D'Souza, Rena N., DDS, MS, PhD

Research Interests

  • Developmental Biology
  • Genetics
  • Matrix Biology
  • Biomaterials
  • Tissue Engineering
  • Stem Cells

Languages

  • English

Academic Information

  • Departments: Dentistry - Professor, Neurobiology & Anatomy - Adjunct Professor, Pathology - Adjunct Professor, Surgery - Adjunct Professor
  • Divisions: Microbiology and Immunology

Academic Office Information

  • 801-587-1203
  • Ray and Tye Noorda Oral Health Sciences Building
    School of Dentistry
    530 South Wakara Way
    Salt Lake City, UT 84108

Email: u0916345@utah.edu

Education History

Type School Degree
Doctoral Training Graduate School of Biomedical Sciences, University of Texas health Sciences Center at Houston
Pathology/Biomedical Sciences		 Ph.D.
Professional Dental University of Texas Health Science Center at Houston
Dentistry		 D.D.S.
Graduate Training Graduate School of Biomedical Sciences, University of Texas health Sciences Center at Houston
Pathology/Biomedical Sciences		 M.S.
Residency University of Bombay
General Practice		 Resident
Undergraduate University of Bombay
Dental Surgery		 B.D.S.

Global Impact

Education History

Type School Degree Country
Residency University of Bombay
General Practice		 Resident India
Undergraduate University of Bombay
Dental Surgery		 B.D.S. India

