Wyatt R. Hume, DDS, PhD

Dean, School of Dentistry

Languages

  • English

Academic Information

  • Departments: Dentistry - Professor (Clinical)

Academic Office Information

  • 801-587-1208
  • Ray and Tye Noorda Oral Health Sciences Building
    530 South Wakara Way, Room: 3010
    Salt Lake City, UT 84108

Education History

Type School Degree
Professional Dental University of Adelaide
D.D.S.
Doctoral Training University of Adelaide
Human Physiology and Pharmacology
Ph.D.
Undergraduate University of Adelaide
Dentistry
B.S.

Global Impact

Education History

Type School Degree Country
Professional Dental University of Adelaide
D.D.S. Australia
Doctoral Training University of Adelaide
Human Physiology and Pharmacology
Ph.D. Australia
Undergraduate University of Adelaide
Dentistry
B.S. Australia

Selected Publications

Journal Article

  1. Paranjpe A, Cacalano NA, Hume WR, Jewett A (2009 Apr). N-acetyl cysteine mediates protection from 2-hydroxyethyl methacrylate induced apoptosis via nuclear factor kappa B-dependent and independent pathways: potential involvement of JNK. Toxicol Sci, 108(2), 356-66.
  2. Paranjpe A, Cacalano NA, Hume WR, Jewett A (2008 Oct). Mechanisms of N-acetyl cysteine-mediated protection from 2-hydroxyethyl methacrylate-induced apoptosis. J Endod, 34(10), 1191-7.
  3. Paranjpe A, Sung EC, Cacalano NA, Hume WR, Jewett A (2008 Jun). N-acetyl cysteine protects pulp cells from resin toxins in vivo. J Dent Res, 87(6), 537-41.
  4. Paranjpe A, Cacalano NA, Hume WR, Jewett A (2007 Nov 15). N-acetylcysteine protects dental pulp stromal cells from HEMA-induced apoptosis by inducing differentiation of the cells. Free Radic Biol Med, 43(10), 1394-408.
  5. Mount GJ, Tyas JM, Duke ES, Hume WR, Lasfargues JJ, Kaleka R (2006 Apr). A proposal for a new classification of lesions of exposed tooth surfaces. Int Dent J, 56(2), 82-91.
  6. Paranjpe A, Bordador LC, Wang MY, Hume WR, Jewett A (2005 Feb). Resin monomer 2-hydroxyethyl methacrylate (HEMA) is a potent inducer of apoptotic cell death in human and mouse cells. J Dent Res, 84(2), 172-7.
  7. Reichl FX, Durner J, Kehe K, Manhart J, Folwaczny M, Kleinsasser N, Hume WR, Hickel R (2002 Sep-Nov). Toxicokinetic of HEMA in guinea pigs. J Dent, 30(7-8), 353-8.
  8. Gu F, Lux R, Anderson MH, del Aguila MA, Wolinsky L, Hume WR, Shi W (2002 Aug). Analyses of Streptococcus mutans in saliva with species-specific monoclonal antibodies. Hybrid Hybridomics, 21(4), 225-32.
  9. Reichl FX, Durner J, Manhart J, Spahl W, Gempel K, Kehe K, Liebl B, Walther UI, Hume WR, Hickel R (2002 May). Biological clearance of HEMA in guinea pigs. Biomaterials, 23(10), 2135-41.
  10. Reichl FX, Durner J, Hickel R, Kunzelmann KH, Jewett A, Wang MY, Spahl W, Kreppel H, Moes GW, Kehe K, Walther U, Forth W, Hume WR (2001 May). Distribution and excretion of TEGDMA in guinea pigs and mice. J Dent Res, 80(5), 1412-5.
  11. Reichl FX, Durner J, Kunzelmann KH, Hickel R, Spahl W, Hume WR, Moes GW, Kehe K, Walther U, Forth W (2001 Mar). Biological clearance of TEGDMA in guinea pigs. Arch Toxicol, 75(1), 22-7.
  12. Reichl FX, Walther UI, Durner J, Kehe K, Hickel R, Kunzelmann KH, Spahl W, Hume WR, Benschop H, Forth W (2001 Mar). Cytotoxicity of dental composite components and mercury compounds in lung cells. Dent Mater, 17(2), 95-101.
  13. Okada K, Tosaki S, Hirota K, Hume WR (2001 Jan). Surface hardness change of restorative filling materials stored in saliva. Dent Mater, 17(1), 34-9.
  14. Jewett A, Hume WR, Le H, Huynh TN, Han YW, Cheng G, Shi W (2000 Apr). Induction of apoptotic cell death in peripheral blood mononuclear and polymorphonuclear cells by an oral bacterium, Fusobacterium nucleatum. Infect Immun, 68(4), 1893-8.
  15. Reichl FX, Durner J, Muckter H, Elsenhans B, Forth W, Kunzelmann KH, Hickel R, Spahl W, Hume WR, Moes GW (1999 Sep). Effect of dental materials on gluconeogenesis in rat kidney tubules. Arch Toxicol, 73(7), 381-6.
  16. Hume WR (1998 Oct). Restorative dentistry: current status and future directions. J Dent Educ, 62(10), 781-90.
  17. Shi W, Jewett A, Hume WR (1998 Aug). Rapid and quantitative detection of Streptococcus mutans with species-specific monoclonal antibodies. Hybridoma, 17(4), 365-71.
  18. Mount GJ, Hume WR (1998 Jun). A new cavity classification. Aust Dent J, 43(3), 153-9.
