Joshua A. Sonnen, MD

Languages

  • English

Academic Information

  • Departments: Pathology - Adjunct Associate Professor
  • Divisions: Anatomic Pathology

Board Certification

  • American Board of Pathology (Sub: Neuropathology)
  • American Board of Pathology (Sub: Anatomic Path)

Academic Office Information

  • 801-581-2507
  • Huntsman Cancer Hospital
    Anatomic Pathology
    1950 Circle of Hope, Room: N3100
    Salt Lake City, UT 84112

Email: joshua.sonnen@path.utah.edu

Education History

Type School Degree
Fellowship University of Washington, Seattle
Neuropathology
Fellow
Residency University of Arizona, Tucson
Resident
Professional Medical Keck School of Medicine, University of Southern California
Medicine
M.D.
Undergraduate University of Southern California
B.S.

Selected Publications

Journal Article

  1. Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, Raj T, Ertekin-Taner N, Logue M, Baldwin CT, Green RC, Barnes LL, Cantwell LB, Fallin MD, Go RC, Griffith P, Obisesan TO, Manly JJ, Lunetta KL, Kamboh MI, Lopez OL, Bennett DA, Hendrie H, Hall KS, Goate AM, Byrd GS, Kukull WA, Foroud TM, Haines JL, Farrer LA, Pericak-Vance MA, Schellenberg GD, Mayeux R (2013 Apr 10). Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E 4,and the risk of late-onset Alzheimer disease in African Americans. JAMA, 309(14), 1483-92.
  2. Cholerton B, Larson EB, Baker LD, Craft S, Crane PK, Millard SP, Sonnen JA, Montine TJ (2013). Neuropathologic correlates of cognition in a population-based sample. J Alzheimers Dis, 36(4), 699-709.
  3. Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R (2013). SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians. PLoS ONE, 8(4), e58618.
  4. Jun G, Vardarajan BN, Buros J, Yu CE, Hawk MV, Dombroski BA, Crane PK, Larson EB, Mayeux R, Haines JL, Lunetta KL, Pericak-Vance MA, Schellenberg GD, Farrer LA (2012 Oct). Comprehensive search for Alzheimer disease susceptibility loci in the APOE region. Arch Neurol, 69(10), 1270-9.
  5. Montine TJ, Sonnen JA, Montine KS, Crane PK, Larson EB (2012 Jul). Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics. Curr Alzheimer Res, 9(6), 718-23.
  6. Postupna N, Rose SE, Bird TD, Gonzalez-Cuyar LF, Sonnen JA, Larson EB, Keene CD, Montine TJ (2012 Jul). Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults. Brain Pathol, 22(4), 472-84.
  7. Chan WF, Gurnot C, Montine TJ, Sonnen JA, Guthrie KA, Nelson JL (2012). Male microchimerism in the human female brain. PLoS ONE, 7(9), e45592.
  8. Zou F, Chai HS, Younkin CS, Allen M, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, Lincoln S, Bisceglio G, Georgescu C, Kouri N, Kolbert CP, Jen J, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD, Petersen RC, Graff-Radford NR, Dickson DW, Younkin SG, Ertekin-Taner N (2012). Brain expression genome-wide association study (eGWAS) identifies human disease-associated variants. PLoS Genet, 8(6), e1002707.
  9. SantaCruz KS, Sonnen JA, Pezhouh MK, Desrosiers MF, Nelson PT, Tyas SL (2011 Oct). Alzheimer disease pathology in subjects without dementia in 2 studies of aging: the Nun Study and the Adult Changes in Thought Study. J Neuropathol Exp Neurol, 70(10), 832-40.
  10. Back SA, Kroenke CD, Sherman LS, Lawrence G, Gong X, Taber EN, Sonnen JA, Larson EB, Montine TJ (2011 Sep). White matter lesions defined by diffusion tensor imaging in older adults. Ann Neurol, 70(3), 465-76.
  11. Sonnen JA, Santa Cruz K, Hemmy LS, Woltjer R, Leverenz JB, Montine KS, Jack CR, Kaye J, Lim K, Larson EB, White L, Montine TJ (2011 Aug). Ecology of the aging human brain. Arch Neurol, 68(8), 1049-56.
  12. Reed BR, Dowling M, Tomaszewski Farias S, Sonnen J, Strauss M, Schneider JA, Bennett DA, Mungas D (2011 Jul). Cognitive activities during adulthood are more important than education in building reserve. J Int Neuropsychol Soc, 17(4), 615-24.
  13. Dowling NM, Tomaszewski Farias S, Reed BR, Sonnen JA, Strauss ME, Schneider JA, Bennett DA, Mungas D (2011 Jul). Neuropathological associates of multiple cognitive functions in two community-based cohorts of older adults. J Int Neuropsychol Soc, 17(4), 602-14.
  14. Nelson PT, Schmitt FA, Lin Y, Abner EL, Jicha GA, Patel E, Thomason PC, Neltner JH, Smith CD, Santacruz KS, Sonnen JA, Poon LW, Gearing M, Green RC, Woodard JL, Van Eldik LJ, Kryscio RJ (2011 May). Hippocampal sclerosis in advanced age: clinical and pathological features. Brain, 134(Pt 5), 1506-18.
