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Kevin B. Jones, MD

Languages spoken: English, Spanish

Academic Information

Departments: Orthopaedics - Professor, Oncological Sciences - Adjunct Professor

Academic Office Information

Board Certification

  • American Board of Orthopaedic Surgery

Research Interests

  • Sarcoma, Synovial
  • Osteosarcoma
  • Mouse Models
  • Ewing's Sarcoma
  • Chondrosarcoma
  • Sarcoma
  • Soft Tissue Sarcomas
  • Sarcoma, Clear Cell

Kevin B. Jones, MD

Leader, Huntsman Cancer Institute Sarcoma Disease Center

Division Chief, Sarcoma, Department of Orthopaedics

Professor, Department of Orthopaedics and

Adjunct Professor of Oncological Sciences

As an orthopaedic surgeon specialized in the care of pediatric and adult patients with sarcoma, I see first-hand the limitations and frank failures of the currently available treatment options. Not only do we fail to cure far too many young patients with sarcomas, but the long-term effects of our treatments create other major challenges to the health of the survivors in the long term.

With protected time for basic investigation, I dedicate my entire laboratory to the study of pediatric and young adult fusion oncogene-associated sarcomas. In efforts always angling toward improved targeted therapies, we use mouse genetic models of sarcomagenesis to dissect pathways of importance to initiation and progression of tumors. This work utilizes conditional activation of translocation-associated fusion oncogenes as well as manipulation of additional modifying genes directed toward improved understanding of the conditions that promote or inhibit sarcomagenesis. This work has led to generous experience with comparative genomics and epigenomics.

The simple genetic changes that drive translocation-associated sarcomas make a strong argument for cancer being defined as a transcriptional state for cells, rather than a state of accumulated mutations or genetic losses and gains. The study of the epigenetic determinants of this transcriptional state in cells that harbor very few genetic code alterations has already revealed important knowledge that pertains to more complex genome cancer types as well as to transcriptional biology more generally.

I also believe firmly in the synergy possible in collaborative team science. Such efforts are required for progress toward improved treatments for rare malignancies that can never be studied with optimal efficacy in a silo. With such collaborative work as direct goal, I have participated in and assembled teams to work on pediatric sarcomas both within my institution and internationally.

Research Statement

With 80 percent protected time for academic pursuits, and an independent laboratory at the Huntsman Cancer Institute, I focus most of my research on dissecting the genetic and epigenetic underpinnings of sarcoma initiation. Although sarcomas are rare cancers, the tissues which give rise to sarcomas when they become cancerous are the predominant tissues in the human body, the muscles, tendons, bones, vessels, fat, etc. These tissues derive from mesenchyme or mesoderm. While many organ-based cancer cells gain some characteristics of mesenchyme or mesoderm as they become malignant, turning mesenchyme itself into cancer is much more difficult. The intrinsic resistance to transformation (the process of becoming cancerous) in mesenchyme has brought particular focus to any factor capable of overcoming that resistance and forming cancers from connective tissues.Thus, sarcomas--not only in spite of, but actually because of their low frequency in the general population--have played a central role in the fundamental discoveries of cancer biology. For example, radium dial painters developing osteosarcomas led to the discovery that radiation causes cancer. Oncogenes, the tumor causing genes, were discovered by study of a virus that caused sarcomas in birds. Tumor suppressor genes, the genes that when turned off lead to cancer, were discovered because families had too many sarcomas (Even two is way too common in any one family!) We therefore pursue sarcoma biology vigorously not only because we need to generate better treatment strategies for this horrible group of cancers that impacts young people disproportionately, but also because sarcoma will likely yet teach us much more about cancer biology in general, especially its beginnings.