  19. Hamid A, Okamoto A, Iwaku M, Hume WR (1998 Feb). Component release from light-activated glass ionomer and compomer cements. J Oral Rehabil, 25(2), 94-9.
  20. Mount GJ, Hume WR (1997 May). A revised classification of carious lesions by site and size. Quintessence Int, 28(5), 301-3.
  21. Hamid A, Hume WR (1997 Mar). A study of component release from resin pit and fissure sealants in vitro. Dent Mater, 13(2), 98-102.
  22. Hamid A, Hume WR (1997 Feb). Diffusion of resin monomers through human carious dentin in vitro. Endod Dent Traumatol, 13(1), 1-5.
  23. Hamid A, Hume WR (1997 Jan). The effect of dentine thickness on diffusion of resin monomers in vitro. J Oral Rehabil, 24(1), 20-5.
  24. Hamid A, Sutton W, Hume WR (1996 Oct). Variation in phosphoric acid concentration and treatment time and HEMA diffusion through dentin. Am J Dent, 9(5), 211-4.
  25. Gerzina TM, Hume WR (1996 Jan-Mar). Diffusion of monomers from bonding resin-resin composite combinations through dentine in vitro. J Dent, 24(1-2), 125-8.
  26. Gerzina TM, Hume WR (1995 Jan). Effect of hydrostatic pressure on the diffusion of monomers through dentin in vitro. J Dent Res, 74(1), 369-73.
  27. Gerzina TM, Hume WR (1994 Jul). Effect of dentine on release of TEGDMA from resin composite in vitro. J Oral Rehabil, 21(4), 463-8.
  28. al-Fawaz A, Gerzina TM, Hume WR (1993 May). Movement of resin cement components through acid-treated dentin during crown cementation in vitro. J Endod, 19(5), 219-23.
  29. Massey WL, Romberg DM, Hunter N, Hume WR (1993 Feb). The association of carious dentin microflora with tissue changes in human pulpitis. Oral Microbiol Immunol, 8(1), 30-5.
  30. Hume WR (1992 Apr). Challenges facing dental schools in Australia. Aust Dent J, 37(2), 134-9.
  31. Abbott PV, Heijkoop PS, Cardaci SC, Hume WR, Heithersay GS (1991 Nov). An SEM study of the effects of different irrigation sequences and ultrasonics. Int Endod J, 24(6), 308-16.
  32. Smales RJ, Gerke DC, Hume WR (1990 Feb). Clinical behaviour of high-copper amalgams with time, site, size and class of cavity preparation. J Dent, 18(1), 49-53.
  33. Earl MS, Mount GJ, Hume WR (1989 Aug). The effect of varnishes and other surface treatments on water movement across the glass ionomer cement surface. II. Aust Dent J, 34(4), 326-9.
  34. Abbott PV, Hume WR, Heithersay GS (1989 Aug). Effects of combining Ledermix and calcium hydroxide pastes on the diffusion of corticosteroid and tetracycline through human tooth roots in vitro. Endod Dent Traumatol, 5(4), 188-92.
  35. Abbott PV, Hume WR, Heithersay GS (1989 Apr). Barriers to diffusion of Ledermix paste in radicular dentine. Endod Dent Traumatol, 5(2), 98-104.
  36. Abbott PV, Hume WR, Heithersay GS (1989 Apr). The release and diffusion through human coronal dentine in vitro of triamcinolone and demeclocycline from Ledermix paste. Endod Dent Traumatol, 5(2), 92-7.
  37. Hume WR (1988 Aug). Endodontic materials: reactor response. Adv Dent Res, 2(1), 29-32.
  38. Hume WR, Mount GJ (1988 Jun). In vitro studies on the potential for pulpal cytotoxicity of glass-ionomer cements. J Dent Res, 67(6), 915-8.
  39. Abbott PV, Heithersay GS, Hume WR (1988 Apr). Release and diffusion through human tooth roots in vitro of corticosteroid and tetracycline trace molecules from Ledermix paste. Endod Dent Traumatol, 4(2), 55-62.
  40. Hume WR (1988 Mar). In vitro studies on the local pharmacodynamics, pharmacology and toxicology of eugenol and zinc oxide-eugenol. Int Endod J, 21(2), 130-4.
  41. Hume WR (1988 Mar). Methods of assessment in vitro of restorative material cytotoxicity using an intact human dentine diffusion step. Int Endod J, 21(2), 85-8.
  42. Hume WR (1988). How can we stop killing pulps? Australian Prosthodontic Journal, 2, 35-9.
  43. Wang JD, Hume WR (1988 Jan). Diffusion of hydrogen ion and hydroxyl ion from various sources through dentine. Int Endod J, 21(1), 17-26.
  44. Hume WR (1985 Nov). A new technique for screening chemical toxicity to the pulp from dental restorative materials and procedures. J Dent Res, 64(11), 1322-5.
  45. Earl MS, Hume WR, Mount GJ (1985 Aug). Effect of varnishes and other surface treatments on water movement across the glass-ionomer cement surface. Aust Dent J, 30(4), 298-301.
