Thomas J. O'Hare, PhD
- Design and Synthesis of Targeted Cancer Drugs
- Tyrosine Kinase Activating Mutations
- Leukemia, Myeloid, Philadelphia-Positive
- Drug Resistance
- Departments: Internal Medicine - Research Professor
- Divisions: Hematology/BMT
- Cancer Center Programs: Cell Response & Regulation
Academic Office Information
Huntsman Cancer Institute
2000 Circle of Hope, Room: HCI 4264
Salt Lake City, UT 84112
Thomas J. O'Hare, Ph.D. is a Research Professor of Medicine (career track) in the Division of Hematology and Hematologic Malignancies, Department of Internal Medicine at the University of Utah. His lab is located in the Huntsman Cancer Institute and he is a member of the Cell Response and Regulation Program. He received his B.Sc. in Chemistry from Southern Oregon University in Ashland, followed by his Ph.D. in Chemistry at the University of Washington in Seattle. Dr. O'Hare completed two Postdoctoral Fellowships: one in Chemistry at Oregon State University and one in Molecular Microbiology and Immunology at Oregon Health & Science University in Portland.
Dr. O'Hare's research focuses on Chronic Myeloid Leukemia, Acute Myeloid Leukemia and other blood cancers. He also has a research interest in non-small cell lung cancer driven by misregulated fusion kinases such as ROS1.
|Postdoctoral Fellowship||Oregon Health & Science University
Molecular Microbiology and Immunology
|Postdoctoral Fellowship||Oregon State University
|Doctoral Training||University of Washington
|Undergraduate||Southern Oregon University
- Yan D, Pomicter AD, Tantravahi S, Mason CC, Senina AV, Ahmann JM, Wang Q, Than H, Patel AB, Heaton WL, Eiring AM, Clair PM, Gantz KC, Redwine HM, Swierczek SI, Halverson BJ, Baloglu E, Shacham S, Khorashad JS, Kelley TW, Salama ME, Miles RR, Boucher KM, Prchal JT, OHare T, Deininger MW (2018). Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis. Clin Cancer Res, 25(7), 2323-2335.
- Shouksmith AE, Shah F, Grimard ML, Gawel JM, Raouf YS, Geletu M, Berger-Becvar A, de Araujo ED, Luchman HA, Heaton WL, Bakhshinyan D, Adile AA, Venugopal C, OHare T, Deininger MW, Singh SK, Konieczny SF, Weiss S, Fishel ML, Gunning PT (2019). Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer. J Med Chem, 62(5), 2651-2665.