Tim Jenkins, PhD

Research Interests

  • Sperm Epigenetic Research
  • Effect of Age on the Sperm Epigenome
  • Germline Aging Calculator

Languages

  • English

Academic Information

  • Departments: Surgery - Assistant Professor
  • Divisions: Urology

Academic Bio

Tim Jenkins received his B.S. in Physiology and Developmental Biology from Brigham Young University in 2008. He received his Ph.D. in Physiology from the University of Utah in 2013. Tim’s dissertation research evaluated the impact of age on male fertility and offspring health. Following completion of his Ph.D. he was offered a fellowship at the University of Utah and soon thereafter a faculty position with the Division of Urology. Tim’s research efforts as a faculty member at the University of Utah have been focussed on improving reproductive outcomes in patients with male factor infertility by optimizing clinical treatment options for couples seeking fertility care. One key project has been the improvement of sperm preparation procedures for intrauterine insemination with the use of microfluidic technology. This line of study is designed to improve the reliability of sperm preparation methods while decreasing exposures and stresses to sperm cells. As a result, the procedures being assessed have the capacity to increase success rates of commonly utilized assisted reproductive therapies. In his free time, he loves to spend time with his wife and three kids, fly fish, and mountain bike.

Education History

Type School Degree
Postdoctoral Fellowship University of Utah School of Medicine
Postdoctoral Fellow
Doctoral Training University of Utah
Physiology
Ph.D.
Undergraduate Brigham Young University
Physiology and Developmental Biology
B.S.

Selected Publications

Journal Article

  1. Samuel R, Feng H, Jafek A, Despain D, Jenkins T, Gale B (2018). Microfluidic-based sperm sorting & analysis for treatment of male infertility. Transl Androl Urol, 7(Suppl 3), S336-S347.
  2. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2018). Proton-pump inhibitor use does not affect semen quality in subfertile men. Asian J Androl, 20(3), 290-293.
  3. Jenkins TG, Liu L, Aston KI, Carrell DT (2018). Pre-screening method for somatic cell contamination in human sperm epigenetic studies. Syst Biol Reprod Med, 64(2), 146-155.
  4. Jenkins TG, James ER, Alonso DF, Hoidal JR, Murphy PJ, Hotaling JM, Cairns BR, Carrell DT, Aston KI (2017). Cigarette smoking significantly alters sperm DNA methylation patterns. Andrology, 5(6), 1089-1099.
  5. Keihani S, Craig JR, Zhang C, Presson AP, Myers JB, Brant WO, Aston KI, Emery BR, Jenkins TG, Carrell DT, Hotaling JM (2017). Impacts of Abstinence Time on Semen Parameters in a Large Population-based Cohort of Subfertile Men. Urology, 108, 90-95.
  6. Jenkins TG, Aston KI, James ER, Carrell DT (2017). Sperm epigenetics in the study of male fertility, offspring health, and potential clinical applications. Syst Biol Reprod Med, 63(2), 69-76.
  7. Jenkins T, Shamsi MB, James E, Aston KI, Carrell DT (2017). Thermo stability of DNA methylation marks in human sperm. J Genet Genome Res, 4(1).
  8. Jenkins TG, Aston KI, Hotaling JM, Shamsi MB, Simon L, Carrell DT (2016). Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures. Andrology, 4(5), 843-9.
  9. Jenkins TG, Aston KI, Meyer TD, Hotaling JM, Shamsi MB, Johnstone EB, Cox KJ, Stanford JB, Porucznik CA, Carrell DT (2016). Decreased fecundity and sperm DNA methylation patterns. Fertil Steril, 105(1), 51-7.e1-3.
  10. Aston KI, Uren PJ, Jenkins TG, Horsager A, Cairns BR, Smith AD, Carrell DT (2015). Aberrant sperm DNA methylation predicts male fertility status and embryo quality. Fertil Steril, 104(6), 1388-97.e1-5.
  11. Hotaling JM, Jenkins TG (2015). MicroRNA: a step beyond bulk seminal parameters? Fertil Steril, 104(3), 554.
  12. Ge SQ, Grifin J, Liu LH, Aston KI, Simon L, Jenkins TG, Emery BR, Carrell DT (2015). Associations of single nucleotide polymorphisms in the Pygo2 coding sequence with idiopathic oligospermia and azoospermia. Genet Mol Res, 14(3), 9053-61.
  13. Jenkins TG, Aston KI, Trost C, Farley J, Hotaling JM, Carrell DT (2015). Intra-sample heterogeneity of sperm DNA methylation. Mol Hum Reprod, 21(4), 313-9.
  14. Jenkins TG, Aston KI, Pflueger C, Cairns BR, Carrell DT (2014). Age-associated sperm DNA methylation alterations: possible implications in offspring disease susceptibility. PLoS Genet, 10(7), e1004458.
  15. Jenkins TG, Aston KI, Cairns BR, Carrell DT (2013). Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels. Fertil Steril, 100(4), 945-51.
  16. Ge SQ, Jeanine G, Liu LH, Kenneth IA, Luke S, Timothy GJ, Benjamin RE, Douglas TC (2013). [Association of single nucleotide polymorphisms(SNPs) in Pygo2 coding gene with idiopathic oligospermia and azoospermia]. Hereditas, 35(5), 616-22.
  17. Jenkins TG, Carrell DT (2012). Dynamic alterations in the paternal epigenetic landscape following fertilization. Front Genet, 3, 143.
  18. Jenkins TG, Aston KI, Carrell DT (2011). Supplementation of cryomedium with ascorbic acid-2-glucoside (AA2G) improves human sperm post-thaw motility. Fertil Steril, 95(6), 2001-4.

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