Clement Y. Chow, PhD

Research Interests

  • Genetic Variation
  • Rare Diseases
  • Genetic Modifiers
  • ER Stress
  • Drosophila
  • Human and Mouse Genetics

Languages

  • English

Academic Information

  • Departments: Human Genetics - Associate Professor

Education History

Type School Degree
Postdoctoral Fellowship Cornell University
Postdoctoral Fellow
Doctoral Training University of Michigan
Human Genetics
Ph.D.
Undergraduate Cornell University
Biology/Neurobiology and Behavior
B.A.

Selected Publications

Journal Article

  1. Talsness DM, Owings KG, Coelho E, Mercenne G, Pleinis JM, Zuberi AR, Partha R, Clark NL, Lutz CM, Rodan AR, Chow CY (2020). A Drosophila natural variation screen identifies NKCC1 as a substrate of NGLY1 deglycosylation and a modifier of NGLY1 deficiency. https://www.biorxiv.org/content/10.1101/2020.04.13.039651v1.
  2. Palu RAS, Dalton HM, Chow CY (2020). Decoupling of Apoptosis from Activation of the ER Stress Response by the Drosophila Metallopeptidase superdeath. Genetics, 214(4), 913-925.
  3. Palu RAS, Ong E, Stevens K, Chung S, Owings KG, Goodman AG, Chow CY (2019). Natural Genetic Variation Screen in Drosophila Identifies Wnt Signaling, Mitochondrial Metabolism, and Redox Homeostasis Genes as Modifiers of Apoptosis. G3 (Bethesda), 9(12), 3995-4005.
  4. Ahlers LRH, Trammell CE, Carrell GF, Mackinnon S, Torrevillas BK, Chow CY, Luckhart S, Goodman AG (2019). Insulin Potentiates JAK/STAT Signaling to Broadly Inhibit Flavivirus Replication in Insect Vectors. Cell Rep, 29(7), 1946-1960.e5.
  5. Palu RAS, Chow CY (2018). Baldspot/ELOVL6 is a conserved modifier of disease and the ER stress response. PLoS Genet, 14(8), e1007557.
  6. Lavoy S, Chittoor-Vinod VG, Chow CY, Martin I (2018). Genetic Modifiers of Neurodegeneration in a Drosophila Model of Parkinson's Disease. Genetics, 209(4), 1345-1356.
  7. Owings KG, Lowry JB, Bi Y, Might M, Chow CY (2018). Transcriptome and functional analysis in a Drosophila model of NGLY1 deficiency provides insight into therapeutic approaches. Hum Mol Genet, 27(6), 1055-1066.
  8. Delbare SYN, Chow CY, Wolfner MF, Clark AG (2017). Roles of Female and Male Genotype in Post-Mating Responses in Drosophila melanogaster. J Hered, 108(7), 740-753.
  9. Chow CY, Kelsey KJ, Wolfner MF, Clark AG (2016). Candidate genetic modifiers of retinitis pigmentosa identified by exploiting natural variation in Drosophila. Hum Mol Genet, 25(4), 651-9.
  10. Chow CY (2016). Bringing genetic background into focus. Nat Rev Genet, 17(2), 63-4.
  11. Chow CY, Avila FW, Clark AG, Wolfner MF (2015). Induction of excessive endoplasmic reticulum stress in the Drosophila male accessory gland results in infertility. PLoS One, 10(3), e0119386.
  12. Chow CY, Wang X, Riccardi D, Wolfner MF, Clark AG (2015). The genetic architecture of the genome-wide transcriptional response to ER stress in the mouse. PLoS Genet, 11(2), e1004924.
  13. Chow CY, Wolfner MF, Clark AG (2013). Using natural variation in Drosophila to discover previously unknown endoplasmic reticulum stress genes. Proc Natl Acad Sci U S A, 110(22), 9013-8.
  14. Chow CY, Wolfner MF, Clark AG (2013). Large neurological component to genetic differences underlying biased sperm use in Drosophila. Genetics, 193(1), 177-85.
