Erica F. Andersen, PhD, FACMG

Research Interests

  • Clinical Cytogenetics Laboratory
  • Constitutional and Acquired Genetic Abnormalities
  • Heritable Genetic Conditions
  • Hematologic Neoplasms
  • Histiocytic and Dendritic Cell Neoplasms

Languages

  • English
  • Spanish

Academic Information

  • Departments: Pathology - Assistant Professor (Clinical)
  • Divisions: Clinical Pathology

Board Certification

  • American Board of Medical Genetics (Clinical Cytogenetics)

Academic Office Information

  • 801-583-2787-Ext-2705
  • ARUP Laboratories
    500 S Chipeta Way, Room: MS-H01
    Salt Lake City, UT 84108

Email: erica.f.andersen@aruplab.com

Academic Bio

Erica Andersen is an Assistant Professor of Pathology at the University of Utah and Medical Director in the Cytogenetics and Genomic Microarray Laboratories at ARUP Laboratories in Salt Lake City, Utah. She received a PhD in Genetics from the University of Wisconsin-Madison and completed a Clinical Cytogenetics fellowship at the ARUP Laboratories and the University of Utah. She is board certified by the American Board of Medical Genetics and Genomics and is also a fellow of the American College of Medical Genetics and Genomics.

Research Statement

Erica Andersen is an Assistant Professor of Pathology at the University of Utah and Medical Director in the Cytogenetics and Genomic Microarray Laboratories at ARUP Laboratories in Salt Lake City, Utah. She received a PhD in Genetics from the University of Wisconsin-Madison and completed a Clinical Cytogenetics fellowship at ARUP Laboratories and the University of Utah. She is board certified by the American Board of Medical Genetics and Genomics and is a fellow of the American College of Medical Genetics and Genomics. Dr. Andersen's research interests span both heritable and acquired genetic diseases. She has published novel genetic findings in association with developmental disorders and is an active member of the Clinical Genome Resource (ClinGen) group's efforts to improve constitutional copy number variant interpretation in the clinical setting. Her genetic oncology research projects include improving the diagnosis and monitoring for hematologic disease and understanding the genetic etiology of rare hematologic tumors, including histiocytic and dendritic cell neoplasms.

Education History

Type School Degree
Fellowship University of Utah and ARUP Laboratories
Clinical Cytogenetics
Fellow
Doctoral Training University of Wisconsin-Madison
Genetics
Ph.D.
Undergraduate Macalester College
Major: Biology, Genetics, Cell, and Developmental Biology; Core: Chemistry
B.A.

Selected Publications

Journal Article

  1. Zhou XA, Louissaint A Jr, Wenzel A, Yang J, Martinez-Escala ME, Moy AP, Morgan EA, Paxton CN, Hong B, Andersen EF, Guitart J, Behdad A, Cerroni L, Weinstock DM, Choi J (2018). Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type.LID - S0022-202X(18)31988-2 [pii]LID - 10.1016/j.jid.2018.04.038 [doi]. (Epub ahead of print) J Invest Dermatol.
  2. Herriges JC, Brown S, Longhurst M, Ozmore J, Moeschler J, Janze A, Meck J, South S, Andersen EF (2018). Identification of two 14q32 deletions involving DICER1 associated with the development of DICER1-related tumors. doi: 10.1016/j.ejmg.2018.04.011. [Epub ahead of print]. PubMed PMID 29698806. Eur J Med Genet.
  3. Paxton CN, OMalley DP, Bellizzi AM, Alkapalan D, Fedoriw Y, Hornick JL, Perkins SL, South ST, Andersen EF (2017). Genetic evaluation of juvenile xanthogranuloma: genomic abnormalities are uncommon in solitary lesions, advanced cases may show more complexity. PubMed PMID: 28752840. Mod Pathol, 30(9), 1234-1240.
  4. Andersen EF, Paxton CN, OMalley DP, Louissaint Jr A, Hornick JL, Griffin GK, Fedoriw Y, Kim YS, Weiss LM, Perkins SL, South ST (2017). Genomic analysis of follicular dendritic cell sarcoma by molecular inversion probe array reveals tumor suppressor-driven biology. PubMed PMID: 28621320. Mod Pathol, 30(9), 1321-1334.
  5. Andersen EF, Baldwin EE, Ellingwood S, Smith R, Lamb AN (2014). Xq28 duplication overlapping the int22h-1/int22h-2 region and including RAB39B and CLIC2 in a family with intellectual and developmental disability. Am J Med Genet A, 164A(7), 1795-801.
  6. Andersen EF, Carey JC, Earl DL, Corzo D, Suttie M, Hammond P, South ST (2014). Deletions involving genes WHSC1 and LETM1 may be necessary, but are not sufficient to cause Wolf-Hirschhorn Syndrome. Eur J Hum Genet, 22(4), 464-70.
  7. Riggs ER, Nelson T, Merz A, Ackley T, Bunke B, Collins CD, Collinson MN, Fan Y, Goodenberger ML, Golden DM, Haglund-Hazy L, Krgovic D, Lamb AN, Lewis Z, Li G, Liu Y, Meck J, Neufeld-Kaiser W, Runke CL, Sanmann JN, Stavropoulos DJ, Strong E, Su M, Tayeh MK, Vokac NK, Thorland EC, Andersen EF, Martin CL (In Press). Copy Number Variant Discrepancy Resolution Using the ClinGen Dosage Sensitivity Map Results in Updated Clinical Interpretations in ClinVar. Hum Mutat.

