Robin M. Shaw, MD, PhD

Academic Information

  • Departments: Internal Medicine - Professor
  • Divisions: Cardiovascular Medicine

Board Certification

  • American Board of Internal Medicine (Sub: Cardiovascular Disease)

Selected Publications

Journal Article

  1. Nikolova AP, Hitzeman TC, Baum R, Caldaruse AM, Agvanian S, Xie Y, Geft DR, Chang DH, Moriguchi JD, Hage A, Azarbal B, Czer LS, Kittleson MM, Patel JK, Wu AHB, Kobashigawa JA, Hamilton M, Hong T, Shaw RM (2018). Association of a Novel Diagnostic Biomarker, the Plasma Cardiac Bridging Integrator 1 Score, With Heart Failure With Preserved Ejection Fraction and Cardiovascular Hospitalization. JAMA Cardiol, 3(12), 1206-1210.
  2. Basheer WA, Fu Y, Shimura D, Xiao S, Agvanian S, Hernandez DM, Hitzeman TC, Hong T, Shaw RM (2018). Stress response protein GJA1-20k promotes mitochondrial biogenesis, metabolic quiescence, and cardioprotection against ischemia/reperfusion injury. JCI Insight, 3(20).
  3. Epifantseva I, Shaw RM (2017). Intracellular trafficking pathways of Cx43 gap junction channels. Biochim Biophys Acta Biomembr, 1860(1), 40-47.
  4. Fu Y, Zhang SS, Xiao S, Basheer WA, Baum R, Epifantseva I, Hong T, Shaw RM (2017). Cx43 Isoform GJA1-20k Promotes Microtubule Dependent Mitochondrial Transport. Front Physiol, 8, 905.
  5. Basheer WA, Xiao S, Epifantseva I, Fu Y, Kleber AG, Hong T, Shaw RM (2017). GJA1-20k Arranges Actin to Guide Cx43 Delivery to Cardiac Intercalated Discs. Circ Res, 121(9), 1069-1080.
  6. Xu B, Fu Y, Liu Y, Agvanian S, Wirka RC, Baum R, Zhou K, Shaw RM, Hong T (2017). The ESCRT-III pathway facilitates cardiomyocyte release of cBIN1-containing microparticles. PLoS Biol, 15(8), e2002354.
  7. Hong T, Shaw RM (2016). Cardiac T-Tubule Microanatomy and Function. Physiol Rev, 97(1), 227-252.
  8. Levitan BM, Manning JR, Withers CN, Smith JD, Shaw RM, Andres DA, Sorrell VL, Satin J (2016). Rad-deletion Phenocopies Tonic Sympathetic Stimulation of the Heart. J Cardiovasc Transl Res, 9(5-6), 432-444.
  9. Basheer W, Shaw R (2015). The "tail" of Connexin43: An unexpected journey from alternative translation to trafficking. Biochim Biophys Acta, 1863(7 Pt B), 1848-56.
  10. Basheer WA, Shaw RM (2015). Connexin 43 and CaV1.2 Ion Channel Trafficking in Healthy and Diseased Myocardium. Circ Arrhythm Electrophysiol, 9(6), e001357.
  11. Xiao S, Shaw RM (2014). Cardiomyocyte protein trafficking: Relevance to heart disease and opportunities for therapeutic intervention. Trends Cardiovasc Med, 25(5), 379-89.
  12. Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM (2014). Na+ channel function, regulation, structure, trafficking and sequestration. J Physiol, 593(6), 1347-60.
  13. Shaw RM (2014). Desmosomal hotspots, microtubule delivery, and cardiac arrhythmogenesis. Dev Cell, 31(2), 139-40.
  14. Smyth JW, Zhang SS, Sanchez JM, Lamouille S, Vogan JM, Hesketh GG, Hong T, Tomaselli GF, Shaw RM (2014). A 14-3-3 mode-1 binding motif initiates gap junction internalization during acute cardiac ischemia. Traffic, 15(6), 684-99.
  15. Hong T, Yang H, Zhang SS, Cho HC, Kalashnikova M, Sun B, Zhang H, Bhargava A, Grabe M, Olgin J, Gorelik J, Marbn E, Jan LY, Shaw RM (2014). Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. Nat Med, 20(6), 624-32.
  16. Zhang SS, Hong S, Klber AG, Lee LP, Shaw RM (2014). A micropatterning approach for imaging dynamic Cx43 trafficking to cell-cell borders. FEBS Lett, 588(8), 1439-45.
  17. Schumacher-Bass SM, Vesely ED, Zhang L, Ryland KE, McEwen DP, Chan PJ, Frasier CR, McIntyre JC, Shaw RM, Martens JR (2014). Role for myosin-V motor proteins in the selective delivery of Kv channel isoforms to the membrane surface of cardiac myocytes. Circ Res, 114(6), 982-92.