Selected Publications

Journal Article

  1. Ioannidou E, DSouza RN, Macdougall MJ (2014 Jan). Gender equity in dental academics: gains and unmet challenges. J Dent Res, 93(1), 5-7.
  2. Mues G, Bonds J, Xiang L, Vieira AR, Seymen F, Klein O, DSouza RN (2014 Oct). The WNT10A gene in ectodermal dysplasias and selective tooth agenesis. Am J Med Genet A, 164A(10), 2455-60.
  3. Huang Y, Lu Y, Mues G, Wang S, Bonds J, DSouza R (2013 Aug). Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutation. European Journal of Oral Sciences Online, 121(4), 313-8.
  4. Gibson MP, Zhu Q, Liu Q, DSouza RN, Feng JQ, Qin C (2013 Apr). Loss of dentin sialophosphoprotein leads to periodontal diseases in mice. J Periodontal Res, 48(2), 221-7.
  5. Gibson MP, Zhu Q, Wang S, Liu Q, Liu Y, Wang X, Yuan B, Ruest LB, Feng JQ, DSouza RN, Qin C, Lu Y (2013 Mar 8). The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis. J Biol Chem, 288(10), 7204-14.
  6. Sun Y, Jiang Y, Liu Q, Gao T, Feng JQ, Dechow P, DSouza RN, Qin C, Liu X (2013 Aug). Biomimetic engineering of nanofibrous gelatin scaffolds with noncollagenous proteins for enhanced bone regeneration. Tissue Eng Part A, 19(15-16), 1754-63.
  7. Vieira AR, DSouza RN, Mues G, Deeley K, Hsin HY, Kuchler EC, Meira R, Patir A, Tannure PN, Lips A, Costa MC, Granjeiro JM, Seymen F, Modesto A (2013 Dec). Candidate gene studies in hypodontia suggest role for FGF3. Eur Arch Paediatr Dent, 14(6), 405-10.
  8. Chang JY, Wang C, Jin C, Yang C, Huang Y, Liu J, McKeehan WL, DSouza RN, Wang F (2013 Jul 1). Self-renewal and multilineage differentiation of mouse dental epithelial stem cells. Stem Cell Res, 11(3), 990-1002.
  9. Chang JY, Wang C, Liu J, Huang Y, Jin C, Yang C, Hai B, Liu F, DSouza RN, McKeehan WL, Wang F (2013 Oct 4). Fibroblast Growth Factor Signaling Is Essential for Self-renewal of Dental Epithelial Stem Cells. J Biol Chem, 288(40), 28952-28961.
  10. DSouza RN, Dunnwald M, Frazier-Bowers S, Polverini PJ, Wright JT, de Rouen T, Vieira AR (2013 Dec). Translational genetics: advancing fronts for craniofacial health. J Dent Res, 92(12), 1058-64.
  11. Napierala D, Sun Y, Maciejewska I, Bertin TK, Dawson B, DSouza R, Qin C, Lee B (2012 Aug). Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice. J Bone Miner Res, 27(8), 1735-45.
  12. Ebersole JL, DSouza RN, Gordon S, Fox C (). AADR Fall Focused Symposium. Oral health disparities and the future face of America. J Dent Res, 91(11), 997-1002.
  13. Galler KM, Hartgerink JD, Cavender AC, Schmalz G, DSouza RN (2012 Jan). A customized self-assembling peptide hydrogel for dental pulp tissue engineering. Tissue Eng Part A, 18(1-2), 176-84.
  14. DSouza RN (2012 Aug). Shaping our future. J Dent Res, 91(8), 729-30.
  15. Siyam A, Wang S, Qin C, Mues G, Stevens R, DSouza RN, Lu Y (2012 Aug 3). Nuclear localization of DMP1 proteins suggests a role in intracellular signaling. Biochem Biophys Res Commun, 424(3), 641-6.
  16. Lu Y, Li Y, Cavender AC, Wang S, Mansukhani A, DSouza RN (2012 Nov). Molecular studies on the roles of Runx2 and Twist1 in regulating FGF signaling. Dev Dyn, 241(11), 1708-15.
  17. Hinton RJ, Dechow PC, Abdellatif H, Jones DL, Schneiderman ED, McCann AL, DSouza RN (). The winds of change: Creating an “EBD culture” at Baylor College of Dentistry. J Dent Educ, 75(3), 279-90.
  18. Mues G, Wang Y, Kong H, DSouza RN (). Molecular insights into Bmp4 signaling during tooth morphogenesis. Cells Tissues Organs, 194(2-4), 156-60.
  19. Sun Y, Lu Y, Chen L, Gao T, DSouza R, Feng JQ, Qin C (2011 May). DMP1 processing is essential to dentin and jaw formation. J Dent Res, 90(5), 619-24.
  20. Wang Y, Kong H, Mues G, DSouza R (2011 Mar). Msx1 mutations: how do they cause tooth agenesis? J Dent Res, 90(3), 311-6.
  21. Hinton RJ, Dechow PC, Abdellatif H, Jones DL, McCann AL, Schneiderman ED, DSouza R (2011 Mar). Creating an evidence-based dentistry culture at Baylor College of Dentistry: the winds of change. J Dent Educ, 75(3), 279-90.
  22. Jones DL, Hinton RJ, Dechow PC, Abdellatif H, McCann AL, Schneiderman ED, DSouza R (2011 Feb). The evidence-based dentistry initiative at Baylor College of Dentistry. Tex Dent J, 128(2), 177-80.
  23. Galler KM, Schweikl H, Hiller KA, Cavender AC, Bolay C, DSouza RN, Schmalz G (2011 Feb). TEGDMA reduces mineralization in dental pulp cells. J Dent Res, 90(2), 257-62.
  24. Galler KM, DSouza RN (2011 Jan). Tissue engineering approaches for regenerative dentistry. Regen Med, 6(1), 111-24.
  25. Galler KM, Cavender AC, Koeklue U, Suggs LJ, Schmalz G, DSouza RN (2011 Mar). Bioengineering of dental stem cells in a PEGylated fibrin gel. Regen Med, 6(2), 191-200.
  26. Galler KM, DSouza RN, Federlin M, Cavender AC, Hartgerink JD, Hecker S, Schmalz G (2011 Nov). Dentin conditioning codetermines cell fate in regenerative endodontics. J Endod, 37(11), 1536-41.
  27. Li Y, Lu Y, Maciejewska I, Galler KM, Cavender A, DSouza RN (2011 Jul). TWIST1 promotes the odontoblast-like differentiation of dental stem cells. Adv Dent Res, 23(3), 280-4.
  28. Galler KM, DSouza RN, Hartgerink JD (). Biomaterials and their potential applications for dental tissue engineering. J Mater Chem, 20, 8730-46.
  29. Sun Y, Prasad M, Gao T, Wang X, Zhu Q, DSouza R, Feng JQ, Qin C (2010 Oct 8). Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem, 285(41), 31713-22.
  30. Mues G, Tardivel A, Willen L, Kapadia H, Seaman R, Frazier-Bowers S, Schneider P, DSouza RN (2010 Jan). Functional analysis of Ectodysplasin-A mutations causing selective tooth agenesis. Eur J Hum Genet, 18(1), 19-25.
  31. Galler KM, Aulisa L, Regan KR, DSouza RN, Hartgerink JD (2010 Mar 10). Self-assembling multidomain peptide hydrogels: designed susceptibility to enzymatic cleavage allows enhanced cell migration and spreading. J Am Chem Soc, 132(9), 3217-23.
