Anthony J. Donato, PhD, MS

Languages

  • English

Academic Information

  • Departments: Biochemistry - Adjunct Associate Professor, Internal Medicine - Associate Professor, Nutrition and Integrative Physiology - Adjunct Associate Professor
  • Divisions: Geriatrics

Academic Office Information

  • 801-584-2522
  • VA - Building #2
    VA Salt Lake City GRECC
    500 S Foothill Dr
    Salt Lake City, UT 84148

Academic Bio

My primary research focus is vascular aging, in particular the cellular, molecular and tissue specific events that induce reductions in muscle blood flow during exercise, impair arterial endothelial function and stiffen large elastic arteries in older rodents/adults. These vascular phenotypes contribute to the age related decline in functional capacity and the development of cardiovascular disease, and can be ameliorated by lifestyle interventions such as habitual exercise and caloric restriction. My secondary focus, is to elucidate the cellular pathways which confer the vaso-protective effects of these lifestyle interventions and try to activate these pathways pharmacologically to see if this will confer some of the same benefits. I have used human, rodent, and cell models to address these questions and utilized a wide range of contemporary translational experimental techniques from microRNA gene expression to ultrasonography to investigate the aforementioned interests.

Education History

Type School Degree
Postdoctoral Fellowship University of Colorado, Department of Integrative Physiology
Integrative Physiology of Aging Laboratory, Dr. Doug Seals
Postdoctoral Fellow
Postdoctoral Fellowship University of California at San Diego, Department of Medicine, Dr. Russell Richardson
Postdoctoral Fellow
Doctoral Training Texas A&M University
Kinesiology
Ph.D.
Graduate Training University of Colorado, Boulder
Kinesiology and Applied Physiology
M.S.
Undergraduate University of Colorado, Boulder
Kinesiology
B.A.

Global Impact

Presentations

Description Country
"Telomere uncapping causes cellular senescence and inflammation in arteries: implications for arterial aging and hypertensionā€¯ First International Medical Science Summit of the Tongji Hospital Wuhan, China China

