Oleg Yarishkin, PhD

Research Interests

  • Glaucoma
  • Ion Channels
  • Mechanotransduction, Cellular
  • Neurodegenerative Disorders
  • Retinal Degeneration and Cell Biology
  • Neuron-Glia Interaction

Languages

  • English
  • Russian

Academic Information

  • Departments: Ophthalmology/Visual Sciences - Research Assistant Professor

Research Statement

My research interests focus on cellular and molecular mechanisms coupling the activity of plasma membrane ion channels to intracellular signaling pathways in health and disease.

Education History

Type School Degree
Certification National University of Uzbekistan
Biophysics
Ph.D.
Diploma National University of Uzbekistan
Biology
M.S.

Selected Publications

Journal Article

  1. Lapajne L, Lakk M, Yarishkin O, Gubeljak L, Hawlina M, Kriaj D (2020). Polymodal Sensory Transduction in Mouse Corneal Epithelial Cells. Invest Ophthalmol Vis Sci, 61(4), 2.
  2. Cho CH, Lee S, Kim A, Yarishkin O, Ryoo K, Lee YS, Jung HG, Yang E, Lee DY, Lee B, Kim H, Oh U, Im HI, Hwang EM, Park JY (2019). TMEM16A expression in cholinergic neurons of the medial habenula mediates anxiety-related behaviors. EMBO Rep, 21(2), e48097.
  3. Yarishkin O, Baumann JM, Kriaj D (2019). Mechano-electrical transduction in trabecular meshwork involves parallel activation of TRPV4 and TREK-1 channels. Channels (Austin), 13(1), 168-171.
  4. Toft-Bertelsen TL, Yarishkin O, Redmon S, Phuong TTT, Kriaj D, MacAulay N (2019). Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type-specific and mediated by an N-terminal volume-sensing domain. J Biol Chem, 294(48), 18421-18434.
  5. Yarishkin O, Phuong TTT, Kriaj D (2019). Trabecular Meshwork TREK-1 Channels Function as Polymodal Integrators of Pressure and pH. Invest Ophthalmol Vis Sci, 60(6), 2294-2303.
  6. Memon T, Yarishkin O, Reilly CA, Kriaj D, Olivera BM, Teichert RW (2019). trans-Anethole of Fennel Oil is a Selective and Nonelectrophilic Agonist of the TRPA1 Ion Channel. Mol Pharmacol, 95(4), 433-441.
  7. Park JH, Ju YH, Choi JW, Song HJ, Jang BK, Woo J, Chun H, Kim HJ, Shin SJ, Yarishkin O, Jo S, Park M, Yeon SK, Kim S, Kim J, Nam MH, Londhe AM, Kim J, Cho SJ, Cho S, Lee C, Hwang SY, Kim SW, Oh SJ, Cho J, Pae AN, Lee CJ, Park KD (2019). Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer's disease. Sci Adv, 5(3), eaav0316.
  8. Yarishkin O, Phuong TTT, Bretz CA, Olsen KW, Baumann JM, Lakk M, Crandall A, Heurteaux C, Hartnett ME, Kriaj D (2018). TREK-1 channels regulate pressure sensitivity and calcium signaling in trabecular meshwork cells. J Gen Physiol, 150(12), 1660-1675.
  9. Choi JH, Yarishkin O, Kim E, Bae Y, Kim A, Kim SC, Ryoo K, Cho CH, Hwang EM, Park JY (2018). TWIK-1/TASK-3 heterodimeric channels contribute to the neurotensin-mediated excitation of hippocampal dentate gyrus granule cells. Exp Mol Med, 50(11), 1-13.