  15. Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, Evans D, Schneider JA, Carrasquillo MM, Ertekin-Taner N, Younkin SG, Cruchaga C, Kauwe JS, Nowotny P, Kramer P, Hardy J, Huentelman MJ, Myers AJ, Barmada MM, Demirci FY, Baldwin CT, Green RC, Rogaeva E, St George-Hyslop P, Arnold SE, Barber R, Beach T, Bigio EH, Bowen JD, Boxer A, Burke JR, Cairns NJ, Carlson CS, Carney RM, Carroll SL, Chui HC, Clark DG, Corneveaux J, Cotman CW, Cummings JL, DeCarli C, DeKosky ST, Diaz-Arrastia R, Dick M, Dickson DW, Ellis WG, Faber KM, Fallon KB, Farlow MR, Ferris S, Frosch MP, Galasko DR, Ganguli M, Gearing M, Geschwind DH, Ghetti B, Gilbert JR, Gilman S, Giordani B, Glass JD, Growdon JH, Hamilton RL, Harrell LE, Head E, Honig LS, Hulette CM, Hyman BT, Jicha GA, Jin LW, Johnson N, Karlawish J, Karydas A, Kaye JA, Kim R, Koo EH, Kowall NW, Lah JJ, Levey AI, Lieberman AP, Lopez OL, Mack WJ, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Parisi JE, Perl DP, Peskind E, Petersen RC, Poon WW, Quinn JF, Rajbhandary RA, Raskind M, Reisberg B, Ringman JM, Roberson ED, Rosenberg RN, Sano M, Schneider LS, Seeley W, Shelanski ML, Slifer MA, Smith CD, Sonnen JA, Spina S, Stern RA, Tanzi RE, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Williamson J, Woltjer RL, Cantwell LB, Dombroski BA, Beekly D, Lunetta KL, Martin ER, Kamboh MI, Saykin AJ, Reiman EM, Bennett DA, Morris JC, Montine TJ, Goate AM, Blacker D, Tsuang DW, Hakonarson H, Kukull WA, Foroud TM, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Schellenberg GD (2011 May). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet, 43(5), 436-41.
  16. Sonnen JA, Larson EB, Walker RL, Haneuse S, Crane PK, Gray SL, Breitner JC, Montine TJ (2010 Sep 28). Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques. Neurology, 75(13), 1203-10.
  17. Rostomily RC, Born DE, Beyer RP, Jin J, Alvord EC Jr, Mikheev AM, Matthews RT, Pan C, Khorasani L, Sonnen JA, Montine TJ, Shi M, Zhang J (2010 May 7). Quantitative proteomic analysis of oligodendrogliomas with and without 1p/19q deletion. J Proteome Res, 9(5), 2610-8.
  18. Tsuang D, Larson EB, Li G, Shofer JB, Montine KS, Thompson ML, Sonnen JA, Crane PK, Leverenz JB, Montine TJ (2010 Mar). Association between lifetime cigarette smoking and lewy body accumulation. Brain Pathol, 20(2), 412-8.
  19. Luria S, Waitayawinyu T, Conniff J, Morton HJ, Nemechek NM, Sonnen JA, Katolik LI, Trumble TE (2010 Feb). Glatiramer acetate immune system augmentation for peripheral nerve regeneration in rat crushed sciatic nerve model. J Bone Joint Surg Am, 92(2), 396-403.
  20. Montine TJ, Sonnen JA, Milne G, Baker LD, Breitner JC (2010). Elevated ratio of urinary metabolites of thromboxane and prostacyclin is associated with adverse cardiovascular events in ADAPT. PLoS ONE, 5(2), e9340.
  21. Wang LY, Larson EB, Sonnen JA, Shofer JB, McCormick W, Bowen JD, Montine TJ, Li G (2009 Nov). Blood pressure and brain injury in older adults: findings from a community-based autopsy study. J Am Geriatr Soc, 57(11), 1975-81.
  22. Woltjer RL, Sonnen JA, Sokal I, Rung LG, Yang W, Kjerulf JD, Klingert D, Johnson C, Rhew I, Tsuang D, Crane PK, Larson EB, Montine TJ (2009 Jul). Quantitation and mapping of cerebral detergent-insoluble proteins in the elderly. Brain Pathol, 19(3), 365-74.
  23. Longstreth WT Jr, Sonnen JA, Koepsell TD, Kukull WA, Larson EB, Montine TJ (2009 Jul-Sep). Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases. Alzheimer Dis Assoc Disord, 23(3), 291-4.
  24. Sonnen JA, Larson EB, Brickell K, Crane PK, Woltjer R, Montine TJ, Craft S (2009 Mar). Different patterns of cerebral injury in dementia with or without diabetes. Arch Neurol, 66(3), 315-22.
  25. Sonnen JA, Larson EB, Gray SL, Wilson A, Kohama SG, Crane PK, Breitner JC, Montine TJ (2009 Feb). Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking. Ann Neurol, 65(2), 226-9.
  26. Haneuse S, Larson E, Walker R, Montine T, Sonnen J (2009). Neuropathology-based risk scoring for dementia diagnosis in the elderly. J Alzheimers Dis, 17(4), 875-85.
  27. Haneuse S, Schildcrout J, Crane P, Sonnen J, Breitner J, Larson E (2009). Adjustment for selection bias in observational studies with application to the analysis of autopsy data. Neuroepidemiology, 32(3), 229-39.
  28. Sonnen JA, Larson EB, Crane PK, Haneuse S, Li G, Schellenberg GD, Craft S, Leverenz JB, Montine TJ (2007 Oct). Pathological correlates of dementia in a longitudinal, population-based sample of aging. Ann Neurol, 62(4), 406-13.
  29. Li G, Larson EB, Sonnen JA, Shofer JB, Petrie EC, Schantz A, Peskind ER, Raskind MA, Breitner JC, Montine TJ (2007 Aug 28). Statin therapy is associated with reduced neuropathologic changes of Alzheimer disease. Neurology, 69(9), 878-85.
  30. Allen CT, Sonnen J, Leslie MJ, Kidoguchi L, Harris C, Gambetti P, Montine TJ (2007 Apr). Washington statewide pathology surveillance for prion disease. Ann Neurol, 61(4), 371-2.