Selected Publications

Journal Article

  1. Yuen LH, Dana S, Liu Y, Bloom SI, Thorsell AG, Neri D, Donato AJ, Kireev D, Schuler H, Franzini RM (2019). A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD(+)-Dependent Enzymes. J Am Chem Soc, 141(13), 5169-5181.
  2. Hazra S, Henson GD, Bramwell RC, Donato AJ, Lesniewski LA (2019). Impact of high-fat diet on vasoconstrictor reactivity of white and brown adipose tissue resistance arteries. Am J Physiol Heart Circ Physiol, 316(3), H485-H494.
  3. Phuong TTT, Walker AE, Henson GD, Machin DR, Li DY, Donato AJ, Lesniewski LA (2019). Deletion of Robo4 prevents high-fat diet-induced adipose artery and systemic metabolic dysfunction. Microcirculation, e12540.
  4. Walker AE, Breevoort SR, Durrant JR, Liu Y, Machin DR, Dobson PS, Nielson EI, Meza AJ, Islam MT, Donato AJ, Lesniewski LA (2019). The pro-atherogenic response to disturbed blood flow is increased by a western diet, but not by old age. Sci Rep, 9(1), 2925.
  5. Morgan RG, Walker AE, Trott DW, Machin DR, Henson GD, Reihl KD, Cawthon RM, Denchi EL, Liu Y, Bloom SI, Phuong TT, Richardson RS, Lesniewski LA, Donato AJ (2019). Induced Trf2 deletion leads to aging vascular phenotype in mice associated with arterial telomere uncapping, senescence signaling, and oxidative stress. J Mol Cell Cardiol, 127, 74-82.
  6. Walker AE, Kronquist EK, Chinen KT, Reihl KD, Li DY, Lesniewski LA, Donato AJ (2019). Cerebral and skeletal muscle feed artery vasoconstrictor responses in a mouse model with greater large elastic artery stiffness.LID - 10.1113/EP087453 [doi]. (Epub ahead of print) Exp Physiol.
  7. Clifton HL, Machin DR, Groot HJ, Frech TM, Donato AJ, Richardson RS, Wray DW (2018). Attenuated nitric oxide bioavailability in systemic sclerosis: Evidence from the novel assessment of passive leg movement. Exp Physiol, 103(10), 1412-1424.
  8. Ungvari Z, Tarantini S, Donato AJ, Galvan V, Csiszar A (2018). Mechanisms of Vascular Aging. Circ Res, 123(7), 849-867.
  9. Donato AJ, Machin DR, Lesniewski LA (2018). Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease. Circ Res, 123(7), 825-848.
  10. Machin DR, Bloom SI, Campbell RA, Phuong TTT, Gates PE, Lesniewski LA, Rondina MT, Donato AJ (2018). Advanced age results in a diminished endothelial glycocalyx. Am J Physiol Heart Circ Physiol, 315(3), H531-H539.
  11. Trott DW, Henson GD, Ho MHT, Allison SA, Lesniewski LA, Donato AJ (2018). Age-related arterial immune cell infiltration in mice is attenuated by caloric restriction or voluntary exercise. Exp Gerontol, 109, 99-107.
  12. Morgan RG, Donato AJ, Walker AE (2018). Telomere uncapping and vascular aging. Am J Physiol Heart Circ Physiol, 315(1), H1-H5.
  13. Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ (2017). Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol, 313(5), H890-H895.
  14. Machin DR, Gates PE, Vink H, Frech TM, Donato AJ (2017). Automated Measurement of Microvascular Function Reveals Dysfunction in Systemic Sclerosis: A Cross-sectional Study. J Rheumatol, 44(11), 1603-1611.
  15. Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ (2017). Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis. Cell Metab, 26(3), 509-522.e6.
  16. Machin DR, Clifton HL, Richardson RS, Wray DW, Donato AJ, Frech TM (2017). Acute oral tetrahydrobiopterin administration ameliorates endothelial dysfunction in systemic sclerosis. Clin Exp Rheumatol, 35 Suppl 106(4), 167-172.
  17. Trott DW, Lesniewski LA, Donato AJ (2017). Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries. Cytokine, 96, 102-106.
  18. Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ (2017). Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell, 16(1), 17-26.