  32. Wright JT, Morris C, Clements SE, DSouza R, Gaide O, Mikkola M, Zonana J (). Classifying ectodermal dysplasias: Incorporating the molecular basis and pathways (Workshop II). Am J Med Genet A, 149A(9), 2062-67.
  33. Maciejewska I, Cowan C, Svoboda K, Butler WT, DSouza R, Qin C (2009 Feb). The NH2-terminal and COOH-terminal fragments of dentin matrix protein 1 (DMP1) localize differently in the compartments of dentin and growth plate of bone. J Histochem Cytochem, 57(2), 155-66.
  34. Lin Y, Cheng YS, Qin C, Lin C, DSouza R, Wang F (2009 Feb). FGFR2 in the dental epithelium is essential for development and maintenance of the maxillary cervical loop, a stem cell niche in mouse incisors. Dev Dyn, 238(2), 324-30.
  35. Mues GI, Griggs R, Hartung AJ, Whelan G, Best LG, Srivastava AK, DSouza R (2009 Sep). From ectodermal dysplasia to selective tooth agenesis. Am J Med Genet A, 149A(9), 2037-41.
  36. Peng T, Huang B, Sun Y, Lu Y, Bonewald L, Chen S, Butler WT, Feng JQ, DSouza RN, Qin C (2009). Blocking of proteolytic processing and deletion of glycosaminoglycan side chain of mouse DMP1 by substituting critical amino acid residues. Cells Tissues Organs, 189(1-4), 192-7.
  37. Wang Y, Wu H, Wu J, Zhao H, Zhang X, Mues G, DSouza RN, Feng H, Kapadia H (2009). Identification and functional analysis of two novel PAX9 mutations. Cells Tissues Organs, 189(1-4), 80-7.
  38. Komabayashi T, DSouza RN, Dechow PC, Safavi KE, Spangberg LS (2009 Feb). Particle size and shape of calcium hydroxide. J Endod, 35(2), 284-7.
  39. Wang Y, Groppe JC, Wu J, Ogawa T, Mues G, DSouza RN, Kapadia H (2009 Aug 1). Pathogenic mechanisms of tooth agenesis linked to paired domain mutations in human PAX9. Hum Mol Genet, 18(15), 2863-74.
  40. Galler KM, Cavender A, Yuwono V, Dong H, Shi S, Schmalz G, Hartgerink JD, DSouza RN (2008 Dec). Self-assembling peptide amphiphile nanofibers as a scaffold for dental stem cells. Tissue Eng Part A, 14(12), 2051-8.
  41. Venugopalan SR, Amen MA, Wang J, Wong L, Cavender AC, DSouza RN, Akerlund M, Brody SL, Hjalt TA, Amendt BA (2008 Dec 1). Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis. Hum Mol Genet, 17(23), 3643-54.
  42. Christgau M, Caffesse RG, Schmalz G, DSouza RN (2007 Aug). Extracellular matrix expression and periodontal wound-healing dynamics following guided tissue regeneration therapy in canine furcation defects. J Clin Periodontol, 34(8), 691-708.
  43. Galler KM, Yasue A, Cavender AC, Bialek P, Karsenty G, DSouza RN (2007 Oct). A novel role for Twist-1 in pulp homeostasis. J Dent Res, 86(10), 951-5.
  44. Kapadia H, Frazier-Bowers S, Ogawa T, DSouza RN (2006 Apr). Molecular characterization of a novel PAX9 missense mutation causing posterior tooth agenesis. Eur J Hum Genet, 14(4), 403-9.
  45. Ogawa T, Kapadia H, Feng JQ, Raghow R, Peters H, DSouza RN (2006 Jul 7). Functional consequences of interactions between Pax9 and Msx1 genes in normal and abnormal tooth development. J Biol Chem, 281(27), 18363-9.
  46. Galler KM, Schweikl H, Thonemann B, DSouza RN, Schmalz G (2006 Apr). Human pulp-derived cells immortalized with Simian Virus 40 T-antigen. Eur J Oral Sci, 114(2), 138-46.
  47. Ogawa T, Kapadia H, Wang B, DSouza RN (2005 Feb). Studies on Pax9-Msx1 protein interactions. Arch Oral Biol, 50(2), 141-5.
  48. Bronckers AL, Sasaguri K, Cavender AC, DSouza RN, Engelse MA (2005 Mar). Expression of Runx2/Cbfa1/Pebp2alphaA during angiogenesis in postnatal rodent and fetal human orofacial tissues. J Bone Miner Res, 20(3), 428-37.
  49. Mensah JK, Ogawa T, Kapadia H, Cavender AC, DSouza RN (2004 Feb 13). Functional analysis of a mutation in PAX9 associated with familial tooth agenesis in humans. J Biol Chem, 279(7), 5924-33.
  50. Aberg T, Cavender A, Gaikwad JS, Bronckers AL, Wang X, Waltimo-Siren J, Thesleff I, DSouza RN (2004 Jan). Phenotypic changes in dentition of Runx2 homozygote-null mutant mice. J Histochem Cytochem, 52(1), 131-9.
  51. Sreenath T, Thyagarajan T, Hall B, Longenecker G, DSouza R, Hong S, Wright JT, MacDougall M, Sauk J, Kulkarni AB (2003 Jul 4). Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III. J Biol Chem, 278(27), 24874-80.
  52. Zou SJ, DSouza RN, Ahlberg T, Bronckers AL (2003 Sep). Tooth eruption and cementum formation in the Runx2/Cbfa1 heterozygous mouse. Arch Oral Biol, 48(9), 673-7.
  53. Hoffmann M, Gaikwad J, Schmalz G, Cavender A, DSouza R (2002). Analysis of odontoblast gene expression using a novel approach, laser capture microdissection. Connect Tissue Res, 43(2-3), 376-80.
  54. Frazier-Bowers SA, Guo DC, Cavender A, Xue L, Evans B, King T, Milewicz D, DSouza RN (2002 Feb). A novel mutation in human PAX9 causes molar oligodontia. J Dent Res, 81(2), 129-33.
  55. Das P, Stockton DW, Bauer C, Shaffer LG, DSouza RN, Wright T, Patel PI (2002 Apr). Haploinsufficiency of PAX9 is associated with autosomal dominant hypodontia. Hum Genet, 110(4), 371-6.
  56. Frazier-Bowers SA, Scott MR, Cavender A, Mensah J, DSouza RN (2002). Mutational analysis of families affected with molar oligodontia. Connect Tissue Res, 43(2-3), 296-300.
  57. Bronckers AL, Engelse MA, Cavender A, Gaikwad J, DSouza RN (2001 Mar). Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues. Mech Dev, 101(1-2), 255-8.
  58. Gaikwad JS, Cavender A, DSouza RN (2001 Nov 14). Identification of tooth-specific downstream targets of Runx2. Gene, 279(1), 91-7.
  59. Hoffmann M, Olson K, Cavender A, Pasqualini R, Gaikwad J, DSouza RN (2001 Nov). Gene expression in a pure population of odontoblasts isolated by laser-capture microdissection. J Dent Res, 80(11), 1963-7.
  60. Gaikwad JS, Hoffmann M, Cavender A, Bronckers AL, DSouza RN (2001 Aug). Molecular insights into the lineage-specific determination of odontoblasts: the role of Cbfa1. Adv Dent Res, 15, 19-24.
  61. Stockton DW, Das P, Goldenberg M, DSouza RN, Patel PI (2000 Jan). Mutation of PAX9 is associated with oligodontia. Nat Genet, 24(1), 18-9.
