Wan-Lin Lo, PhD

Languages

  • English

Academic Information

  • Departments: Pathology - Assistant Professor
  • Divisions: Microbiology and Immunology

Email: wan-lin.lo@path.utah.edu

Education History

Type School Degree
Professional Medical Washington University School of Medicine in St. Louis
Immunology
Ph.D.
Fellowship Genomic Research Center, Academia Sinica
Immunology
Postbaccalaureate Research Fellow
Undergraduate National Taiwan University School of Medicine
Biochemistry
B.Pharm
Undergraduate National Taiwan University School of Medicine
Life Sciences (Zoology)
B.S.
Fellowship University of California, San Francisco
Immunology
Postdoctoral Fellow

Selected Publications

Journal Article

  1. Lo WL, Shah NH, Rubin SA, Zhang W, Horkova V, Fallahee IR, Stepanek O, Zon LI, Kuriyan J, Weiss A (2019). Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. Nat Immunol, 20(11), 1481-1493.
  2. Courtney AH, Shvets AA, Lu W, Griffante G, Mollenauer M, Horkova V, Lo WL, Yu S, Stepanek O, Chakraborty AK, Weiss A (2019). CD45 functions as a signaling gatekeeper in T cells. Sci Signal, 12(604).
  3. Lo WL, Shah NH, Ahsan N, Horkova V, Stepanek O, Salomon AR, Kuriyan J, Weiss A (2018). Lck promotes Zap70-dependent LAT phosphorylation by bridging Zap70 to LAT. Nat Immunol, 19(7), 733-741.
  4. Courtney AH, Lo WL, Weiss A (2017). TCR Signaling: Mechanisms of Initiation and Propagation. Trends Biochem Sci, 43(2), 108-123.
  5. Ransdell JL, Dranoff E, Lau B, Lo WL, Donermeyer DL, Allen PM, Nerbonne JM (2017). Loss of NavĪ²4-Mediated Regulation of Sodium Currents in Adult Purkinje Neurons Disrupts Firing and Impairs Motor Coordination and Balance. Cell Rep, 20(6), 1502.
  6. Persaud SP, Parker CR, Lo WL, Weber KS, Allen PM (2014). Intrinsic CD4+ T cell sensitivity and response to a pathogen are set and sustained by avidity for thymic and peripheral complexes of self peptide and MHC. Nat Immunol, 15(3), 266-74.
  7. Lo WL, Allen PM (2013). Self-peptides in TCR repertoire selection and peripheral T cell function. Curr Top Microbiol Immunol, 373, 49-67.
  8. Lo WL, Solomon BD, Donermeyer DL, Hsieh CS, Allen PM (2014). T cell immunodominance is dictated by the positively selecting self-peptide. eLife, 3, e01457.
  9. Lo WL, Allen PM (2012). Self-awareness: how self-peptide/MHC complexes are essential in the development of T cells. Mol Immunol, 55(2), 186-9.
  10. Lo WL, Donermeyer DL, Allen PM (2012). A voltage-gated sodium channel is essential for the positive selection of CD4(+) T cells. Nat Immunol, 13(9), 880-7.
  11. Huang CH, Chuang MH, Lo WL, Wu MS, Wu YH, Wu DC, Chiou SH (2011). Alkylhydroperoxide reductase of Helicobacter pylori as a biomarker for gastric patients with different pathological manifestations. Biochimie, 93(7), 1115-23.
  12. Morley SC, Wang C, Lo WL, Lio CW, Zinselmeyer BH, Miller MJ, Brown EJ, Allen PM (2010). The actin-bundling protein L-plastin dissociates CCR7 proximal signaling from CCR7-induced motility. J Immunol, 184(7), 3628-38.
  13. Lo WL, Felix NJ, Walters JJ, Rohrs H, Gross ML, Allen PM (2009). An endogenous peptide positively selects and augments the activation and survival of peripheral CD4+ T cells. Nat Immunol, 10(11), 1155-61.
  14. Lin YC, Kuo MW, Yu J, Kuo HH, Lin RJ, Lo WL, Yu AL (2008). c-Myb is an evolutionary conserved miR-150 target and miR-150/c-Myb interaction is important for embryonic development. Mol Biol Evol, 25(10), 2189-98.
  15. Lin YC, Hsieh LC, Kuo MW, Yu J, Kuo HH, Lo WL, Lin RJ, Yu AL, Li WH (2007). Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. Mol Biol Evol, 24(11), 2525-34.
  16. Chuang MH, Wu MS, Lo WL, Lin JT, Wong CH, Chiou SH (2006). The antioxidant protein alkylhydroperoxide reductase of Helicobacter pylori switches from a peroxide reductase to a molecular chaperone function. Proc Natl Acad Sci U S A, 103(8), 2552-7.

Conference Proceedings

  1. Ganti RS, Lo WL, McAffee DB, Groves JT, Weiss A, Chakraborty AK (2020). How the T cell signaling network processes information to discriminate between self and agonist ligands. Proceedings of the National Academy of Sciences of the United States of America.