  19. Morgan RG, Venturelli M, Gross C, Tarperi C, Schena F, Reggiani C, Naro F, Pedrinolla A, Monaco L, Richardson RS, Donato AJ (2017). Age-Associated ALU Element Instability in White Blood Cells Is Linked to Lower Survival in Elderly Adults: A Preliminary Cohort Study. PLoS ONE, 12(1), e0169628.
  20. Bell ED, Donato AJ, Monson KL (2017). Cerebrovascular dysfunction following subfailure axial stretch. J Mech Behav Biomed Mater, 65, 627-633.
  21. Machin DR, Clifton HL, Garten RS, Gifford JR, Richardson RS, Wray DW, Frech TM, Donato AJ (2016). Exercise-induced brachial artery blood flow and vascular function is impaired in systemic sclerosis. Am J Physiol Heart Circ Physiol, 311(6), H1375-H1381.
  22. Machin DR, Leary ME, He Y, Shiu YT, Tanaka H, Donato AJ (2016). Ultrasound Assessment of Flow-Mediated Dilation of the Brachial and Superficial Femoral Arteries in Rats.LID - 10.3791/54762 [doi]. J Vis Exp, (117).
  23. Hazra S, Henson GD, Morgan RG, Breevoort SR, Ives SJ, Richardson RS, Donato AJ, Lesniewski LA (2016). Experimental reduction of miR-92a mimics arterial aging. Exp Gerontol, 83, 165-70.
  24. Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD (2016). Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. Circ Res, 118(5), 856-66.
  25. Trinity JD, Barrett-OKeefe Z, Ives SJ, Morgan G, Rossman MJ, Donato AJ, Runnels S, Morgan DE, Gmelch BS, Bledsoe AD, Richardson RS, Wray DW (2016). Endogenous endothelin-1 and femoral artery shear rate: impact of age and implications for atherosclerosis. J Hypertens, 34(2), 266-73.
  26. Walker AE, Morgan RG, Ives SJ, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2016). Age-related arterial telomere uncapping and senescence is greater in women compared with men. Exp Gerontol, 73, 65-71.
  27. Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR (2015). Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor kappa B signalling. J Hypertens, 33(12), 2477-82.
  28. Frech T, Walker AE, Barrett-OKeefe Z, Hopkins PN, Richardson RS, Wray DW, Donato AJ (2015). Systemic sclerosis induces pronounced peripheral vascular dysfunction characterized by blunted peripheral vasoreactivity and endothelial dysfunction. Clin Rheumatol, 34(5), 905-13.
  29. Barrett-OKeefe Z, Ives SJ, Trinity JD, Morgan G, Rossman MJ, Donato AJ, Runnels S, Morgan DE, Gmelch BS, Bledsoe AD, Richardson RS, Wray DW (2015). Endothelin-A-mediated vasoconstriction during exercise with advancing age. J Gerontol A Biol Sci Med Sci, 70(5), 554-65.
  30. Walker AE, Henson GD, Reihl KD, Morgan RG, Dobson PS, Nielson EI, Ling J, Mecham RP, Li DY, Lesniewski LA, Donato AJ (2015). Greater impairments in cerebral artery compared with skeletal muscle feed artery endothelial function in a mouse model of increased large artery stiffness. J Physiol, 593(8), 1931-43.
  31. Ghosh P, Mora Solis FR, Dominguez JM 2nd, Spier SA, Donato AJ, Delp MD, Muller-Delp JM (2015). Exercise training reverses aging-induced impairment of myogenic constriction in skeletal muscle arterioles. J Appl Physiol (1985), 118(7), 904-11.
  32. Gibson CC, Zhu W, Davis CT, Bowman-Kirigin JA, Chan AC, Ling J, Walker AE, Goitre L, Delle Monache S, Retta SF, Shiu YT, Grossmann AH, Thomas KR, Donato AJ, Lesniewski LA, Whitehead KJ, Li DY (2015). Strategy for identifying repurposed drugs for the treatment of cerebral cavernous malformation. Circulation, 131(3), 289-99.
  33. Gibson CC, Davis CT, Zhu W, Bowman-Kirigin JA, Walker AE, Tai Z, Thomas KR, Donato AJ, Lesniewski LA, Li DY (2015). Dietary Vitamin D and Its Metabolites Non-Genomically Stabilize the Endothelium. PLoS ONE, 10(10), e0140370.
  34. Tajbakhsh S, Aliakbari K, Hussey DJ, Lower KM, Donato AJ, Sokoya EM (2015). Differential Telomere Shortening in Blood versus Arteries in an Animal Model of Type 2 Diabetes. J Diabetes Res, 2015, 153829.
  35. Gano LB, Donato AJ, Pasha HM, Hearon CM Jr, Sindler AL, Seals DR (2014). The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol, 307(12), H1754-63.