Education History

Other Training Mario Capecchi Laboratory, University of Utah
Mentored Scientific Training-Mouse Genetic Modeling of Sarcoma
Fellowship Mount Sinai Hospital
Musculoskeletal Oncology
Residency University of Iowa Hospitals and Clinics
Orthopaedic Surgery
Professional Medical Johns Hopkins University
Undergraduate Harvard University
English and American Literature and Language

Selected Publications

  1. Bove JV, Webster F, Amary F, Baumhoer D, Bloem JLH, Bridge J, Cates JM, de Alava E, Dei Tos AP, Jones KB, Mahar A, Nielsen GP, Righi A, Wagner AJ, Yoshida A, Fletcher CD (2022). Datasets for the reporting of primary tumour in bone: recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathology.
  2. Stacchiotti S, Maria Frezza A, Demetri GD, Blay JY, Bajpai J, Baldi GG, Baldini EH, Benjamin RS, Bonvalot S, Bove JVMG, Callegaro D, Casali PG, DAngelo SP, Davis EJ, Dei Tos AP, Demicco EG, Desai J, Dileo P, Eriksson M, Gelderblom H, George S, Gladdy RA, Gounder MM, Gupta AA, Haas R, Hayes A, Hohenberger P, Jones KB, Jones RL, Kasper B, Kawai A, Kirsch DG, Kleinerman ES, Le Cesne A, Maestro R, Martin Broto J, Maki RG, Miah AB, Palmerini E, Patel SR, Raut CP, Razak ARA, Reed DR, Rutkowski P, Sanfilippo RG, Sbaraglia M, Schaefer IM, Strauss DC, Strauss SJ, Tap WD, Thomas DM, Trama A, Trent JC, van der Graaf WTA, van Houdt WJ, von Mehren M, Wilky BA, Fletcher CDM, Gronchi A, Miceli R, Wagner AJ (2022). Retrospective observational studies in ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society (CTOS) community of experts on the minimum requirements for the evaluation of activity of systemic treatments. [Review]. Cancer Treat Rev, 110, 102455.
  3. Brown JM, Rakoczy K, Tokson JH, Jones KB, Groundland JS (2022). Ewing sarcoma of the pelvis: Clinical features and overall survival(). Cancer Treat Res Commun, 33, 100634.
  4. Burns J, Brown JM, Jones KB, Huang PH (2022). The Cancer Genome Atlas: Impact and Future Directions in Sarcoma. [Review]. Surg Oncol Clin N Am, 31(3), 559-568.
  5. Himbert C, Hathaway CA, Daniels B, Salas K, Ashworth A, Gigic B, Lin T, Viskochil R, Kirchhoff AC, Grossman D, Ose J, Tward J, Scaife C, Figueiredo JC, Toriola AT, Beck A, Shibata D, Gonzalez BD, Matsen C, Christenson C, Ma DS, Colman H, Hunt JP, Jones KB, Lee CJ, Larson M, Onega T, Akerley WL, Li CI, Schneider M, Penedo FJ, Siegel EM, Tworoger SS, Ulrich CM, Peoples AR (2022). Factors associated with changes in exercise behaviors during the COVID-19 pandemic. Cancer Causes Control, 33(7), 939-950.
  6. Pires G, Moss WD, Luo J, Zhang R, Jones KB, Kwok AC, Agarwal JP (2022). Free Vascularized Fibula Salvage of Failed CPH in Pediatric Sarcoma Patients. Sarcoma, 2022, 6240293.
  7. Brashears CB, Prudner BC, Rathore R, Caldwell KE, Dehner CA, Buchanan JL, Lange SES, Poulin N, Sehn JK, Roszik J, Spitzer D, Jones KB, OKeefe RJ, Nielsen TO, Taylor EB, Held JM, Hawkins W, Van Tine BA (2022). Malic Enzyme 1 Absence in Synovial Sarcoma Shifts Antioxidant System Dependence and Increases Sensitivity to Ferroptosis Induction with ACXT3102. Clin Cancer Res, 28, 3573-3589.