Review

  1. Nelson PT, Alafuzoff I, Bigio EH, Bouras C, Braak H, Cairns NJ, Castellani RJ, Crain BJ, Davies P, Del Tredici K, Duyckaerts C, Frosch MP, Haroutunian V, Hof PR, Hulette CM, Hyman BT, Iwatsubo T, Jellinger KA, Jicha GA, Kovari E, Kukull WA, Leverenz JB, Love S, Mackenzie IR, Mann DM, Masliah E, McKee AC, Montine TJ, Morris JC, Schneider JA, Sonnen JA, Thal DR, Trojanowski JQ, Troncoso JC, Wisniewski T, Woltjer RL, Beach TG (2012 May). Correlation of Alzheimer disease neuropathologic changes with cognitive status: a review of the literature. [Review]. J Neuropathol Exp Neurol, 71(5), 362-81.
  2. Gonzalez-Cuyar LF, Sonnen JA, Montine KS, Keene CD, Montine TJ (2011 Oct). Role of cerebrospinal fluid and plasma biomarkers in the diagnosis of neurodegenerative disorders and mild cognitive impairment. [Review]. Curr Neurol Neurosci Rep, 11(5), 455-63.
  3. Sonnen JA, Postupna N, Larson EB, Crane PK, Rose SE, Montine KS, Leverenz JB, Montine TJ (2010 May). Pathologic correlates of dementia in individuals with Lewy body disease. [Review]. Brain Pathol, 20(3), 654-9.
  4. Sonnen JA, Montine KS, Quinn JF, Breitner JC, Montine TJ (2010). Cerebrospinal fluid biomarkers in mild cognitive impairment and dementia. [Review]. J Alzheimers Dis, 19(1), 301-9.
  5. Sonnen JA, Larson EB, Haneuse S, Woltjer R, Li G, Crane PK, Craft S, Montine TJ (2009). Neuropathology in the adult changes in thought study: a review. [Review]. J Alzheimers Dis, 18(3), 703-11.
  6. Sonnen JA, Breitner JC, Lovell MA, Markesbery WR, Quinn JF, Montine TJ (2008 Aug 1). Free radical-mediated damage to brain in Alzheimer's disease and its transgenic mouse models. [Review]. Free Radic Biol Med, 45(3), 219-30.
  7. Sonnen JA, Montine KS, Quinn JF, Kaye JA, Breitner JC, Montine TJ (2008 Aug). Biomarkers for cognitive impairment and dementia in elderly people. [Review]. Lancet Neurol, 7(8), 704-14.