  36. Donato AJ, Lesniewski LA, Stuart D, Walker AE, Henson G, Sorensen L, Li D, Kohan DE (2014). Smooth muscle specific disruption of the endothelin-A receptor in mice reduces arterial pressure, and vascular reactivity and affects vascular development. Life Sci, 118(2), 238-43.
  37. Donato AJ, Henson GD, Hart CR, Layec G, Trinity JD, Bramwell RC, Enz RA, Morgan RG, Reihl KD, Hazra S, Walker AE, Richardson RS, Lesniewski LA (2014). The impact of ageing on adipose structure, function and vasculature in the B6D2F1 mouse: evidence of significant multisystem dysfunction. J Physiol, 592(18), 4083-96.
  38. Venturelli M, Morgan GR, Donato AJ, Reese V, Bottura R, Tarperi C, Milanese C, Schena F, Reggiani C, Naro F, Cawthon RM, Richardson RS (2014). Cellular aging of skeletal muscle: telomeric and free radical evidence that physical inactivity is responsible and not age. Clin Sci (Lond), 127(6), 415-21.
  39. Morgan RG, Ives SJ, Walker AE, Cawthon RM, Andtbacka RH, Noyes D, Lesniewski LA, Richardson RS, Donato AJ (2014). Role of arterial telomere dysfunction in hypertension: relative contributions of telomere shortening and telomere uncapping. J Hypertens, 32(6), 1293-9.
  40. Walker AE, Henson GD, Reihl KD, Nielson EI, Morgan RG, Lesniewski LA, Donato AJ (2014). Beneficial effects of lifelong caloric restriction on endothelial function are greater in conduit arteries compared to cerebral resistance arteries. Age (Dordr), 36(2), 559-69.
  41. Henson GD, Walker AE, Reihl KD, Donato AJ, Lesniewski LA (2014). Dichotomous mechanisms of aortic stiffening in high-fat diet fed young and old B6D2F1 mice. Physiol Rep, 2(3), e00268.
  42. Lesniewski LA, Zigler ML, Durrant JR, Nowlan MJ, Folian BJ, Donato AJ, Seals DR (2013). Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise. Exp Gerontol, 48(11), 1218-25.
  43. Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR (2013). Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell, 12(5), 772-83.
  44. Morgan RG, Ives SJ, Lesniewski LA, Cawthon RM, Andtbacka RH, Noyes RD, Richardson RS, Donato AJ (2013). Age-related telomere uncapping is associated with cellular senescence and inflammation independent of telomere shortening in human arteries. Am J Physiol Heart Circ Physiol, 305(2), H251-8.
  45. Barrett-OKeefe Z, Ives SJ, Trinity JD, Morgan G, Rossman MJ, Donato AJ, Runnels S, Morgan DE, Gmelch BS, Bledsoe AD, Richardson RS, Wray DW (2013). Taming the "sleeping giant": the role of endothelin-1 in the regulation of skeletal muscle blood flow and arterial blood pressure during exercise. Am J Physiol Heart Circ Physiol, 304(1), H162-9.
  46. Park Y, Prisby RD, Behnke BJ, Dominguez JM 2nd, Lesniewski LA, Donato AJ, Muller-Delp J, Delp MD (2012). Effects of aging, TNF-alpha, and exercise training on angiotensin II-induced vasoconstriction of rat skeletal muscle arterioles. J Appl Physiol, 113(7), 1091-100.
  47. Ives SJ, Andtbacka RH, Park SY, Donato AJ, Gifford JR, Noyes RD, Lesniewski LA, Richardson RS (2012). Human skeletal muscle feed arteries: evidence of regulatory potential. Acta Physiol (Oxf), 206(2), 135-41.
  48. Donato AJ, Henson GD, Morgan RG, Enz RA, Walker AE, Lesniewski LA (2012). TNF-alpha impairs endothelial function in adipose tissue resistance arteries of mice with diet-induced obesity. Am J Physiol Heart Circ Physiol, 303(6), H672-9.
  49. Lesniewski LA, Zigler MC, Durrant JR, Donato AJ, Seals DR (2012). Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism. Mech Ageing Dev, 133(5), 368-71.
  50. Rippe C, Blimline M, Magerko KA, Lawson BR, LaRocca TJ, Donato AJ, Seals DR (2012). MicroRNA changes in human arterial endothelial cells with senescence: relation to apoptosis, eNOS and inflammation. Exp Gerontol, 47(1), 45-51.