  15. Im KM, Kirchhoff T, Wang X, Green T, Chow CY, Vijai J, Korn J, Gaudet MM, Fredericksen Z, Shane Pankratz V, Guiducci C, Crenshaw A, McGuffog L, Kartsonaki C, Morrison J, Healey S, Sinilnikova OM, Mai PL, Greene MH, Piedmonte M, Rubinstein WS, Hogervorst FB, Rookus MA, Collee JM, Hoogerbrugge N, van Asperen CJ, Meijers-Heijboer HE, Van Roozendaal CE, Caldes T, Perez-Segura P, Jakubowska A, Lubinski J, Huzarski T, Blecharz P, Nevanlinna H, Aittomaki K, Lazaro C, Blanco I, Barkardottir RB, Montagna M, DAndrea E, Devilee P, Olopade OI, Neuhausen SL, Peissel B, Bonanni B, Peterlongo P, Singer CF, Rennert G, Lejbkowicz F, Andrulis IL, Glendon G, Ozcelik H, Toland AE, Caligo MA, Beattie MS, Chan S, Domchek SM, Nathanson KL, Rebbeck TR, Phelan C, Narod S, John EM, Hopper JL, Buys SS, Daly MB, Southey MC, Terry MB, Tung N, Hansen TV, Osorio A, Benitez J, Duran M, Weitzel JN, Garber J, Hamann U, Peock S, Cook M, Oliver CT, Frost D, Platte R, Evans DG, Eeles R, Izatt L, Paterson J, Brewer C, Hodgson S, Morrison PJ, Porteous M, Walker L, Rogers MT, Side LE, Godwin AK, Schmutzler RK, Wappenschmidt B, Laitman Y, Meindl A, Deissler H, Varon-Mateeva R, Preisler-Adams S, Kast K, Venat-Bouvet L, Stoppa-Lyonnet D, Chenevix-Trench G, Easton DF, Klein RJ, Daly MJ, Friedman E, Dean M, Clark AG, Altshuler DM, Antoniou AC, Couch FJ, Offit K, Gold B (2011). Haplotype structure in Ashkenazi Jewish BRCA1 and BRCA2 mutation carriers. Hum Genet, 130(5), 685-99.
  16. Lenk GM, Ferguson CJ, Chow CY, Jin N, Jones JM, Grant AE, Zolov SN, Winters JJ, Giger RJ, Dowling JJ, Weisman LS, Meisler MH (2011). Pathogenic mechanism of the FIG4 mutation responsible for Charcot-Marie-Tooth disease CMT4J. PLoS Genet, 7(6), e1002104.
  17. Chow CY, Wolfner MF, Clark AG (2010). The genetic basis for male x female interactions underlying variation in reproductive phenotypes of Drosophila. Genetics, 186(4), 1355-65.
  18. Sirot LK, LaFlamme BA, Sitnik JL, Rubinstein CD, Avila FW, Chow CY, Wolfner MF (2009). Molecular social interactions: Drosophila melanogaster seminal fluid proteins as a case study. Adv Genet, 68, 23-56.
  19. Chow CY, Landers JE, Bergren SK, Sapp PC, Grant AE, Jones JM, Everett L, Lenk GM, McKenna-Yasek DM, Weisman LS, Figlewicz D, Brown RH, Meisler MH (2009). Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS. Am J Hum Genet, 84(1), 85-8.
  20. Jin N, Chow CY, Liu L, Zolov SN, Bronson R, Davisson M, Petersen JL, Zhang Y, Park S, Duex JE, Goldowitz D, Meisler MH, Weisman LS (2008). VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouse. EMBO J, 27(24), 3221-34.
  21. Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J (2008). Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain, 131(Pt 8), 1990-2001.
  22. McKinney BC, Chow CY, Meisler MH, Murphy GG (2008). Exaggerated emotional behavior in mice heterozygous null for the sodium channel Scn8a (Nav1.6). Genes Brain Behav, 7(6), 629-38.
  23. Zhang Y, Zolov SN, Chow CY, Slutsky SG, Richardson SC, Piper RC, Yang B, Nau JJ, Westrick RJ, Morrison SJ, Meisler MH, Weisman LS (2007). Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice. Proc Natl Acad Sci U S A, 104(44), 17518-23.
  24. Chow CY, Zhang Y, Dowling JJ, Jin N, Adamska M, Shiga K, Szigeti K, Shy ME, Li J, Zhang X, Lupski JR, Weisman LS, Meisler MH (2007). Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J. Nature, 448(7149), 68-72.

Review

  1. Chow CY, Reiter LT (2017). Etiology of Human Genetic Disease on the Fly. [Review]. Trends Genet, 33(6), 391-398.