Robert A. Campbell, PhD


  • English

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor
  • Divisions: General Internal Medicine

Academic Office Information

  • 801-585-0706
  • George and Dolores Eccles Institute of Human Genetics
    15 N 2030 E, Room: 4225
    Salt Lake City, UT 84112

Education History

Type School Degree
Postdoctoral Fellowship University of Utah
Molecular Medicine
Postdoctoral Fellow
Postdoctoral Fellowship University of North Carolina at Chapel Hill
Pathology and Laboratory Medicine
Postdoctoral Fellow
Doctoral Training University of North Carolina at Chapel Hill
Pathology and Laboratory Medicine
Undergraduate Furman University

Selected Publications

Journal Article

  1. Rondina MT, Voora D, Simon LM, Schwertz H, Harper JF, Lee O, Bhatlekar SC, Li Q, Eustes AS, Montenont E, Campbell RA, Tolley ND, Kosaka Y, Weyrich AS, Bray PF, Rowley JW (2019). Longitudinal RNA-Seq Analysis of the Repeatability of Gene Expression and Splicing in Human Platelets Identifies a Platelet SELP Splice QTL. Circ Res, 126(4), 501-516.
  2. Denorme F, Manne BK, Portier I, Eustes AS, Kosaka Y, Kile BT, Rondina MT, Campbell RA (2019). Platelet necrosis mediates ischemic stroke outcome in mice. Blood, 135(6), 429-440.
  3. Azevedo-Quintanilha IG, Vieira-de-Abreu A, Ferreira AC, Reis PA, Silva TI, Nascimento DO, Campbell RA, Estato V, Weyrich AS, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC (2019). Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria. PLoS ONE, 14(12), e0224610.
  4. Bhatlekar S, Basak I, Edelstein LC, Campbell RA, Lindsey CR, Italiano JE Jr, Weyrich AS, Rowley JW, Rondina MT, Sola-Visner M, Bray PF (2019). Anti-apoptotic BCL2L2 increases megakaryocyte proplatelet formation in cultures of human cord blood. Haematologica, 104(10), 2075-2083.
  5. Middleton EA, Rowley JW, Campbell RA, Grissom CK, Brown SM, Beesley SJ, Schwertz H, Kosaka Y, Manne BK, Krauel K, Tolley ND, Eustes AS, Guo L, Paine R 3rd, Harris ES, Zimmerman GA, Weyrich AS, Rondina MT (2019). Sepsis alters the transcriptional and translational landscape of human and murine platelets. Blood, 134(12), 911-923.
  6. Montenont E, Rondina MT, Campbell RA (2020). Altered functions of platelets during aging. Curr Opin Hematol, 26(5), 336-342.
  7. Davizon-Castillo P, McMahon B, Aguila S, Bark D, Ashworth K, Allawzi A, Campbell RA, Montenont E, Nemkov T, DAlessandro A, Clendenen N, Shih L, Sanders NA, Higa K, Cox A, Padilla-Romo Z, Hernandez G, Wartchow E, Trahan GD, Nozik-Grayck E, Jones K, Pietras EM, DeGregori J, Rondina MT, Di Paola J (2019). TNF-α-driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging. Blood, 134(9), 727-740.
  8. Campbell RA, Cody MJ, Manne BK, Zimmerman GA, Yost CC (2019). Interleukin 6 receptor alpha expression in PMNs isolated from prematurely born neonates: decreased expression is associated with differential mTOR signaling. Pediatr Res, 86(1), 55-62.
  9. Campbell RA, Schwertz H, Hottz ED, Rowley JW, Manne BK, Washington AV, Hunter-Mellado R, Tolley ND, Christensen M, Eustes AS, Montenont E, Bhatlekar S, Ventrone CH, Kirkpatrick BD, Pierce KK, Whitehead SS, Diehl SA, Bray PF, Zimmerman GA, Kosaka Y, Bozza PT, Bozza FA, Weyrich AS, Rondina MT (2019). Human megakaryocytes possess intrinsic antiviral immunity through regulated induction of IFITM3. Blood, 133(19), 2013-2026.