Abstract

  1. Andersen E, Burnside R, Coe B, Conlin L, Herriges J, Higginbotham T, Hilton B, Jobanputra V, Kearney H, Ouyang K, Paulraj P, Riggs E, Rowsey R, Speevak M, Thorland E, Zhang L, Martin C, on behalf of the Clinical Genome Resource ClinGen (June 2018). Dosage Sensitivity Curation of Recurrent Copy Number Variant Regions. 2018 American Cytogenomics Conference. DOI: https://doi.org/10.1016/j.cancergen.2018.04.011 [Abstract]. Cancer Genetics, 224-225(Aug 2018), 61.
  2. Zockle J, Chandler B, Delgado K, Quigley D, Toydemir R, Andersen E (June 2018). An evidence-based approach to guide IGH-based reflex testing for plasma cell neoplasms. 2018 American Cytogenomics Conference. DOI: https://doi.org/10.1016/j.cancergen.2018.04.011 [Abstract]. Cancer Genetics, 224-225(August 2018), 53.
  3. Paulraj P, Hilton B, Herriges J, Serrano M, Hong B, Andersen E, Lamb A, Xu X, Salama M, Toydemir RM (November 2017). Multi-year review of cytogenetic abnormalities in patients with Multiple Myeloma from a single institution and a proposed testing algorithm [Abstract]. Journal of Molecular Diagnostics, 19(6), 963.
  4. Longhurst MC, Salama M, VanNess M, Kovacsovics TJ, Rodgers GM, Shami PJ, Deininger MW, South ST, Andersen EF (November 2016). Increased sensitivity for detection of genomic abnormalities from plasma cell-free DNA in myelodysplastic syndromes by SNP-Array [Abstract]. The Journal of Molecular Diagnostics, 18(6), 1052.
  5. Andersen EF, Salama ME, Sederberg MC, Toydemir RM, Kovacsovics TJ, Parker CJ, Rodgers GM, Shami PJ, Deininger MW, South ST (April 2015). Evaluating the clinical utility of peripheral blood samples for molecular evaluation of MDS by SNP-A [Abstract]. Leukemia Research, 39(Supp 1), S72.
  6. Andersen EF, Baldwin EE, Ellingswood S, Smith R, Lamb A (2012). Duplication Xq28 and Deletion of SHOX in a family with short stature, intellectual and developmental disability, Poster [Abstract].

Video/Film/CD/Web/Podcast

  1. Andersen EF (06/06/2018). Introduction to Cytogenetics [Video]. University of Utah School of Medicine, Department of Pathology, and ARUP Laboratories. Available: arup.utah.edu/education/andersen-introCyto-2018.php/.
  2. Andersen EF (06/01/2016). Genomic Microarray in Constitutional and Oncology Settings [Video]. University of Utah School of Medicine, Department of Pathology and ARUP Laboratories, Institute for Learning. Available: arup.utah.edu/education/genomicMicroarray.php/.