  10. Lakk M, Vazquez-Chona F, Yarishkin O, Kriaj D (2018). Dyslipidemia modulates Müller glial sensing and transduction of ambient information. Neural Regen Res, 13(2), 207-210.
  11. Yarishkin O, Phuong TTT, Lakk M, Kriaj D (2018). TRPV4 Does Not Regulate the Distal Retinal Light Response. Adv Exp Med Biol, 1074, 553-560.
  12. Lakk M, Yarishkin O, Baumann JM, Iuso A, Kriaj D (2017). Cholesterol regulates polymodal sensory transduction in Müller glia. Glia, 65(12), 2038-2050.
  13. Phuong TTT, Redmon SN, Yarishkin O, Winter JM, Li DY, Kriaj D (2017). Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells. J Physiol, 595(22), 6869-6885.
  14. Jo AO, Noel JM, Lakk M, Yarishkin O, Ryskamp DA, Shibasaki K, McCall MA, Kriaj D (2017). Mouse retinal ganglion cell signalling is dynamically modulated through parallel anterograde activation of cannabinoid and vanilloid pathways. J Physiol, 595(20), 6499-6516.
  15. Phuong TT, Yarishkin O, Kriaj D (2016). Subcellular propagation of calcium waves in Müller glia does not require autocrine/paracrine purinergic signaling. Channels (Austin), 10(5), 421-427.
  16. Ryskamp DA, Frye AM, Phuong TT, Yarishkin O, Jo AO, Xu Y, Lakk M, Iuso A, Redmon SN, Ambati B, Hageman G, Prestwich GD, Torrejon KY, Kriaj D (2016). TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Sci Rep, 6, 30583.
  17. Jo AO, Lakk M, Frye AM, Phuong TT, Redmon SN, Roberts R, Berkowitz BA, Yarishkin O, Kriaj D (2016). Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels. Proc Natl Acad Sci U S A, 113(14), 3885-90.
  18. Molnr T, Yarishkin O, Iuso A, Barabas P, Jones B, Marc RE, Phuong TT, Kriaj D (2016). Store-Operated Calcium Entry in Müller Glia Is Controlled by Synergistic Activation of TRPC and Orai Channels. J Neurosci, 36(11), 3184-98.
  19. Jo AO, Ryskamp DA, Phuong TT, Verkman AS, Yarishkin O, MacAulay N, Kriaj D (2015). TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Müller Glia. J Neurosci, 35(39), 13525-37.
  20. Yarishkin O, Lee J, Jo S, Hwang EM, Lee CJ (2015). Disinhibitory Action of Astrocytic GABA at the Perforant Path to Dentate Gyrus Granule Neuron Synapse Reverses to Inhibitory in Alzheimer's Disease Model. Exp Neurobiol, 24(3), 211-8.
  21. Yarishkin O, Lee DY, Kim E, Cho CH, Choi JH, Lee CJ, Hwang EM, Park JY (2014). TWIK-1 contributes to the intrinsic excitability of dentate granule cells in mouse hippocampus. Molecular Brain, 7, 80.
  22. Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ (2014). GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease. Nat Med, 20(8), 886-96.
  23. Cho CH, Kim E, Lee YS, Yarishkin O, Yoo JC, Park JY, Hong SG, Hwang EM (2014). Depletion of 14-3-3γ reduces the surface expression of Transient Receptor Potential Melastatin 4b (TRPM4b) channels and attenuates TRPM4b-mediated glutamate-induced neuronal cell death. Molecular Brain, 7, 52.