  46. Wolinsky LE, Hume WR (1985 Aug). Effects of extracellular plaque components on the chlorhexidine sensitivity of strains of Streptococcus mutans and human dental plaque. J Dent Res, 64(8), 1051-4.
  47. Lindemann RA, Hume WR, Wolcott RB (1985 Mar). Dentin permeability and pulpal response to EDTA. J Prosthet Dent, 53(3), 341-3.
  48. Lekka M, Hume WR, Wolinsky LE (1984 Winter). Comparison between formaldehyde and glutaraldehyde diffusion through the root tissues of pulpotomy-treated teeth. J Pedod, 8(2), 185-91.
  49. Hume WR (1984 Nov). Effect of eugenol on respiration and division in human pulp, mouse fibroblasts, and liver cells in vitro. J Dent Res, 63(11), 1262-5.
  50. Hume WR (1984 Jun). An analysis of the release and the diffusion through dentin of eugenol from zinc oxide-eugenol mixtures. J Dent Res, 63(6), 881-4.
  51. Woolfe SN, Kenney EB, Hume WR, Carranza FA Jr (1984 Mar). Relationship of ascorbic acid levels of blood and gingival tissue with response to periodontal therapy. J Clin Periodontol, 11(3), 159-65.
  52. Becker RM, Hume WR, Wolinksy LE (1983 Fall). Release of eugenol from mixtures of ZOE in vitro. J Pedod, 8(1), 71-7.
  53. Hume WR (1983 Sep). Effect of eugenol on constrictor responses in blood vessels of the rabbit ear. J Dent Res, 62(9), 1013-5.
  54. Makinson OF, Hume WR (1982 Apr). Pen and instrument grips and clinical performance in dental students. Aust Dent J, 27(2), 86-90.
  55. Hume WR, Kenney AE (1981 Nov). Release of 3H-triamcinolone from Ledermix. J Endod, 7(11), 509-14.
  56. Florence VM, Hume WR, Matsunaga ML (1981 Jul). Choline acetyltransferase activity in the sympathetic nerves of the rabbit ear artery. Br J Pharmacol, 73(3), 721-4.
  57. Hume WR, Yoon NA, Matsunaga ML (1981). Comparison of fluoride toxicity between periodontal pathogenic bacteria and rabbit gingiva. Arch Oral Biol, 26(6), 467-72.
  58. MacLean AG, Bevan RD, Hume WR, Ransom RW, Bevan JA (1980 Dec). Rapid onset of vascular wall protein synthesis with increase in lability of blood pressure in rabbits. Clin Sci (Lond), 59 Suppl 6, 327s-329s.
  59. Hume WR (1980 Nov-Dec). Proline and thymidine uptake in rabbit ear artery segments in vitro increased by chronic tangential load. Hypertension, 2(6), 738-43.
  60. Bevan RD, Eggena P, Hume WR, Van Marthens E, Bevan JA (1980 Jan-Feb). Transient and persistent changes in rabbit blood vessels associated with maintained elevation in arterial pressure. Hypertension, 2(1), 63-72.
  61. Bevan RD, Eggena P, Hume WR, Lais LT, Van Marthens E, Bevan JA (1979 Dec). An 8 month longitudinal study of changes in elastic and muscular arteries and veins of the rabbit with sustained hypertension after abdominal aorta constriction. Clin Sci (Lond), 57 Suppl 5, 7s-9s.
  62. Hume WR (1978 Aug). The expectations of the dental graduate. Aust Dent J, 23(4), 353-5.
  63. Hume WR, Makinson OF (1978 Summer). Sterilizing dental instruments: evaluation of lubricating oils and microwave radiation. Oper Dent, 3(3), 93-6.
  64. Lee TJ, Hume WR, Su C, Bevan JA (1978 Apr). Neurogenic vasodilation of cat cerebral arteries. Circ Res, 42(4), 535-42.
  65. Hume WR, Bevan JA (1978 Feb). Amino acid uptake in rabbit blood vessels two weeks after induction of hypertension by coarctation of the abdominal aorta. Cardiovasc Res, 12(2), 106-13.
  66. Hume WR, Waterson JG (1978). The innervation of the rabbit ear artery. An ultrastructural study. Blood Vessels, 15(6), 348-64.
  67. Waterson JG, Hume WR (1973 Jan). A simple tissue holder for formaldehyde vapor-induced fluorescence. J Appl Physiol, 34(1), 116.
  68. Hume WR, De la Lande IS, Waterson JG (1972 Feb). Effect of acetylcholine on the response of the isolated rabbit ear artery to stimulation of the perivascular sympathetic nerves. Eur J Pharmacol, 17(2), 227-33.
  69. Frewin DB, Hume WR, Waterson JG, Whelan RF (1971 Dec). The histochemical localisation of sympathetic nerve endings in human gingival blood vessels. Aust J Exp Biol Med Sci, 49(6), 573-80.
  70. Waterson JG, Hume WR, De la Lande IS (1970 Mar). The distribution of cholinesterase in the rabbit ear artery. J Histochem Cytochem, 18(3), 211-6.
  71. Hume WR (1967). Possible odontoblast receptor function. Probe (Adelaide), 12-3.
  72. Hume WR (1967). Mouth guards: how and why. Probe (Adelaide), 20-1.

