Lisa A. Lesniewski, MA, PhD

Labs

Lab Website

Languages

  • English

Academic Information

  • Departments: Internal Medicine - Associate Professor
  • Divisions: Geriatrics

Academic Office Information

  • 801-584-2522
  • VA - Building #2
    VA Salt Lake City GRECC 182
    500 S Foothill Dr
    Salt Lake City, UT 84148

Academic Bio

Dr. Lesniewski is an Associate Professor in the Division of Geriatrics and is an Adjunct Associate Professor with the Department of Nutrition and Integrative Physiology. She is a GRECC investigator and the Co-Principal Investigator of the Translational Vascular Physiology Lab.

Research Statement

Dr. Lesniewski's primary research interests are to understand how aging modulates the susceptibility of the vascular and metabolic systems to high fat feeding/obesity and to understand how aging modifies atherosclerotic burden and severity. Within these general research areas, Dr. Lesniewski examines the role that adipose inflammation plays in inducing systemic metabolic and vascular dysfunction with aging and high fat feeding, as well as the role of adipose tissue a in this systemic dysfunction. To examine these interests, Dr. Lesniewski utilizes dietary and genetic manipulation of rodent models to examine whole body and in vitro metabolic and vascular function. In addition, Dr. Lesniewski utilizes genetic and surgical models of atherosclerosis to elucidate novel pathways that modulate atheroslcerotic burden and severity across the lifespan.

Education History

Type School Degree
Postdoctoral Fellowship University of Colorado-Boulder
Physiology
Postdoctoral Fellow
Postdoctoral Fellowship University of California-San Diego
Endocrinology/Metabolism
Postdoctoral Fellow
Doctoral Training Texas A&M University
Exercise Physiology
Ph.D.
Graduate Training Kent State University
Exercise Physiology
M.A.
Undergraduate Ohio State University
Exercise Physiology
B.S.

Selected Publications

Journal Article

  1. Zhu W, Shi DS, Winter JM, Rich BE, Tong Z, Sorensen LK, Zhao H, Huang Y, Tai Z, Mleynek TM, Yoo JH, Dunn C, Ling J, Bergquist JA, Richards JR, Jiang A, Lesniewski LA, Hartnett ME, Ward DM, Mueller AL, Ostanin K, Thomas KR, Odelberg SJ, Li DY (2017). Small GTPase ARF6 controls VEGFR2 trafficking and signaling in diabetic retinopathy.LID - 10.1172/JCI91770 [doi]LID - 91770 [pii]. (Epub ahead of print) J Clin Invest.
  2. Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ (2016). Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient sensing, cell-cycle and senescence pathways. Aging Cell, 6, 17-26.
  3. Trott DW, Lesniewski LA, Donato AJ (2017). Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. Cytokine, 96, 102-106.
  4. Trott DW, Henson GD, Ho MH, Allison SA, Lesniewski LA, Donato AJ (2016). Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise.LID - S0531-5565(16)30348-5 [pii]LID - 10.1016/j.exger.2016.12.016 [doi]. (Epub ahead of print) Exp Gerontol.
  5. Hazra S, Henson GD, Morgan RG, Breevoort SR, Ives SJ, Richardson RS, Donato AJ, Lesniewski LA (2016). Experimental reduction of miR-92a mimics arterial aging. Exp Gerontol, 83, 165-70.
  6. Walker AE, Morgan RG, Ives SJ, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2016). Age-related arterial telomere uncapping and senescence is greater in women compared with men. Exp Gerontol, 73, 65-71.
  7. Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY (2015). Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium. PLoS One, 10(10), e0140370.
  8. Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ (2015). Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. J Physiol, 593(8), 1931-43.
  9. Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation, 131(3), 289-99.

Review

  1. Donato AJ, Morgan RG, Walker AE, Lesniewski LA (2015). Cellular and molecular biology of aging endothelial cells. [Review]. J Mol Cell Cardiol, 89(Pt B), 122-35.