  24. Kim DG, Yoo JC, Kim E, Lee YS, Yarishkin OV, Lee DY, Lee KH, Hong SG, Hwang EM, Park JY (2014). A Novel Cytosolic Isoform of Mitochondrial Trans-2-Enoyl-CoA Reductase Enhances Peroxisome Proliferator-Activated Receptor α Activity. Endocrinol Metab (Seoul), 29(2), 185-94.
  25. Hwang EM, Kim E, Yarishkin O, Woo DH, Han KS, Park N, Bae Y, Woo J, Kim D, Park M, Lee CJ, Park JY (2013). A disulphide-linked heterodimer of TWIK-1 and TREK-1 mediates passive conductance in astrocytes. Nat Commun, 5, 3227.
  26. Kim E, Hwang EM, Yarishkin O, Yoo JC, Kim D, Park N, Cho M, Lee YS, Sun CH, Yi GS, Yoo J, Kang D, Han J, Hong SG, Park JY (2010). Enhancement of TREK1 channel surface expression by protein-protein interaction with beta-COP. Biochem Biophys Res Commun, 395(2), 244-50.
  27. Yoo JC, Yarishkin OV, Hwang EM, Kim E, Kim DG, Park N, Hong SG, Park JY (2009). Cloning and characterization of rat transient receptor potential-melastatin 4 (TRPM4). Biochem Biophys Res Commun, 391(1), 806-11.
  28. Yarishkin OV, Hwang EM, Kim D, Yoo JC, Kang SS, Kim DR, Shin JH, Chung HJ, Jeong HS, Kang D, Han J, Park JY, Hong SG (2009). Diclofenac, a Non-steroidal Anti-inflammatory Drug, Inhibits L-type Ca Channels in Neonatal Rat Ventricular Cardiomyocytes. Korean J. Physiol. Pharmacol, 13(6), 437-42.
  29. Jang SH, Choi C, Hong SG, Yarishkin OV, Bae YM, Kim JG, OGrady SM, Yoon KA, Kang KS, Ryu PD, Lee SY (2009). Silencing of Kv4.1 potassium channels inhibits cell proliferation of tumorigenic human mammary epithelial cells. Biochem Biophys Res Commun, 384(2), 180-6.
  30. Yarishkin OV, Hwang EM, Park JY, Kang D, Han J, Hong SG (2008). Endogenous TRPM4-like channel in Chinese hamster ovary (CHO) cells. Biochem Biophys Res Commun, 369(2), 712-7.
  31. Park JY, Hwang EM, Yarishkin O, Seo JH, Kim E, Yoo J, Yi GS, Kim DG, Park N, Ha CM, La JH, Kang D, Han J, Oh U, Hong SG (2008). TRPM4b channel suppresses store-operated Ca2+ entry by a novel protein-protein interaction with the TRPC3 channel. Biochem Biophys Res Commun, 368(3), 677-83.
  32. Yarishkin OV, Ryu HW, Park JY, Yang MS, Hong SG, Park KH (2007). Sulfonate chalcone as new class voltage-dependent K+ channel blocker. Bioorg Med Chem Lett, 18(1), 137-40.
  33. Mirkhodjaev UZ, Boldyrev VA, Yarishkin OV, Tashmukhamedov BA (2005). On the mechanism of action of dibenzo-18-crown-6-derivatives on malignant tumors. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 53, 191-196.
  34. Yarishkin OV, Tashmukhamedova AK, Mirkhodjaev UZ, Tashmukhamedov BA (2004).  Characteristics of single ionic channels induced by sulfonic acid derivatives of dibenzo-18-crown-6 in bilayers. Journal of Inclusion Phenomena and Macrocyclic Chemistry, 49(1-2), 139-144.