  62. Goldenberg M, Das P, Messersmith M, Stockton DW, Patel PI, DSouza RN (2000 Jul). Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia. J Dent Res, 79(7), 1469-75.
  63. DSouza RN, Aberg T, Gaikwad J, Cavender A, Owen M, Karsenty G, Thesleff I (1999 Jul). Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development, 126(13), 2911-20.
  64. DSouza RN, Cavender A, Sood R, Tarnuzzer R, Dickinson DP, Roberts A, Letterio J (). Dental abnormalities in mice lacking a functional transforming growth factor-beta 1 (TGF-?1) gene indicate a role for TGF-?1 in biomineralization. International Journal of Oral Biology, 23(3), 119-131.
  65. Helder MN, Karg H, Bervoets TJ, Vukicevic S, Burger EH, DSouza RN, Woltgens JH, Karsenty G, Bronckers AL (1998 Apr). Bone morphogenetic protein-7 (osteogenic protein-1, OP-1) and tooth development. J Dent Res, 77(4), 545-54.
  66. DSouza RN, Cavender A, Dickinson D, Roberts A, Letterio J (1998 Jan). TGF-beta1 is essential for the homeostasis of the dentin-pulp complex. Eur J Oral Sci, 106 Suppl 1, 185-91.
  67. Feng JQ, Luan X, Wallace J, Jing D, Ohshima T, Kulkarni AB, DSouza RN, Kozak CA, MacDougall M (1998 Apr 17). Genomic organization, chromosomal mapping, and promoter analysis of the mouse dentin sialophosphoprotein (Dspp) gene, which codes for both dentin sialoprotein and dentin phosphoprotein. J Biol Chem, 273(16), 9457-64.
  68. Christgau M, Caffesse RG, Newland JR, Schmalz G, DSouza RN (1998 Dec). Characterization of immunocompetent cells in the diseased canine periodontium. J Histochem Cytochem, 46(12), 1443-54.
  69. MacDougall M, Nydegger J, Gu TT, Simmons D, Luan X, Cavender A, DSouza RN (1998). Developmental regulation of dentin sialophosphoprotein during ameloblast differentiation: a potential enamel matrix nucleator. Connect Tissue Res, 39(1-3), 25-37; discussion 63-7.
  70. DSouza RN, Cavender A, Sunavala G, Alvarez J, Ohshima T, Kulkarni AB, MacDougall M (1997 Dec). Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. J Bone Miner Res, 12(12), 2040-9.
  71. Haaijman A, DSouza RN, Bronckers AL, Goei SW, Burger EH (1997 Nov). OP-1 (BMP-7) affects mRNA expression of type I, II, X collagen, and matrix Gla protein in ossifying long bones in vitro. J Bone Miner Res, 12(11), 1815-23.
  72. Bronckers AL, Lyaruu DM, Goei W, Litz M, Luo G, Karsenty G, Woltgens JH, DSouza RN (1996 Apr). Nuclear DNA fragmentation during postnatal tooth development of mouse and hamster and during dentin repair in the rat. Eur J Oral Sci, 104(2 [Pt1]), 102-11.
  73. Bronckers AL, Goei W, Luo G, Karsenty G, DSouza RN, Lyaruu DM, Burger EH (1996 Sep). DNA fragmentation during bone formation in neonatal rodents assessed by transferase-mediated end labeling. J Bone Miner Res, 11(9), 1281-91.
  74. Luo G, DSouza R, Hogue D, Karsenty G (1995 Feb). The matrix Gla protein gene is a marker of the chondrogenesis cell lineage during mouse development. J Bone Miner Res, 10(2), 325-34.
  75. Niederreither K, DSouza R, Metsaranta M, Eberspaecher H, Toman PD, Vuorio E, De Crombrugghe B (1995 Dec). Coordinate patterns of expression of type I and III collagens during mouse development. Matrix Biol, 14(9), 705-13.
  76. DSouza RN, Litz M (1995). Analysis of tooth development in mice bearing a TGF-beta 1 null mutation. Connect Tissue Res, 32(1-4), 41-6.
  77. DSouza RN, Bachman T, Baumgardner KR, Butler WT, Litz M (1995 Feb). Characterization of cellular responses involved in reparative dentinogenesis in rat molars. J Dent Res, 74(2), 702-9.
  78. Bronckers AL, DSouza RN, Butler WT, Lyaruu DM, van Dijk S, Gay S, Woltgens JH (1993 May). Dentin sialoprotein: biosynthesis and developmental appearance in rat tooth germs in comparison with amelogenins, osteocalcin and collagen type-I. Cell Tissue Res, 272(2), 237-47.
  79. DSouza RN, Niederreither K, de Crombrugghe B (1993 Sep). Osteoblast-specific expression of the alpha 2(I) collagen promoter in transgenic mice: correlation with the distribution of TGF-beta 1. J Bone Miner Res, 8(9), 1127-36.
  80. DSouza RN, Flanders K, Butler WT (1992). Colocalization of TGF-beta 1 and extracellular matrix proteins during rat tooth development. Proc Finn Dent Soc, 88 Suppl 1, 419-26.
  81. DSouza RN, Bronckers AL, Happonen RP, Doga DA, Farach-Carson MC, Butler WT (1992 Mar). Developmental expression of a 53 KD dentin sialoprotein in rat tooth organs. J Histochem Cytochem, 40(3), 359-66.
  82. Butler WT, Bhown M, Brunn JC, DSouza RN, Farach-Carson MC, Happonen RP, Schrohenloher RE, Seyer JM, Somerman MJ, Foster RA, et al (1992 Nov). Isolation, characterization and immunolocalization of a 53-kDal dentin sialoprotein (DSP). Matrix, 12(5), 343-51.
  83. Niederreither K, DSouza RN, de Crombrugghe B (1992 Dec). Minimal DNA sequences that control the cell lineage-specific expression of the pro alpha 2(I) collagen promoter in transgenic mice. J Cell Biol, 119(5), 1361-70.
  84. DSouza RN, Happonen RP, Ritter NM, Butler WT (1990). Temporal and spatial patterns of transforming growth factor-beta 1 expression in developing rat molars. Arch Oral Biol, 35(12), 957-65.
  85. DSouza RN, Happonen RP, Flanders KC, Butler WT (1990 Dec). Histochemical localization of transforming growth factor-beta 1 in developing rat molars using antibodies to different epitopes. J Biol Buccale, 18(4), 299-306.
  86. DSouza R, Brown LR, Newland JR, Levy BM, Lachman LB (1989). Detection and characterization of interleukin-1 in human dental pulps. Arch Oral Biol, 34(5), 307-13.
  87. DSouza R (1986 Dec). Pulpal and periapical immune response to electrosurgical contact of cervical metallic restorations in monkeys. Quintessence Int, 17(12), 803-8.
  88. Hanson S, Hemmati P, DSouza RN (). Hydrogel-stem cell constructs for immunomodulation in composite tissue engineering. Tissue Engineering.
  89. Bonds J, Pollan-White S, Xiang L, Mues G, DSouza RN (). The relationship between ovarian cancer and tooth agenesis. J Dent Res.

