). DNA methylation among firefighters. PLoS ONE, 14(3), e0214282.
  2. Jenkins TG, Aston KI, Cairns B, Smith A, Carrell DT (2018 Oct 22). Paternal germ line aging: DNA methylation age prediction from human sperm. BMC Genomics, 19(1), 763.
  3. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2018 May-Jun). Proton-pump inhibitor use does not affect semen quality in subfertile men. Asian J Androl, 20(3), 290-293.
  4. Jenkins TG, Liu L, Aston KI, Carrell DT (2018 Apr). Pre-screening method for somatic cell contamination in human sperm epigenetic studies. Syst Biol Reprod Med, 64(2), 146-155.
  5. R Samuel, N Miller, O Badamjav, T Jenkins, D Carrell, J Hotaling, BK Gale (). Design and operation of a microfluidic chip for trapping, and off-chip collection of a few human sperm. Journal of Micromechanics and Microengineering, 20(3), 290.
  6. Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI (2017 Nov). Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology, 5(6), 1089-1099.
  7. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2017 Oct). Impacts of Abstinence Time on Semen Parameters in a Large Population-based Cohort of Subfertile Men. Urology, 108, 90-95.
  8. Martin L, Mullaney S, Peche W, Peterson K, Chan S, Morton R, Wan Y, Zhang C, Presson AP, Emery B, Aston K, Jenkins T, Carrell D, Hotaling J (2017 Sep). Population-based Semen Analysis Results and Fertility Among Patients With Inflammatory Bowel Disease: Results From Subfertility Health Assisted Reproduction and the Environment (SHARE) Study. Urology, 107, 114-119.
  9. Jenkins TG, Aston KI, James ER, Carrell DT (2017 Apr). Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications. Syst Biol Reprod Med, 63(2), 69-76.
  10. Jenkins T, Shamsi MB, James E, Aston KI, Carrell DT (). Thermo stability of DNA methylation marks in human sperm. J Genet Genome Res, 4(1).
  11. Jenkins TG, Aston KI, Hotaling JM, Shamsi MB, Simon L, Carrell DT (2016 Sep). Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures. Andrology, 4(5), 843-9.
  12. Jenkins TG, Aston KI, Meyer TD, Hotaling JM, Shamsi MB, Johnstone EB, Cox KJ, Stanford JB, Porucznik CA, Carrell DT (2016 Jan). Decreased fecundity and sperm DNA methylation patterns. Fertil Steril, 105(1), 51-7.e1-3.
  13. Aston KI, Uren PJ, Jenkins TG, Horsager A, Cairns BR, Smith AD, Carrell DT (2015 Dec). Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril, 104(6), 1388-97.e1-5.
  14. Hotaling JM, Jenkins TG (2015 Sep). MicroRNA: a step beyond bulk seminal parameters? Fertil Steril, 104(3), 554.
  15. Ge SQ, Grifin J, Liu LH, Aston KI, Simon L, Jenkins TG, Emery BR, Carrell DT (2015 Aug 7). Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. Genet Mol Res, 14(3), 9053-61.
  16. Jenkins TG, Aston KI, Trost C, Farley J, Hotaling JM, Carrell DT (2015 Apr). Intra-sample heterogeneity of sperm DNA methylation. Mol Hum Reprod, 21(4), 313-9.
  17. Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT (2014 Jul). Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet, 10(7), e1004458.
  18. Jenkins TG, Aston KI, Cairns BR, Carrell DT (2013 Oct). Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril, 100(4), 945-51.
  19. Ge SQ, Jeanine G, Liu LH, Kenneth IA, Luke S, Timothy GJ, Benjamin RE, Douglas TC (2013 May). [Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. Hereditas, 35(5), 616-22.
  20. Jenkins TG, Carrell DT (2012). Dynamic alterations in the paternal epigenetic landscape following fertilization. Front Genet, 3, 143.
  21. Jenkins TG, Aston KI, Carrell DT (2011 May). Supplementation of cryomedium with ascorbic acid-2-glucoside (AA2G) improves human sperm post-thaw motility. Fertil Steril, 95(6), 2001-4.

