Yashar Kalani, MD, PhD

Research Interests

  • Central Nervous System Development and Regeneration
  • Central Nervous System Tumors
  • Extracellular RNAs (ex-RNAs) as Signaling Molecules and Biomarkers in Development and Disease
  • Stem Cell Biology
  • Vascular Development
  • Central Nervous System Vascular Malformations
  • Cerebral Aneurysms
  • Stroke

Languages

  • English
  • Farsi

Academic Information

  • Departments: Neurobiology and Anatomy - Adjunct Assistant Professor, Radiology and Imaging Sciences - Adjunct Assistant Professor
  • Divisions: Clinical Radiology

Academic Office Information

  • 801-581-6908
  • Clinical Neurosciences Center
    Department of Neurosurgery - U of U
    175 North Medical Drive East
    Salt Lake City, UT 84132

Email: yashar.kalani@hsc.utah.edu

Research Statement

Dr. Kalani is an inaugral University of Utah EDGE Scholar. Dr. Kalani’s research interests include stem cell biology, vascular biology, regenerative medicine and biomarker development for cerebrovascular disease. He is the Principal Investigator of a National Institutes of Health grant focusing on the development of blood and cerebrospinal fluid-based biomarkers for brain injury, notably after subarachnoid hemorrhage and stroke.

Academic Bio

Dr. Kalani completed undergraduate training in Chemistry and Biochemistry at UCLA, followed by his doctorate at the California Institute of Technology. After completing his Ph.D. he matriculated at Stanford University School of Medicine where he completed medical school with an emphasis in the molecular basis of medicine. His postdoctoral studies focused on the role of Wnt signaling on the cell fate decisions of neural stem cells, which was also conducted at Stanford University School of Medicine and was supported by the Howard Hughes Medical Institute. He subsequently went on to complete his clinical training, including residency and fellowship in Skull Base Surgery, Cerebrovascular and Endovascular Neurosurgery, at the Barrow Neurological Institute in Phoenix, Arizona under the guidance of Dr. Robert Spetzler. He also completed a fellowship in neuro-oncology and endoscopic skull base surgery at the Centre for Minimally Invasive Neurosurgery in Sydney, Australia.

Dr. Kalani has published more than 150 articles and 40 book chapters in the neuroscience literature. He has edited a number of neurosurgical textbooks, including Neurovascular Surgery, Comprehensive Management of Arteriovenous Malformations of the Brain and Spine, and the Color Atlas of Brainstem Surgery.

Education History

Type School Degree
Chief Resident Barrow Neurological Institute
Neurological Surgery
Chief Resident
Fellowship Barrow Neurological Institute
Endovascular Neurosurgery
Fellow
Fellowship Prince of Wales Hospital
Neuro-Endoscopy and Neuro-Oncology
Fellow
Fellowship Barrow Neurological Institute
Complex Spine Surgery
Fellow
Fellowship Barrow Neurological Institute
Cerebrovascular and Skull Base Surgery
Fellow
Residency Barrow Neurological Institute
Neurological Surgery
Resident
Internship Barrow Neurological Institute
Neurological Surgery
Intern
Research Fellow Howard Hughes Medical Institute & Stanford University School of Medicine
Stem Cell Biology and Regenerative Medicine
Postdoctoral Research Fellow
Professional Medical Stanford University School of Medicine
Molecular Basis of Medicine
M.D.
Doctoral Training California Institute of Technology
Chemistry: Biochemistry
M.S., Ph.D.
Undergraduate University of California, Los Angeles
Biochemistry
B.S., M.S.

Global Impact

Education History

Type School Degree Country
Fellowship Prince of Wales Hospital
Neuro-Endoscopy and Neuro-Oncology
Fellow Australia

Awards & Honors

Description Country
Sir Keith Murdoch Fellowship, American Australian Association Australia