  8. Peoples AR, Oswald LB, Ose J, Daniels B, Himbert C, Hathaway CA, Gigic B, Kirchhoff AC, Lin T, Grossman D, Tward J, Varghese TK Jr, Figueiredo JC, Toriola AT, Beck A, Scaife C, Shibata D, LaStayo P, Gonzalez B, Salas K, Ashworth A, Matsen C, Christenson C, Ma DS, Colman H, Hunt JP, Jones KB, Lee CJ, Larson M, Onega T, Akerley WL, Li CI, Schneider M, Penedo FJ, Siegel EM, Tworoger SS, Ulrich CM (2022). Impact of the COVID-19 pandemic on rural and urban cancer patients' experiences, health behaviors, and perceptions. J Rural Health, 38, 886-899.
  9. Guillen KP, Fujita M, Butterfield AJ, Scherer SD, Bailey MH, Chu Z, DeRose YS, Zhao L, Cortes-Sanchez E, Yang CH, Toner J, Wang G, Qiao Y, Huang X, Greenland JA, Vahrenkamp JM, Lum DH, Factor RE, Nelson EW, Matsen CB, Poretta JM, Rosenthal R, Beck AC, Buys SS, Vaklavas C, Ward JH, Jensen RL, Jones KB, Li Z, Oesterreich S, Dobrolecki LE, Pathi SS, Woo XY, Berrett KC, Wadsworth ME, Chuang JH, Lewis MT, Marth GT, Gertz J, Varley KE, Welm BE, Welm AL (2022). A human breast cancer-derived xenograft and organoid platform for drug discovery and precision oncology. Nat Cancer, 3(2), 232-250.
  10. Brown JM, Rakoczy K, Hart J, Jones KB, Groundland JS (2022). Presenting features and overall survival of chondrosarcoma of the pelvis. Cancer Treat Res Commun, 30, 100510.
  11. Groundland J, Brown JM, Monument M, Bernthal N, Jones KB, Randall RL (2021). What Are the Long-term Surgical Outcomes of Compressive Endoprosthetic Osseointegration of the Femur with a Minimum 10-year Follow-up Period? Clin Orthop Relat Res, 480, 539-548.
  12. Himbert C, Hathaway CA, Daniels B, Salas K, Ashworth A, Gigic B, Lin T, Viskochil R, Kirchhoff AC, Grossman D, Ose J, Tward J, Scaife C, Figueiredo JC, Toriola AT, Beck A, Shibata D, Gonzalez BD, Matsen C, Christenson C, Ma DS, Colman H, Hunt JP, Jones KB, Lee CJ, Larson M, Onega T, Akerley WL, Li CI, Schneider M, Penedo FJ, Siegel EM, Tworoger SS, Ulrich CM, Peoples AR (2021). Impact of the COVID-19 pandemic on exercise habits among cancer patients. United States.
  13. Kraus RD, Weil CR, Wells S, Tward JD, Groundland JS, Jones KB, Cannon DM (2021). Radiation Therapy in Conjunction With Surgical Stabilization of Impending or Pathologic Fractures Secondary to Metastasis: Is There a Difference Between Single and Multifraction Regimens? Adv Radiat Oncol, 7(2), 100795.
  14. Kim SK, Nguyen C, Jones KB, Tashjian RZ (2021). A genome-wide association study for shoulder impingement and rotator cuff disease. J Shoulder Elbow Surg, 30(9), 2134-2145.
  15. Stacchiotti S, Frezza AM, Blay JY, Baldini EH, Bonvalot S, Bove JVMG, Callegaro D, Casali PG, Chiang RC, Demetri GD, Demicco EG, Desai J, Eriksson M, Gelderblom H, George S, Gounder MM, Gronchi A, Gupta A, Haas RL, Hayes-Jardon A, Hohenberger P, Jones KB, Jones RL, Kasper B, Kawai A, Kirsch DG, Kleinerman ES, Le Cesne A, Lim J, Chirlaque Lpez MD, Maestro R, Marcos-Gragera R, Martin Broto J, Matsuda T, Mir O, Patel SR, Raut CP, Razak ARA, Reed DR, Rutkowski P, Sanfilippo RG, Sbaraglia M, Schaefer IM, Strauss DC, Sundby Hall K, Tap WD, Thomas DM, van der Graaf WTA, van Houdt WJ, Visser O, von Mehren M, Wagner AJ, Wilky BA, Won YJ, Fletcher CDM, Dei Tos AP, Trama A (2021). Ultra-rare sarcomas: A consensus paper from the Connective Tissue Oncology Society community of experts on the incidence threshold and the list of entities. Cancer, 127(16), 2934-2942.