  18. Zhang SS, Shaw RM (2014). Trafficking highways to the intercalated disc: new insights unlocking the specificity of connexin 43 localization. Cell Commun Adhes, 21(1), 43-54.
  19. Samson SC, Ferrer T, Jou CJ, Sachse FB, Shankaran SS, Shaw RM, Chi NC, Tristani-Firouzi M, Yost HJ (2013). 3-OST-7 regulates BMP-dependent cardiac contraction. PLoS Biol, 11(12), e1001727.
  20. Smyth JW, Shaw RM (2013). Autoregulation of connexin43 gap junction formation by internally translated isoforms. Cell Rep, 5(3), 611-8.
  21. Shaw RM, Colecraft HM (2013). L-type calcium channel targeting and local signalling in cardiac myocytes. Cardiovasc Res, 98(2), 177-86.
  22. Gao D, Zhang L, Dhillon R, Hong TT, Shaw RM, Zhu J (2013). Dynasore protects mitochondria and improves cardiac lusitropy in Langendorff perfused mouse heart. PLoS ONE, 8(4), e60967.
  23. Zhang SS, Shaw RM (2012). Multilayered regulation of cardiac ion channels. Biochim Biophys Acta, 1833(4), 876-85.
  24. Cogswell R, McGlothlin D, Kobashigawa E, Shaw R, De Marco T (2012). Performance of the REVEAL model in WHO Group 2 to 5 pulmonary hypertension: application beyond pulmonary arterial hypertension. J Heart Lung Transplant, 32(3), 293-8.
  25. Cogswell R, Kobashigawa E, McGlothlin D, Shaw R, De Marco T (2012). Validation of the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) pulmonary hypertension prediction model in a unique population and utility in the prediction of long-term survival. J Heart Lung Transplant, 31(11), 1165-70.
  26. Hong TT, Cogswell R, James CA, Kang G, Pullinger CR, Malloy MJ, Kane JP, Wojciak J, Calkins H, Scheinman MM, Tseng ZH, Ganz P, De Marco T, Judge DP, Shaw RM (2012). Plasma BIN1 correlates with heart failure and predicts arrhythmia in patients with arrhythmogenic right ventricular cardiomyopathy. Heart Rhythm, 9(6), 961-7.
  27. Hong TT, Smyth JW, Chu KY, Vogan JM, Fong TS, Jensen BC, Fang K, Halushka MK, Russell SD, Colecraft H, Hoopes CW, Ocorr K, Chi NC, Shaw RM (2011). BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. Heart Rhythm, 9(5), 812-20.
  28. Smyth JW, Vogan JM, Buch PJ, Zhang SS, Fong TS, Hong TT, Shaw RM (2012). Actin cytoskeleton rest stops regulate anterograde traffic of connexin 43 vesicles to the plasma membrane. Circ Res, 110(7), 978-89.
  29. Smyth JW, Shaw RM (2011). The gap junction life cycle. Heart Rhythm, 9(1), 151-3.
  30. Smyth JW, Shaw RM (2012). Visualizing cardiac ion channel trafficking pathways. Methods Enzymol, 505, 187-202.
  31. Zhang SS, Kim KH, Rosen A, Smyth JW, Sakuma R, Delgado-Olgun P, Davis M, Chi NC, Puviindran V, Gaborit N, Sukonnik T, Wylie JN, Brand-Arzamendi K, Farman GP, Kim J, Rose RA, Marsden PA, Zhu Y, Zhou YQ, Miquerol L, Henkelman RM, Stainier DY, Shaw RM, Hui CC, Bruneau BG, Backx PH (2011). Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network. Proc Natl Acad Sci U S A, 108(33), 13576-81.
  32. Smyth JW, Shaw RM (2010). Forward trafficking of ion channels: what the clinician needs to know. Heart Rhythm, 7(8), 1135-40.
  33. Shaw RM, Rudy Y (2009). Cardiac muscle is not a uniform syncytium. Biophys J, 98(12), 3102-3; discussion 3104-5.
  34. Hong TT, Smyth JW, Gao D, Chu KY, Vogan JM, Fong TS, Jensen BC, Colecraft HM, Shaw RM (2010). BIN1 localizes the L-type calcium channel to cardiac T-tubules. PLoS Biol, 8(2), e1000312.
  35. Smyth JW, Hong TT, Gao D, Vogan JM, Jensen BC, Fong TS, Simpson PC, Stainier DY, Chi NC, Shaw RM (2009). Limited forward trafficking of connexin 43 reduces cell-cell coupling in stressed human and mouse myocardium. J Clin Invest, 120(1), 266-79.