Poster

  1. Andersen E, Burnside R, Coe B, Conlin L, Herriges J, Higginbotham T, Hilton B, Goodenberger M, Jobanputra V, Kearney H, Ouyang K, Paulraj P, Riggs ER, Rowsey R, Runke C, Speevak M, Thorland E, Zhang L, Martin C, on behalf of the Clinical Genome Resource ClinGen Equal contribution (10/18/18). Constructing a framework for evaluating recurrent CNVs with reduced penetrance or variable expressivity: a guide for clinical interpretation (Reviewer's Choice Abstract- Top 10%). Poster session presented at 2018 American Society of Human Genetics Annual Meeting, San Diego.
  2. Pineda-Alvarez D, Riggs E, Andersen E, Cherry A, Kantarci S, Kearney H, Patel A, Raca G, Ritter D, South S, Thorland E, Aradhya S, Martin C, On behalf of the ACMGClinGen Copy Number Variant Interpretation Guidelines Working Group (October 2017). New systematic rubric for clinical interpretation of copy number variants (CNVs) improves interpretation consistency across laboratories. Poster session presented at American Society of Human Genetics (ASHG) 2017 Annual Meeting, Orlando, FL.
  3. Riggs ER, Nelson T, Andersen E, Aradhya S, Canto O, Hilton BA, Jobanputra V, Kantarci S, Khan WA, Kearney H, Lorentz CP, Paulraj P, Pineda-Alvarez D, Rowsey RA, Ritter D, Shen Y, Speevak MD, Thorland E, Martin C (October 2017). Copy number variant discrepancy resolution using the ClinGen Dosage Sensitivity Map. Poster session presented at American Society of Human Genetics (ASHG) 2017 Annual Meeting, Orlando, FL.
  4. Herriges JC, Brown S, Ozmore J, Janze A, Meck J, Andersen EF (March 2017). The first clinical reports of 14q32 deletions that encompass DICER1 and are associated with DICER1-related tumor development. Poster session presented at 2017 ACMG Annual Clinical Genetics Meeting, Phoenix, AZ.
  5. Ritter DI, Riggs E, Andersen E, Cherry A, Kantarci S, Kearney H, Lorentz CP, Meck JM, Patel A, Plon SE, Raca G, South S, Thorland E, Vanzo R, Pineda-Alvarez D, Aradhya S, Martin CL, on behalf of the Clinical Genome Resource, Co-chairs of ClinGen Dosage WG amp SV Interpretation WG (October 2016). What have genes got to do with it? Analyzing gene content across interpreted CNVs in the Clinical Genome Resource Structural Variation Interpretation Working Group. (Reviewers' Choice Abstract-Top 10%). Poster session presented at American Society of Human Genetics (ASHG) 2016 Annual Meeting, Vancouver, Canada.
  6. Ritter D, Andersen E, Thorland E, Brandt T, Burnside R, Herriges J, Jobanputra V, Kantarci S, Kearney H, Lorentz C, Pineda-Alvarez D, Risheg H, Shen Y, Speevak M, Aradhya S, Riggs E, Martin C, Plon S, on behalf of the Clinical Genome Resource (June 2016). Understanding the differences between loss-of-function intolerance and haploinsufficiency through review of ExAC, DECIPHER and the ClinGen Dosage Sensitivity Map. Poster session presented at Curating the Clinical Genome-ClinGen/DECIPHER 2016 Meeting, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  7. Andersen E, Thorland E, Brandt T, Burnside R, Herriges J, Jobanputra V, Kantarci S, Kearney H, Lorentz C, Pineda-Alvarez D, Ritter D, Risheg H, Rowsey R, Shen Y, Speevak M, Aradhya S, Riggs E, Martin C, on behalf of the Clinical Genome Resource ClinGen (June 2016). Dosage sensitivity curation of pathogenic CNV regions. Poster session presented at Curating the Clinical Genome-ClinGen/DECIPHER 2016 Meeting, Wellcome Genome Campus, Hinxton, Cambridge, UK.
  8. OMalley DP, Andersen EF, Paxton CN, Louissaint A, Hornick JL, Griffin GK, Fedoriw Y, Kim YS, Weiss LM, South S (March 2015). Genetic array analysis of follicular dendritic cell sarcoma. Poster session presented at 2015 United States and Canadian Academy of Pathology (USCAP) Annual Meeting, Boston, MA.
  9. Paxton CN, Bellizzi AM, Alkapalan D, Fedoriw Y, OMalley DP, Perkins SL, South ST, Andersen EF (March 2015). Genomic analysis of juvenile xanthogranuloma. Poster session presented at 2015 ACMG Annual Clinical Genetics Meeting, Salt Lake City, UT.
  10. Martin C, Pascall J, Aradhya S, Kearney H, South S, Andersen E, Horner V, Kaminsky E, Riggs E, Williams E, Thorland E, Church D, Ledbetter D (March 2012). Improving the quality of chromosomal microarray data and interpretation through collaboration and curation. Poster session presented at 2012 ACMG Annual Clinical Genetics Meeting, Charlotte, NC.