  16. Panza E, Ozenberger BB, Straessler KM, Barrott JJ, Li L, Wang Y, Xie M, Boulet A, Titen SW, Mason CC, Lazar AJ, Ding L, Capecchi MR, Jones KB (2020). The clear cell sarcoma functional genomic landscape. J Clin Invest, 131(15).
  17. Kannan S, Lock I, Ozenberger BB, Jones KB (2021). Genetic drivers and cells of origin in sarcomagenesis. J Pathol, 254(4), 474-493.
  18. Groundland J, Brown J, Jones K, Randall RL (2021). Is osseous reattachment of the greater trochanter necessary compared to soft-tissue-only abductor repair in proximal femoral megaprosthesis reconstruction? J Surg Oncol, 124(1), 115-123.
  19. Li J, Mulvihill TS, Li L, Barrott JJ, Nelson ML, Wagner L, Lock IC, Pozner A, Lambert SL, Ozenberger BB, Ward MB, Grossmann AH, Liu T, Banito A, Cairns BR, Jones KB (2021). A Role for SMARCB1 in Synovial Sarcomagenesis Reveals That SS18-SSX Induces Canonical BAF Destruction. Cancer Discov, 11(10), 2620-2637.
  20. Abbasi AM, Hosein RC, Willis RN Jr, Lelkes VM, Jones KB, Agarwal JP (2020). Modified Rotationplasty as a Composite Free Flap for Femur and Thigh Reconstruction. World J Plast Surg, 10(2), 115-119.
  21. Serpico R, Brown J, Blank A, Jones K, Randall RL, Groundland J (2021). Metastasis of Osteosarcoma to the Abdomen: A Report of Two Cases and a Review of the Literature. Case Rep Oncol, 14(1), 647-658.
  22. Tashjian RZ, Kim SK, Roche MD, Jones KB, Teerlink CC (2020). Genetic variants associated with rotator cuff tearing utilizing multiple population-based genetic resources. J Shoulder Elbow Surg, 30(3), 520-531.
  23. Schneider P, Giglio V, Ghanem D, Wilson D, Turcotte R, Isler M, Mottard S, Miller B, Hayden J, Doung YC, Gundle K, Randall RL, Jones K, Vlez R, Ghert M (2021). Willingness of patients with sarcoma to participate in cancer surveillance research: a cross-sectional patient survey. BMJ Open, 11(2), e042742.
  24. Kim J, Light N, Subasri V, Young EL, Wegman-Ostrosky T, Barkauskas DA, Hall D, Lupo PJ, Patidar R, Maese LD, Jones K, Wang M, Tavtigian SV, Wu D, Shlien A, Telfer F, Goldenberg A, Skapek SX, Wei JS, Wen X, Catchpoole D, Hawkins DS, Schiffman JD, Khan J, Malkin D, Stewart DR (2021). Pathogenic Germline Variants in Cancer Susceptibility Genes in Children and Young Adults With Rhabdomyosarcoma. JCO Precis Oncol, 5.
  25. Nacev BA, Jones KB, Intlekofer AM, Yu JSE, Allis CD, Tap WD, Ladanyi M, Nielsen TO (2020). The epigenomics of sarcoma. Nat Rev Cancer, 20(10), 608-623.
  26. Tashjian RZ, Lock I, Granger EK, Wang Y, Lee Y, Chalmers PN, Jones KB (2020). Gene Expression in Torn Rotator Cuff Tendons Determined by RNA Sequencing. Orthop J Sports Med, 8(6), 2325967120927480.
  27. Blank AT, Larson BM, Shaw S, Wakefield CJ, King T, Jones KB, Randall RL (2020). National Comprehensive Cancer Network guidelines compliance of a sarcoma service: A retrospective review. World J Clin Oncol, 11(6), 389-396.
  28. Lambert SL, Jones KB (2020). SKP2 My Lou, My Darling. Cancer Res, 80(12), 2437-2438.
