Moriel Zelikowsky, PhD
- Social Behavior
- Social Isolation
- Systems Neuroscience
- Departments: Neurobiology and Anatomy - Assistant Professor
Academic Office Information
Biomedical Polymers Research Bldg
20 S 2030 E, Room: 408E
Salt Lake City, UT 84112
Neural circuits underlying psychogenic stress.
Under normal circumstances, stress and fear enable us to flexibly adapt to conditions in our environment, greatly contributing to our success and survival. However, in cases of prolonged or extreme psychogenic stress, this normally advantageous system can exert detrimental effects on the brain and behavior, giving rise to disturbances in mental health such as post-traumatic stress disorder, anxiety disorders, phobias, and social isolation. These disturbances can be extremely debilitating, targeting people regardless of age, sex, or ethnicity, and leading to increases in fear and violence in our society.
My lab is interested in understanding the brain circuits and neural mechanisms underlying various forms of stress. We apply cutting-edge, genetically-targeted molecular tools and techniques to identify, manipulate, and image from specific populations of neurons across a number of brain regions. We combine these techniques with in depth behavioral testing and computational analyses to dissect neural circuits and elucidate the role and function of particular cell populations within them.
Taking this molecular-behavioral approach, we ask questions such as how does the brain encode a single traumatic event? What does the brain look like after an extended period of social isolation? Can we target particular brain regions, cell populations, or signaling molecules to reverse the damaging effects of stress on behavior? In striving to answer these questions, we aim to better understand the brain and behavior, as well as potentially identify novel therapeutic targets for the treatment of mental health disorders.
|Doctoral Training||University of California, Los Angeles
|Undergraduate||University of California, Los Angeles
|Research Fellow||California Institute of Technology
Biology and Biological Engineering
|Postdoctoral Research Fellow|
- Zelikowsky M, Ding K, Anderson DJ (2019). Neuropeptidergic control of an internal brain state produced by prolonged social isolation stress. Cold Spring Harb Symp Quant Biol.
- Zelikowsky M, Hui M, Karigo T, Choe A, Yang B, Blanco MR, Beadle K, Gradinaru V, Deverman BE, Anderson DJ (2018). The Neuropeptide Tac2 Controls a Distributed Brain State Induced by Chronic Social Isolation Stress. Cell, 173(5), 1265-1279.e19.
- Remedios R, Kennedy A, Zelikowsky M, Grewe BF, Schnitzer MJ, Anderson DJ (2017). Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex. Nature, 550(7676), 388-392.
- Hong W, Kennedy A, Burgos-Artizzu XP, Zelikowsky M, Navonne SG, Perona P, Anderson DJ (2015). Automated measurement of mouse social behaviors using depth sensing, video tracking, and machine learning. Proc Natl Acad Sci U S A, 112(38), E5351-60.
- Kunwar PS, Zelikowsky M, Remedios R, Cai H, Yilmaz M, Meister M, Anderson DJ (2015). Ventromedial hypothalamic neurons control a defensive emotion state. eLife, 4.
- Zelikowsky M, Hersman S, Chawla MK, Barnes CA, Fanselow MS (2014). Neuronal ensembles in amygdala, hippocampus, and prefrontal cortex track differential components of contextual fear. J Neurosci, 34(25), 8462-6.
- Fanselow MS, Zelikowsky M, Perusini J, Barrera VR, Hersman S (2014). Isomorphisms between psychological processes and neural mechanisms: from stimulus elements to genetic markers of activity. Neurobiol Learn Mem, 108, 5-13.
- Zelikowsky M, Bissiere S, Hast TA, Bennett RZ, Abdipranoto A, Vissel B, Fanselow MS (2013). Prefrontal microcircuit underlies contextual learning after hippocampal loss. Proc Natl Acad Sci U S A, 110(24), 9938-43.
- Zelikowsky M, Hast TA, Bennett RZ, Merjanian M, Nocera NA, Ponnusamy R, Fanselow MS (2013). Cholinergic blockade frees fear extinction from its contextual dependency. Biol Psychiatry, 73(4), 345-52.
- Zelikowsky M, Pham DL, Fanselow MS (2012). Temporal factors control hippocampal contributions to fear renewal after extinction. Hippocampus, 22(5), 1096-106.
- Zelikowsky M, Bissiere S, Fanselow MS (2012). Contextual fear memories formed in the absence of the dorsal hippocampus decay across time. J Neurosci, 32(10), 3393-7.
- Krasne FB, Fanselow MS, Zelikowsky M (2011). Design of a neurally plausible model of fear learning. Front Behav Neurosci, 5, 41.
- Bissiere S, Zelikowsky M, Ponnusamy R, Jacobs NS, Blair HT, Fanselow MS (2011). Electrical synapses control hippocampal contributions to fear learning and memory. Science, 331(6013), 87-91.
- Zelikowsky M, Fanselow MS (2010). Opioid regulation of Pavlovian overshadowing in fear conditioning. Behav Neurosci, 124(4), 510-9.
- Craske MG, Kircanski K, Zelikowsky M, Mystkowski J, Chowdhury N, Baker A (2008). Optimizing inhibitory learning during exposure therapy. [Review]. Behav Res Ther, 46(1), 5-27.
- Zelikowsky M, Fanselow MS (2011). Conditional analgesia, negative feedback and error correction. In Schachtman TR, Reilly SS (Eds.), Associative Learning and Conditioning: Human and Animal Applications. Oxford Scholarship Online.