Review

  1. Jenkins TG, Aston KI, Carrell DT (2018 Jul). Sperm epigenetics and aging. [Review]. Transl Androl Urol, 7(Suppl 3), S328-S335.
  2. Hanson BM, Aston KI, Jenkins TG, Carrell DT, Hotaling JM (2018 Feb). The impact of ejaculatory abstinence on semen analysis parameters: a systematic review. [Review]. J Assist Reprod Genet, 35(2), 213-220.
  3. R Samuel, H Feng, A Jafek, D Despain, T Jenkins, B Gale (). Microfluidic—based sperm sorting & analysis for treatment of male infertility. [Review]. Transl Androl Urol.
  4. James E, Jenkins TG (2018 Jan). Epigenetics, infertility, and cancer: future directions. [Review]. Fertil Steril, 109(1), 27-32.
  5. Craig JR, Jenkins TG, Carrell DT, Hotaling JM (2017 Apr). Obesity, male infertility, and the sperm epigenome. [Review]. Fertil Steril, 107(4), 848-859.
  6. Jenkins TG, Aston KI, Meyer T, Carrell DT (2015). The Sperm Epigenome, Male Aging, and Potential Effects on the Embryo. [Review]. Adv Exp Med Biol, 868, 81-93.
  7. Gannon JR, Emery BR, Jenkins TG, Carrell DT (2014). The sperm epigenome: implications for the embryo. [Review]. Adv Exp Med Biol, 791, 53-66.
  8. Jenkins TG, Carrell DT (2012 Jun). The sperm epigenome and potential implications for the developing embryo. [Review]. Reproduction, 143(6), 727-34.
  9. Jenkins TG, Carrell DT (2011 Jan). The paternal epigenome and embryogenesis: poising mechanisms for development. [Review]. Asian J Androl, 13(1), 76-80.

Book Chapter

  1. Carrell DT, Jenkins TG, Emery BR, Hotaling JM, Aston KI (). The Role of Reproductive Genetics in Modern Andrology. In Palermo GD and Sills ES (Eds.), Intracytoplasmic Sperm Injection: Indications, Techniques and Applications (pp. 23-38). Springer.
  2. Murphy K, Jenkins TG, Carrell DT (). How the father might epigenetically program the risk for developmental origins of health and disease effects in his offspring. In Rosenfeld C (Ed.), The Epigenome and Developmental Origins of Health and Disease. Elsevier.
  3. Gannon JR, Emery BR, Jenkins TG Carrell DT (). The sperm epigenome: Implications for the embryo. In Baldi E, Muratori M (Eds.), Genetic Damage in Human Spermatozoa, Adv Exp Med Biol. 791: 53-66.
  4. Jenkins TG, Aston KI, Carrell DT (). The Aging Male and Impact on Offspring. In Schlegel PN, Fauser BCJM, Carrell DT, Racowsky C (Eds.), Biennial Review of Infertility. New York, NY: Springer.
  5. Jenkins TG, Emery BR, Carrell DT (). Assays Used in the Study of Sperm Nuclear Proteins. In Zini A, Agarwal A (Eds.), Sperm Chromatin. New York, NY: Springer-Verlag.
  6. Jenkins TG, Carrell DT (). Nucleoprotein Assays. In Zini A, Agarwal A (Eds.), Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction. Springer.

Editorial

  1. Jenkins TG (2018 Jul 1). Semen parameter decline with advancing age: a cause for concern? Fertil Steril, 110(1), 54-55.
  2. Jenkins TG (2017 Oct). Semen characteristics and pregnancy loss: an important step in addressing a complex problem. Fertil Steril, 108(4), 598-599.