  29. Kirkham M, Kalivas A, Fatema K, Luelling S, Dubansky BH, Dubansky B, Jones KB, Barrott JJ (2020). Underlying Ossification Phenotype in a Murine Model of Metastatic Synovial Sarcoma. Int J Mol Sci, 21(7).
  30. Miller DT, Corts-Ciriano I, Pillay N, Hirbe AC, Snuderl M, Bui MM, Piculell K, Al-Ibraheemi A, Dickson BC, Hart J, Jones K, Jordan JT, Kim RH, Lindsay D, Nishida Y, Ullrich NJ, Wang X, Park PJ, Flanagan AM (2020). Genomics of MPNST (GeM) Consortium: Rationale and Study Design for Multi-Omic Characterization of NF1-Associated and Sporadic MPNSTs. Genes (Basel), 11(4).
  31. Blank AT, Shaw S, Wakefield CJ, Zhang Y, Liu WJ, Jones KB, Randall RL (2019). What factors influence patient experience in orthopedic oncology office visits? World J Clin Oncol, 11(3), 136-142.
  32. Abbott D, OBrien S, Farnham JM, Young EL, Yap J, Jones K, Lessnick SL, Randall RL, Schiffman JD, Cannon-Albright LA (2019). Increased risk for other cancers in individuals with Ewing sarcoma and their relatives. Cancer Med, 8(18), 7924-7930.
  33. Jones KB (2019). Dendritic Cells Drive Osteosarcomagenesis through Newly Identified Oncogene and Tumor Suppressor. Cancer Discov, 9(11), 1484-1486.
  34. Goodwin ML, Gundavda MK, Reddy R, Deogaonkar K, Lala M, Baliarsing A, Sciubba DM, Jones KB, Agarwal M (2019). Extracorporeal radiation and reimplantation: a safe and viable option for reconstruction after sacral tumor resection? Ann Transl Med, 7(10), 229.
  35. Blank AT, Wakefield C, Khalighi M, Jones KB, Randall RL (2020). Epithelioid Osteoblastoma of the Proximal Femur in a 19-Year-Old Female: A Case Report and Review of Literature. J Orthop Case Rep, 9(5), 74-77.
  36. Barrott JJ, Illum BE, Jin H, Hedberg ML, Wang Y, Grossmann A, Haldar M, Capecchi MR, Jones KB (2018). Paracrine osteoprotegerin and beta-catenin stabilization support synovial sarcomagenesis in periosteal cells. J Clin Invest, 128(1), 207-218.
  37. Kwok AC, Tatro E, Jones KB, Agarwal JP (2017). Pedicled Retrograde Fibula Flap for Ankle Reconstruction after Oncologic Resection of the Distal Fibula. Plast Reconstr Surg Glob Open, 5(2), e1232.
  38. Barrott JJ, Kafchinski LA, Jin H, Potter JW, Kannan SD, Kennedy R, Mosbruger T, Wang WL, Tsai JW, Araujo DM, Liu T, Capecchi MR, Lazar AJ, Jones KB (2016). Modeling synovial sarcoma metastasis in the mouse: PI3'-lipid signaling and inflammation. J Exp Med, 213(13), 2989-3005.
  39. Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR (2016). The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis. Oncogene, 35(38), 5021-32.
  40. Barrott JJ, Illum BE, Jin H, Zhu JF, Mosbruger T, Monument MJ, Smith-Fry K, Cable MG, Wang Y, Grossmann AH, Capecchi MR, Jones KB (2015). beta-catenin stabilization enhances SS18-SSX2-driven synovial sarcomagenesis and blocks the mesenchymal to epithelial transition. Oncotarget, 6(26), 22758-66.
  41. Quist T, Jin H, Zhu JF, Smith-Fry K, Capecchi MR, Jones KB (2015). The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse. Oncogene, 34(32), 4278-84.
  42. de Andrea CE, Zhu JF, Jin H, Bovee JV, Jones KB (2015). Cell cycle deregulation and mosaic loss of Ext1 drive peripheral chondrosarcomagenesis in the mouse and reveal an intrinsic cilia deficiency. J Pathol, 236(2), 210-8.