  51. Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR (2011). Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell, 10(6), 1032-7.
  52. Donato AJ, Magerko KA, Lawson BR, Durrant JR, Lesniewski LA, Seals DR (2011). SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. J Physiol, 589(Pt 18), 4545-54.
  53. Lesniewski LA, Durrant JR, Connell ML, Henson GD, Black AD, Donato AJ, Seals DR (2011). Aerobic exercise reverses arterial inflammation with aging in mice. Am J Physiol Heart Circ Physiol, 301(3), H1025-32.
  54. Gano LB, Donato AJ, Pierce GL, Pasha HM, Magerko KA, Roeca C, Seals DR (2011). Increased proinflammatory and oxidant gene expression in circulating mononuclear cells in older adults: amelioration by habitual exercise. Physiol Genomics, 43(14), 895-902.
  55. Lesniewski LA, Durrant JR, Connell ML, Folian BJ, Donato AJ, Seals DR (2011). Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation. J Gerontol A Biol Sci Med Sci, 66(4), 409-18.
  56. Wray DW, Nishiyama SK, Donato AJ, Carlier P, Bailey DM, Uberoi A, Richardson RS (2011). The paradox of oxidative stress and exercise with advancing age. Exerc Sport Sci Rev, 39(2), 68-76.
  57. Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL (2010). Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev, 131(11-12), 739-42.
  58. Wray DW, Nishiyama SK, Donato AJ, Richardson RS (2010). Human vascular aging: limb-specific lessons. Exerc Sport Sci Rev, 38(4), 177-85.
  59. Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D (2010). Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell, 9(3), 304-12.
  60. Walker AE, Seibert SM, Donato AJ, Pierce GL, Seals DR (2010). Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension, 55(2), 363-9.
  61. Donato AJ, Uberoi A, Bailey DM, Wray DW, Richardson RS (2010). Exercise-induced brachial artery vasodilation: effects of antioxidants and exercise training in elderly men. Am J Physiol Heart Circ Physiol, 298(2), H671-8.
  62. Silver AE, Christou DD, Donato AJ, Beske SD, Moreau KL, Magerko KA, Seals DR (2010). Protein expression in vascular endothelial cells obtained from human peripheral arteries and veins. J Vasc Res, 47(1), 1-8.
  63. Donato AJ, Pierce GL, Lesniewski LA, Seals DR (2009). Role of NFkappaB in age-related vascular endothelial dysfunction in humans. Aging, 1(8), 678-80.
  64. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR (2009). Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol, 297(1), H425-32.
  65. Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA (2009). Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol, 587(Pt 13), 3271-85.
  66. Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR (2009). B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. J Gerontol A Biol Sci Med Sci, 64(1), 9-20.
  67. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR (2008). Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell, 7(6), 805-12.
  68. Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR (2008). Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol, 105(4), 1359-63.
  69. Pierce GL, Beske SD, Lawson BR, Southall KL, Benay FJ, Donato AJ, Seals DR (2008). Weight loss alone improves conduit and resistance artery endothelial function in young and older overweight/obese adults. Hypertension, 52(1), 72-9.
  70. Colleran PN, Behnke BJ, Wilkerson MK, Donato AJ, Delp MD (2008). Simulated microgravity alters rat mesenteric artery vasoconstrictor dynamics through an intracellular Ca(2+) release mechanism. Am J Physiol Regul Integr Comp Physiol, 294(5), R1577-85.
  71. Lesniewski LA, Donato AJ, Behnke BJ, Woodman CR, Laughlin MH, Ray CA, Delp MD (2008). Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension. Am J Physiol Heart Circ Physiol, 294(4), H1840-50.
  72. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ (2007). High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol, 103(5), 1715-21.
