Dinesh Verma, PhD

Languages

  • English
  • Hindi

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor
  • Divisions: Infectious Diseases

Academic Office Information

  • 801-585-9010
  • Maxwell M. Wintrobe Research and Education Building
    26 N Medical Dr, Room: 527
    Salt Lake City, UT 84132

Academic Bio

Dr. Dinesh Verma received his Ph.D in Biotechnology from Panjab University Chandigarh, India in 2006. He performed Ph.D research work at Postgraduate Institute of Medical Education and Research, Chandigarh, India. He worked as a postdoctoral fellow in the Department of Internal Medicine, Division of Infectious Diseases at University of Florida from April 2006-Sept.2010. He joined University of Utah School of Medicine, Division of Infectious Diseases in October 2010 as a Senior Postdoctoral Research Associate. He was appointed as Research Assistant Professor in October 2011.
Dr. Verma research involves understanding the pathogenesis of tumor viruses, specifically Epstein Barr Virus (EBV) and Kaposi’s sarcoma associated herpesvirus (KSHV). Both viruses undergo lytic replication in epithelial cells during primary infection and during reactivation from latent infection in B-lymphocytes. Epstein Barr virus SM is an RNA binding protein essential for viral replication that enhances EBV gene expression by enhancing RNA stability and RNA export. Dr. Verma has shown that SM interacts with cellular splicing factors and influences splicing of both EBV and cellular pre-mRNAs. Like EBV SM, KSHV ORF57 is also a post-transcriptional regulatory protein, essential for KSHV lytic replication and has high degree of gene specificity. His current research is focused on regulation of gene expression and antiviral drug screening in the following areas:
A. Mechanism and regulation of EBV SM mediated RNA splicing.
B. Role of cellular splicing factors in viral gene regulation.
C. Gene specific effect of ORF57 on KSHV lytic replication and cellular gene expression.
D. Development of a cell-based assay for screening compounds that inhibit EBV SM function and test antiviral activity against human herpesviruses.

Education History

Type School Degree
Postdoctoral Training University of Utah
Virology
Postdoctoral Training
Postdoctoral Training University of Florida
Virology
Postdoctoral Training
Research Fellow Council of Scientific and Industrial Research
Senior Research Fellow
Doctoral Training Panjab University
Biotechnology
Ph.D.
Research Fellow Indian Council of Medical Research
Senior Research Fellow
Graduate Training Dr. Ram Manohar Lohia Avadh University
Microbiology
M.Sc.
Undergraduate Dr. Ram Manohar Lohia Avadh University
Biology
B.Sc.

Global Impact

Education History

Type School Degree Country
Research Fellow Council of Scientific and Industrial Research
Senior Research Fellow India
Doctoral Training Panjab University
Biotechnology
Ph.D. India
Research Fellow Indian Council of Medical Research
Senior Research Fellow India
Graduate Training Dr. Ram Manohar Lohia Avadh University
Microbiology
M.Sc. India
Undergraduate Dr. Ram Manohar Lohia Avadh University
Biology
B.Sc. India

Selected Publications

Journal Article

  1. Verma D, Church TM, Swaminathan S (2020). Epstein–Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters. Proc Natl Acad Sci U S A.
  2. Martin RM, Burke K, Verma D, Xie H, Langer J, Schlaberg R, Swaminathan S, Hanson KE (2020). Contact Transmission of Vaccinia to an Infant Diagnosed by Viral Culture and Metagenomic Sequencing. Open Forum Infect Dis, 7(4).
  3. Li D, Mosbruger T, Verma D, Swaminathan S (2020). Complex Interactions between Cohesin and CTCF in Regulation of Kaposi’s Sarcoma-Associated Herpesvirus Lytic Transcription. J Virol, 94(2).
  4. Fu W, Verma D, Burton A, Swaminathan S (2019). Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication. . J Virol, 15(93), 1244-18.
  5. Church TM, Verma D, Thompson J, Swaminathan S (12/20/2017). Efficient translation of EBV DNA polymerase contributes to the enhanced lytic replication phenotype of M81 EBV. J Virol, 92(6).
  6. Verma D, Thompson J, Swaminathan S (03/29/2016). Spironolactone blocks Epstein-Barr virus production by inhibiting EBV protein SM function. Proc Natl Acad Sci U S A, 111(13).
  7. Thompson J, Verma D, Li D, Mosbruger T, Swaminathan S (01/15/2016). Identification and Characterization of the Physiological Gene Targets of the Essential Lytic Replicative EBV SM Protein. J Virol.
  8. Verma D, Li DJ, Krueger B, Renne R, Swaminathan S (02/01/2015). Identification of the physiological gene targets of the essential lytic replicative KSHV ORF57 protein. J Virol, 89(3).
  9. Da-Jiang Li, Dinesh Verma, Tim Mosbruger and Sankar Swaminathan (01/09/2014). CTCF And Rad21 Act as Host Cell Restriction Factors for Kaposi's Sarcoma-Associated Herpesvirus (KSHV) Lytic Replication By Modulating Viral Gene Transcription. PLoS Pathog.
  10. Verma D, Kim EA, Swaminathan S (10/30/2013). A cell-based screening assay for antiviral compounds targeting the ability of herpesvirus post-transcriptional regulatory proteins to stabilize viral mRNAs. J Virol, 87(19).
  11. Li DJ, Verma D, Swaminathan S (2012). Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication. J Virol.
  12. Verma D, Bais S, Gaillard M, Swaminathan S (2010). Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J Virol, 84(22), 11781-9.
  13. Han Z, Verma D, Hilscher C, Dittmer DP, Swaminathan S (2009). General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein. J Virol, 83(22), 11635-44.
  14. Verma D, Ling C, Johannsen E, Nagaraja T, Swaminathan S (2009). Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein. J Virol, 83(16), 8041-50.
  15. Verma D, Swaminathan S (2008). Epstein-Barr virus SM protein functions as an alternative splicing factor. J Virol, 82(14), 7180-8.
  16. Chopra P, Verma D, Khullar M, Sapru S, Mahmood S (2006). Shiga toxin exposure modulates intestinal brush border membrane functional proteins in rabbit ileum. Mol Cell Biochem, 283(1-2), 85-92.
  17. Chopra P, Verma D, Khullar M, Mahmood S (2006). Inhibitory effect of Shiga toxin on the expression of Na+-d-glucose cotransporter in rabbit ileum. Nutr Res, 26, 356– 361.
  18. Nautiyal CS, Bhaduria S, Kumar P, Lal H, Mondal R, Verma D (2000). Stress induced phosphate solubilization in bactria isolated from alkaline soils. FEMS Microbiol Lett, 291-296.

Abstract

  1. RAHUL AGRAWAL, MICHAEL G MONTGOMERY, DINESH VERMA, GRIFFIN T DURUPT, ADRIANA VIEIRA DE ABREU, SANKAR SWAMINATHAN and SIMON FISHER (2019). MicroRNA-7a-5p Overexpression in the VMH Restores the Sympathoadrenal Response to Hypoglycemia in Recurrently Hypoglycemic Rats [Abstract].
  2. Dinesh Verma, Trenton M Church, Sankar Swaminathan (2018). Spironolactone Blocks EBV Production by Degrading XBP Protein, A Cellular Transcription Factor that Acts as a Cofactor for EBV SM Function.  [Abstract].