Review

  1. Galler KM, DSouza RN, Hartgerink JD, Schmalz G (2011 Jul). Scaffolds for dental pulp tissue engineering. [Review]. Adv Dent Res, 23(3), 333-9.
  2. Mues G, Kapadia H, Wang Y, DSouza RN (2009 Sep). Genetics and human malformations. [Review]. J Craniofac Surg, 20 Suppl 2, 1652-4.
  3. Kapadia H, Mues G, DSouza R (2007 Nov). Genes affecting tooth morphogenesis. [Review]. Orthodontics & Craniofacial Research, 10(4), 237-44.
  4. Qin C, DSouza R, Feng JQ (2007 Dec). Dentin matrix protein 1 (DMP1): new and important roles for biomineralization and phosphate homeostasis. [Review]. J Dent Res, 86(12), 1134-41.
  5. DSouza RN, Klein OD (2007). Unraveling the molecular mechanisms that lead to supernumerary teeth in mice and men: current concepts and novel approaches. [Review]. Cells Tissues Organs, 186(1), 60-9.
  6. Wise GE, Frazier-Bowers S, DSouza RN (). Cellular, Molecular, and Genetic Determinants of Tooth Eruption. [Review]. Crit Rev Oral Biol Med, 13(4), 323-334.
  7. Wise GE, Frazier-Bowers S, DSouza RN (2002). Cellular, molecular, and genetic determinants of tooth eruption. [Review]. Crit Rev Oral Biol Med, 13(4), 323-34.
  8. Stashenko P, Teles R, DSouza R (1998). Periapical inflammatory responses and their modulation. [Review]. Crit Rev Oral Biol Med, 9(4), 498-521.
  9. Butler WT, DSouza RN, Bronckers AL, Happonen RP, Somerman MJ (1992). Recent investigations on dentin specific proteins. [Review]. Proc Finn Dent Soc, 88 Suppl 1, 369-76.
  10. DSouza RN, Chang Y, Klein O (). Stem Cell Applications for Regenerative Dentistry. [Review]. Stem Cells.

Book Chapter

  1. DSouza RN, Regan K, Galler KM (). Dental Tissue Engineering. In John P. Fisher and Antonios G. Mikos (Eds.), The Biomedical Engineering Handbook – Tissue Engineering Section (4th). CRC Press.
  2. DSouza RN, Mues G (). Tooth Development and Dental Anomalies – Clinical correlates. In Martha Somerman and Laurie McCauley (Eds.), Mineralized Tissues in Oral and Craniofacial Sciences: Biological Principles and Clinical Correlates. John Wiley & Sons.
  3. DSouza RN, Ruest LB, Hinton RJ, Svoboda KKH (). Development of the Craniofacial Complex. In Bronner, Felix; Farach-Carson, Mary C.; Roach, Helmtrud I. (Eds.), Bone and Development, Springer Topics in Bone Biology (6). Springer.
  4. DSouza, RN (). Questions and Controversies on Tooth Agenesis and Physiologic Movement of Teeth: Eruption and Shedding. In Antonio Nanci (Ed.), Ten Cate's Oral Histology: Development, Structure, and Function (7th). Mosby.
  5. DSouza RN, Kapadia H, Vieira AR (). Teeth. In Roger E. Stevenson and Judith G. Hall (Eds.), Human Malformations and Related Anomalies (2nd, pp. 425-468). Oxford University Press.
  6. DSouza RN, Shi S (). The Bioengineering of Dental Tissues. In Joseph D. Bronzino (Ed.), Tissue Engineering andArtificial Organs: The Biomedical Engineering Handbook (3rd). CRC Press.
  7. DSouza, RN (). Questions and Controversies on Tooth Agenesis and Physiologic Movement of Teeth: Eruption and Shedding. In Antonio Nanci (Ed.), Ten Cate’s Oral Histology (6th). Mosby.
  8. DSouza RN (). The Development of Dentin and the Pulp. In Ken Hargreaves and Harold Goodis (Eds.), Seltzer and Bender’s The DentalPulp (3rd, pp. 13-40). Chicago: Quintessence.
  9. Gaikwad J, Cavender A, Kapadia H, MacDougall M, DSouza RN (). Global expression patterns of dentin matrix protein-1 (Dmp-1) during mouse development. In Davidovitch and Mah (Eds.), Proceedings of the 2nd International Conference on Biological Mechanisms of Tooth Eruption, Resorption, and Replacement by Implants (pp. 17-21). HSAO.
  10. DSouza RN, Litz M (). Odontoblast gene regulation during development and repair. In Proceedings of The International Conference on Dentin/Pulp Complex II (pp. 99-104). Quintessence Publishing.
  11. Kulkarni AB, Ward JM, Geiser AG, Letterio JJ, Hines K, Christ M, DSouza RN, Huh C, Roberts AB, Sporn M, McCartney-Francis N, Wahl SM, Glick AB, Yuspa SH, Mackall C, Gress RE, Karlson S (). TGF-?1 Knockout Mice: Immune Dysregulation and Pathology. In Molecular Biology of Hematopoiesis (3, pp. 749-757). S Karger Pub.
  12. DSouza RN, Litz M (). Osteoblast-specific type I collagen gene expression in transgenic mice and TGF-?1 knockout mice. In Davidovitch, Z (Eds.), Biological Mechanisms of Tooth Eruption, Resorption and Replacement by Implants, An International Conference (pp. 159-165). Harvard Society for the Advancement of Orthodontics.

Editorial

  1. DSouza RN, Ebersole JL, Fox CH, Polverini PJ, Scannapieco FA (2012 Oct). How practicing dentists can shape dental research: The American Association for Dental Research's vision for the future. J Am Dent Assoc, 143(10), 1069-71.

Letter

  1. Frazier-Bowers SA, Pham KY, Le EV, Cavender AC, Kapadia H, King TM, Milewicz DM, DSouza RN (2003 Jun). A unique form of hypodontia seen in Vietnamese patients: clinical and molecular analysis [Letter to the editor]. J Med Genet, 40(6), e79.

