Adrian Rothenfluh, PhD, MS


  • English
  • French
  • German

Academic Information

  • Departments: Human Genetics - Adjunct Associate Professor, Neurobiology & Anatomy - Adjunct Associate Professor, Psychiatry - Associate Professor
  • Divisions: Adult Psychiatry

Academic Office Information

  • 801-585-5773
  • George and Dolores Eccles Institute of Human Genetics
    15 N 2030 E, Room: 2120
    Salt Lake City, UT 84112


Research Statement

Dr. Rothenfluh's research focuses on the genetics of psychiatric disorders, especially addiction. His lab uses Drosophila to model various neuropsychiatric conditions and to investigate the molecular, signaling, and neuronal mechanisms that mediate behavior. His lab has a continued commitment to translate his findings to human studies.

Education History

Type School Degree
Postdoctoral Fellowship University of California, San Francisco
Postdoctoral Fellow
Postdoctoral Fellowship Rockefeller University
Postdoctoral Fellow
Doctoral Training Rockefeller University
Graduate Training University of Basel
Molecular Biology

Global Impact

Education History

Type School Degree Country
Graduate Training University of Basel
Molecular Biology
M.Sc. Switzerland

Selected Publications

Journal Article

  1. Gonzalez DA, Jia T, Pinzon JH, Acevedo SF, Ojelade SA, Xu B, Tay N, Desrivieres S, Hernandez JL, Banaschewski T, Buchel C, Bokde ALW, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Martinot JL, Paus T, Smolka MN, Rodan AR, Schumann G, Rothenfluh A (2018). The Arf6 activator Efa6/PSD3 confers regional specificity and modulates ethanol consumption in Drosophila and humans. Mol Psychiatry, 23(3), 621-628.
  2. Shalaby NA, Pinzon JH, Narayanan AS, Jin EJ, Ritz MP, Dove RJ, Wolfenberg H, Rodan AR, Buszczak M, Rothenfluh A (2018). JmjC domain proteins modulate circadian behaviors and sleep in Drosophila. Sci Rep, 8(1), 815.
  3. Pinzon JH, Reed AR, Shalaby NA, Buszczak M, Rodan AR, Rothenfluh A (2017). Alcohol-Induced Behaviors Require a Subset of Drosophila JmjC-Domain Histone Demethylases in the Nervous System. Alcohol Clin Exp Res, 41(12), 2015-2024.
  4. Shalaby NA, Sayed R, Zhang Q, Scoggin S, Eliazer S, Rothenfluh A, Buszczak M (2017). Systematic discovery of genetic modulation by Jumonji histone demethylases in Drosophila. Sci Rep, 7(1), 5240.
  5. Jia T, Macare C, Desrivieres S, Gonzalez DA, Tao C, Ji X, Ruggeri B, Nees F, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Buchel C, Conrod PJ, Dove R, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lemaitre H, Martinot JL, Paus T, Pausova Z, Poline JB, Rietschel M, Robbins T, Smolka MN, Muller CP, Feng J, Rothenfluh A, Flor H, Schumann G (2016). Neural basis of reward anticipation and its genetic determinants. Proc Natl Acad Sci U S A, 113(14), 3879-84.
  6. Acevedo SF, Peru y Colon de Portugal RL, Gonzalez DA, Rodan AR, Rothenfluh A (2015). S6 Kinase Reflects and Regulates Ethanol-Induced Sedation. J Neurosci, 35(46), 15396-402.
  7. Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Buchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, Frouin V, Gallinat J, Garavan H, Gowland PA, Heinz A, Ittermann B, Lathrop M, Lubbe S, Martinot JL, Paus T, Smolka MN, Spanagel R, OReilly PF, Laitinen J, Veijola JM, Feng J, Desrivieres S, Jarvelin MR, Schumann G, Rothenfluh A (2015). Rsu1 regulates ethanol consumption in Drosophila and humans. Proc Natl Acad Sci U S A, 112(30), E4085-93.
  8. Ojelade SA, Acevedo SF, Kalahasti G, Rodan AR, Rothenfluh A (2015). RhoGAP18B Isoforms Act on Distinct Rho-Family GTPases and Regulate Behavioral Responses to Alcohol via Cofilin. PLoS ONE, 10(9), e0137465.
  9. Peru Y Colon de Portugal RL, Ojelade SA, Penninti PS, Dove RJ, Nye MJ, Acevedo SF, Lopez A, Rodan AR, Rothenfluh A (2014). Long-lasting, experience-dependent alcohol preference in Drosophila. Addict Biol, 19(3), 392-401.
  10. Chang L, Kreko T, Davison H, Cusmano T, Wu Y, Rothenfluh A, Eaton BA (2013). Normal dynactin complex function during synapse growth in Drosophila requires membrane binding by Arfaptin. Mol Biol Cell, 24(11), 1749-64, S1-5.
  11. Peru Y Colon de Portugal RL, Acevedo SF, Rodan AR, Chang LY, Eaton BA, Rothenfluh A (2012). Adult neuronal Arf6 controls ethanol-induced behavior with Arfaptin downstream of Rac1 and RhoGAP18B. J Neurosci, 32(49), 17706-13.
  12. Chen P, Tu X, Akdemir F, Chew SK, Rothenfluh A, Abrams JM (2012). Effectors of alcohol-induced cell killing in Drosophila. Cell Death Differ, 19(10), 1655-63.
  13. Chan CC, Scoggin S, Wang D, Cherry S, Dembo T, Greenberg B, Jin EJ, Kuey C, Lopez A, Mehta SQ, Perkins TJ, Brankatschk M, Rothenfluh A, Buszczak M, Hiesinger PR (2011). Systematic discovery of Rab GTPases with synaptic functions in Drosophila. Curr Biol, 21(20), 1704-15.
  14. Maples T, Rothenfluh A (2011). A simple way to measure ethanol sensitivity in flies.LID - 10.3791/2541 [doi]LID - 2541 [pii]. J Vis Exp, (48).
  15. Rothenfluh A, Threlkeld RJ, Bainton RJ, Tsai LT, Lasek AW, Heberlein U (2006). Distinct behavioral responses to ethanol are regulated by alternate RhoGAP18B isoforms. Cell, 127(1), 199-211.


  1. Kaun KR, Rothenfluh A (2017). Dopaminergic rules of engagement for memory in Drosophila. [Review]. Curr Opin Neurobiol, 43, 56-62.
  2. Narayanan AS, Rothenfluh A (2016). I Believe I Can Fly!: Use of Drosophila as a Model Organism in Neuropsychopharmacology Research. [Review]. Neuropsychopharmacology, 41(6), 1439-46.
  3. Rothenfluh A, Cowan CW (2013). Emerging roles of actin cytoskeleton regulating enzymes in drug addiction: actin or reactin'? [Review]. Curr Opin Neurobiol, 23(4), 507-12.
  4. Ojelade SA, Acevedo SF, Rothenfluh A (2013). The role of the actin cytoskeleton in regulating Drosophila behavior. [Review]. Rev Neurosci, 24(5), 471-84.
  5. Rodan AR, Rothenfluh A (2010). The genetics of behavioral alcohol responses in Drosophila. [Review]. Int Rev Neurobiol, 91, 25-51.


  1. Blau J, Kloss, B, Rothenfluh A (2018). A speedy version of the double-time story. Japanese Society for Chronobiology, Journal of Chronobiology, 24, 45-49.