Kihoon Nam, PhD

Languages

  • English

Academic Information

  • Departments: Dentistry - Research Assistant Professor

Selected Publications

Journal Article

  1. Nam K, Kim K, Dean SM, Brown CT, Davis RS, Okano T, Baker OJ (2019). Using cell sheets to regenerate mouse submandibular glands. NPJ Regen Med, 4, 16.
  2. Dean S, Wang CS, Nam K, Maruyama CL, Trump BG, Baker OJ (2018). Aspirin Triggered Resolvin D1 reduces inflammation and restores saliva secretion in a Sjögren's syndrome mouse model. Rheumatology (Oxford), 58(7), 1285-1292.
  3. Nam K, Dean SM, Brown CT, Smith RJ Jr, Lei P, Andreadis ST, Baker OJ (2019). Synergistic effects of laminin-1 peptides, VEGF and FGF9 on salivary gland regeneration. Acta Biomater, 91, 186-194.
  4. Nam K, Maruyama CL, Wang CS, Trump BG, Lei P, Andreadis ST, Baker OJ (2017). Laminin-111-derived peptide conjugated fibrin hydrogel restores salivary gland function. PLoS ONE, 12(11), e0187069.
  5. Kasala D, Lee SH, Hong JW, Choi JW, Nam K, Chung YH, Kim SW, Yun CO (2017). Synergistic antitumor effect mediated by a paclitaxel-conjugated polymeric micelle-coated oncolytic adenovirus. Biomaterials, 145, 207-222.
  6. Nam K, Wang CS, Maruyama CLM, Lei P, Andreadis ST, Baker OJ (2017). L1 Peptide-Conjugated Fibrin Hydrogels Promote Salivary Gland Regeneration. J Dent Res, 96(7), 798-806.
  7. Yang R, Nam K, Kim SW, Turkson J, Zou Y, Zuo YY, Haware RV, Chougule MB (2016). Factorial Design Based Multivariate Modeling and Optimization of Tunable Bioresponsive Arginine Grafted Poly(cystaminebis(acrylamide)-diaminohexane) Polymeric Matrix Based Nanocarriers. Mol Pharm, 14(1), 252-263.
  8. Nam K, Jones JP, Lei P, Andreadis ST, Baker OJ (2016). Laminin-111 Peptides Conjugated to Fibrin Hydrogels Promote Formation of Lumen Containing Parotid Gland Cell Clusters. Biomacromol, 17(6), 2293-301.
  9. Nam K, Maruyama CL, Trump BG, Buchmann L, Hunt JP, Monroe MM, Baker OJ (2016). Post-Irradiated Human Submandibular Glands Display High Collagen Deposition, Disorganized Cell Junctions, and an Increased Number of Adipocytes. J Histochem Cytochem, 64(6), 343-52.
  10. Kim H, Nam K, Nam JP, Kim HS, Kim YM, Joo WS, Kim SW (2015). VEGF therapeutic gene delivery using dendrimer type bio-reducible polymer into human mesenchymal stem cells (hMSCs). J Control Release, 220(Pt A), 222-228.
  11. Choi JW, Kim HA, Nam K, Na Y, Yun CO, Kim S (2015). Hepatoma targeting peptide conjugated bio-reducible polymer complexed with oncolytic adenovirus for cancer gene therapy. J Control Release, 220(Pt B), 691-703.
  12. Nam K, Jung S, Nam JP, Kim SW (2015). Poly(ethylenimine) conjugated bioreducible dendrimer for efficient gene delivery. J Control Release, 220(Pt A), 447-455.
  13. Choi JW, Nam JP, Nam K, Lee YS, Yun CO, Kim SW (2015). Oncolytic Adenovirus Coated with Multidegradable Bioreducible Core-Cross-Linked Polyethylenimine for Cancer Gene Therapy. Biomacromol, 16(7), 2132-43.
  14. Nam JP, Nam K, Jung S, Nah JW, Kim SW (2015). Evaluation of dendrimer type bio-reducible polymer as a siRNA delivery carrier for cancer therapy. J Control Release, 209, 179-85.
  15. Nam JP, Nam K, Nah JW, Kim SW (2015). Evaluation of Histidylated Arginine-Grafted Bioreducible Polymer To Enhance Transfection Efficiency for Use as a Gene Carrier. Mol Pharm, 12(7), 2352-64.
  16. Beloor J, Ramakrishna S, Nam K, Seon Choi C, Kim J, Kim SH, Cho HJ, Shin H, Kim H, Kim SW, Lee SK, Kumar P (2014). Effective gene delivery into human stem cells with a cell-targeting Peptide-modified bioreducible polymer. Small, 11(17), 2069-79.
  17. Kim HA, Nam K, Kim SW (2014). Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery. Biomaterials, 35(26), 7543-52.
  18. Florinas S, Kim J, Nam K, Jant-Amsbury MM, Kim SW (2014). Ultrasound-assisted siRNA delivery via arginine-grafted bioreducible polymer and microbubbles targeting VEGF for ovarian cancer treatment. J Control Release, 183, 1-8.
  19. Kim PH, Lee M, Nam K, Kim SW (2014). Enhanced Incretin Effects of Exendin-4 Expressing Chimeric Plasmid Based On Two-Step Transcription Amplification System with Dendritic Bioreducible Polymer for the Treatment of Type 2 Diabetes. 1(1), 7-15.