Review

  1. Allen EP, Bayne SC, Becker IM, Donovan TE, Hume WR, Kois JC (2000 Jul). Annual review of selected dental literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. [Review]. J Prosthet Dent, 84(1), 59-92.
  2. Allen EP, Bayne SC, Becker IM, Donovan TE, Hume WR, Kois JC (1999 Jul). Annual review of selected dental literature: report of the Committee on Scientific Investigation of the American Academy of Restorative Dentistry. [Review]. J Prosthet Dent, 82(1), 27-66.
  3. Hume WR, Gerzina TM (1996). Bioavailability of components of resin-based materials which are applied to teeth. [Review]. Crit Rev Oral Biol Med, 7(2), 172-9.
  4. Hume WR (1994 Jul). Influence of dentine on the pulpward release of eugenol or acids from restorative materials. [Review]. J Oral Rehabil, 21(4), 469-73.
  5. Hume WR (1993 Jun). Need for change in standards of caries diagnosis--perspective based on the structure and behavior of the caries lesion. [Review]. J Dent Educ, 57(6), 439-43.
  6. Abbott PV, Hume WR, Pearman JW (1990 Feb). Antibiotics and endodontics. [Review]. Aust Dent J, 35(1), 50-60.
  7. Hume WR, Massey WL (1990 Feb). Keeping the pulp alive: the pharmacology and toxicology of agents applied to dentine. [Review]. Aust Dent J, 35(1), 32-7.
  8. Hume WR (1986 Nov). The pharmacologic and toxicological properties of zinc oxide-eugenol. [Review]. J Am Dent Assoc, 113(5), 789-91.
  9. Tonelli PM, Hume WR, Kenney EB (1983). Chlorhexidine: a review of the literature. [Review]. J West Soc Periodontol Periodontal Abstr, 31(1), 5-10.
  10. Woolfe SN, Hume WR, Kenney EB (1980). Ascorbic acid and periodontal disease: a review of the literature. [Review]. J West Soc Periodontol Periodontal Abstr, 28(2), 44-56.

Editorial

  1. Hume WR (2010 Jul). Asia-Pacific Journal of Public Health. Global Health and the UAE: Asia-Middle East Connections. Guest editorial. Asia Pac J Public Health, 22(3 Suppl), 10S.
  2. Hume WR (1992 Apr). Research, education, caries, and care--taming and turning the restorative tiger. J Dent Res, 71(4), 1127.
  3. Hume WR (1989 Apr). Continuing concerns about amalgam. Aust Dent J, 34(2), 181-3.

Letter

  1. Mount GJ, Hume WR (1997 Jun). Cavity classification [Letter to the editor]. Aust Dent J, 42(3), 210-1.
  2. Hume WR, Makinson OF (1986 Feb). Microwave sterilization [Letter to the editor]. J Am Dent Assoc, 112(2), 160, 162.