Abstract

  1. Mues G, Bonds A, DSouza R (). A novel Msx2 mutation is associated with tooth agenesis [Abstract]. J Dent Res, 91(B), 3196.
  2. Galler K, DSouza R (). Multidomain peptide hydrogels as a novel biologically-driven pulp therapy [Abstract]. J Dent Res, 91(A), 135.
  3. Chang JYF, DSouza R, Wang F (). CD49f is a putative odontogenic epithelial stem cell marker [Abstract]. J Dent Res, 91(A), 1358.
  4. Lu Y, Wang S, Garzon I, Mues G, Vieira A, DSouza R (). Functional analysis of a hypodontia associated BMP4 mutation [Abstract]. J Dent Res, 91(A), 1571.
  5. Kong H, Glessa H, Mues G, DSouza R (). Differentially expressed genes in Msx1-/- versus Msx1+/+ tooth buds [Abstract]. J Dent Res, 91(A), 1574.
  6. Bonds J, Kong H, Wang Y, Mues G, DSouza R (). Differential gene expression in Pax9+/+ and Pax9-/- mouse tooth buds [Abstract]. J Dent Res, 91(A), 1573.
  7. Williams SA, Williams SL, Lu Y, Wang S, Mues G, DSouza R (). Spatiotemporal expression of the Tcfap2b gene in mouse tooth morphogenesis [Abstract]. J Dent Res, 91(A), 1576.
  8. Mues G, Xiang L, Bonds A, Fairley C, Klein O, Vieira A, DSouza R (). EDAR mutations in non- syndromic tooth agenesis [Abstract]. J Dent Res, 91(A), 1572.
  9. Zhang H, Cao Z, Lu Y, Gao T, Liu Y, DSouza R, Feng J (). Osterix plays a distinct role in root dentinogenesis through ?-catenin [Abstract]. J Dent Res, 91(A), 1259.
  10. Siyam A, Lu Y, Wang S, Qin C, Mues G, Stevens R, DSouza R (). Ubiquitous nuclear localization of DMP1 in various cell lines [Abstract]. J Dent Res, 91(A), 668.
  11. Lu Y, Wang S, Zhang H, Williams SL, Qin C, Mansukhani A, Mues G, DSouza R (). Functional redundancy of Twist1 and Twist 2 in mouse development [Abstract]. J Dent Res, 91(A), 11.
  12. Voisey A, Liu M, Arora S, Dechow P, Opperman LA, Kurimoto P, Ke H, DSouza R, Feng J (). A direct role for DKK1 in calvarial osteogenesis [Abstract]. J Dent Res, 91(A), 1182.
  13. DSouza R (). Research development and independence: Any gender trends? [Abstract]. J Dent Res, 90(A), 2.
  14. Chang JYF, Huang Y, DSouza R, Wang F (). FGF-ERK signaling regulates proper growth of odontogenic epithelial stem cells [Abstract]. J Dent Res, 90(A), 1522.
  15. Yamoah A, DSouza R, Qin C (). Effects of SIBLING family members on MC3T3-E1 cell matrix mineralization [Abstract]. J Dent Res, 90(A).
  16. Lu Y, Xiang L, Regan KR, DSouza R (). Dynamic changes of Twist 1 and Runx2 expression during odontoblast differentiation [Abstract]. J Dent Res, 90(A), 816.
  17. Galler KM, Cavender A, Schmalz G, Hartgerink J, DSouza R (). Customized self-assembling peptide hydrogel for dental pulp tissue engineering [Abstract]. J Dent Res, 90(A), 3001.
  18. Kong H, Wang Y, Mues G, DSouza R (). Pax 9 is bound to the Bmp4 promoter during tooth development [Abstract]. J Dent Res, 90(A), 1524.
  19. Fields KA, Bonds A, Mues G, DSouza R (). Investigating the Bmp4 gene in human tooth agenesis [Abstract]. J Dent Res, 90(A), 2360.
  20. Regan K, Galler K, Hartgerink J, DSouza R (). Self-assembling peptide nanofibers for dentin- pulp regeneration [Abstract]. J Dent Res, 90(A), 484.
  21. Voisey A, Liu M, Han X, Dechow PC, Tefera L, DSouza R, Kurimoto P, Ke H, Feng J (). Roles of DKK1 in cranial osteogenesis and angiogenesis [Abstract]. J Dent Res, 90(A), 1551.
  22. Zhang H, Cao Z, Zhou X, Gao T, Qin C, de Crombrugge B, DSouza R, Feng J (). Osterix is essential for root formation [Abstract]. J Dent Res, 90(A), 3004.
  23. Galler K, Regan K, Cavender A, Hartgerink J, Schmalz G, DSouza R (). Customized self- assembling peptide hydrogels for dental pulp tissue engineering [Abstract]. J Dent Res, 89(SIA).
  24. Kong H, Wang Y, Mues G, DSouza R (). Activation of Bmp4 expression in tooth bud mesenchyme [Abstract]. J Dent Res, 89(A), 1479.
  25. Wang Y, Mues G, DSouza R (). Interaction of Pax9 with homeodomain proteins during odontogenesis [Abstract]. J Dent Res, 89(A), 1478.
  26. Bonds J, Wang Y, Mues G, DSouza R (). Pax9 binding sites in the Bmp4 promoter [Abstract]. J Dent Res, 89(A), 1476.
  27. Wang Y, G Mues G, DSouza R (). Functional evaluation of Msx1 missense mutations [Abstract]. J Dent Res, 89(A), 1475.
  28. Voisey A, Lv K, Ye L, Xie Y, DSouza R, Feng J (). BMPR1A controls tooth/bone cell fate through Wnt/ß-catenin signaling via SOST [Abstract]. J Dent Res, 89(A), 290.
  29. Regan K, Galler K, Cavender A, DSouza R, Hartgerink J (). Bioactive multidomain peptides and their application for dental tissue regeneration [Abstract]. J Dent Res, 89(A), 1001.
  30. Chang JYF, Huang Y, DSouza R, Wang F (). Development of an odontogenic epithelial stem cell culture system [Abstract]. J Dent Res, 89(A), 640.
  31. Patel M, Wang Y, Mues G, DSouza R (). Regulation of human Bmp4 promoter by Pax9, Msx1 and Msx2 [Abstract]. J Dent Res, 89(A), 636.