  43. Monument MJ, Bernthal NM, Bowles AJ, Jones KB, Randall RL (2015). What are the 5-year survivorship outcomes of compressive endoprosthetic osseointegration fixation of the femur? Clin Orthop Relat Res, 473(3), 883-90.
  44. Goodwin ML, Jin H, Straessler K, Smith-Fry K, Zhu JF, Monument MJ, Grossmann A, Randall RL, Capecchi MR, Jones KB (2014). Modeling alveolar soft part sarcomagenesis in the mouse: a role for lactate in the tumor microenvironment. Cancer Cell, 26(6), 851-862.
  45. Jones KB, Su L, Jin H, Lenz C, Randall RL, Underhill TM, Nielsen TO, Sharma S, Capecchi MR (2013). SS18-SSX2 and the mitochondrial apoptosis pathway in mouse and human synovial sarcomas. Oncogene, 32(18), 2365-71, 2375.e1-5.
  46. Jones KB, Datar M, Ravichandran S, Jin H, Jurrus E, Whitaker R, Capecchi MR (2013). Toward an understanding of the short bone phenotype associated with multiple osteochondromas. J Orthop Res, 31(4), 651-7.
  47. Straessler KM, Jones KB, Hu H, Jin H, van de Rijn M, Capecchi MR (2013). Modeling clear cell sarcomagenesis in the mouse: cell of origin differentiation state impacts tumor characteristics. Cancer Cell, 23(2), 215-27.
  48. Jones KB, Ferguson PC, Lam B, Biau DJ, Hopyan S, Deheshi B, Griffin AM, White LM, Wunder JS (2012). Effects of neoadjuvant chemotherapy on image-directed planning of surgical resection for distal femoral osteosarcoma. J Bone Joint Surg Am, 94(15), 1399-405.
  49. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Aqeilan RI (2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
  50. Jones KB, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo GJ, Lovat F, LeBlanc K, Palatini J, Randall RL, Volinia S, Stein GS, Croce CM, Lian JB, Ageilan RI (04/01/2012). miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res, 72(7), 1865-77.
  51. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO (2012). Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics. Cancer Cell, 21(3), 333-47.
  52. Jones KB, Schiffman JD, Kohlmann W, Randall RL, Lessnick SL, Cannon-Albright LA (2011). Complex genotype sarcomas display familial inheritance independent of known cancer predisposition syndromes. Cancer Epidemiol Biomarkers Prev, 20(5), 751-7.
  53. Israelsen RB, Illum BE, Crabtree S, Randall RL, Jones KB (2011). Extremity sarcoma surgery in younger children: ten years of patients ten years and under. Iowa Orthop J, 31, 145-53.
  54. Jones KB, Piombo V, Searby C, Kurriger G, Yang B, Grabellus F, Roughley PJ, Morcuende JA, Buckwalter JA, Capecchi MR, Vortkamp A, Sheffield VC (2010). A mouse model of osteochondromagenesis from clonal inactivation of Ext1 in chondrocytes. Proc Natl Acad Sci U S A, 107(5), 2054-9.
  55. Jones KB (2007). Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones [Skeletal Lesion Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group ]. J Bone Joint Surg Am, 89(10), 2113-2123.
  56. Jones KB, Buckwalter JA, Frassica FJ, McCarthy EF (2005). Intracortical chondroma: a report of two cases. Skeletal Radiol, 35(5), 298-301.

Global Impact

Education History

Type School Degree
Fellowship Mount Sinai Hospital
Musculoskeletal Oncology