  10. Fidler TP, Marti A, Gerth K, Middleton EA, Campbell RA, Rondina MT, Weyrich AS, Abel ED (2019). Glucose Metabolism Is Required for Platelet Hyperactivation in a Murine Model of Type 1 Diabetes. Diabetes, 68(5), 932-938.
  11. Manne BK, Mnzer P, Badolia R, Walker-Allgaier B, Campbell RA, Middleton E, Weyrich AS, Kunapuli SP, Borst O, Rondina MT (2018). PDK1 governs thromboxane generation and thrombosis in platelets by regulating activation of Raf1 in the MAPK pathway. J Thromb Haemost, 16(6), 1211-1225.
  12. Schwertz H, Rowley JW, Schumann GG, Thorack U, Campbell RA, Manne BK, Zimmerman GA, Weyrich AS, Rondina MT (2018). Endogenous LINE-1 (Long Interspersed Nuclear Element-1) Reverse Transcriptase Activity in Platelets Controls Translational Events Through RNA-DNA Hybrids. Arterioscler Thromb Vasc Biol, 38(4), 801-815.
  13. Campbell RA, Franks Z, Bhatnagar A, Rowley JW, Manne BK, Supiano MA, Schwertz H, Weyrich AS, Rondina MT (2018). Granzyme A in Human Platelets Regulates the Synthesis of Proinflammatory Cytokines by Monocytes in Aging. J Immunol, 200(1), 295-304.
  14. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 21(6), 1705.
  15. Campbell RA, Vieira-de-Abreu A, Rowley JW, Franks ZG, Manne BK, Rondina MT, Kraiss LW, Majersik JJ, Zimmerman GA, Weyrich AS (2017). Clots Are Potent Triggers of Inflammatory Cell Gene Expression: Indications for Timely Fibrinolysis. Arterioscler Thromb Vasc Biol, 37(10), 1819-1827.
  16. Fidler TP, Middleton EA, Rowley JW, Boudreau LH, Campbell RA, Souvenir R, Funari T, Tessandier N, Boilard E, Weyrich AS, Abel ED (2017). Glucose Transporter 3 Potentiates Degranulation and Is Required for Platelet Activation. Arterioscler Thromb Vasc Biol, 37(9), 1628-1639.
  17. Paul DS, Casari C, Wu C, Piatt R, Pasala S, Campbell RA, Poe KO, Ghalloussi D, Lee RH, Rotty JD, Cooley BC, Machlus KR, Italiano JE Jr, Weyrich AS, Bear JE, Bergmeier W (2017). Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice. Blood Adv, 1(18), 1398-1408.
  18. Fidler TP, Campbell RA, Funari T, Dunne N, Balderas Angeles E, Middleton EA, Chaudhuri D, Weyrich AS, Abel ED (2017). Deletion of GLUT1 and GLUT3 Reveals Multiple Roles for Glucose Metabolism in Platelet and Megakaryocyte Function. Cell Rep, 20(4), 881-894.
  19. Meidel ZM, Robinson R, Vieira-de-Abreu A, Gormley AJ, Ghandehari H, Grainger D, Campbell RA (2017). RGDfk-coated gold nanorods bind only to activated platelets. J Biomed Mater Res A, 105(1), 209-21.
  20. Nance D, Campbell RA, Rowley JW, Downie JM, Jorde LB, Kahr WH, Mereby SA, Tolley ND, Zimmerman GA, Weyrich AS, Rondina MT (2016). Combined variants in factor VIII and prostaglandin synthase-1 amplify hemorrhage severity across three generations of descendants. J Thromb Haemost, 14(11), 2230-2240.
  21. Yost CC, Schwertz H, Cody MJ, Wallace JA, Campbell RA, Vieira-de-Abreu A, Araujo CV, Schubert S, Harris ES, Rowley JW, Rondina MT, Fulcher JM, Koening CL, Weyrich AS, Zimmerman GA (2016). Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation. J Clin Invest, 126(10), 3783-3798.