Abstract

  1. Kim A, Cho C-H, Lee S, Yarishkin O, Jung H-G, Lee D-Y, Kim H, Oh U, Im H-I, Park J-Y, Hwang EM (2019). TMEM16A-deficient cholinergic neurons of medial habenula mediate anxiogenic behaviors [Abstract]. 6, S275.
  2. Baumann JM, Yarishkin O, Lakk M, Vasquez-Chona F, Krizaj D (2019). Trabecular meshwork cell swelling and osmoregulation is subserved by TRPV4 and TRPM4 cation channels [Abstract]. 60(9), 5143-5143.
  3. Lapajne L, Lakk M, Gubeljak L, Yarishkin O, Hawlina M, Krizaj D (2019). Corneal mechanotransduction drives TRPV4-dependent release of the transmitter ATP [Abstract]. 60(9), 916-916.
  4. Redmon S, Lakk M, Yarishkin O, Krizaj D (2019). Activation of the cAMP signaling pathway sensitizes retinal microglia response to TRPV4 activation [Abstract]. 60(9), 4005-4005.
  5. Lakk M, Vazquez-Chona F, Yarishkin O, Krizaj D (2019). Conditional TRPV4 ablation inhibits pressure-induced retinal inflammation in mouse glaucoma [Abstract]. 60(9), 617-617.
  6. Krizaj D, Yarishkin O, Redmon S, Lakk M (2019). Pressure sensing and inflammatory signaling in glaucoma require TRPV4 channels [Abstract]. 67, E190-E190.
  7. Yarishkin O, Phuong TTT, Baumann JM, Redmon S, Lakk M, Krizaj D (2019). The Mechanogated PIEZO1 Channel Regulates Ca2+ Homeostasis and Formation of Focal Contacts in Human Trabecular Meshwork Cells [Abstract]. 60(9), 2190-2190.
  8. Redmon S, Yarishkin O, Lakk M, Krizaj D (2018). Retinal glial cells respond differently to the activation of the mechanosensitive channel TRPV4 [Abstract]. 59(9), 3939-3939.
  9. Yarishkin O, Phuong TTT, Baumann JB, Crandall AS, Ahmed F, Torrejon KY, Krizaj D (2018). Tandem-pore domain potassium channels are components of intracellular signaling pathways, determinants of pH sensitivity and mechanosensitivity of human trabecular meshwork cells [Abstract]. 59(9), 1600-1600.
  10. Vazquez-Chona FR, Phuong TTT, Yarishkin O, Jones BW, Krizaj D (2018). Metabolic, excitation and functional mapping of diabetic retinopathy [Abstract]. 59(19), 1212-1212.
  11. Krizaj D, Phuong TTT, Baumann JM, Hwang EM, Yarishkin O (2018). Chronic activation of mechanosensitive channels in human trabecular meshwork cells involves dynamic interactions between TRPV4 and TRPM4-mediated signals [Abstract]. 59(9), 3969-3969.
  12. Yarishkin O, Kozhemyakin MB, Ryskamp DA, Krizaj D (2016). TRPV4 AUGMENTS THE EXCITABILITY OF MOUSE RETINAL GANGLION CELLS [Abstract]. 57, 3579-3579.
  13. Iuso A, Jo AO, Yarishkin O, Delic A, Krizaj D (2016). Membrane Cholesterol Differentially Regulates TRPV4 Drug-Channel Efficacy and Osmotic-Evoked Swelling in Müller astroglia [Abstract]. 57, 6425-6425.
  14. Kim E, Hwang E, Yarishkin O, Yoo J, Park N, Kim D, Kang D, Han J, Hong S, Park J (2009). COPI binds with N-terminal region of TREK1 and enhances forward transport of TREK1 [Abstract]. 110, 176-176.
  15. Yoo JC, Yarishkin O, Hwang EM, Kang D, Han J, Hong SG, Park JY (2009). Cloning and characterization of rat Trpm4B [Abstract]. 110, 96-96.
  16. Hong SG, Yarishkin OV, Hwang EM, Shin H-J, Chung H-J, Jeong H-S, Kang D, Han J, Park J-Y (2009). A non-steroidal anti-inflammatory drug (NSAID), diclofenac inhibits L-type Ca2+ channel in cardiac myocytes [Abstract]. 59, 126-126.
  17. Yarishkin OV, Ryu HW, Park J-Y, Yang MS, Hong S-G, Park KH (2008). Sulfonate Chalcone as New Class Voltage‐Dependent K+ Channel Blocker [Abstract]. 39(24).
  18. Kim E-J, Hwang EM, Yarishkin O, Kim D-G, Park N-M, Kang D, Han J-H, Hong S-G, Park J-Y (2007). The Pore Regions of TREK1 K+ Channel Subunits Are Important in Their Homodimerization [Abstract]. 11, 12-0.
  19. Yarishkin O, Hwang EM, Kim M, Oh U, Kang D, Park J, Han J, Hong S (2006). A possible role of human TRPM4B in the capacitive Ca2+ entry [Abstract]. 10, 182.