  20. Lee Y, McGinn AN, Olsen CD, Nam K, Lee M, Shin SK, Kim SW (2013). Human erythropoietin gene delivery for cardiac remodeling of myocardial infarction in rats. J Control Release, 171(1), 24-32.
  21. Kim HA, Nam K, Lee M, Kim SW (2013). Hypoxia/hepatoma dual specific suicide gene expression plasmid delivery using bio-reducible polymer for hepatocellular carcinoma therapy. J Control Release, 171(1), 1-10.
  22. Won YW, Lee M, Kim HA, Nam K, Bull DA, Kim SW (2013). Synergistically combined gene delivery for enhanced VEGF secretion and antiapoptosis. Mol Pharm, 10(10), 3676-83.
  23. Won YW, McGinn AN, Lee M, Nam K, Bull DA, Kim SW (2013). Post-translational regulation of a hypoxia-responsive VEGF plasmid for the treatment of myocardial ischemia. Biomaterials, 34(26), 6229-38.
  24. Bai CZ, Choi S, Nam K, An S, Park JS (2013). Arginine modified PAMAM dendrimer for interferon beta gene delivery to malignant glioma. Int J Pharm, 445(1-2), 79-87.
  25. An S, Nam K, Choi S, Bai CZ, Lee Y, Park JS (2013). Nonviral gene therapy in vivo with PAM-RG4/apoptin as a potential brain tumor therapeutic. Int J Nanomedicine, 8, 821-34.
  26. Nam K, Nam HY, Kim PH, Kim SW (2012). Paclitaxel-conjugated PEG and arginine-grafted bioreducible poly (disulfide amine) micelles for co-delivery of drug and gene. Biomaterials, 33(32), 8122-30.
  27. Joo WS, Jeong JH, Nam K, Blevins KS, Salama ME, Kim SW (2012). Polymeric delivery of therapeutic RAE-1 plasmid to the pancreatic islets for the prevention of type 1 diabetes. J Control Release, 162(3), 606-11.
  28. Nam HY, Nam K, Lee M, Kim SW, Bull DA (2012). Dendrimer type bio-reducible polymer for efficient gene delivery. J Control Release, 160(3), 592-600.
  29. Kwon MJ, An S, Choi S, Nam K, Jung HS, Yoon CS, Ko JH, Jun HJ, Kim TK, Jung SJ, Park JH, Lee Y, Park JS (2012). Effective healing of diabetic skin wounds by using nonviral gene therapy based on minicircle vascular endothelial growth factor DNA and a cationic dendrimer. J Gene Med, 14(4), 272-8.
  30. Jang SH, Choi SJ, Oh JH, Chae SW, Nam K, Park JS, Lee HJ (2010). Nonviral gene delivery to human ovarian cancer cells using arginine-grafted PAMAM dendrimer. Drug Dev Ind Pharm, 37(1), 41-6.
  31. Kim ID, Lim CM, Kim JB, Nam HY, Nam K, Kim SW, Park JS, Lee JK (2009). Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain. J Control Release, 142(3), 422-30.
  32. Koo H, Jin GW, Kang H, Lee Y, Nam K, Zhe Bai C, Park JS (2009). Biodegradable branched poly(ethylenimine sulfide) for gene delivery. Biomaterials, 31(5), 988-97.
  33. Kim TI, Bai CZ, Nam K, Park JS (2009). Comparison between arginine conjugated PAMAM dendrimers with structural diversity for gene delivery systems. J Control Release, 136(2), 132-9.
  34. Nam HY, Nam K, Hahn HJ, Kim BH, Lim HJ, Kim HJ, Choi JS, Park JS (2008). Biodegradable PAMAM ester for enhanced transfection efficiency with low cytotoxicity. Biomaterials, 30(4), 665-73.
  35. Nam HY, Hahn HJ, Nam K, Choi WH, Jeong Y, Kim DE, Park JS (2008). Evaluation of generations 2, 3 and 4 arginine modified PAMAM dendrimers for gene delivery. Int J Pharm, 363(1-2), 199-205.
  36. Mi Bae Y, Choi H, Lee S, Ho Kang S, Tae Kim Y, Nam K, Sang Park J, Lee M, Sig Choi J (2007). Dexamethasone-conjugated low molecular weight polyethylenimine as a nucleus-targeting lipopolymer gene carrier. Bioconjug Chem, 18(6), 2029-36.
  37. Kim JB, Choi JS, Nam K, Lee M, Park JS, Lee JK (2006). Enhanced transfection of primary cortical cultures using arginine-grafted PAMAM dendrimer, PAMAM-Arg. J Control Release, 114(1), 110-7.
  38. Kim JB, Sig Choi J, Yu YM, Nam K, Piao CS, Kim SW, Lee MH, Han PL, Park JS, Lee JK (2006). HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain. J Neurosci, 26(24), 6413-21.
  39. Choi JS, Nam K, Park JY, Kim JB, Lee JK, Park JS (2003). Enhanced transfection efficiency of PAMAM dendrimer by surface modification with L-arginine. J Control Release, 99(3), 445-56.