  22. de Azevedo-Quintanilha IG, Vieira-de-Abreu A, Ferreira AC, Nascimento DO, Siqueira AM, Campbell RA, Teixeira Ferreira TP, Gutierrez TM, Ribeiro GM, E Silva PM, Carvalho AR, Bozza PT, Zimmerman GA, Castro-Faria-Neto HC (2016). Integrin alphaDbeta2 (CD11d/CD18) mediates experimental malaria-associated acute respiratory distress syndrome (MA-ARDS). Malaria Journal, 15(1), 393.
  23. Rowley JW, Chappaz S, Corduan A, Chong MM, Campbell R, Khoury A, Manne BK, Wurtzel JG, Michael JV, Goldfinger LE, Mumaw MM, Nieman MT, Kile BT, Provost P, Weyrich AS (2016). Dicer1-mediated miRNA processing shapes the mRNA profile and function of murine platelets. Blood, 127(14), 1743-51.
  24. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE Jr (2016). Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood, 127(11), 1468-80.
  25. Staddon JH, Smock KJ, Schiffman JD, Fluchel MN, Engel ME, Weyrich AS, Campbell RA (2015). Pegasparaginase treatment alters thrombin generation by modulating the protein C and S system in acute lymphoblastic leukaemia/lymphoma. Blood Coagul Fibrinolysis, 26(7), 840-3.
  26. Stefanini L, Paul DS, Robledo RF, Chan ER, Getz TM, Campbell RA, Kechele DO, Casari C, Piatt R, Caron KM, Mackman N, Weyrich AS, Parrott MC, Boulaftali Y, Adams MD, Peters LL, Bergmeier W (2015). RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest, 125(4), 1419-32.
  27. Shi DS, Smith MC, Campbell RA, Zimmerman PW, Franks ZB, Kraemer BF, Machlus KR, Ling J, Kamba P, Schwertz H, Rowley JW, Miles RR, Liu ZJ, Sola-Visner M, Italiano JE Jr, Christensen H, Kahr WH, Li DY, Weyrich AS (2014). Proteasome function is required for platelet production. J Clin Invest, 124(9), 3757-66.
  28. Major HD, Campbell RA, Silver RM, Branch DW, Weyrich AS (2014). Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia. Am J Obstet Gynecol, 210(6), 547.e1-7.
  29. Schmid DI, Schwertz H, Jiang H, Campbell RA, Weyrich AS, McIntyre TM, Zimmerman GA, Kraiss LW (2013). Translational control of JunB, an AP-1 transcription factor, in activated human endothelial cells. J Cell Biochem, 114(7), 1519-28.
  30. Franks Z, Campbell RA, Vieira de Abreu A, Holloway JT, Marvin JE, Kraemer BF, Zimmerman GA, Weyrich AS, Rondina MT (2013). Methicillin-resistant Staphylococcus aureus-induced thrombo-inflammatory response is reduced with timely antibiotic administration. Thromb Haemost, 109(4), 684-95.
  31. Kraemer BF, Campbell RA, Schwertz H, Franks ZG, Vieira de Abreu A, Grundler K, Kile BT, Dhakal BK, Rondina MT, Kahr WH, Mulvey MA, Blaylock RC, Zimmerman GA, Weyrich AS (2012). Bacteria differentially induce degradation of Bcl-xL, a survival protein, by human platelets. Blood, 120(25), 5014-20.
  32. Jones CF, Campbell RA, Brooks AE, Assemi S, Tadjiki S, Thiagarajan G, Mulcock C, Weyrich AS, Brooks BD, Ghandehari H, Grainger DW (2012). Cationic PAMAM dendrimers aggressively initiate blood clot formation. ACS Nano, 6(11), 9900-10.