  32. DSouza R (). Keynote Address: Nanostructured peptide hydrogels for the regeneration of the dentin-pulp complex [Abstract]. J Dent Res, 89(A), 182.
  33. Lu Y, Cavender A, Li Y, DSouza R (). Runx2 regulates FGF3/10 through controlling E12/47 expression in dental mesenchyme [Abstract]. J Dent Res, 89(A), 79.
  34. Li Y, Lu Y, Cavender A, Mansukhani A, DSouza R (). Runx2 indirectly regulates FGFR2 expression [Abstract]. J Dent Res, 89(A), 77.
  35. Napierala D, Sun Y, Maciejewska I, Munivez E, Dawson B, DSouza R, Qin C, Lee B (). Role of the Trps1 transcription factor in odontoblasts [Abstract]. J Dent Res, 89(A), 76.
  36. Galler K, Schmalz G, DSouza R, Hartgerink J (). Growth factor binding to peptide=based hydrogels via heparin [Abstract]. J Dent Res, 89(A), 76.
  37. Voisey A, Lv K, Ye L, Xie Y, DSouza R, Feng J (). BMPR1A controls tooth/bone cell fate through WNT-catenin signaling via SOST [Abstract]. J Dent Res, 89(B), 3827.
  38. Li Y, Lu Y, Maciejewska I, Galler K, Cavender A, DSouza R (). Novel roles of Runx2 andTwist1 in odontoblast differentiation [Abstract]. J Dent Res, 89(B), 132.
  39. Komabayashi T, DSouza RN, Dechow PC, Safavi K, Spngberg LS (). Particle size and shape of calcium hydroxide in Endodontics [Abstract]. J Dent Res, 88(A), 944.
  40. Chang JYF, Lin Y, Cheng YSL, Qin C, DSouza RN, Wang F (). FGFR2 is essential for the development of mouse maxillary incisors [Abstract]. J Dent Res, 88(A), 3585.
  41. Wang Y, Groppe JC, Wu J, Mues G, DSouza RN, Kapadia H (). Pathogenic mechanisms of tooth agenesis linked to PAX9 DNA-binding domain [Abstract]. J Dent Res, 88(A), 3105.
  42. Galler K, Schweikl H, Hiller KA, Cavender AC, Bolay C, DSouza RN, Schmalz G (). TEGDMA reduces mineralization in dental pulp cells [Abstract]. J Dent Res, 88(A), 2931.
  43. Galler K, Aulisa L, Schmalz G, Hartgerink J, DSouza RN (). Self-assembling peptide nanofiber hydrogels targeted for dental tissue regeneration [Abstract]. J Dent Res, 88(A), 2620.
  44. Venugopalan SR, Florez S, Cao H, Wang J, DSouza RN, Amendt BA (). Dlx-2 regulation of FoxJ1 expression during tooth morphogenesis [Abstract]. J Dent Res, 88(A), 1497.
  45. Mues G, Tardivel A, Willen L, Kapadia H, Schneider PS, DSouza RN (). Functional analysis of Ectodysplasin A in selective tooth agenesis [Abstract]. J Dent Res, 88(A), 1494.
  46. Maciejewska I, Lu Y, Li Y, Cavender A, DSouza RN (). Functional studies on Runx2 and Twist1 roles in tooth morphogenesis [Abstract]. J Dent Res, 88(A), 1493.
  47. Yasue A, Cavender AC, Galler K, Mues G, DSouza RN (). Mechanism of incisor overeruption in Twist-1 null heterozygous mice [Abstract]. J Dent Res, 88(A), 1467.
  48. Best L, Griggs R, Kapadia H, Mues G, Hartung A, Whelan G, DSouza RN, Srivastava A (). A NEW Eda mutation causing selective tooth agenesis [Abstract]. J Dent Res, 88(A), 445.
  49. Pollan White S, Mues G, Chalothorn LA, Beeman CS, DSouza RN (). Association of ovarian disease with tooth agenesis: A study update [Abstract]. J Dent Res, 88(A), 1443.
  50. Maciejewska I, Cavender A, DSouza RN (). Isolation and characterization of pericytes from dental pulp [Abstract]. J Dent Res, 88(A), 409.
  51. Kang Y, Kapadia H, Xie Y, Zhou X, Crombrugghe BD, DSouza RN, Feng JQ (). Osterix is critical for odontogenesis and condyle formation [Abstract]. J Dent Res, 88(A), 85.
  52. Galler KM, Regan K, Aulisa L, Cavender A, Schmalz G, Hartgerink JD, DSouza RN (). Injectable hydrogel systems for dental tissue engineering [Abstract]. J Dent Res, 88(B), 144.
  53. Mues G, Pollan-White S, Chalothorn LA, Beeman CS, DSouza RN (). Investigating the association of ovarian disease with tooth agenesis [Abstract]. J Dent Res, 87(A), 958.
  54. Pollan-White S, MuesG, Kapadia H, Schneiderman E, DSouza RN (). Frequency of common polymorphisms A240PPAX9 and A34GMSX1 in tooth agenesis [Abstract]. J Dent Res, 87(A), 173.
  55. Kapadia H, Mues G, Pollan-White S, DSouza RN (). Witkop syndrome is not always caused by MSX1 mutation [Abstract]. J Dent Res, 87(A), 586.
  56. Cavender AC, Pham QP, Mikos AG, DSouza RN (). Bone-like extracellular matrix enhances osteoblastic differentiation of BMSCs [Abstract]. J Dent Res, 87(A), 1169.
  57. Dar S, Peng T, Cavender AC, DSouza RN (). Different transfection methods for human bone and dental stem cells [Abstract]. J Dent Res, 87(A), 771.
  58. Yasue A, Klein O, Cavender AC, DSouza RN (). Analysis of over erupted incisors in Twist-1 deficient mice [Abstract]. J Dent Res, 87(A), 957.
  59. Galler K, Koeklue U, Cavender AC, Suggs L, Schmalz G, DSouza RN (). Bioengineering of dental stem cells in a 3-dimensional fibrin hydrogel [Abstract]. J Dent Res, 87(A), 737.
