Helena Safavi, PhD

Labs

Lab Website

Languages

  • English
  • German

Academic Information

  • Departments: Biochemistry - Adjunct Assistant Professor

Research Statement

Venomous animals have evolved large libraries of bioactive compounds that disrupt the physiology and/or behavior of prey, predators and competitors. The venoms of predatory marine cone snails have been particularly useful because of the high diversity and specificity of peptides that potently target receptors, ion channels and transporters in prey. These molecular targets play critical roles in health and disease rendering cone snail venoms ideal sources for the discovery of pharmacological tools and therapeutics for a wide range of conditions, including pain, epilepsy, stroke and autoimmune disease.

Our research centers on applying novel computational and experimental tools for the discovery of toxins with therapeutic potential. We are particularly interested in small peptide toxins that mimic endogenous receptor ligands in prey, including toxins implicated in regulating glucose homeostasis (e.g., insulin) and pain (e.g., neurotensin-like peptides).

Education History

Type School Degree
Research Fellow University of Copenhagen
Postdoctoral Research Fellow
Research Fellow University of Utah
Postdoctoral Research Fellow
Research Fellow University of Melbourne
Postdoctoral Research Fellow
Doctoral Training University of Melbourne
Biochemistry and Molecular Biology
Ph.D.
Graduate Training University of Cologne
Biology
M.Sc.

Global Impact

Education History

Type School Degree Country
Research Fellow University of Copenhagen
Postdoctoral Research Fellow Denmark
Research Fellow University of Melbourne
Postdoctoral Research Fellow Australia
Doctoral Training University of Melbourne
Biochemistry and Molecular Biology
Ph.D. Australia
Graduate Training University of Cologne
Biology
M.Sc. Germany

Selected Publications

Patent

  1. Safavi-Hemami H (2019). Insulin Analogs and Methods of Using.
  2. Gerbrandt Tasman Menting J, Smith B, Hung-Chieh Chou D, Safavi-Hemami H, Lawrence MC, Baldomero OM (2019). Insulin analogs. U.S. Patent No. WO2018014091A1. Washington, D.C.:U.S. Patent and Trademark Office.
  3. Safavi-Hemami H, Olivera BM, Gajewiak J, Karanth S, Schlegel A, Bandyopadhyay PK, Yandell M, Robinson SD (2016). Insulin analogs having shortened B chain peptides and associated methods. U.S. Patent No. PCT/US2016/028526. Washington, D.C.:U.S. Patent and Trademark Office.