Dinesh Verma, PhD

Languages

  • English
  • Hindi

Academic Information

  • Departments: Internal Medicine - Research Assistant Professor
  • Divisions: Infectious Diseases

Academic Office Information

  • 801-585-9010
  • Maxwell M. Wintrobe Research and Education Building
    26 N Medical Dr, Room: 527
    Salt Lake City, UT 84132

Academic Bio

Dr. Dinesh Verma received his Ph.D in Biotechnology from Panjab University Chandigarh, India in 2006. He performed Ph.D research work at Postgraduate Institute of Medical Education and Research, Chandigarh, India. He worked as a postdoctoral fellow in the Department of Internal Medicine, Division of Infectious Diseases at University of Florida from April 2006-Sept.2010. He joined University of Utah School of Medicine, Division of Infectious Diseases in October 2010 as a Senior Postdoctoral Research Associate. He was appointed as Research Assistant Professor in October 2011.
Dr. Verma research involves understanding the pathogenesis of tumor viruses, specifically Epstein Barr Virus (EBV) and Kaposi’s sarcoma associated herpesvirus (KSHV). Both viruses undergo lytic replication in epithelial cells during primary infection and during reactivation from latent infection in B-lymphocytes. Epstein Barr virus SM is an RNA binding protein essential for viral replication that enhances EBV gene expression by enhancing RNA stability and RNA export. Dr. Verma has shown that SM interacts with cellular splicing factors and influences splicing of both EBV and cellular pre-mRNAs. Like EBV SM, KSHV ORF57 is also a post-transcriptional regulatory protein, essential for KSHV lytic replication and has high degree of gene specificity. His current research is focused on regulation of gene expression and antiviral drug screening in the following areas:
A. Mechanism and regulation of EBV SM mediated RNA splicing.
B. Role of cellular splicing factors in viral gene regulation.
C. Gene specific effect of ORF57 on KSHV lytic replication and cellular gene expression.
D. Development of a cell-based assay for screening compounds that inhibit EBV SM function and test antiviral activity against human herpesviruses.

Education History

Type School Degree
Postdoctoral Training University of Utah
Virology
Postdoctoral Training
Postdoctoral Training University of Florida
Virology
Postdoctoral Training
Research Fellow Council of Scientific and Industrial Research
Senior Research Fellow
Doctoral Training Panjab University
Biotechnology
Ph.D.
Research Fellow Indian Council of Medical Research
Senior Research Fellow
Graduate Training Dr. Ram Manohar Lohia Avadh University
Microbiology
M.Sc.
Undergraduate Dr. Ram Manohar Lohia Avadh University
Biology
B.Sc.

Global Impact

Education History

Type School Degree Country
Research Fellow Council of Scientific and Industrial Research
Senior Research Fellow India
Doctoral Training Panjab University
Biotechnology
Ph.D. India
Research Fellow Indian Council of Medical Research
Senior Research Fellow India
Graduate Training Dr. Ram Manohar Lohia Avadh University
Microbiology
M.Sc. India
Undergraduate Dr. Ram Manohar Lohia Avadh University
Biology
B.Sc. India

Selected Publications

Journal Article

  1. Dinesh Verma, Jacob Thompson, and Sankar Swaminathan (03/29/2016). Spironolactone blocks Epstein-Barr virus production by inhibiting EBV protein SM function. Proc Natl Acad Sci U S A.
  2. Li DJ, Verma D, Swaminathan S (2012). Binding of cellular export factor REF/Aly by Kaposi's sarcoma-associated herpesvirus (KSHV) ORF57 protein is not required for efficient KSHV lytic replication. J Virol.
  3. Verma D, Bais S, Gaillard M, Swaminathan S (2010). Epstein-Barr Virus SM protein utilizes cellular splicing factor SRp20 to mediate alternative splicing. J Virol, 84(22), 11781-9.
  4. Han Z, Verma D, Hilscher C, Dittmer DP, Swaminathan S (2009). General and target-specific RNA binding properties of Epstein-Barr virus SM posttranscriptional regulatory protein. J Virol, 83(22), 11635-44.
  5. Verma D, Ling C, Johannsen E, Nagaraja T, Swaminathan S (2009). Negative autoregulation of Epstein-Barr virus (EBV) replicative gene expression by EBV SM protein. J Virol, 83(16), 8041-50.