  60. Galler K, Yuwono V, Cavender AC, Dong H, Hartgerink JD, DSouza RN (). Self- assembling peptide nanofiber hydrogels targeted for dental tissue regeneration [Abstract]. J Dent Res, 87(A), 570.
  61. Venugopalan SR, Amen M, Wang J, Cavender AC, DSouza RN, Akerlund M, Brody SL, Hjalt TA, Amendt BA (). Novel expression and regulation of FoxJ1 during craniofacial/tooth morphogenesis [Abstract]. J Dent Res, 87(A), 570.
  62. Peng T, Cavender AC, Feng JQ, Qin C, DSouza RN (). Functional assays of human tooth- derived stem cells [Abstract]. J Dent Res, 87(A), 171.
  63. Seaman R, DSouza R, Mues G (). A novel mutation in EDA causes X-linked recessive tooth agenesis [Abstract]. J Dent Res, 87(A), 814.
  64. Wu H, Wang Y, Wu J, Zhao HS, Zhang X, Feng H, Kapadia H, DSouza RN (). Identification and functional analysis of two novel PAX9 mutations [Abstract]. J Dent Res, 87(A), 952.
  65. Zarchi E, Mues G, Wang Y, DSouza RN, Kapadia H (). The role of the HAND genes in Pierre Robin Sequence [Abstract]. J Dent Res, 87(A), 812.
  66. Wang Y, Wu J, DSouza RN, Kapadia H (). Functional studies of human PAX9 paired domain mutations [Abstract]. J Dent Res, 87(A), 178.
  67. Venugopalan SR, Amen M, Wang J, Cavender AC, DSouza RN, Brody SL, Hjalt TA, Amendt BA (). Molecular basis of PITX2 regulation of FoxJ1 expression during odontogenesis [Abstract]. J Dent Res, 87(B), 221.
  68. Zarchi E, Mues G, Wang Y, DSouza RN, Kapadia H (). The genetic basis of Pierre Robin Sequence [Abstract]. J Dent Res, 87(B), 3561.
  69. Wang Y, Wu J, DSouza RN, Kapadia H (). PAX9 mutations disrupt the Pax9-Msx1-Bmp4 signaling pathway [Abstract]. J Dent Res, 87(B), 3561.
  70. Galler K, Cavender AC, Schmalz G, Hartgerink JD, DSouza RN (). Novel hydrogel systems for dentin regeneration [Abstract]. J Dent Res, 87(B), 2613.
  71. Kapadia H, Ogawa T, Cavender AC, DSouza RN (). Genotype-phenotype correlations in PAX9 mutations [Abstract]. J Dent Res, 86(A), 21.
  72. Galler K, Cavender AC, Syamken M, Collin S, Suggs L, DSouza RN (). Bioengineering of dental stem cells in a 3-dimensional fibrin patch [Abstract]. J Dent Res, 86(A), 1785.
  73. Galler K, DSouza RN, Hartgerink JD (). Self-assembling peptide-amphiphile nanofibers as a scaffold for dental stem cells [Abstract]. J Dent Res, 86(A), 1448.
  74. Milburn J, Lin C, Lin Y, DSouza RN, Wang F (). Critical role of Fgfr2 in maxillary incisor development [Abstract]. J Dent Res, 86(A), 781.
  75. Seaman R, DSouza RN, Daiger SP (). A model for identifying genes and mutations causing dental diseases [Abstract]. J Dent Res, 86(A 780).
  76. Kapadia H, Ogawa T, Cavender AC, DSouza RN (). Molecular characterization of human PAX9 paired domain missense mutations [Abstract]. J Dent Res, 85(B), 489.
  77. Phan HT, Galler KM, Cavender AC, Javarone J, DSouza RN (). Expression analysis of Twist-1 in developing and adult mouse organs [Abstract]. J Dent Res, 85(A), 1787.
  78. Javarone JA, Galler KM, Phan HT, Cavender AC, DSouza RN (). Phenotypic analysis of Twist-1+/- mouse dental development [Abstract]. J Dent Res, 85(A), 1575.
  79. Ogawa T, Feng JQ, Raghow R, Kapadia H, Peters H, DSouza RN (). Functional consequences of interactions between Pax9 and Msx1 in tooth development [Abstract]. J Dent Res, 85(A), 1571.
  80. Kapadia H, Shevchenko L, Ogawa T, DSouza RN (). Structure-function analysis of human PAX9 paired domain missense mutations [Abstract]. J Dent Res, 85(A), 1219.
  81. Kapadia H, Frazier-Bowers SA, Ogawa T, DSouza, RN (). Molecular characterization of a novel PAX9 mutation causing tooth agenesis [Abstract]. J Dent Res, 85(A), 1215.
  82. Syamken M, Cavender AC, Galler KM, Shi S, Collins S, Suggs L, DSouza RN (). Studies of dental stem cells in a PEGylated fibrin matrix [Abstract]. J Dent Res, 85(A), 583.
  83. Galler KM, Javarone J, Cavender AC, Bialek P, Karsenty G, Schmalz G, DSouza RN (). Novel insights into the genetic etiology of pulp stones [Abstract]. J Dent Res, 85(A), 45.
  84. Galler KM, Javarone J, Cavender AC, DSouza RN (). Twist-1 as a potential regulator of mineralization in dental pulp [Abstract]. J Dent Res, 85(B), 2026.
  85. Javarone J, Galler KM, Cavender AC, Bialek P, Karsenty G, DSouza RN (). Genetic loss-of- function studies indicate tooth-specific functions of Twist-1 during postnatal-development [Abstract]. J Dent Res, 85, 2580.
  86. Kiss J, DSouza R, Taschner P (1975 Jan 29). [Preparative production of 5-desoxy-L-arabinose, xylitol and D-ribose from "diacetone glucose"] [Abstract]. Patient Exp J, 58(1), 311-7.

Other

  1. Ebersole JL, DSouza R, Gordon S, Fox CH (2012 Nov). Oral Health Disparities and the Future Face of America. Patient Exp J (91(11), pp. 997-1002). United States.

Report

  1. DSouza RN (). Workshop on the Genetics of Human Dentition. NIH.

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