  36. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, Srivastava D (2008). Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. Dev Cell, 16(2), 233-44.
  37. Smyth JW, Shaw RM (2008). Visualizing ion channel dynamics at the plasma membrane. Heart Rhythm, 5(6 Suppl), S7-11.
  38. Chi NC, Shaw RM, Jungblut B, Huisken J, Ferrer T, Arnaout R, Scott I, Beis D, Xiao T, Baier H, Jan LY, Tristani-Firouzi M, Stainier DY (2007). Genetic and physiologic dissection of the vertebrate cardiac conduction system. PLoS Biol, 6(5), e109.
  39. Saxena A, Fish JE, White MD, Yu S, Smyth JW, Shaw RM, DiMaio JM, Srivastava D (2008). Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation, 117(17), 2224-31.
  40. Chi NC, Shaw RM, De Val S, Kang G, Jan LY, Black BL, Stainier DY (2008). Foxn4 directly regulates tbx2b expression and atrioventricular canal formation. Genes Dev, 22(6), 734-9.
  41. Shaw RM, Fay AJ, Puthenveedu MA, von Zastrow M, Jan YN, Jan LY (2006). Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions. Cell, 128(3), 547-60.
  42. Ionescu-Zanetti C, Shaw RM, Seo J, Jan YN, Jan LY, Lee LP (2005). Mammalian electrophysiology on a microfluidic platform. Proc Natl Acad Sci U S A, 102(26), 9112-7.
  43. Viswanathan PC, Shaw RM, Rudy Y (1999). Effects of IKr and IKs heterogeneity on action potential duration and its rate dependence: a simulation study. Circulation, 99(18), 2466-74.
  44. Shaw RM, Rudy Y (1997). Ionic mechanisms of propagation in cardiac tissue. Roles of the sodium and L-type calcium currents during reduced excitability and decreased gap junction coupling. Circ Res, 81(5), 727-41.
  45. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia: a theoretical study of altered cell excitability and action potential duration. Cardiovasc Res, 35(2), 256-72.
  46. Shaw RM, Rudy Y (1997). Electrophysiologic effects of acute myocardial ischemia. A mechanistic investigation of action potential conduction and conduction failure. Circ Res, 80(1), 124-38.
  47. Rudy Y, Shaw RM (1997). Cardiac excitation: an interactive process of ion channels and gap junctions. Adv Exp Med Biol, 430, 269-79.
  48. Shaw RM, Rudy Y (1995). The vulnerable window for unidirectional block in cardiac tissue: characterization and dependence on membrane excitability and intercellular coupling. J Cardiovasc Electrophysiol, 6(2), 115-31.
  49. Clarke LP, Cullom SJ, Shaw R, Reece C, Penney BC, King MA, Silbiger M (1992). Bremsstrahlung imaging using the gamma camera: factors affecting attenuation. J Nucl Med, 33(1), 161-6.


  1. Hong T, Shaw RM (2018). Editorial commentary: Extracellular vesicles in cardiovascular diagnosis and therapy. Trends Cardiovasc Med, 29(6), 324-325.
  2. Shaw RM, Nikolova AP (2018). The Clinical Course of a Genetic Dilated Cardiomyopathy: Letting the Cat Out of the BAG3. J Am Coll Cardiol, 72(20), 2482-2484.
  3. Nikolova AP, Shaw RM (2018). Editorial commentary: Are cytokines ready for prime time? Insights from markers and trials. Trends Cardiovasc Med, 28(6), 380-381.
  4. Shaw RM, Nikolova AP (2017). A Surprising Noncanonical Role for Calcineurin in Pressure-Induced Cardiac Hypertrophy. J Am Coll Cardiol, 71(6), 668-669.
  5. Fu Y, Shaw RM (2017). CASAAV Technology to Examine Regulators of Heart Failure: Cause or Effect. Circ Res, 120(12), 1846-1848.
  6. Fu Y, Xiao S, Hong T, Shaw RM (2015). Cytoskeleton regulation of ion channels. Circulation, 131(8), 689-91.
  7. Shaw RM (2012). Reduced sodium channels in human ARVC. Heart Rhythm, 10(3), 420-1.