Book Chapter

  1. Sonnen JA, Keene CD, Hevner RF, Montine TJ (). Molecular Basis of Diseases of the Nervous System. In Coleman WB, Tsongalis G (Eds.), Essential Concepts in Molecular Pathology (1st Edition). Elsevier Academic Press.
  2. Sonnen JA, Keene CD, Hevner RF, Montine TJ (). Molecular Pathology: Neuropathology (Chapter 27). In Coleman WB, Tsongalis G (Eds.), Molecular Pathology: The Molecular Basis of Human Disease (pp. 551-83). Elsevier Academic Press.
  3. Sonnen J, Keene C, Montine K, Li G, Peskind E, Zhang J, Montine T (). Biomarkers for Alzheimer’s Disease. In Mazotti E (Ed.), Expert Rev. Neurotheraputics (7980, pp. 1021-1028). London: Future Drugs Ltd.

Case Report

  1. Chen DH, Raskind WH, Parson WW, Sonnen JA, Vu T, Zheng Y, Matsushita M, Wolff J, Lipe H, Bird TD (2010 Sep 15). A novel mutation in FHL1 in a family with X-linked scapuloperoneal myopathy: phenotypic spectrum and structural study of FHL1 mutations. J Neurol Sci, 296(1-2), 22-9.
  2. Keene CD, Sonnen JA, Swanson PD, Kopyov O, Leverenz JB, Bird TD, Montine TJ (2007 Jun 12). Neural transplantation in Huntington disease: long-term grafts in two patients. Neurology, 68(24), 2093-8.

Letter

  1. Cole B, Montine TJ, True L, Sonnen J (2008 Oct). 70-year-old man with enlarged pineal gland [Letter to the editor]. Brain Pathol, 18(4), 602-4.

Abstract

  1. White L, Gelber R, Launer L, Zarow C, Sonnen JA, Uyehara-Lock J, Masaki K, Ross GW, Petrovitch H (). Beta Blocker Treatment of Hypertensive Older Persons Ameliorates the Brain Lesions of Dementia Measured at Autopsy: the Honolulu-Asia Aging Study. New Orleans, LA [Abstract]. American Academy of Neurology.
  2. Zhong N, Oakes P, Sonnen JA, Ransom B, Longstreth W, Mrugala M (). Clinical Spectrum and Course in Individuals with Intravascular Large B-cell Lymphoma: A Case Series. New Orleans, LA [Abstract]. American Academy of Neurology.
  3. Sonnen JA, Larson EB, Lopez A, Montine TJ (). Alteration in structural proteins in white matter injury is associated with vascular brain injury. Paris, France [Abstract]. International Conference on Alzheimer's Disease.
  4. Sonnen JA (). Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques. Honolulu, HI [Abstract]. International Conference on Alzheimer's Disease.
  5. Sonnen JA, Larson EB, Walker R, Haneuse S, Breitner JCS, Montine T (). Late-life NSAID exposure increases the risk for Alzheimer-type neuropathology in a community-based population: The Adult Changes in Thought Study. San Antonio, TX [Abstract]. American Association of Neuropathologists Annual Meeting.
  6. Crane PK, Sonnen JA (). Cortical gray matter microvascular brain infarcts were independently associated with cognitive impairment and with dementia: The Honolulu Asia aging study. Singapore [Abstract]. VAS-COG.
  7. Sonnen JA, Gray SL, Larson EB, Wilson A, Kohama S, Anderson ML, Crane PK, Breitner JC, Montine TJ (). Alzheimer’s Disease, Microscopic Vascular Injury and Current Smoking Increase Oxidative Damage to Brain in the Adult Changes in Thought Study. San Diego, CA [Abstract]. American Association of Neuropathology at Experimental Biology.
  8. Sonnen JA, Larson EB, Li G, Shofer J, Hanuese S, Crane PK, Tsuang D, Leverenz J, Breitner JCS, Montine TJ (). Higher Systolic Blood Pressure Was Associated with Increased Risk For Cortical and Subcortical Microinfarcts and Atherosclerosis of The Circle Of Willis At Autopsy, While Higher Diastolic Blood Pressure Was Only Associated with Atherosclerosis. Chicago, IL [Abstract]. International Conference on Alzheimer's Disease.
  9. Sonnen J, Montine T (). Cognitive impairment and dementia due to Alzheimer disease and cerebrovascular pathology in autopsied ACT study patients. Washington, DC [Abstract]. American Association of Neuropathology at Experimental Biology.
  10. Sonnen J, Larson EB, Li G, Montine TJ (). Microvascular injury as a cause of dementia in the population-based, primarily Caucasian ACT study, the Japanese-American, male only HAAS study and the Japanese-American, male-and-female Kame study. San Antonio, TX [Abstract]. VAS-COG.
  11. Lin C, Williams C, Zhou L, Sonnen J, McCleary C, Spann B, Miller C (). Activation of neurogenesis genes and synaptic terminal regeneration in AD. Arlington, VA [Abstract]. American Association of Neuropathology.
  12. Bourgon DB, Erly WK, Sonnen J (). Cerebritis due to Coccidioides immitis; A report of 5 cases [Abstract]. Western Neuroradiology Society.