Selected Publications

Journal Article

  1. Kalani MYS, Yagmurlu K, Martirosyan NL, Spetzler RF (2017). Transsylvian, Transanterior Sulcus Approach to Basal Ganglia Cavernous Malformations.LID - 10.1093/ons/opx025 [doi]. (Epub ahead of print) Oper Neurosurg (Hagerstown).
  2. Mulholland CB, Kalani MYS, Albuquerque FC (2017). Endovascular management of intracranial dural arteriovenous fistulas. Handb Clin Neurol, 143, 117-123.
  3. Awad AW, Moon K, Yoon N, Mazur MD, Kalani MYS, Taussky P, McDougall CG, Albuquerque FC, Park MS (2017). Flow diversion of tandem cerebral aneurysms: a multi-institutional retrospective study. Neurosurg Focus, 42(6), E10.
  4. Taylor LI, Dickerson JC, Dambrino RJ, Kalani MYS, Taussky P, Washington CW, Park MS (2017). Platelet testing in flow diversion: a review of the evidence. Neurosurg Focus, 42(6), E5.
  5. Yagmurlu K, Kalani MYS, Martirosyan NL, Safavi-Abbasi S, Belykh E, Laarakker AS, Nakaji P, Zabramski JM, Preul MC, Spetzler RF (2017). Maxillary Artery to Middle Cerebral Artery Bypass: A Novel Technique for Exposure of the Maxillary Artery. World Neurosurg, 100, 540-550.
  6. Safavi-Abbasi S, Kalani MY, Frock B, Sun H, Yagmurlu K, Moron F, Snyder LA, Hlubek RJ, Zabramski JM, Nakaji P, Spetzler RF (2017). Techniques and outcomes of microsurgical management of ruptured and unruptured fusiform cerebral aneurysms. J Neurosurg, 1-8.
  7. Kalani MYS, Wanebo JE, Martirosyan NL, Nakaji P, Zabramski JM, Spetzler RF (2017). A raised bar for aneurysm surgery in the endovascular era. J Neurosurg, 126(5), 1731-1739.
  8. Kilburg C, Scott McNally J, de Havenon A, Taussky P, Kalani MY, Park MS (2017). Advanced imaging in acute ischemic stroke. Neurosurg Focus, 42(4), E10.
  9. Yoon NK, Awad AW, Kalani MY, Taussky P, Park MS (2017). Stent technology in ischemic stroke. Neurosurg Focus, 42(4), E11.
  10. Karsy M, Brock A, Guan J, Taussky P, Kalani MY, Park MS (2017). Neuroprotective strategies and the underlying molecular basis of cerebrovascular stroke. Neurosurg Focus, 42(4), E3.
  11. Levitt MR, Hlubek RJ, Moon K, Kalani MY, Nakaji P, Smith KA, Little AS, Knievel K, Chan JW, McDougall CG, Albuquerque FC (2017). Incidence and predictors of dural venous sinus pressure gradient in idiopathic intracranial hypertension and non-idiopathic intracranial hypertension headache patients: results from 164 cerebral venograms. J Neurosurg, 126(2), 347-353.
  12. Chen T, Kalani MY, Ducruet AF, Albuquerque FC, McDougall CG (2017). Development of syndrome of inappropriate antidiuretic hormone secretion (SIADH) after Onyx embolisation of a cavernous carotid fistula. J Neurointerv Surg, 9(1), e3.
  13. Wilson CD, Safavi-Abbasi S, Sun H, Kalani MY, Zhao YD, Levitt MR, Hanel RA, Sauvageau E, Mapstone TB, Albuquerque FC, McDougall CG, Nakaji P, Spetzler RF (2017). Meta-analysis and systematic review of risk factors for shunt dependency after aneurysmal subarachnoid hemorrhage. J Neurosurg, 126(2), 586-595.
  14. Fennell VS, Martirosyan NL, Atwal GS, Kalani MY, Spetzler RF, Lemole GM, Dumont T (2017). Effective Surgical Management of Competitive Venous Outflow Restriction After Radiosurgery for Cerebral AVMs: Report of 2 Cases. World Neurosurg, 98, 882.e1-882.e7.
  15. Martirosyan NL, Turner GH, Kaufman J, Patel AA, Belykh E, Kalani MY, Theodore N, Preul MC (2016). Manganese-enhanced MRI Offers Correlation with Severity of Spinal Cord Injury in Experimental Models. Open Neuroimag J, 10, 139-147.