  73. Wray DW, Nishiyama SK, Donato AJ, Sander M, Wagner PD, Richardson RS (2007). Endothelin-1-mediated vasoconstriction at rest and during dynamic exercise in healthy humans. Am J Physiol Heart Circ Physiol, 293(4), H2550-6.
  74. Prisby RD, Ramsey MW, Behnke BJ, Dominguez JM 2nd, Donato AJ, Allen MR, Delp MD (2007). Aging reduces skeletal blood flow, endothelium-dependent vasodilation, and NO bioavailability in rats. J Bone Miner Res, 22(8), 1280-8.
  75. Donato AJ (2007). Ageing and vascular adrenoceptor desensitization: too little, too late? J Physiol, 582(Pt 1), 9-10.
  76. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR (2007). Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res, 100(11), 1659-66.
  77. Richardson RS, Donato AJ, Uberoi A, Wray DW, Lawrenson L, Nishiyama S, Bailey DM (2007). Exercise-induced brachial artery vasodilation: role of free radicals. Am J Physiol Heart Circ Physiol, 292(3), H1516-22.
  78. Donato AJ, Lesniewski LA, Delp MD (2007). Ageing and exercise training alter adrenergic vasomotor responses of rat skeletal muscle arterioles. J Physiol, 579(Pt 1), 115-25.
  79. Silver AE, Beske SD, Christou DD, Donato AJ, Moreau KL, Eskurza I, Gates PE, Seals DR (2007). Overweight and obese humans demonstrate increased vascular endothelial NAD(P)H oxidase-p47(phox) expression and evidence of endothelial oxidative stress. Circulation, 115(5), 627-37.
  80. Wray DW, Donato AJ, Nishiyama SK, Richardson RS (2007). Acute sympathetic vasoconstriction at rest and during dynamic exercise in cyclists and sedentary humans. J Appl Physiol, 102(2), 704-12.
  81. Behnke BJ, Prisby RD, Lesniewski LA, Donato AJ, Olin HM, Delp MD (2006). Influence of ageing and physical activity on vascular morphology in rat skeletal muscle. J Physiol, 575(Pt 2), 617-26.
  82. Donato AJ, Uberoi A, Wray DW, Nishiyama S, Lawrenson L, Richardson RS (2006). Differential effects of aging on limb blood flow in humans. Am J Physiol Heart Circ Physiol, 290(1), H272-8.
  83. Wray DW, Donato AJ, Uberoi A, Merlone JP, Richardson RS (2005). Onset exercise hyperaemia in humans: partitioning the contributors. J Physiol, 565(Pt 3), 1053-60.
  84. Donato AJ, Lesniewski LA, Delp MD (2005). The effects of aging and exercise training on endothelin-1 vasoconstrictor responses in rat skeletal muscle arterioles. Cardiovasc Res, 66(2), 393-401.
  85. Spier SA, Delp MD, Meininger CJ, Donato AJ, Ramsey MW, Muller-Delp JM (2004). Effects of ageing and exercise training on endothelium-dependent vasodilatation and structure of rat skeletal muscle arterioles. J Physiol, 556(Pt 3), 947-58.
  86. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H (2003). Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res, 57(3), 861-8.
  87. Moreau KL, Donato AJ, Tanaka H, Jones PP, Gates PE, Seals DR (2003). Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol, 547(Pt 1), 309-16.
  88. Donato AJ, Tench K, Glueck DH, Seals DR, Eskurza I, Tanaka H (2003). Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance. J Appl Physiol, 94(2), 764-9.
  89. Bell C, Monahan KD, Donato AJ, Hunt BE, Seals DR, Beck KC (2003). Use of acetylene breathing to determine cardiac output in young and older adults. Med Sci Sports Exerc, 35(1), 58-64.
  90. Miyachi M, Donato AJ, Yamamoto K, Takahashi K, Gates PE, Moreau KL, Tanaka H (2003). Greater age-related reductions in central arterial compliance in resistance-trained men. Hypertension, 41(1), 130-5.
  91. Moreau KL, Donato AJ, Seals DR, Dinenno FA, Blackett SD, Hoetzer GL, Desouza CA, Tanaka H (2002). Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol, 283(4), H1409-17.
  92. Eskurza I, Donato AJ, Moreau KL, Seals DR, Tanaka H (2002). Changes in maximal aerobic capacity with age in endurance-trained women: 7-yr follow-up. J Appl Physiol, 92(6), 2303-8.