  33. Jones CF, Campbell RA, Franks Z, Gibson CC, Thiagarajan G, Vieira-de-Abreu A, Sukavaneshvar S, Mohammad SF, Li DY, Ghandehari H, Weyrich AS, Brooks BD, Grainger DW (2012). Cationic PAMAM dendrimers disrupt key platelet functions. Mol Pharm, 9(6), 1599-611.
  34. Schwertz H, Rowley JW, Tolley ND, Campbell RA, Weyrich AS (2012). Assessing protein synthesis by platelets. Methods Mol Biol, 788, 141-53.
  35. Gray LD, Hussey MA, Larson BM, Machlus KR, Campbell RA, Koch G, Ezban M, Hedner U, Wolberg AS (2011). Recombinant factor VIIa analog NN1731 (V158D/E296V/M298Q-FVIIa) enhances fibrin formation, structure and stability in lipidated hemophilic plasma. Thromb Res, 128(6), 570-6.
  36. Kraemer BF, Campbell RA, Schwertz H, Cody MJ, Franks Z, Tolley ND, Kahr WH, Lindemann S, Seizer P, Yost CC, Zimmerman GA, Weyrich AS (2011). Novel anti-bacterial activities of beta-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation. PLoS Pathog, 7(11), e1002355.
  37. Rondina MT, Schwertz H, Harris ES, Kraemer BF, Campbell RA, Mackman N, Grissom CK, Weyrich AS, Zimmerman GA (2011). The septic milieu triggers expression of spliced tissue factor mRNA in human platelets. J Thromb Haemost, 9(4), 748-58.
  38. Campbell RA, Tolley ND, Schwertz H, Weyrich AS (2011). Platelet protein synthesis and translational control. Curr Proteomics, 8(3), 200-7.
  39. Carter JC, Campbell RA, Gibbons JA, Gramling MW, Wolberg AS, Church FC (2010). Enhanced cell-associated plasminogen activator pathway but not coagulation pathway activity contributes to motility in metastatic breast cancer cells. J Thromb Haemost, 8(6), 1323-32.
  40. Rowley JW, Weyrich AS, Campbell RA (2009). TGFBIp: more than meets the eye? Blood, 114(25), 5113-4.
  41. Campbell RA, Overmyer KA, Selzman CH, Sheridan BC, Wolberg AS (2009). Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability. Blood, 114(23), 4886-96.
  42. Campbell RA, Overmyer KA, Bagnell CR, Wolberg AS (2008). Cellular procoagulant activity dictates clot structure and stability as a function of distance from the cell surface. Arterioscler Thromb Vasc Biol, 28(12), 2247-54.
  43. Campbell RA, Fischer TH, Wolberg AS (2007). A novel approach to improving recombinant factor VIIa activity with a preserved platelet preparation. Br J Haematol, 138(1), 82-93.
  44. Allen GA, Persson E, Campbell RA, Ezban M, Hedner U, Wolberg AS (2007). A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia. Arterioscler Thromb Vasc Biol, 27(3), 683-9.


  1. Vieira-de-Abreu A, Campbell RA, Weyrich AS, Zimmerman GA (2012). Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum. [Review]. Semin Immunopathol, 34(1), 5-30.
  2. Franks ZG, Campbell RA, Weyrich AS, Rondina MT (2010). Platelet-leukocyte interactions link inflammatory and thromboembolic events in ischemic stroke. [Review]. Ann N Y Acad Sci, 1207, 11-7.
  3. Wolberg AS, Campbell RA (2008). Thrombin generation, fibrin clot formation and hemostasis. [Review]. Transfus Apheresis Sci, 38(1), 15-23.


  1. Campbell RA, Aleman M, Gray LD, Falvo MR, Wolberg AS (2010). Flow profoundly influences fibrin network structure: implications for fibrin formation and clot stability in haemostasis. [Letter to the editor]. Thromb Haemost, 104(6), 1281-4.