  16. Martirosyan NL, Georges J, Kalani MY, Nakaji P, Spetzler RF, Feuerstein BG, Preul MC (2016). Handheld confocal laser endomicroscopic imaging utilizing tumor-specific fluorescent labeling to identify experimental glioma cells in vivo. Surg Neurol Int, 7(Suppl 40), S995-S1003.
  17. Almefty RO, Kalani MY, Ducruet AF, Crowley RW, McDougall CG, Albuquerque FC (2016). Middle meningeal arteriovenous fistulas: A rare and potentially high-risk dural arteriovenous fistula. Surg Neurol Int, 7(Suppl 9), S219-22.
  18. Kalani MY (2016). Intraoperative Motor-Evoked Potential Monitoring as a Predictive Tool for Recovery From Spontaneous Intracerebral Hemorrhage. World Neurosurg, 92, 546-7.
  19. Levitt MR, McGah PM, Moon K, Albuquerque FC, McDougall CG, Kalani MY, Kim LJ, Aliseda A (2016). Computational Modeling of Venous Sinus Stenosis in Idiopathic Intracranial Hypertension. (Epub ahead of print) AJNR Am J Neuroradiol.
  20. Gross BA, Moon K, Kalani MY, Albuquerque FC, McDougall CG, Nakaji P, Zabramski JM, Spetzler RF (2016). Clinical and Anatomic Insights From a Series of Ethmoidal Dural Arteriovenous Fistulas at Barrow Neurological Institute. World Neurosurg, 93, 94-9.
  21. Kalani MY, Spetzler RF, Wanebo JE (2016). Keyhole Supraorbital Craniotomy for Aneurysm Clipping in the Setting of Bypass for Moyamoya Disease. World Neurosurg, 94, 442-446.
  22. Kalani MY, Spetzler RF (2016). Woman With Sudden-Onset Headache. Ann Emerg Med, 68(3), e69-70.
  23. Kalani MY, Yagmurlu K, Martirosyan NL, Cavalcanti DD, Spetzler RF (2016). Approach selection for intrinsic brainstem pathologies. J Neurosurg, 125(6), 1596-1607.
  24. Boroumand MR, Kalani MY, Spetzler RF (2016). Combined endovascular and microsurgical treatment of a complex spinal arteriovenous fistula associated with CLOVES syndrome in an adult patient. J Clin Neurosci, 34, 232-234.
  25. Yagmurlu K, Safavi-Abbasi S, Belykh E, Kalani MY, Nakaji P, Rhoton AL Jr, Spetzler RF, Preul MC (2016). Quantitative anatomical analysis and clinical experience with mini-pterional and mini-orbitozygomatic approaches for intracranial aneurysm surgery. J Neurosurg, 1-14.
  26. Yagmurlu K, Kalani MY, Preul MC, Spetzler RF (2016). The superior fovea triangle approach: a novel safe entry zone to the brainstem. J Neurosurg, 1-5.
  27. Zabramski J, Kalani MY, et al (2016). Beta-Blocker Administration for Symptomatic Cerebral Cavernous Malformations in Adults. World Neurosurg.
  28. Yagmurlu K, Kalani MY, et al (2016). The Internal Maxillary Artery to Middle Cerebral Artery Bypass: A Novel Technique For Exposure of the Internal Maxillary Artery. Neurosurgery.
  29. Kalb S, Perez-Orribo L, Kalani MY, Snyder LA, Martirosyan NL, Burns K, Standerfer RJ, Kakarla UK, Dickman CA, Theodore N (2016). The Influence of Common Medical Conditions on the Outcome of Anterior Lumbar Interbody Fusion. Clin Spine Surg, 29(7), 285-90.
  30. Levitt MR, Albuquerque FC, Ducruet AF, Kalani MY, Mulholland CB, McDougall CG (2016). Venous sinus stenting for idiopathic intracranial hypertension is not associated with cortical venous occlusion. J Neurointerv Surg, 8(6), 594-5.
  31. Levitt MR, Moon K, Albuquerque FC, Mulholland CB, Kalani MY, McDougall CG (2016). Intraprocedural abciximab bolus versus pretreatment oral dual antiplatelet medication for endovascular stenting of unruptured intracranial aneurysms. J Neurointerv Surg, 8(9), 909-12.
  32. Moon K, Albuquerque FC, Levitt MR, Ahmed AS, Kalani MY, McDougall CG (2016). The myth of restenosis after carotid angioplasty and stenting. J Neurointerv Surg, 8(10), 1006-10.