Abstract

  1. Jafek A, Brady H, Feng H, Hotaling JM, Carrell DT, Gale B, Samuel R, Aston KI, Jenkins TG (). Rapid microfluidic sperm preparation for intrauterine insemination. Presented at the 114th American Urological Association Annual Meeting, Chicago IL, May 3-6 [Abstract]. Journal of Urology, 201(S4).
  2. Jafek A, Feng H, Jenkins TG, Aston KI, Carrell DT, Gale B, Samuel R, Hotaling JM (). A novel microfluidic device to improve sperm searching in microdissection TESE samples. Presented at the 114tj American Urological Association Annual Meeting, Chicago IL, May 3-6 [Abstract]. Journal of Urology, 201(S4).
  3. Anderson R, Hanson H, Zhang C, Presson A, Kingbury M, Jenkins TG, Smith K, Hotaling JM (). The initial male infertility evaluation and pregnancy - what really matters? A study from the Utah Population Database using a predictive analysis model. Presented at the 114th American Urological Association Annual Meeting, Chicago IL, May 3-6 [Abstract]. Journal of Urology, 201(S4).
  4. Salas-Huetos A, Babio N, Carrell DT, Jenkins TG, Aston KI, Bullo M, Salas-Salvado J (). Adherece to the Mediterranean diet is positively associted with sperm motility: A cross-sectional analysis. Presented at the American Society of Andrology 44th Annual Conference, Chicago IL, April 6-9 [Abstract]. Andrology, 7(S1).
  5. Salas-Huetos A, James ER, Bullo M, Salas-Salvado J, Carrell DT, Aston KI, Jenkins TG (). Sperm DNA methylation changes after nut supplementation in healthy males consuming a western-style diet. Presented at The American Society of Andrology 44th Annual Conference, Chicago IL, April 6-9 [Abstract]. Andrology, 7(S1).
  6. Broberg D, Jenkins T, Aston KI, Carrell DT (). The combined effect of BMI and aging on DNA methylation signatures in human sperm [Abstract]. American Society of Andrology 43rd Annual Meeting, Portland, OR, April 21-24.
  7. Simon L, Jenkins T, Aston KI, Carrell DT (). Differential RNA expression in the sperm of couples with recurrent pregnancy loss [Abstract]. American Society of Andrology 43rd Annual Meeting, Portland, OR, April 21-24.
  8. Jenkins T, Aston KI, Carrell DT (). paterns of epigenetic instability provide novel insight into human sperm function as well as potential diagnostic utility [Abstract]. American Socity of Andrology 43rd Annual Meeting, Portland, OR, April 21-24.
  9. Aston KI, Murphy P, Jenkins T, Carrell DT, Cairns B (). Cigarette smoke-induced sperm DNA methylation (DNAME) changes in mice and partial recovery following smoking cessation [Abstract]. American Society of Andrology 43rd Annual Meeting, Portland, OR, April 21-24.
  10. Jenkins T, Samuel r, Jafek A, Feng H, Gale B, Carrell DT, Hotaling JM (). Rapid microfluidic sperm isolation from microtese samples in men with non-obstructive azoospermia. Scientific Congress of the American Society for Reproductive Medicine, San Antonio, TX, Oct 28-Nov 1 [Abstract].
  11. Jenkins T, Aston KI, Carrell DT (). Sperm aging calculator: DNA methylation-based assessment of "germ line age" and potential research and clinical applications. Scientific Congress of the American Society for Reproductive Medicine, San Antonio, TX, Oct 28-Nov 1 [Abstract].
  12. Craig JR, Keihani S, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (). Impact of abstinence time on semen parameters in a large population based cohort of subfertile men [Abstract]. Annual Meeting of the American Urological Association, Boston MA, May 12-16.
  13. James E, Jenkins T, Alonso D, Hotaling J, Carrell DT, Aston KI (). Sperm DNA methylation and epigenetic variability in tobacco smokers [Abstract]. At the Annual Meeting of the American Society of Andrology, Miami FL, April 21-25.
  14. Martin L, Peche W, Peterson K, Chan S, Morton R, Wan Yuan, Emery BR, Aston KI, Jenkins T, Presson A, Zhang C, Carrell DT, Hotaling JM (). Population-based semen analysis results among patients with inflammatory bowel disease [Abstract]. At the Annual Meeting of the American Society of Andrology, Miami FL, May 12-16.
  15. Jenkins T, Aston K, Hotaling J, Carrell D (). The impact of grand paternal aging on sperm DNA methylation patterns [Abstract]. 42nd Annual conference for the American Society of Andrology, Miami, FL, April 21-25.
  16. Jenkins T, Aston KI, Johnstone E, Carrell DT (). Sperm DNA methylation and recurrent miscarriage [Abstract]. XXIV North American Testis Workshop, Miami FL, April 17-22.
  17. Patel B, Johnstone EB, Presson A, Zhang C, Jenkins T, Aston KI, Carrell DT, Hotaling JM (). The Effect of ADHD Medications on Semen Analysis In Sub-Fertile Couples. 72nd American Society for Reproductive Medicine Scientific Congress & Expo, Oct. 15-19, Salt Lake City, UT [Abstract]. Fert & Steril, 106(3S), 197.
  18. Jenkins T, Carrell DT, Hotaling JM, Aston KI (). Cigarette Smoking and Associated Effects on the Rate of Aging in Sperm DNA Methylation Patterns. 72nd American Society for Reproductive Medicine Scientific Congress & Expo, Oct. 15-19, Salt Lake City, UT [Abstract]. Fert & Steril, 106(3S), 198.
  19. Son J, Gale B, Samuel R, Jafek A, Jenkins TG, Hotaling J, Carrell DT (). Purification of sperm from high WBC semen sample using a spiral channel [Abstract]. MicroTAS 2016: The 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Dublin, Ireland, October 9-13.

Other

  1. Trofimenko V, Jenkins TG, Carrell DT, Hotaling JM (). Genetics in Urology: A urologist's guide to the genetic revolution. CE Publication for Urologists.
  2. Jenkins TG, Trofimenko V, Hotaling JM (). Genetics in Urology: Is medicine now just a branch of genetics? CE Publication for Urologists.

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