Patent

  1. Baker O, Nam K, Le Pi, Andreadis ST (2019). Salivary Tissue Regeneration Using Laminin Peptide-Modified Hydrogels. European Patent No. EP3515502A2. Munich, Germany: European Patent Office.
  2. Baker O, Nam K, Le Pi, Andreadis ST (2019). Salivary Tissue Regeneration Using Laminin Peptide-Modified Hydrogels. U.S. Patent No. US20190192739A1. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Baker O, Nam K, Le Pi, Andreadis ST (2019). Salivary Tissue Regeneration Using Laminin Peptide-Modified Hydrogels. Patent Cooperation Treaty No. WO2018053470A3. Geneva, Switzerland: World Intellectual Property Organization.
  4. Nam K (2019). Salivary Gland Cell Sheets and Methods for Their Production and Use. U.S. Patent No. 62/815,079. Washington, D.C.:U.S. Patent and Trademark Office.
  5. Nam K, Kim SW (2018). A polymeric carrier for delivery of a payload to a cell. U.S. Patent No. US20180256730A1. Washington, D.C.:U.S. Patent and Trademark Office.
  6. Kim SW, Nam HY, Nam K, Bull DA (2018). High Molecular Weight Arginine-Grafted Bioreducible Polymers. U.S. Patent No. US9907861B2. Washington, D.C.:U.S. Patent and Trademark Office.
  7. Nam K, Kim SW (2017). A polymeric carrier for delivery of a payload to a cell. Patent Cooperation Treaty No. WO2017049209A1. Geneva, Switzerland: World Intellectual Property Organization.
  8. Kim SW, Nam HY, Nam K, Bull DA (2013). High Molecular Weight Arginine-Grafted Bioreducible Polymers. Patent Cooperation Treaty No. WO2013109983A1. Geneva, Switzerland: World Intellectual Property Organization.
  9. Nam K (2007). PAMAM derivatives for delivery of materials into cells and method for transferring desired materials into cells using the derivatives. South Korea Patent No. KR1020050038931. Daejeon, South Korea: Korean Intellectual Property Office.