We are proud to share that Dipayan Chaudhuri, MD, PhD, Associate Professor in the Division of Cardiovascular Medicine and Principal Investigator at the Nora Eccles Harrison Cardiovascular Research and Training Institute, has received a Notice of Award (NOA) for a $3.7 million R01 grant from the National Institutes of Health.

His project, titled “Mechanisms of mitochondria-driven hepatocyte injury,” will investigate how mitochondrial dysfunction contributes to hepatocyte injury, inflammation, and fibrosis during metabolic-associated steatohepatitis (MASH)—the most common liver disease worldwide. The findings from this work aim to advance understanding of disease mechanisms and potentially inform future therapeutic strategies.

The project will focus on a gene called EFHD1, which early research suggests may play a key role in how liver cells respond to metabolic stress. Dr. Chaudhuri and his team will study whether blocking this gene could help protect the liver from damage and reduce harmful inflammation. Their work could uncover a new pathway to develop much-needed therapies for MASH, a disease that currently has very few treatment options.

Dr. Chaudhuri earned his MD and PhD from the Johns Hopkins University School of Medicine, followed by residency training in internal medicine at the University of California, San Francisco.