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You Han Bae

You Han Bae, PhD

Languages spoken: Korean, English

Academic Information

Departments Primary -

Academic Office Information

Research Interests

  • Protein drug stabilization and controlled release
  • Polymeric systems for rechargeable cell delivery
  • Self-assembled super intelligent nanoparticulates for sensitive and resistant tumor targeting

You Han Bae, PhD, is a distinguished professor in the Department of Pharmaceutics & Pharmaceutical Chemistry and an Adjunct Professor in the Department of Bioengineering at the University of Utah. He is an investigator of the Huntsman Cancer Institute and a member of the Experimental Therapeutics Program.

Dr. Bae’s research interests include selective targeting of drugs to acidic extracellular environment, which often surrounds cancer cells. His lab also studies self-assembled super pH-sensitive nanoparticles as a potential drug delivery system for treating cancers which are multidrug resistant. He is also interested in developing oral delivery systems for protein biologics, genetic materials as well as most injectable small molecule drugs

Bae received a PhD from and completed postdoctoral training at the University of Utah.

Education History

Postdoctoral Fellowship University of Utah
Postdoctoral Fellow
University of Utah
Undergraduate Seoul National University

Selected Publications

Journal Article

  1. Kim KS, Park W, Hu J, Bae YH, Na K (2014). A cancer-recognizable MRI contrast agents using pH-responsive polymeric micelle. Biomaterials, 35(1), 337-43.
  2. Hu J, Miura S, Na K, Bae YH (2013). pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment. J Control Release, 172(1), 69-76.
  3. Yim H, Park SJ, Bae YH, Na K (2013). Biodegradable cationic nanoparticles loaded with an anticancer drug for deep penetration of heterogeneous tumours. Biomaterials, 34(31), 7674-82.
  4. Nichols JW, Bae YH (2012). Odyssey of a cancer nanoparticle: from injection site to site of action. Nano Today, 7(6), 606-618.
  5. Lee YJ, Kang HC, Hu J, Nichols JW, Jeon YS, Bae YH (2012). pH-Sensitive polymeric micelle-based pH probe for detecting and imaging acidic biological environments. Biomacromolecules, 13(9), 2945-51.
  6. Bae YH (2011). Apoptosis-targeted drug delivery. J Control Release, 154(3), 213.
  7. Bae YH, Park K (2011). Targeted drug delivery to tumors: myths, reality and possibility. J Control Release, 153(3), 198-205.
  8. Gao ZG, Tian L, Hu J, Park IS, Bae YH (2011). Prevention of metastasis in a 4T1 murine breast cancer model by doxorubicin carried by folate conjugated pH sensitive polymeric micelles. J Control Release, 152(1), 84-9.
  9. Mishra D, Kang HC, Bae YH (2011). Reconstitutable charged polymeric (PLGA)(2)-b-PEI micelles for gene therapeutics delivery. Biomaterials, 32(15), 3845-54.
  10. Kang HC, Samsonova O, Bae YH (2010). Trafficking microenvironmental pHs of polycationic gene vectors in drug-sensitive and multidrug-resistant MCF7 breast cancer cells. Biomaterials, 31(11), 3071-8.
  11. Kim D, Gao ZG, Lee ES, Bae YH (2009). In vivo evaluation of doxorubicin-loaded polymeric micelles targeting folate receptors and early endosomal pH in drug-resistant ovarian cancer. Mol Pharm, 6(5), 1353-62.
  12. Park KM, Kang HC, Cho JK, Chung IJ, Cho SH, Bae YH, Na K (2009). All-trans-retinoic acid (ATRA)-grafted polymeric gene carriers for nuclear translocation and cell growth control. Biomaterials, 30(13), 2642-52.
  13. Kim D, Lee ES, Oh KT, Gao ZG, Bae YH (2008). Doxorubicin-loaded polymeric micelle overcomes multidrug resistance of cancer by double-targeting folate receptor and early endosomal pH. Small, 4(11), 2043-50.
  14. Kim D, Lee ES, Park K, Kwon IC, Bae YH (2008). Doxorubicin loaded pH-sensitive micelle: antitumoral efficacy against ovarian A2780/DOXR tumor. Pharm Res, 25(9), 2074-82.
  15. Lee ES, Gao Z, Kim D, Park K, Kwon IC, Bae YH (2008). Super pH-sensitive multifunctional polymeric micelle for tumor pH(e) specific TAT exposure and multidrug resistance. J Control Release, 129(3), 228-36.
  16. Oh KT, Lee ES, Kim D, Bae YH (2008). L-histidine-based pH-sensitive anticancer drug carrier micelle: reconstitution and brief evaluation of its systemic toxicity. Int J Pharm, 358(1-2), 177-83.
  17. Sethuraman VA, Lee MC, Bae YH (2008). A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm Res, 25(3), 657-66.
  18. Qiu LY, Bae YH (2007). Self-assembled polyethylenimine-graft-poly(epsilon-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials, 28(28), 4132-42.
  19. Mohajer G, Lee ES, Bae YH (2007). Enhanced intercellular retention activity of novel pH-sensitive polymeric micelles in wild and multidrug resistant MCF-7 cells. Pharm Res, 24(9), 1618-27.
  20. Na K, Lee ES, Bae YH (2007). Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug release and in vitro cytotoxicity against MCF-7 cells. Bioconjug Chem, 18(5), 1568-74.


  1. Bae YH (2004). Ph-sensitive polymeric micelles for drug delivery.
  2. Bae YH (2003). Tumor Environment induced ligand expressing system.
  3. Bae YH (2003). Stabilization and controlled delivery of ionic biophamaceuticals.
  4. Bae YH (2002). Glucose biosensor. U.S. Patent No. 6475750. Washington, D.C.:U.S. Patent and Trademark Office.
  5. Bae YH (2001). Biosensor. U.S. Patent No. 6268161. Washington, D.C.:U.S. Patent and Trademark Office.
  6. Bae YH (2001). Method for synthesizing a composite of a conductive macromolecule and a protein. U.S. Patent No. 6326178. Washington, D.C.:U.S. Patent and Trademark Office.
  7. Bae YH (2001). pH-sensitive polymer containing sulfonamide and its synthesis method. U.S. Patent No. 6103865. Washington, D.C.:U.S. Patent and Trademark Office.
  8. Bae YH (1997). Thermosensitive biodegradable polymers based on poly(ether-ester)block copolymers. U.S. Patent No. 5702717. Washington, D.C.:U.S. Patent and Trademark Office.
  9. Bae YH (1996). pH and temperature sensitive terpolymers for oral drug delivery. U.S. Patent No. 5484610. Washington, D.C.:U.S. Patent and Trademark Office.
  10. Bae YH (1994). Gas pressure driven infusion system by hydrogel electrolysis. U.S. Patent No. 5354264. Washington, D.C.:U.S. Patent and Trademark Office.
  11. Bae YH (1993). Pulsatile drug delivery device using stimuli sensitive hydrogel. U.S. Patent No. 5226902. Washington, D.C.:U.S. Patent and Trademark Office.
  12. Bae YH (1993). Implantable and refillable biohybrid artificial pancreas. U.S. Patent No. 5262055. Washington, D.C.:U.S. Patent and Trademark Office.
  13. Bae YH (1990). Heterogeneous interpenetrating polymer networks for the controlled release of drugs. U.S. Patent No. 4931287. Washington, D.C.:U.S. Patent and Trademark Office.

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