  33. Levitt MR, Park MS, Albuquerque FC, Moon K, Kalani MY, McDougall CG (2016). Posterior Inferior Cerebellar Artery Patency after Flow-Diverting Stent Treatment. AJNR Am J Neuroradiol, 37(3), 487-9.
  34. Kalani MY, Siniard AL, Corneveaux JJ, Bruhns R, Richholt R, Forseth J, Zabramski JM, Nakaji P, Spetzler RF, Huentelman MJ (2016). Rare Variants in Cardiomyopathy Genes Associated With Stress-Induced Cardiomyopathy. Neurosurgery, 78(6), 835-43.
  35. Kalani MY, Yagmurlu K, Martirosyan NL, Spetzler RF (2016). The Retrosigmoid Petrosal Fissure Transpeduncular Approach to Central Pontine Lesions. World Neurosurg, 87, 235-41.
  36. Kalani MY, Martirosyan NL, Nakaji P, Spetzler RF (2016). The supracerebellar infratentorial approach to the dorsal midbrain. Neurosurg Focus, 40 Video Suppl 1, 2016.1.FocusVid.15462.
  37. Kalani MY, Albuquerque FC, Levitt M, Nakaji P, Spetzler RF, McDougall C (2016). Pipeline embolization for definitive endoluminal reconstruction of blister-type carotid aneurysms after clip wrapping. J Neurointerv Surg, 8(5), 495-500.
  38. Cavalcanti DD, Preul MC, Kalani MY, Spetzler RF (2016). Microsurgical anatomy of safe entry zones to the brainstem. J Neurosurg, 124(5), 1359-76.
  39. Zabramski JM, Kalani MY, Filippidis AS, Spetzler RF (2016). Propranolol Treatment of Cavernous Malformations with Symptomatic Hemorrhage. World Neurosurg, 88, 631-9.
  40. Kalani MY, Lei T, Martirosyan NL, Oppenlander ME, Spetzler RF, Nakaji P (2016). Endoscope-assisted supracerebellar transtentorial approach to the posterior medial temporal lobe for resection of cavernous malformation. Neurosurg Focus, 40 Video Suppl 1, 2016.1.FocusVid.15465.
  41. Martirosyan NL, Kalani MY, Nakaji P, Spetzler RF (2016). The anterior interhemispheric approach to a third ventricular cavernous malformation. Neurosurg Focus, 40 Video Suppl 1, 2016.1.FocusVid.15461.
  42. Kalani MY, Zabramski JM, Martirosyan NL, Spetzler RF (2016). Developmental venous anomaly, capillary telangiectasia, cavernous malformation, and arteriovenous malformation: spectrum of a common pathological entity? Acta Neurochir (Wien), 158(3), 547-50.
  43. Kalani MY, Spetzler RF (2016). Internal carotid artery-to-posterior cerebral artery bypass for revascularization of the brainstem. J Clin Neurosci, 24, 151-4.
  44. Safavi-Abbasi S, Moron F, Sun H, Oppenlander ME, Kalani MY, Mulholland CB, Zabramski JM, Nakaji P, Spetzler RF (2016). Techniques and long-term outcomes of cotton-clipping and cotton-augmentation strategies for management of cerebral aneurysms. J Neurosurg, 125(3), 720-9.
  45. Mooney MA, Kalani MY, Nakaji P, Albuquerque FC, McDougall CG, Spetzler RF, Zabramski JM (2015). Long-term Patient Outcomes After Microsurgical Treatment of Blister-Like Aneurysms of the Basilar Artery. Neurosurgery, 11 Suppl 3, 387-93.
  46. Martirosyan NL, Kalani MY, Lemole GM Jr, Spetzler RF, Preul MC, Theodore N (2015). Microsurgical anatomy of the arterial basket of the conus medullaris. J Neurosurg Spine, 22(6), 672-6.
  47. Kalani MY, Wilson DA, Koechlin NO, Abuhusain HJ, Dlouhy BJ, Gunawardena MP, Nozue-Okada K, Teo C (2015). Pineal cyst resection in the absence of ventriculomegaly or Parinaud's syndrome: clinical outcomes and implications for patient selection. J Neurosurg, 123(2), 352-6.

Book

  1. Spetzler RF, Kalani MY, Nakaji P (2015). Neurovascular Surgery (2nd Edition). New York: Thieme.

Book Chapter

  1. Kalani MY, Porter RW (2016). Craniofacial Approaches for Large Juvenile Nasopharyngeal Angiofibromas. In Dubey SP, Schick B (Eds.), Juvenile Angiofibroma. Springer.